Hantavirus Pulmonary Syndrome

Common Name(s)

Hantavirus Pulmonary Syndrome

Hantavirus pulmonary syndrome (HPS) is a severe, respiratory disease caused by infection with a hantavirus. People can become infected with a hantavirus through contact with hantavirus-infected rodents or their saliva, urine and/or droppings. Early symptoms universally include fatigue, fever and muscle aches (especially in the thighs, hips, and/or back), and sometimes include headaches, dizziness, chills, and abdominal problems such as nausea, vomiting, diarrhea, and pain. Later symptoms of the syndrome occur 4 to 10 days after initial onset and include coughing and shortness of breath. HPS can be fatal; approximately 38% of individuals with HPS do not survive. There is no cure or specific treatment for HPS, but early diagnosis and treatment in intensive care may increase the chance of recovery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hantavirus Pulmonary Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hantavirus Pulmonary Syndrome" returned 111 free, full-text research articles on human participants. First 3 results:

Hantavirus pulmonary syndrome, Southern Chile, 1995-2012.
 

Author(s): Raúl Riquelme, María Luisa Rioseco, Lorena Bastidas, Daniela Trincado, Mauricio Riquelme, Hugo Loyola, Francisca Valdivieso

Journal: Emerging Infect. Dis.. 2015 Apr;21(4):562-8.

 

Hantavirus is endemic to the Region de Los Lagos in southern Chile; its incidence is 8.5 times higher in the communes of the Andean area than in the rest of the region. We analyzed the epidemiologic aspects of the 103 cases diagnosed by serology and the clinical aspects of 80 hospitalized ...

Last Updated: 30 Mar 2015

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DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome.
 

Author(s): Jay W Hooper, Rebecca L Brocato, Steven A Kwilas, Christopher D Hammerbeck, Matthew D Josleyn, Michael Royals, John Ballantyne, Hua Wu, Jin-an Jiao, Hiroaki Matsushita, Eddie J Sullivan

Journal: Sci Transl Med. 2014 Nov;6(264):264ra162.

 

Polyclonal immunoglobulin-based medical products have been used successfully to treat diseases caused by viruses for more than a century. We demonstrate the use of DNA vaccine technology and transchromosomal bovines (TcBs) to produce fully human polyclonal immunoglobulins (IgG) with ...

Last Updated: 27 Nov 2014

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Novel camelid antibody fragments targeting recombinant nucleoprotein of Araucaria hantavirus: a prototype for an early diagnosis of Hantavirus Pulmonary Syndrome.
 

Author(s): Soraya S Pereira, Leandro S Moreira-Dill, Michelle S S Morais, Nidiane D R Prado, Marcos L Barros, Andrea C Koishi, Giovanny A C A Mazarrotto, Giselle M Gonçalves, Juliana P Zuliani, Leonardo A Calderon, Andreimar M Soares, Luiz H Pereira da Silva, Claudia N Duarte dos Santos, Carla F C Fernandes, Rodrigo G Stabeli

Journal:

 

In addition to conventional antibodies, camelids produce immunoglobulins G composed exclusively of heavy chains in which the antigen binding site is formed only by single domains called VHH. Their particular characteristics make VHHs interesting tools for drug-delivery, passive immunotherapy ...

Last Updated: 23 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hantavirus Pulmonary Syndrome" returned 10 free, full-text review articles on human participants. First 3 results:

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects.
 

Author(s): Vitor Laerte Pinto Junior, Amani Moura Hamidad, Dalcy de Oliveira Albuquerque Filho, Vitorino Modesto dos Santos

Journal:

 

Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, ...

Last Updated: 12 Feb 2014

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The Syrian hamster model of hantavirus pulmonary syndrome.
 

Author(s): David Safronetz, Hideki Ebihara, Heinz Feldmann, Jay W Hooper

Journal: Antiviral Res.. 2012 Sep;95(3):282-92.

 

Hantavirus pulmonary syndrome (HPS) is a relatively rare, but frequently fatal disease associated with New World hantaviruses, most commonly Sin Nombre and Andes viruses in North and South America, respectively. It is characterized by fever and the sudden, rapid onset of severe respiratory ...

Last Updated: 22 Aug 2012

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Treatment of hantavirus pulmonary syndrome.
 

Author(s): Colleen B Jonsson, Jay Hooper, Gregory Mertz

Journal: Antiviral Res.. 2008 Apr;78(1):162-9.

 

Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the ...

Last Updated: 18 Mar 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnostic of Puumala Virus Infection in France
 

Status: Recruiting

Condition Summary: Nephropathia Epidemica; Hemorrhagic Fever With Renal Syndrome

 

Last Updated: 22 Apr 2016

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Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever
 

Status: Recruiting

Condition Summary: Hemorrhagic Fever With Renal Syndrome

 

Last Updated: 30 Oct 2015

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