HELLP syndrome

Common Name(s)

HELLP syndrome

HELLP syndrome is a rare but serious illness in pregnancy. This condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). It can also start soon after the baby is delivered. HELLP stands for Hemolysis, Elevated Liver enzyme levels and a Low Platelet count. These problems are often found in women with this syndrome. These problems, along with the high blood pressure commonly found in association with HELLP syndrome, can lead to problems for both the mother and the baby.  Many cases of HELLP syndrome are associated with  preeclampsia or eclampsia.  The exact cause of HELLP syndrome remains unknown, making it difficult to determine which women will be affected.  Treatment may involve medication and/or delivery of the baby.    
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HELLP syndrome" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 20 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HELLP syndrome" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 20 May 2014

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General Support Organizations

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General Resources

Antiphospholipid Antibody Syndrome (APS) & Pregnancy

Antiphospholipid antibody syndrome (APS) is an illness that involve the immune system, and causes increased clotting of the blood. Normally antibodies, chemicals made by the immune system, are helpful in fighting germs or viral infections from outsid

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "HELLP syndrome" returned 71 free, full-text research articles on human participants. First 3 results:

Spectrum of neurological complications in HELLP syndrome.
 

Author(s): Birinder S Paul, Sunil K Juneja, Gunchan Paul, Shweta Gupta

Journal: Neurol India. ;61(5):467-71.

 

Hemolysis (H), elevated liver enzymes (EL), and low platelets (LP), HELLP syndrome is the extended spectrum of severe preeclampsia and is associated with high mortality. A large proportion of mortality can be attributed to catastrophic central nervous system events.

Last Updated: 22 Nov 2013

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Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome.
 

Author(s): K John, S Wielgosz, K Schulze-Osthoff, H Bantel, R Hass

Journal:

 

HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome represents a life-threatening pregnancy disorder with high fetal and maternal mortality, but its underlying molecular mechanisms remain unknown. Although apoptosis has been implicated in HELLP syndrome, its pathogenic ...

Last Updated: 25 Oct 2013

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Predictive value of umbilical artery Doppler for adverse perinatal outcome in patients with HELLP syndrome.
 

Author(s): Y Simsek, S Celen, A Simsek, N Danisman, L Mollamahmutoglu

Journal: Eur Rev Med Pharmacol Sci. 2013 Jun;17(12):1599-603.

 

In this study, we aimed to evaluate in a prospective design the importance of pathologic umbilical artery (UA) Doppler findings as a predictive marker for neonatal outcome in patients with HELLP syndrome.

Last Updated: 8 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "HELLP syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Inability to have children caused by recurrent HELLP syndrome in early pregnancies - implications for a review of literature.
 

Author(s): Małgorzata Pawelec, Andrzej Karmowski, Mikołaj Karmowski, Joanna Krzemieniewska, Aleksandra Kulczycka, Marian Stanisław Gabryś, Jerzy Koryś, Bohdan Gworys

Journal: Adv Clin Exp Med. ;22(5):753-8.

 

This review is inspired by a case of two pregnancies of the same patient complicated by HELLP syndrome, which suggests that there is a predisposition for the occurrence of preeclampsia and HELLP syndrome in early pregnancy. HELLP syndrome, uncommon below the 20th week and rarer still ...

Last Updated: 28 Nov 2013

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Molecular genetics of preeclampsia and HELLP syndrome - a review.
 

Author(s): Jiska Jebbink, Astrid Wolters, Febilla Fernando, Gijs Afink, Joris van der Post, Carrie Ris-Stalpers

Journal: Biochim. Biophys. Acta. 2012 Dec;1822(12):1960-9.

 

Preeclampsia is characterised by new onset hypertension and proteinuria and is a major obstetrical problem for both mother and foetus. Haemolysis elevated liver enzymes and low platelets (HELLP) syndrome is an obstetrical emergency and most cases occur in the presence of preeclampsia. ...

Last Updated: 5 Nov 2012

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[HELLP syndrome: report of 61 cases and literature review].
 

Author(s): Nisrine Mamouni, Hakima Bougern, Ali Derkaoui, Karima Bendahou, Samira Fakir, Chehrazad Bouchikhi, Hikmat Chaara, Abdelaziz Banani, Moulay Abdelilah Melhouf

Journal: Pan Afr Med J. 2012 ;11():30.

 

Last Updated: 19 Apr 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effectivity of Postpartum Dexamethasone for Women With Class I HELLP Syndrome
 

Status: Recruiting

Condition Summary: HELLP Syndrome

 

Last Updated: 28 May 2014

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The Preeclampsia Registry
 

Status: Recruiting

Condition Summary: Preeclampsia; Eclampsia; HELLP Syndrome; Toxemia; Hypertensive Disorder of Pregnancy

 

Last Updated: 18 Dec 2013

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Dexamethasone Efficacy in HELLP I Syndrome
 

Status: Recruiting

Condition Summary: HELLP Syndrome

 

Last Updated: 4 Jun 2010

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