Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 291 free, full-text research articles on human participants. First 3 results:

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity.
 

Author(s): Valentina Pettirossi, Alessia Santi, Elisa Imperi, Guido Russo, Alessandra Pucciarini, Barbara Bigerna, Gianluca Schiavoni, Elisabetta Fortini, Ariele Spanhol-Rosseto, Paolo Sportoletti, Roberta Mannucci, Maria Paola Martelli, Ludger Klein-Hitpass, Brunangelo Falini, Enrico Tiacci

Journal: Blood. 2015 Feb;125(8):1207-16.

 

Hairy cell leukemia (HCL) shows unique clinicopathological and biological features. HCL responds well to purine analogs but relapses are frequent and novel therapies are required. BRAF-V600E is the key driver mutation in HCL and distinguishes it from other B-cell lymphomas, including ...

Last Updated: 21 Feb 2015

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Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia.
 

Author(s): Xuan J Wang, Annette Kim, Shaoying Li

Journal:

 

Hairy cell leukemia (HCL) is usually diagnosed by morphology and flow cytometry studies. However, it is challenging sometimes to distinguish HCL from its mimics. Recently, the BRAF V600E mutation has been described as a disease-defining molecular marker for HCL which is present in ...

Last Updated: 14 Aug 2014

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Chance identification of synchronous hairy cell leukemia and plasma cell myeloma in a potential HSC donor.
 

Author(s): Xiangrong Zhao, Irina Maric

Journal: Blood. 2014 Jun;123(24):3694.

 

Last Updated: 22 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 13 free, full-text review articles on human participants. First 3 results:

Hairy cell leukemia: Update on molecular profiling and therapeutic advances.
 

Author(s): Michael R Grever, James S Blachly, Leslie A Andritsos

Journal: Blood Rev.. 2014 Sep;28(5):197-203.

 

Hairy cell leukemia was initially described as a clinicopathologic entity more than 50 years ago. We have subsequently discovered that HCL is really at least two diseases: classical HCL and the hairy cell leukemia variant. The former is among a small group of cancers exceptional for ...

Last Updated: 30 Aug 2014

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Update on the biology and treatment options for hairy cell leukemia.
 

Author(s): Preetesh Jain, Naveen Pemmaraju, Farhad Ravandi

Journal: Curr Treat Options Oncol. 2014 Jun;15(2):187-209.

 

Hairy cell leukemia (HCL) is an uncommon chronic leukemia of mature B cells. Leukemic B cells of HCL exhibit a characteristic morphology and immunophenotype and coexpress multiple clonally related immunoglobulin isotypes. Precise diagnosis and detailed workup is essential, because ...

Last Updated: 6 Jun 2014

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Immunoconjugates and new molecular targets in hairy cell leukemia.
 

Author(s): Robert J Kreitman

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():660-6.

 

Hairy cell leukemia (HCL) is a B-cell malignancy that in its classic form is exquisitely sensitive to single-agent purine analog therapy, but that is associated in many patients with late relapse and eventual purine analog resistance. Minimal residual disease, which is present in ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia; Hairy Cell Leukemia Variant

 

Last Updated: 16 Jul 2015

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LMB-2 to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 31 Mar 2015

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Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 17 Jun 2015

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