Hemimegalencephaly

Common Name(s)

Hemimegalencephaly

Hemimegalencephaly is a rare malformation involving one side of the brain. It may occur alone or in association with epidermal nevus syndrome, Proteus syndrome, or Klippel-Trenaunay syndrome. It usually causes partial epilepsy, which may be treated with hemispherectomy. Hemimegalencephaly can also cause intellectual disability and impair normal movement on the side of the body opposite of the malformation. Symptoms range from mild to severe. The cause of this condition is not fully understood, but involves a disturbance of cells early in development and likely involves genes involved in patterning and symmetry.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemimegalencephaly" for support, advocacy or research.

Logo
Hemispherectomy Foundation

To Encourage and Support impacted families by connecting them with other families who have had a hemispherectomy or similar surgery To Work together with medical professionals to fund research into the cause of the diseases that lead to intractable epilepsy, hemispherectomy, and the surgery itself To Raise Money for camp fees, scholarships for trade schools and higher education as well as provide financial relief for struggling families

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemimegalencephaly" for support, advocacy or research.

Logo
Hemispherectomy Foundation

To Encourage and Support impacted families by connecting them with other families who have had a hemispherectomy or similar surgery To Work together with medical professionals to fund research into the cause of the diseases that lead to intractable epilepsy, hemispherectomy, and the surgery itself To Raise Money for camp fees, scholarships for trade schools and higher education as well as provide financial relief for struggling families

http://hemifoundation.intuitwebsites.com/welcome.html

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemimegalencephaly" returned 16 free, full-text research articles on human participants. First 3 results:

Happle-Tinschert syndrome: report of a case with hemimegalencephaly.
 

Author(s): Anıl Özgur, Gonca Çabuk, Rabia Arpacı, Kıymet Baz, Demet Katar

Journal: Korean J Radiol. ;15(4):534-7.

 

Happle-Tinschert syndrome is a disorder causing unilateral segmentally arranged basaloid follicular hamartomas of the skin associated with ipsilateral osseous, dental and cerebral abnormalities including tumors. Although a case with hemimegalencephaly was previously described, this ...

Last Updated: 23 Jul 2014

Go To URL
Hemimegalencephaly presenting as microcephaly.
 

Author(s): Vivek Kumar

Journal: Indian Pediatr. 2010 Sep;47(9):811.

 

Last Updated: 4 Nov 2010

Go To URL
Asymmetrical interhemispheric fiber tracts in patients with hemimegalencephaly on diffusion tensor magnetic resonance imaging.
 

Author(s): T Takahashi, N Sato, M Ota, Y Nakata, F Yamashita, Y Adachi, Y Saito, K Sugai, M Sasaki, T Asada

Journal: J Neuroradiol. 2009 Dec;36(5):249-54.

 

The internal structures of cerebral white matter in patients with hemimegalencephaly have not yet been investigated except for one, which evaluated aberrant fibers. We examined interhemispheric fiber tracts (FT) passing through the corpus callosum using magnetic resonance (MR) diffusion ...

Last Updated: 7 Dec 2009

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemimegalencephaly" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.