HELLP syndrome

Common Name(s)

HELLP syndrome

HELLP syndrome is a rare but serious illness in pregnancy. This condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). It can also start soon after the baby is delivered. HELLP stands for Hemolysis, Elevated Liver enzyme levels and a Low Platelet count. These problems are often found in women with this syndrome. These problems, along with the high blood pressure commonly found in association with HELLP syndrome, can lead to problems for both the mother and the baby.  Many cases of HELLP syndrome are associated with  preeclampsia or eclampsia.  The exact cause of HELLP syndrome remains unknown, making it difficult to determine which women will be affected.  Treatment may involve medication and/or delivery of the baby.    
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HELLP syndrome" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HELLP syndrome" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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General Support Organizations

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General Resources

Antiphospholipid Antibody Syndrome (APS) & Pregnancy

Antiphospholipid antibody syndrome (APS) is an illness that involve the immune system, and causes increased clotting of the blood. Normally antibodies, chemicals made by the immune system, are helpful in fighting germs or viral infections from outsid

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "HELLP syndrome" returned 97 free, full-text research articles on human participants. First 3 results:

Anesthesia in pregnant women with HELLP syndrome: case report.
 

Author(s): Eduardo Barbin Zuccolotto, Eugenio Pagnussatt Neto, Glínia Cavalcante Nogueira, José Roberto Nociti

Journal: Braz J Anesthesiol. ;66(6):657-660.

 

HELLP syndrome, characterized by hemolysis, high levels of liver enzyme, and low platelet count, is an advanced clinical stage of pre-eclampsia, progressing to high maternal (24%) and perinatal (up 40%) mortality, despite childbirth care in a timely manner. The goal is to describe ...

Last Updated: 29 Oct 2016

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A comparison of the diagnostic utility of the sFlt-1/PlGF ratio versus PlGF alone for the detection of preeclampsia/HELLP syndrome.
 

Author(s): H Stepan, M Hund, M Gencay, B Denk, C Dinkel, W E Kaminski, P Wieloch, B Semus, T Meloth, L-A Dröge, S Verlohren

Journal: Hypertens Pregnancy. 2016 Aug;35(3):295-305.

 

The Elecsys(®) immunoassay sFlt-1/PlGF ratio and the Triage(®) PlGF assay were compared (in a prospective, multicenter, case-control study) for diagnosis of preeclampsia/hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome.

Last Updated: 9 Sep 2016

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Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome.
 

Author(s): Arthur J Vaught, Eleni Gavriilaki, Nancy Hueppchen, Karin Blakemore, Xuan Yuan, Sara M Seifert, Sarah York, Robert A Brodsky

Journal: Exp. Hematol.. 2016 May;44(5):390-8.

 

HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence and clinical similarities suggest a link to atypical hemolytic uremic syndrome, a disease of excessive activation of the alternative ...

Last Updated: 22 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "HELLP syndrome" returned 17 free, full-text review articles on human participants. First 3 results:

No Hypertensive Disorder of Pregnancy; No Preeclampsia-eclampsia; No Gestational Hypertension; No Hellp Syndrome. Vascular Disorder of Pregnancy Speaks for All.
 

Author(s): Yifru Berhan

Journal: Ethiop J Health Sci. 2016 Mar;26(2):177-86.

 

Hypertensive disorders complicate 5%-10% of pregnancies with increasing incidence mainly due to upward trends in obesity globally. In the last century, several terminologies have been introduced to describe the spectrum of this disease. The current and widely used classification of ...

Last Updated: 25 May 2016

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Corticosteroid Therapy for Management of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Meta-Analysis.
 

Author(s): Minhong Mao, Chen Chen

Journal:

 

BACKGROUND Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a severe condition of pregnancy that is associated with significant morbidity and mortality. Corticoteroid (CORT) therapy is common in the management of HELLP syndrome. This study evaluates the ...

Last Updated: 4 Dec 2015

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The management of the surgical complications of HELLP syndrome.
 

Author(s): S G Wilson, A D White, A L Young, M H Davies, S G Pollard

Journal: Ann R Coll Surg Engl. 2014 Oct;96(7):512-6.

 

Complications from HELLP (Haemolysis, Elevated Liver enzymes and Low Platelet) syndrome may present as an emergency to any surgeon. We review the ten-year experience of a tertiary hepatobiliary centre managing HELLP patients. Three selected cases are described to highlight our management ...

Last Updated: 23 Sep 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

General Anesthesia Versus Spinal Anesthesia in Patients of HELLP Syndrome
 

Status: Not yet recruiting

Condition Summary: HELLP Syndrome

 

Last Updated: 7 Apr 2017

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Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome
 

Status: Recruiting

Condition Summary: Preeclampsia; Superimposed Preeclampsia; HELLP Syndrome

 

Last Updated: 4 Jan 2017

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Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features
 

Status: Recruiting

Condition Summary: Pre-Eclampsia; HELLP Syndrome; Eclampsia

 

Last Updated: 14 Nov 2016

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