Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 227 free, full-text research articles on human participants. First 3 results:

Genetic Profiles of Korean Patients With Glucose-6-Phosphate Dehydrogenase Deficiency.
 

Author(s): Jaewoong Lee, Joonhong Park, Hayoung Choi, Jiyeon Kim, Ahlm Kwon, Woori Jang, Hyojin Chae, Myungshin Kim, Yonggoo Kim, Jae Wook Lee, Nack Gyun Chung, Bin Cho

Journal: Ann Lab Med. 2017 Mar;37(2):108-116.

 

We describe the genetic profiles of Korean patients with glucose-6-phosphate dehydrogenase (G6PD) deficiencies and the effects of G6PD mutations on protein stability and enzyme activity on the basis of in silico analysis.

Last Updated: 28 Dec 2016

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Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis.
 

Author(s): Z Rostami-Far, K Ghadiri, M Rostami-Far, F Shaveisi-Zadeh, A Amiri, B Rahimian Zarif

Journal: J Med Life. ;9(1):34-38.

 

Introduction.Neonatal sepsis is a disease process, which represents the systemic response of bacteria entering the bloodstream during the first 28 days of life. The prevalence of sepsis is higher in male infants than in females, but the exact cause is unknown. Glucose-6-phosphate ...

Last Updated: 15 Dec 2016

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Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: A retrospective observational study.
 

Author(s): Maria P Dore, Agnese Davoli, Nunzio Longo, Giuseppina Marras, Giovanni M Pes

Journal: Medicine (Baltimore). 2016 Nov;95(44):e5254.

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been associated with a lower cancer risk, possibly via a reduction of mutagenic oxygen-free radicals and by reducing nicotinamide-adeninedinucleotide-phosphate for replicating cells. In Sardinia, the enzyme defect is frequent ...

Last Updated: 18 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 8 free, full-text review articles on human participants. First 3 results:

Dual Antiplatelet Therapy in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency undergoing PCI with Drug-Eluting Stents.
 

Author(s): Simone Biscaglia, Alessandra Ferri, Rita Pavasini, Gianluca Campo, Roberto Ferrari

Journal: J. Atheroscler. Thromb.. 2015 ;22(5):535-41.

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. In patients with G6PD deficiency, the use of aspirin is controversial, since past studies have reported a potential risk of haemolysis related ...

Last Updated: 21 May 2015

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Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
 

Author(s): R O Francis, J S Jhang, H P Pham, E A Hod, J C Zimring, S L Spitalnik

Journal: Vox Sang.. 2013 Nov;105(4):271-82.

 

The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce haemolysis ...

Last Updated: 14 Oct 2013

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report.
 

Author(s): Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price

Journal:

 

The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving ...

Last Updated: 5 Apr 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diet Challenge in G6PD Deficient Egyptian Children: A One- Year Prospective Single Center Study With Genotype - Phenotype Correlation
 

Status: Not yet recruiting

Condition Summary: Glucose-6-Phosphate Dehydrogenase Deficiency

 

Last Updated: 14 Jul 2015

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Last Updated: 31 Oct 2015

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Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
 

Status: Not yet recruiting

Condition Summary: G6PD Deficiency

 

Last Updated: 14 Oct 2016

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