Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 9 Oct 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 9 Oct 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 573 free, full-text research articles on human participants. First 3 results:

Metastatic papillary carcinoma of the thyroid in a patient previously treated for Graves' disease.
 

Author(s): Garba H Yunusa, Tessa Kotze, Anita Brink

Journal: Ann Afr Med. ;13(2):91-4.

 

Incidental papillary carcinoma of the thyroid in patients treated surgically for benign thyroid diseases including Graves' disease is a known phenomenon. However, the management of these patients remains an issue of concern and controversy for those who care for them. We report a ...

Last Updated: 7 Apr 2014

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Association of TLR7 and TSHR copy number variation with Graves' disease and Graves' ophthalmopathy in Chinese population in Taiwan.
 

Author(s): Wen-Ling Liao, Lei Wan, Tzu-Yuan Wang, Ching-Chu Chen, Siu-San Tse, Chieh-Hsiang Lu, Fuu-Jen Tsai

Journal:

 

Graves' disease (GD) and Graves' ophthalmopathy (GO) are autoimmune disorders, which might be influenced by genetic factors. Copy number variation (CNV) is an important source of genomic diversity in humans, and influences disease susceptibility. This study investigated the association ...

Last Updated: 20 Feb 2014

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Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and Graves' disease risk: a meta-analysis of 11 case-control studies.
 

Author(s): Min-Li Chen, Ning Liao, Hua Zhao, Jian Huang, Zheng-Fu Xie

Journal:

 

Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.

Last Updated: 27 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 37 free, full-text review articles on human participants. First 3 results:

Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
 

Author(s): Tetsuya Mizokami, Ayumi Yamauchi, Yuichi Sato, Masae Toyonaga, Hirofumi Imoto, Hiroto Kojima, Hiroh Saji, Kiyohide Nunoi

Journal: Intern. Med.. 2013 ;52(22):2537-43.

 

Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune ...

Last Updated: 18 Nov 2013

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[Selenium in Graves' disease].
 

Author(s): Jadwiga Kryczyk, PaweĊ‚ Zagrodzki

Journal:

 

The aim of this study was to present the current state of knowledge of the role of selenium in Graves' disease. Recently, in the pathogenesis and course of this autoimmune disease, more attention has been paid to the relationship between oxidative stress and the antioxidant system, ...

Last Updated: 11 Jun 2013

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[Treatment of hyperthyroidism due to Graves' disease: what is the recommended antithyroid drug during pregnancy?].
 

Author(s): P Caron

Journal: J Gynecol Obstet Biol Reprod (Paris). 2013 May;42(3):232-7.

 

Clinical hyperthyroidism during the first trimester of pregnancy due to Graves' disease can be associated with maternal, obstetrical and fetal complications, indicating an active treatment to restore normal thyroid function. Antithyroid drugs are the first line treatment in pregnant ...

Last Updated: 1 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparative Study of Different I-131 Doses in Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Apr 2014

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Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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Shared Decision Making in Graves Disease - Graves Disease (GD) Choice
 

Status: Recruiting

Condition Summary: Graves' Disease; Thyroid Disease; Hyperthyroidism

 

Last Updated: 17 Sep 2014

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