Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 423 free, full-text research articles on human participants. First 3 results:

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.
 

Author(s): Enrico Tiacci, Jae H Park, Luca De Carolis, Stephen S Chung, Alessandro Broccoli, Sasinya Scott, Francesco Zaja, Sean Devlin, Alessandro Pulsoni, Young R Chung, Michele Cimminiello, Eunhee Kim, Davide Rossi, Richard M Stone, Giovanna Motta, Alan Saven, Marzia Varettoni, Jessica K Altman, Antonella Anastasia, Michael R Grever, Achille Ambrosetti, Kanti R Rai, Vincenzo Fraticelli, Mario E Lacouture, Angelo M Carella, Ross L Levine, Pietro Leoni, Alessandro Rambaldi, Franca Falzetti, Stefano Ascani, Monia Capponi, Maria P Martelli, Christopher Y Park, Stefano A Pileri, Neal Rosen, Robin Foà, Michael F Berger, Pier L Zinzani, Omar Abdel-Wahab, Brunangelo Falini, Martin S Tallman

Journal: N. Engl. J. Med.. 2015 Oct;373(18):1733-47.

 

BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed the safety and activity of the oral BRAF inhibitor vemurafenib in patients with hairy-cell leukemia that had relapsed after treatment with a purine analogue or who had disease that was refractory to purine analogues.

Last Updated: 29 Oct 2015

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New mutation in hairy cell leukemia.
 

Author(s): Tadeusz Robak, Piotr Smolewski

Journal: Blood. 2015 Aug;126(8):930-1.

 

In this issue of Blood, Dietrich et al make the first observation of the presence of deleterious CDKN1B mutation in 16% of patients with hairy cell leukemia (HCL). Furthermore, in the majority of patients, the CDKN1B mutation was clonal, suggesting that this mutation plays a role ...

Last Updated: 21 Aug 2015

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A case of hairy cell leukemia variant.
 

Author(s): Amelia Maria Găman, Camelia Marioara Dobrea, Mihnea Alexandru Găman

Journal: Rom J Morphol Embryol. 2015 ;56(2):553-6.

 

Hairy cell leukemia variant (HCLv) is a rare B-cell chronic lymphoproliferative disorder with features of the classic HCL but presenting some particularities, a poor response to conventional therapy of classic HCL and a more aggressive course of disease with shorter survival than ...

Last Updated: 21 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 18 free, full-text review articles on human participants. First 3 results:

Hairy cell leukemia: Update on molecular profiling and therapeutic advances.
 

Author(s): Michael R Grever, James S Blachly, Leslie A Andritsos

Journal: Blood Rev.. 2014 Sep;28(5):197-203.

 

Hairy cell leukemia was initially described as a clinicopathologic entity more than 50 years ago. We have subsequently discovered that HCL is really at least two diseases: classical HCL and the hairy cell leukemia variant. The former is among a small group of cancers exceptional for ...

Last Updated: 30 Aug 2014

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Update on the biology and treatment options for hairy cell leukemia.
 

Author(s): Preetesh Jain, Naveen Pemmaraju, Farhad Ravandi

Journal: Curr Treat Options Oncol. 2014 Jun;15(2):187-209.

 

Hairy cell leukemia (HCL) is an uncommon chronic leukemia of mature B cells. Leukemic B cells of HCL exhibit a characteristic morphology and immunophenotype and coexpress multiple clonally related immunoglobulin isotypes. Precise diagnosis and detailed workup is essential, because ...

Last Updated: 6 Jun 2014

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The microenvironment in hairy cell leukemia: pathways and potential therapeutic targets.
 

Author(s): Jan A Burger, Mariela Sivina, Farhad Ravandi

Journal: Leuk. Lymphoma. 2011 Jun;52 Suppl 2():94-8.

 

Hairy cell leukemia (HCL) cells accumulate and proliferate in the spleen and the bone marrow. In these tissue compartments, HCL cells interact with accessory cells, matrix proteins, and various cyctokines, collectively referred to as the 'microenvironment.' Surface receptors expressed ...

Last Updated: 23 May 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia; Hairy Cell Leukemia Variant

 

Last Updated: 20 Jul 2016

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LMB-2 to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 30 Jun 2016

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Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 17 Jun 2015

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