Heart Defects

Common Name(s)

Heart Defects

Congenital heart defects are problems with the heart’s structure that are present at birth. These problems may affect the overall shape of the heart, the heart’s valves, and the arteries and veins that carry blood to the heart or the body. Congenital heart defects affect 8 out of every 1,000 newborns, and more than 35,000 babies in the United States are born with a heart defect. Although the exact causes are unknown, heart defects may be linked to heredity factors, other genetic disorders (i.e. Down syndrome), and smoking during pregnancy. Severity ranges from defects with no symptoms to life-threatening defects. Many heart defects are easily fixed, although the more serious ones require attention throughout a person’s lifetime. Diagnosis may include a physical examination, X-rays, or various heart function tests. Defects can be treated with medication, surgery or through minimally invasive catheter procedures. In such procedures, a needle is used to insert a catheter into a vein or artery to repair the defect.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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General Resources

 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heart Defects" returned 409 free, full-text research articles on human participants. First 3 results:

Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome.
 

Author(s): Elisabeth E Mlynarski, Michael Xie, Deanne Taylor, Molly B Sheridan, Tingwei Guo, Silvia E Racedo, Donna M McDonald-McGinn, Eva W C Chow, Jacob Vorstman, Ann Swillen, Koen Devriendt, Jeroen Breckpot, Maria Cristina Digilio, Bruno Marino, Bruno Dallapiccola, Nicole Philip, Tony J Simon, Amy E Roberts, Małgorzata Piotrowicz, Carrie E Bearden, Stephan Eliez, Doron Gothelf, Karlene Coleman, Wendy R Kates, Marcella Devoto, Elaine Zackai, Damian Heine-Suñer, Elizabeth Goldmuntz, Anne S Bassett, Bernice E Morrow, Beverly S Emanuel,

Journal: Hum. Genet.. 2016 Mar;135(3):273-85.

 

The 22q11.2 deletion syndrome (22q11DS; velocardiofacial/DiGeorge syndrome; VCFS/DGS; MIM #192430; 188400) is the most common microdeletion syndrome. The phenotypic presentation of 22q11DS is highly variable; approximately 60-75 % of 22q11DS patients have been reported to have a congenital ...

Last Updated: 18 Feb 2016

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Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: Arrhythmias and Conduction Defects: A Scientific Statement From the American Heart Association and American College of Cardiology.
 

Author(s): Douglas P Zipes, Mark S Link, Michael J Ackerman, Richard J Kovacs, Robert J Myerburg, N A Mark Estes

Journal: J. Am. Coll. Cardiol.. 2015 Dec;66(21):2412-23.

 

Last Updated: 27 Nov 2015

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Systematic Tracking of Disrupted Modules Identifies Altered Pathways Associated with Congenital Heart Defects in Down Syndrome.
 

Author(s): Denghong Chen, Zhenhua Zhang, Yuxiu Meng

Journal:

 

This work aimed to identify altered pathways in congenital heart defects (CHD) in Down syndrome (DS) by systematically tracking the dysregulated modules of reweighted protein-protein interaction (PPI) networks.

Last Updated: 3 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heart Defects" returned 45 free, full-text review articles on human participants. First 3 results:

Detection of critical congenital heart defects: Review of contributions from prenatal and newborn screening.
 

Author(s): Richard S Olney, Elizabeth C Ailes, Marci K Sontag

Journal: Semin. Perinatol.. 2015 Apr;39(3):230-7.

 

In 2011, statewide newborn screening programs for critical congenital heart defects began in the United States, and subsequently screening has been implemented widely. In this review, we focus on data reports and collection efforts related to both prenatal diagnosis and newborn screening. ...

Last Updated: 18 May 2015

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Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence.
 

Author(s): Yu Feng, Di Yu, Lei Yang, Min Da, Zhiqi Wang, Yuan Lin, Bixian Ni, Song Wang, Xuming Mo

Journal:

 

The prognosis of children with congenital heart defects(CHDs) continues to improve with advancing surgical techniques; however, lack of information about modifiable risk factors for malformations in cardiovascular development impeded the prevention of CHDs. We investigated an association ...

Last Updated: 28 Apr 2015

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Diabetes and congenital heart defects: a systematic review, meta-analysis, and modeling project.
 

Author(s): Regina M Simeone, Owen J Devine, Jessica A Marcinkevage, Suzanne M Gilboa, Hilda Razzaghi, Barbara H Bardenheier, Andrea J Sharma, Margaret A Honein

Journal: Am J Prev Med. 2015 Feb;48(2):195-204.

 

Maternal pregestational diabetes (PGDM) is a risk factor for development of congenital heart defects (CHDs). Glycemic control before pregnancy reduces the risk of CHDs. A meta-analysis was used to estimate summary ORs and mathematical modeling was used to estimate population attributable ...

Last Updated: 20 Jan 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Basis of Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 5 Nov 2010

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Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Heterotaxy Syndrome; Congenital Heart Defects

 

Last Updated: 23 Feb 2016

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Pediatric Exercise With Congenital Heart Defects (Kinderturnen Mit Angeborenem Herzfehler)
 

Status: Recruiting

Condition Summary: Heart Defects, Congenital

 

Last Updated: 26 Aug 2008

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