Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 287 free, full-text research articles on human participants. First 3 results:

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity.
 

Author(s): Valentina Pettirossi, Alessia Santi, Elisa Imperi, Guido Russo, Alessandra Pucciarini, Barbara Bigerna, Gianluca Schiavoni, Elisabetta Fortini, Ariele Spanhol-Rosseto, Paolo Sportoletti, Roberta Mannucci, Maria Paola Martelli, Ludger Klein-Hitpass, Brunangelo Falini, Enrico Tiacci

Journal: Blood. 2015 Feb;125(8):1207-16.

 

Hairy cell leukemia (HCL) shows unique clinicopathological and biological features. HCL responds well to purine analogs but relapses are frequent and novel therapies are required. BRAF-V600E is the key driver mutation in HCL and distinguishes it from other B-cell lymphomas, including ...

Last Updated: 21 Feb 2015

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[Detection of BRAF V600E mutation in hairy cell leukemia by high- resolution melting analysis].
 

Author(s): Yanru Zhang, Huimin Liu, Junyuan Qi, Wei Liu, Lugui Qiu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Mar;35(3):207-9.

 

To explore the feasibility and diagnostic implication of BRAF V600E mutation identified by high-resolution melting (HRM) assay in patients with hairy cell leukemia (HCL).

Last Updated: 26 Mar 2014

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Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes.
 

Author(s): Nicola J Weston-Bell, Francesco Forconi, Hanneke C Kluin-Nelemans, Surinder S Sahota

Journal:

 

A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated. Typical Hairy Cell Leukemia (HCL) is a rare B-cell tumor, and unique in expressing multiple surface immunoglobulin ...

Last Updated: 5 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 11 free, full-text review articles on human participants. First 3 results:

Immunoconjugates and new molecular targets in hairy cell leukemia.
 

Author(s): Robert J Kreitman

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():660-6.

 

Hairy cell leukemia (HCL) is a B-cell malignancy that in its classic form is exquisitely sensitive to single-agent purine analog therapy, but that is associated in many patients with late relapse and eventual purine analog resistance. Minimal residual disease, which is present in ...

Last Updated: 12 Dec 2012

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The microenvironment in hairy cell leukemia: pathways and potential therapeutic targets.
 

Author(s): Jan A Burger, Mariela Sivina, Farhad Ravandi

Journal: Leuk. Lymphoma. 2011 Jun;52 Suppl 2():94-8.

 

Hairy cell leukemia (HCL) cells accumulate and proliferate in the spleen and the bone marrow. In these tissue compartments, HCL cells interact with accessory cells, matrix proteins, and various cyctokines, collectively referred to as the 'microenvironment.' Surface receptors expressed ...

Last Updated: 23 May 2011

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Chemo-immunotherapy for hairy cell leukemia.
 

Author(s): Farhad Ravandi

Journal: Leuk. Lymphoma. 2011 Jun;52 Suppl 2():72-4.

 

With the introduction of the nucleoside analogs cladribine and pentostatin the treatment of patients with hairy cell leukemia (HCL) has been revolutionized, and the majority of patients achieve a long-lasting complete remission with rare patients ever needing the traditional treatment ...

Last Updated: 23 May 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia; Hairy Cell Leukemia Variant

 

Last Updated: 9 Apr 2015

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LMB-2 to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 31 Mar 2015

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Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 2 May 2014

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