Gonadal Dysgenesis

Common Name(s)

Gonadal Dysgenesis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gonadal Dysgenesis" for support, advocacy or research.

Turner Syndrome Society of the United States

The TSSUS creates awareness, promotes research, and provides support for all persons touched by Turner syndrome. Our programs include patient support, support of TS research, nationwide conferences and events, chapters and support groups and awareness initiatives. Our vision is to "Crush ignorance of TS by 2018", with the intention of decreasing the age of diagnosis of those with TS from age 15 to pre-school age. Our Society was formed in 1987 by four women with TS and now includes parents, spouses, people worldwide and professionals. Over 30 countries have a TS Society.

Last Updated: 27 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gonadal Dysgenesis" for support, advocacy or research.

Turner Syndrome Society of the United States

The TSSUS creates awareness, promotes research, and provides support for all persons touched by Turner syndrome. Our programs include patient support, support of TS research, nationwide conferences and events, chapters and support groups and awareness initiatives. Our vision is to "Crush ignorance of TS by 2018", with the intention of decreasing the age of diagnosis of those with TS from age 15 to pre-school age. Our Society was formed in 1987 by four women with TS and now includes parents, spouses, people worldwide and professionals. Over 30 countries have a TS Society.

http://www.turnersyndrome.org

Last Updated: 27 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gonadal Dysgenesis" returned 78 free, full-text research articles on human participants. First 3 results:

Identification of X monosomy cells from a gonad of mixed gonadal dysgenesis with a 46,XY karyotype: case report.
 

Author(s): Noriko Nishina-Uchida, Ryuji Fukuzawa, Yukihiro Hasegawa, Ian M Morison

Journal: Medicine (Baltimore). 2015 Apr;94(14):e720.

 

Mixed gonadal dysgenesis (MGD) is a disorder of sexual development that typically has a mosaic 45,X/46,XY karyotype. A 1-year-old infant with 46,XY identified by peripheral blood karyotype demonstrated clinical manifestations and gonadal pathologic features of MGD. Fluorescence in ...

Last Updated: 11 Apr 2015

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Long-term growth hormone treatment in a boy with 45,X/46,X,idic(Yp) mixed gonadal dysgenesis: comparison with growth pattern of an untreated patient.
 

Author(s): Silvano Bertelloni, Eleonora Dati, Angelo Valetto, Veronica Bertini, Alfredo Danti, Giampiero I Baroncelli

Journal: Hormones (Athens). ;14(1):142-7.

 

Mixed gonadal dysgenesis (MGD) is a rare disorder. Short stature is a well known feature of this condition. Although growth hormone (GH) treatment has been suggested to treat growth impairment, conflicting data surround this issue.

Last Updated: 18 Apr 2015

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Screening of Y chromosome microdeletions in 46,XY partial gonadal dysgenesis and in patients with a 45,X/46,XY karyotype or its variants.
 

Author(s): Ana Paula dos Santos, Juliana Gabriel Ribeiro Andrade, Cristiane Santos Cruz Piveta, Juliana de Paulo, Gil Guerra, Maricilda Palandi de Mello, Andréa Trevas Maciel-Guerra

Journal:

 

Partial and mixed gonadal dysgenesis (PGD and MGD) are characterized by genital ambiguity and the finding of either a streak gonad and a dysgenetic testis or two dysgenetic testes. The karyotype in PGD is 46,XY, whereas a 45,X/46,XY mosaicism or its variants (more than two lineages ...

Last Updated: 17 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gonadal Dysgenesis" returned 5 free, full-text review articles on human participants. First 3 results:

[Gonadal dysgenesis and tumors: genetic and clinical features].
 

Author(s): Mônica V Nunes Lipay, Bianca Bianco, Ieda T N Verreschi

Journal: Arq Bras Endocrinol Metabol. 2005 Feb;49(1):60-70.

 

Gonadal dysgenesis comprises a clinical spectrum of anomalies in patients with female, ambiguous or male phenotype, absent or impaired puberty and karyotype with or without Y chromosome and/or chromosome markers. Although Y-specific sequences are seldom cytogenetically evident, dysgenetic ...

Last Updated: 17 Mar 2006

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Testis-determining factor and gonadal dysgenesis.
 

Author(s): H Shima, T Kuraoka, T Hashimoto

Journal: Int. J. Urol.. 1997 Jan;4(1):3-7.

 

Last Updated: 11 Aug 1997

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A case of mixed gonadal dysgenesis (MGD)--with a review of MGD patients reported in Japan.
 

Author(s): N Yamakita, K Yasuda, H Mori, M Kuriyama, Y Kumamoto, K Miura

Journal: Jpn. J. Med.. ;28(6):744-52.

 

A 17-year-old patient with mixed gonadal dysgenesis (MGD) showing ambiguous genitalia and hypergonadotropic hypogonadism was described. By intraabdominal exploration, a poorly developed uterus with a fallopian tube and a streak gonad was found on the right side and a poorly developed ...

Last Updated: 31 May 1990

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Turner Syndrome Prenatal Diagnosis Study
 

Status: Recruiting

Condition Summary: Turner Syndrome

 

Last Updated: 14 Aug 2012

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Risk of Diabetes in Young Turner Syndrome Patients
 

Status: Recruiting

Condition Summary: Turner Syndrome

 

Last Updated: 25 Sep 2015

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Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome
 

Status: Recruiting

Condition Summary: Turner Syndrome

 

Last Updated: 23 May 2013

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