Heart Defects

Common Name(s)

Heart Defects

Congenital heart defects are problems with the heart’s structure that are present at birth. These problems may affect the overall shape of the heart, the heart’s valves, and the arteries and veins that carry blood to the heart or the body. Congenital heart defects affect 8 out of every 1,000 newborns, and more than 35,000 babies in the United States are born with a heart defect. Although the exact causes are unknown, heart defects may be linked to heredity factors, other genetic disorders (i.e. Down syndrome), and smoking during pregnancy. Severity ranges from defects with no symptoms to life-threatening defects. Many heart defects are easily fixed, although the more serious ones require attention throughout a person’s lifetime. Diagnosis may include a physical examination, X-rays, or various heart function tests. Defects can be treated with medication, surgery or through minimally invasive catheter procedures. In such procedures, a needle is used to insert a catheter into a vein or artery to repair the defect.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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General Resources

 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heart Defects" returned 361 free, full-text research articles on human participants. First 3 results:

Congenital Heart Defects and Receipt of Special Education Services.
 

Author(s): Tiffany Riehle-Colarusso, Andrew Autry, Hilda Razzaghi, Coleen A Boyle, William T Mahle, Kim Van Naarden Braun, Adolfo Correa

Journal: Pediatrics. 2015 Sep;136(3):496-504.

 

We investigated the prevalence of receipt of special education services among children with congenital heart defects (CHDs) compared with children without birth defects.

Last Updated: 24 Sep 2015

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Hand-held Echo is Not So Handy in Everyone's Hands: Misdiagnosing Congenital Septal Defects in Patients with Heart Murmurs.
 

Author(s): Biljana Putniković, Ivan Stanković, Predrag Miličević, Miloje Marjanović, Aleksandar N Nešković

Journal: Srp Arh Celok Lek. ;143(5-6):322-5.

 

Echocardiography is a highly operator-dependant technique which requires adequate training and skills that are frequently not present, considering the widespread use of cardiovascular ultrasound. This could particularly be true for hand-held echo devices which made echocardiography ...

Last Updated: 11 Aug 2015

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State Legislation, Regulations, and Hospital Guidelines for Newborn Screening for Critical Congenital Heart Defects - United States, 2011-2014.
 

Author(s): Jill Glidewell, Richard S Olney, Cynthia Hinton, Jim Pawelski, Marci Sontag, Thalia Wood, James E Kucik, Rachel Daskalov, Jeff Hudson,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2015 Jun;64(23):625-30.

 

Critical congenital heart defects (CCHD) occur in approximately two of every 1,000 live births. Newborn screening provides an opportunity for reducing infant morbidity and mortality. In September 2011, the U.S. Department of Health and Human Services (HHS) Secretary endorsed the recommendation ...

Last Updated: 19 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heart Defects" returned 42 free, full-text review articles on human participants. First 3 results:

Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence.
 

Author(s): Yu Feng, Di Yu, Lei Yang, Min Da, Zhiqi Wang, Yuan Lin, Bixian Ni, Song Wang, Xuming Mo

Journal:

 

The prognosis of children with congenital heart defects(CHDs) continues to improve with advancing surgical techniques; however, lack of information about modifiable risk factors for malformations in cardiovascular development impeded the prevention of CHDs. We investigated an association ...

Last Updated: 28 Apr 2015

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Diabetes and congenital heart defects: a systematic review, meta-analysis, and modeling project.
 

Author(s): Regina M Simeone, Owen J Devine, Jessica A Marcinkevage, Suzanne M Gilboa, Hilda Razzaghi, Barbara H Bardenheier, Andrea J Sharma, Margaret A Honein

Journal: Am J Prev Med. 2015 Feb;48(2):195-204.

 

Maternal pregestational diabetes (PGDM) is a risk factor for development of congenital heart defects (CHDs). Glycemic control before pregnancy reduces the risk of CHDs. A meta-analysis was used to estimate summary ORs and mathematical modeling was used to estimate population attributable ...

Last Updated: 20 Jan 2015

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Array comparative genomic hybridization and fetal congenital heart defects: a systematic review and meta-analysis.
 

Author(s): F A R Jansen, Y J Blumenfeld, A Fisher, J M Cobben, A O Odibo, A Borrell, M C Haak

Journal: Ultrasound Obstet Gynecol. 2015 Jan;45(1):27-35.

 

Array comparative genomic hybridization (aCGH) is a molecular cytogenetic technique that is able to detect the presence of copy number variants (CNVs) within the genome. The detection rate of imbalances by aCGH compared to standard karyotyping and 22q11 microdeletion analysis by fluorescence ...

Last Updated: 5 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Basis of Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 5 Nov 2010

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Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Heterotaxy Syndrome; Congenital Heart Defects

 

Last Updated: 30 Apr 2015

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Pediatric Exercise With Congenital Heart Defects (Kinderturnen Mit Angeborenem Herzfehler)
 

Status: Recruiting

Condition Summary: Heart Defects, Congenital

 

Last Updated: 26 Aug 2008

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