Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 717 free, full-text research articles on human participants. First 3 results:

Associations of melatonin receptor gene polymorphisms with Graves' disease.
 

Author(s): Jiunn-Diann Lin, Shun-Fa Yang, Yuan-Hung Wang, Wen-Fang Fang, Ying-Chin Lin, Bing-Chun Liou, Yuh-Feng Lin, Kam-Tsun Tang, Chao-Wen Cheng

Journal:

 

Melatonin plays an important role in immunity and has been linked to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of melatonin receptor type 1A (MTNR1A) and 1B (MTNR1B), with autoimmune thyroid disease in an ethnic Chinese (i.e., Taiwanese) ...

Last Updated: 29 Sep 2017

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Graves' Disease in Pediatric and Elderly Patients with 22q11.2 Deletion Syndrome.
 

Author(s): Yoko Ueda, Shinsuke Uraki, Hidefumi Inaba, Sakiko Nakashima, Hiroyuki Ariyasu, Hiroshi Iwakura, Takayuki Ota, Hiroto Furuta, Masahiro Nishi, Takashi Akamizu

Journal: Intern. Med.. 2017 ;56(10):1169-1173.

 

22q11.2 Deletion Syndrome (22qDS) is often complicated by autoimmune diseases. To clarify the causal relationship, we examined the lymphocyte subset distribution and the human leucocyte antigen (HLA) in two female patients (one child and an elderly) with Graves' disease (GD) and 22qDS. ...

Last Updated: 15 May 2017

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Novel Application of Quantitative Single-Photon Emission Computed Tomography/Computed Tomography to Predict Early Response to Methimazole in Graves' Disease.
 

Author(s): Hyun Joo Kim, Ji-In Bang, Ji-Young Kim, Jae Hoon Moon, Young So, Won Woo Lee

Journal: Korean J Radiol. ;18(3):543-550.

 

Since Graves' disease (GD) is resistant to antithyroid drugs (ATDs), an accurate quantitative thyroid function measurement is required for the prediction of early responses to ATD. Quantitative parameters derived from the novel technology, single-photon emission computed tomography/computed ...

Last Updated: 1 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 52 free, full-text review articles on human participants. First 3 results:

MANAGEMENT OF ENDOCRINE DISEASE: Arguments for the prolonged use of antithyroid drugs in children with Graves' disease.
 

Author(s): Juliane Léger, Jean-Claude Carel

Journal: Eur. J. Endocrinol.. 2017 Aug;177(2):R59-R67.

 

Graves' disease is an autoimmune disorder. It is the leading cause of hyperthyroidism, but is rare in children. Patients are initially managed with antithyroid drugs (ATDs), such as methimazole/carbimazole. A major disadvantage of treatment with ATD is the high risk of relapse, exceeding ...

Last Updated: 6 Apr 2017

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Management of Fetal and Neonatal Graves' Disease.
 

Author(s): Juliane Léger

Journal: Horm Res Paediatr. 2017 ;87(1):1-6.

 

Fetal and neonatal autoimmune hyperthyroidism is a rare, serious but transient disorder. Early diagnosis and treatment are key objectives for an optimal prognosis and the well-being of the child. This review focuses on the management of these patients during the fetal and neonatal ...

Last Updated: 15 Dec 2016

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Can we predict relapse in Graves' disease? Results from a systematic review and meta-analysis.
 

Author(s): Tristan Struja, Hannah Fehlberg, Alexander Kutz, Larissa Guebelin, Christian Degen, Beat Mueller, Philipp Schuetz

Journal: Eur. J. Endocrinol.. 2017 Jan;176(1):87-97.

 

Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options.

Last Updated: 26 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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HIFU vs RAI in the Relapsed Graves' Disease
 

Status: Recruiting

Condition Summary: Graves Disease

 

Last Updated: 12 Jul 2017

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K1-70 - A Study in Subjects With Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Oct 2016

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