Alopecia Areata

Common Name(s)

Alopecia Areata

Alopecia areata (AA) is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. In most cases, hair falls out in small, round patches on the scalp. Although uncommon, hair loss can be more extensive in some people and affect other parts of the body. This condition can progress to complete loss of scalp hair (alopecia totalis) or total loss of all body hair (alopecia universalis).  Although the exact cause of AA is unknown, roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of the condition. There is no cure or approved therapy for AA; however, some people find that medications approved for other purposes can help regrow hair.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alopecia Areata" for support, advocacy or research.

Bald Girls Do Lunch Inc

Bald Girls Do Lunch (BGDL) helps women with alopecia areata live full and fulfilling lives, and it’s all centered around the idea of getting together for “lunch.” Our lunches and other events are fun, friendly, educational, relaxing and, most of all, totally empowering. By being with people who experience the same things as you, your self-esteem improves and you gain confidence, camaraderie and a powerful sense of community.

Last Updated: 14 Aug 2014

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Children's Alopecia Project, Inc.

We help children living with hair loss due to all forms of Alopecia. We raise awareness and build self-esteem so the kids can become stronger teens and more productive adults and the advocates of tomorrow.

Last Updated: 20 Mar 2013

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National Alopecia Areata Foundation

The National Alopecia Areata Foundation (NAAF) supports research to find a cure or acceptable treatment for alopecia areata, supports those with the disease, and educates the public about alopecia areata.

Last Updated: 8 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alopecia Areata" for support, advocacy or research.

Bald Girls Do Lunch Inc

Bald Girls Do Lunch (BGDL) helps women with alopecia areata live full and fulfilling lives, and it’s all centered around the idea of getting together for “lunch.” Our lunches and other events are fun, friendly, educational, relaxing and, most of all, totally empowering. By being with people who experience the same things as you, your self-esteem improves and you gain confidence, camaraderie and a powerful sense of community.

http://www.baldgirlsdolunch.org

Last Updated: 14 Aug 2014

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Children's Alopecia Project, Inc.

We help children living with hair loss due to all forms of Alopecia. We raise awareness and build self-esteem so the kids can become stronger teens and more productive adults and the advocates of tomorrow.

http://www.childrensalopeciaproject.org

Last Updated: 20 Mar 2013

View Details
National Alopecia Areata Foundation

The National Alopecia Areata Foundation (NAAF) supports research to find a cure or acceptable treatment for alopecia areata, supports those with the disease, and educates the public about alopecia areata.

http://www.naaf.org

Last Updated: 8 Mar 2013

View Details

 

General Support Organizations

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General Resources

How Are You Nurturing Your Self Image

Patient-focused education for women with alopecia diagnoses.

Updated 14 Aug 2014

Open Doc
Understanding the Lives of Women with Alopecia Areata

Public awareness and patient-focused Infographic suitable for printing

Updated 14 Aug 2014

Open Doc
Video: Bald Girls Do Lunch (NYC)

"Spring in the City": Bald Girls Do Lunch Founder Thea Chassin hosts a BGDL evening in New York City

Updated 14 Aug 2014

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VIDEO: BGDL on the TODAY SHOW

The TODAY show came on location with Thea Chassin and Bald Girls Do Lunch in Illinois

Updated 14 Aug 2014

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National Public Radio on location with BGDL

NPR producer Patrick Skahill interviews Thea Chassin on location at Bald Girls Do Lunch in Connecticut.

Updated 14 Aug 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alopecia Areata" returned 148 free, full-text research articles on human participants. First 3 results:

Efficacy and safety of methotrexate in alopecia areata.
 

Author(s): Mariana Hammerschmidt, Fabiane Mulinari Brenner

Journal: An Bras Dermatol. ;89(5):729-34.

 

Alopecia areata is a chronic disorder of the hair follicles and nails, of unknown etiology, with clear autoimmune components and genetic factors. Several therapeutic options have been suggested; however, no treatment is able to modify the disease course. Methotrexate is an immunosuppressant ...

Last Updated: 4 Sep 2014

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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
 

Author(s): Luzhou Xing, Zhenpeng Dai, Ali Jabbari, Jane E Cerise, Claire A Higgins, Weijuan Gong, Annemieke de Jong, Sivan Harel, Gina M DeStefano, Lisa Rothman, Pallavi Singh, Lynn Petukhova, Julian Mackay-Wiggan, Angela M Christiano, Raphael Clynes

Journal: Nat. Med.. 2014 Sep;20(9):1043-9.

 

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies ...

Last Updated: 9 Sep 2014

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Association between vitamin D levels and alopecia areata.
 

Author(s): Mahmud Mahamid, Omar Abu-Elhija, Mosab Samamra, Ammad Mahamid, William Nseir

Journal: Isr. Med. Assoc. J.. 2014 Jun;16(6):367-70.

 

Alopecia areata (AA) is an autoimmune disease, based on the response to local and/or systemic corticosteroid treatment. The role of vitamin D in the pathogenesis of immune/autoimmune mediated diseases has been widely studied.

Last Updated: 25 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alopecia Areata" returned 25 free, full-text review articles on human participants. First 3 results:

Current treatment of alopecia areata.
 

Author(s): Jerry Shapiro

Journal: J. Investig. Dermatol. Symp. Proc.. 2013 Dec;16(1):S42-4.

 

Treatment of alopecia areata is dependent on age of patient as well as the extent and duration of scalp involvement. Treatments include steroids, topical immunotherapy, topical minoxidil, anthralin, and immunosuppressants. Each case must be dealt with on a customized individual basis.

Last Updated: 11 Dec 2013

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A new humanized mouse model for alopecia areata.
 

Author(s): Amos Gilhar, Aviad Keren, Ralf Paus

Journal: J. Investig. Dermatol. Symp. Proc.. 2013 Dec;16(1):S37-8.

 

Although alopecia areata (AA) is not life threatening, it may lead to severe psychological disturbances, reducing the quality of life in all ages. Thus, a new animal model is needed for shedding more light onto the pathogenesis of this cell-mediated, organ-specific autoimmune disease ...

Last Updated: 11 Dec 2013

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What can the genetics of psoriasis teach us about alopecia areata?
 

Author(s): James T Elder

Journal: J. Investig. Dermatol. Symp. Proc.. 2013 Dec;16(1):S34-6.

 

Previous genetic epidemiological studies of psoriasis and alopecia areata demonstrated strong heritability in first-degree relatives and in twins. In recent years, these two conditions have emerged as two skin diseases that are starting to yield their secrets through genome-wide association ...

Last Updated: 11 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alopecia Areata Registry
 

Status: Recruiting

Condition Summary: Alopecia Areata; Alopecia Totalis; Alopecia Universalis; Autoimmune Hair Loss; Alopecia Partialis

 

Last Updated: 27 Apr 2015

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Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata
 

Status: Recruiting

Condition Summary: Alopecia Areata; Alopecia; Balding

 

Last Updated: 29 Jun 2011

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Excimer Light for Alopecia Areata
 

Status: Recruiting

Condition Summary: Alopecia Areata

 

Last Updated: 30 Jun 2015

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