Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 658 free, full-text research articles on human participants. First 3 results:

Metamorphic thyroid autoimmunity in Down Syndrome: from Hashimoto's thyroiditis to Graves' disease and beyond.
 

Author(s): Tommaso Aversa, Mariella Valenzise, Mariacarolina Salerno, Andrea Corrias, Lorenzo Iughetti, Giorgio Radetti, Filippo De Luca, Malgorzata Wasniewska

Journal:

 

It is known that Hashimoto's thyroiditis (HT) may progress to Graves' disease (GD) and that this phenomenon may be more frequent in the patients with Down syndrome (DS).

Last Updated: 12 Nov 2015

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Association of Primary Biliary Cirrhosis-autoimmune Hepatitis Overlap Syndrome with Immune Thrombocytopenia and Graves' Disease.
 

Author(s): Ryosuke Koyamada, Takakazu Higuchi, Ayako Kitada, Tomoko Nakagawa, Takashi Ikeya, Sadamu Okada, Yoshiyuki Fujita

Journal: Intern. Med.. 2015 ;54(16):2013-6.

 

A 54-year-old woman suffering from pruritus for five years was diagnosed to have Graves' disease and immune thrombocytopenia (ITP) associated with primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome, which was confirmed histologically after a prompt recovery ...

Last Updated: 17 Aug 2015

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Total thyroidectomy in Basedow-Graves' disease treatment: our experience.
 

Author(s): M Barbuscia, A Querci, A Tonante, D Paparo, F Taranto, A Ilacqua, E Gagliano, A Milone

Journal: G Chir. ;36(3):117-21.

 

In the present study the authors, after a short historical description of the Basedow-Graves' disease, describe their case-study gathered over the last five years. They mention the most widely accepted hypothesis regarding disease's etiology, strongly linked to autoimmune disorders, ...

Last Updated: 20 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 40 free, full-text review articles on human participants. First 3 results:

Dendritic cells in Graves' disease.
 

Author(s): Dyah Purnamasari, Pradana Soewondo, Samsuridjal Djauzi

Journal: Acta Med Indones. 2015 Jan;47(1):61-9.

 

Dendritic cells are major antigen-presenting cells (APC) that stimulate naive T cells, which induce adaptive immune responses. Graves' disease (GD) is an autoimmune disease characterized by the presence of autoantibodies against Thyroid Stimulating Hormone Receptor (TSHR). The autoantibodies ...

Last Updated: 7 May 2015

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Graves' disease presenting as bi-ventricular heart failure with severe pulmonary hypertension and pre-eclampsia in pregnancy--a case report and review of the literature.
 

Author(s): Khandker Mohammad Nurus Sabah, Abdul Wadud Chowdhury, Mohammad Shahidul Islam, Fathima Aaysha Cader, Shamima Kawser, Md Imam Hosen, Mohammed Abaye Deen Saleh, Md Shariful Alam, Mohammad Monjurul Kader Chowdhury, Humayara Tabassum

Journal:

 

Graves' disease, a well-known cause of hyperthyroidism, is an autoimmune disease with multi-system involvement. More prevalent among young women, it appears as an uncommon cardiovascular complication during pregnancy, posing a diagnostic challenge, largely owing to difficulty in detecting ...

Last Updated: 1 May 2015

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Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
 

Author(s): Tetsuya Mizokami, Ayumi Yamauchi, Yuichi Sato, Masae Toyonaga, Hirofumi Imoto, Hiroto Kojima, Hiroh Saji, Kiyohide Nunoi

Journal: Intern. Med.. 2013 ;52(22):2537-43.

 

Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune ...

Last Updated: 18 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparative Study of Different I-131 Doses in Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Apr 2014

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Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves' Disease

 

Last Updated: 15 Mar 2016

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