Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 417 free, full-text research articles on human participants. First 3 results:

Impact of telomere length on survival in classic and variant hairy cell leukemia.
 

Author(s): Evgeny Arons, Hong Zhou, Daniel C Edelman, Allison Gomez, Seth M Steinberg, David Petersen, Yonghong Wang, Paul S Meltzer, Robert J Kreitman

Journal: Leuk. Res.. 2015 Dec;39(12):1360-6.

 

Telomeres, which protect the ends of chromosomes, are shortened in several hematologic malignancies, often with adverse prognostic implications, but their effect on prognosis of classic and variant hairy cell leukemia (HCL and HCLv) has not been reported. HCL/HCLv genomic DNA from ...

Last Updated: 25 Nov 2015

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Complete recovery of pyoderma gangrenosum after successful treatment of underlying hairy cell leukemia with cladribine.
 

Author(s): Anıl Tombak, Sinan Aygün, Ebru Serinsöz, Eyüp Naci Tiftik

Journal: Korean J. Intern. Med.. 2015 Sep;30(5):739-41.

 

Last Updated: 10 Sep 2015

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Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.
 

Author(s): Enrico Tiacci, Jae H Park, Luca De Carolis, Stephen S Chung, Alessandro Broccoli, Sasinya Scott, Francesco Zaja, Sean Devlin, Alessandro Pulsoni, Young R Chung, Michele Cimminiello, Eunhee Kim, Davide Rossi, Richard M Stone, Giovanna Motta, Alan Saven, Marzia Varettoni, Jessica K Altman, Antonella Anastasia, Michael R Grever, Achille Ambrosetti, Kanti R Rai, Vincenzo Fraticelli, Mario E Lacouture, Angelo M Carella, Ross L Levine, Pietro Leoni, Alessandro Rambaldi, Franca Falzetti, Stefano Ascani, Monia Capponi, Maria P Martelli, Christopher Y Park, Stefano A Pileri, Neal Rosen, Robin Foà, Michael F Berger, Pier L Zinzani, Omar Abdel-Wahab, Brunangelo Falini, Martin S Tallman

Journal: N. Engl. J. Med.. 2015 Oct;373(18):1733-47.

 

BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed the safety and activity of the oral BRAF inhibitor vemurafenib in patients with hairy-cell leukemia that had relapsed after treatment with a purine analogue or who had disease that was refractory to purine analogues.

Last Updated: 29 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 20 free, full-text review articles on human participants. First 3 results:

Hairy cell leukemia: Past, present and future.
 

Author(s): Bartlomiej M Getta, Jae H Park, Martin S Tallman

Journal: Best Pract Res Clin Haematol. 2015 Dec;28(4):269-72.

 

This brief review highlights the sequence of therapeutic milestones and advances in our understanding of the biology of hairy cell leukemia (HCL) with a focus on recent molecular findings and how these may be applied to improve disease outcomes in the future. Targeted therapy is discussed ...

Last Updated: 29 Nov 2015

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Immunoconjugates in the management of hairy cell leukemia.
 

Author(s): Robert J Kreitman, Ira Pastan

Journal: Best Pract Res Clin Haematol. 2015 Dec;28(4):236-45.

 

Hairy cell leukemia (HCL) is an indolent B-cell malignancy effectively treated but not often cured by purine analog therapy; after multiple courses of purine analogs, patients can become purine analog resistant and in need of alternative therapies. Complete remission to single-agent ...

Last Updated: 29 Nov 2015

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Hairy cell leukemia: Update on molecular profiling and therapeutic advances.
 

Author(s): Michael R Grever, James S Blachly, Leslie A Andritsos

Journal: Blood Rev.. 2014 Sep;28(5):197-203.

 

Hairy cell leukemia was initially described as a clinicopathologic entity more than 50 years ago. We have subsequently discovered that HCL is really at least two diseases: classical HCL and the hairy cell leukemia variant. The former is among a small group of cancers exceptional for ...

Last Updated: 30 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 25 Oct 2016

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Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 1 Dec 2016

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