Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 417 free, full-text research articles on human participants. First 3 results:

Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens.
 

Author(s): Kazuya Okada, Akane Kunitomi, Kazuya Sakai, Hiroyuki Muranushi, Yusuke Okamoto, Taku Tsukamoto, Hiroyuki Sugiura, Hiroyuki Matsui, Tomoyasu Jo, Tomoaki Ueda, Tatsuhito Onishi, Masaru Ide, Shinya Kimura, Kenji Notohara, Yasunori Ueda

Journal: Intern. Med.. 2015 ;54(11):1397-402.

 

A 47-year-old woman with pancytopenia, excessive systemic lymphadenopathy and splenomegaly was referred to our hospital. The peripheral blood (PB) smear findings indicated neutropenia with lymphoid cells exhibiting hairy projections, while the histological findings of the cervical ...

Last Updated: 1 Jun 2015

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Accurate flow cytometric gating of the large lymphocyte region is a powerful screening method for detecting hairy cell leukemia presenting with a low tumor burden.
 

Author(s): Hajime Yasuda, Miyuki Tsutsui, Masaru Tanaka, Marito Araki, Soji Morishita, Makoto Sasaki, Akimichi Ohsaka, Norio Komatsu

Journal: Intern. Med.. 2015 ;54(10):1287-9.

 

Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia. Making an accurate diagnosis is crucial, as treatment with the purine analogues cladribine and pentostatin brings about durable complete remission in the majority of patients. Surface kappa ...

Last Updated: 19 May 2015

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Hairy cell leukemia with ascites and coexistent histoplasmosis.
 

Author(s): Neeraj Arora, Aroonima Mishra, Poonam Santra, Reena Nair

Journal: Indian J Pathol Microbiol. ;58(1):125-6.

 

Last Updated: 12 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 19 free, full-text review articles on human participants. First 3 results:

Hairy cell leukemia: Update on molecular profiling and therapeutic advances.
 

Author(s): Michael R Grever, James S Blachly, Leslie A Andritsos

Journal: Blood Rev.. 2014 Sep;28(5):197-203.

 

Hairy cell leukemia was initially described as a clinicopathologic entity more than 50 years ago. We have subsequently discovered that HCL is really at least two diseases: classical HCL and the hairy cell leukemia variant. The former is among a small group of cancers exceptional for ...

Last Updated: 30 Aug 2014

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Update on the biology and treatment options for hairy cell leukemia.
 

Author(s): Preetesh Jain, Naveen Pemmaraju, Farhad Ravandi

Journal: Curr Treat Options Oncol. 2014 Jun;15(2):187-209.

 

Hairy cell leukemia (HCL) is an uncommon chronic leukemia of mature B cells. Leukemic B cells of HCL exhibit a characteristic morphology and immunophenotype and coexpress multiple clonally related immunoglobulin isotypes. Precise diagnosis and detailed workup is essential, because ...

Last Updated: 6 Jun 2014

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Immunoconjugates and new molecular targets in hairy cell leukemia.
 

Author(s): Robert J Kreitman

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():660-6.

 

Hairy cell leukemia (HCL) is a B-cell malignancy that in its classic form is exquisitely sensitive to single-agent purine analog therapy, but that is associated in many patients with late relapse and eventual purine analog resistance. Minimal residual disease, which is present in ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia; Hairy Cell Leukemia Variant

 

Last Updated: 25 Jan 2016

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LMB-2 to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 23 Jan 2016

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Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 17 Jun 2015

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