Growth Hormone Deficiency

Common Name(s)

Growth Hormone Deficiency

Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.  In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Growth Hormone Deficiency" returned 248 free, full-text research articles on human participants. First 3 results:

[Diagnostic value of the propranolol-exercise provocative test for growth hormone deficiency in children].
 

Author(s): Fang-Yuan Zheng, Xue-Mei Wang, Xin-Li Wang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Feb;17(2):180-4.

 

To assess the diagnostic value of the propranolol-exercise provocative test for growth hormone deficiency (GHD) in children.

Last Updated: 12 Mar 2015

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Limited usefulness of the test of spontaneous growth hormone (GH) nocturnal secretion as a screening procedure in diagnosing GH deficiency in children with short stature.
 

Author(s): Joanna Smyczyńska, Renata Stawerska, Andrzej Lewiński, Maciej Hilczer

Journal: Ann Agric Environ Med. 2014 ;21(4):893-7.

 

In Poland, the assessment of nocturnal GH secretion has gained the status of screening test; however, this procedure is not included in international recommendations. The aim of the study was to assess the accuracy and predictive value of the test of nocturnal GH secretion as a screening ...

Last Updated: 22 Dec 2014

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Impact of adult growth hormone deficiency on daily functioning and well-being.
 

Author(s): Meryl Brod, Betsy Pohlman, Lise Højbjerre, Johan Erpur Adalsteinsson, Michael Højby Rasmussen

Journal:

 

Adult Growth Hormone Deficiency (AGHD) is a debilitating condition resulting from tumors, pituitary surgery, radiation of the head, head injury, or hypothalamic-pituitary disease. This qualitative study was conducted to better understand the multi-faceted impacts and treatment effects ...

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Growth Hormone Deficiency" returned 17 free, full-text review articles on human participants. First 3 results:

Prader-Willi syndrome and growth hormone deficiency.
 

Author(s): Zehra Aycan, Veysel Nijat Baş

Journal: J Clin Res Pediatr Endocrinol. 2014 ;6(2):62-7.

 

Prader-Willi syndrome (PWS) is a rare multisystem genetic disorder demonstrating great variability with changing clinical features during patient's life. It is characterized by severe hypotonia with poor sucking and feeding difficulties in early infancy, followed by excessive eating ...

Last Updated: 17 Jun 2014

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[STAT5B deficiency: a new growth hormone insensitivity syndrome associated to immunological dysfunction].
 

Author(s): Renata C Scalco, Patrícia N Pugliese-Pires, Alexander A L Jorge

Journal: Arq Bras Endocrinol Metabol. 2013 Jul;57(5):333-8.

 

A new presentation of growth hormone insensitivity (GHI) caused by homozygous mutations in STAT5B (signal transducer and activator of transcription 5B) gene has been characterized in the last years. Its particularity is the association with severe immune dysfunction, especially with ...

Last Updated: 30 Jul 2013

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Idiopathic adult growth hormone deficiency.
 

Author(s): Shlomo Melmed

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2187-97.

 

GH secretion is controlled by hypothalamic as well as intrapituitary and peripheral signals, all of which converge upon the somatotroph, resulting in integrated GH synthesis and secretion. Enabling an accurate diagnosis of idiopathic adult GH deficiency (IAGHD) is challenged by the ...

Last Updated: 3 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 23 Mar 2015

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Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 21 Dec 2010

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Study to Assess Safety and Tolerability in Adults With Growth Hormone-Deficiency (GHD)
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 21 Aug 2015

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