Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 170 free, full-text research articles on human participants. First 3 results:

The role of erythrocyte enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency in the pathogenesis of anemia in patients on hemodialysis.
 

Author(s): Elshazali Widaa Ali, Emad Eldean Mohammed Ahmed

Journal: Saudi J Kidney Dis Transpl. 2013 Nov;24(6):1153-6.

 

Anemia is a common feature among patients with chronic renal failure (CRF). Low activity of the erythrocyte enzyme glucose-6-phosphate dehydrogenase (G6PD), which plays a major role in protecting red blood cells against oxidative agents, has been described as one of the contributing ...

Last Updated: 15 Nov 2013

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Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
 

Author(s): Rosemary Rochford, Colin Ohrt, Paul C Baresel, Brice Campo, Aruna Sampath, Alan J Magill, Babu L Tekwani, Larry A Walker

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Oct;110(43):17486-91.

 

Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs), an important class of antimalarial/antiinfective therapeutics. However, there is no suitable animal model that can predict ...

Last Updated: 23 Oct 2013

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Evaluation of the phenotypic test and genetic analysis in the detection of glucose-6-phosphate dehydrogenase deficiency.
 

Author(s): Duangdao Nantakomol, Rick Paul, Attakorn Palasuwan, Nicholas P J Day, Nicholas J White, Mallika Imwong

Journal:

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is particularly prevalent in historically malaria-endemic countries. Although most individuals with G6PD deficiency are asymptomatic, deficiency can result in acute haemolytic anaemia after exposure to oxidative agents. A reliable ...

Last Updated: 28 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 7 free, full-text review articles on human participants. First 3 results:

Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report.
 

Author(s): Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price

Journal:

 

The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving ...

Last Updated: 5 Apr 2013

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Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.
 

Author(s): Peter A Hecker, Jane A Leopold, Sachin A Gupte, Fabio A Recchia, William C Stanley

Journal: Am. J. Physiol. Heart Circ. Physiol.. 2013 Feb;304(4):H491-500.

 

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its ...

Last Updated: 18 Feb 2013

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Glucose-6-phosphate dehydrogenase deficiency and malaria: cytochemical detection of heterozygous G6PD deficiency in women.
 

Author(s): Anna L Peters, Cornelis J F Van Noorden

Journal: J. Histochem. Cytochem.. 2009 Nov;57(11):1003-11.

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a X-chromosomally transmitted disorder of the erythrocyte that affects 400 million people worldwide. Diagnosis of heterozygously-deficient women is complicated: as a result of lyonization, these women have a normal and a G6PD-deficient ...

Last Updated: 19 Oct 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Different G6PD Testing Platforms
 

Status: Not yet recruiting

Condition Summary: Glucose-6-Phosphate Dehydrogenase Deficiency

 

Last Updated: 3 Apr 2014

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Last Updated: 25 Jun 2014

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