Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 97 free, full-text research articles on human participants. First 3 results:

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.
 

Author(s): Courtney L Jones, Christy M Gearheart, Susan Fosmire, Cristina Delgado-Martin, Nikki A Evensen, Karen Bride, Angela J Waanders, Faye Pais, Jinhua Wang, Teena Bhatla, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita Dandekar, Eugene Park, Tamara M Burleson, Pillai Pallavi Madhusoodhan, David T Teachey, Elizabeth A Raetz, Michelle L Hermiston, Markus Müschen, Mignon L Loh, Stephen P Hunger, Jinghui Zhang, Michael J Garabedian, Christopher C Porter, William L Carroll

Journal: Blood. 2015 Nov;126(19):2202-12.

 

The outcome for pediatric acute lymphoblastic leukemia (ALL) patients who relapse is dismal. A hallmark of relapsed disease is acquired resistance to multiple chemotherapeutic agents, particularly glucocorticoids. In this study, we performed a genome-scale short hairpin RNA screen ...

Last Updated: 6 Nov 2015

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Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.
 

Author(s): Lindsay Nicholson, Caroline A Evans, Elizabeth Matheson, Lynne Minto, Christopher Keilty, Maryna Sanichar, Marian Case, Claire Schwab, Daniel Williamson, Johannes Rainer, Christine J Harrison, Reinhard Kofler, Andrew G Hall, Christopher P F Redfern, Anthony D Whetton, Julie A E Irving

Journal: Br. J. Haematol.. 2015 Nov;171(4):595-605.

 

Glucocorticoid (GC) resistance is a continuing clinical problem in childhood acute lymphoblastic leukaemia (ALL) but the underlying mechanisms remain unclear. A proteomic approach was used to compare profiles of the B-lineage ALL GC-sensitive cell line, PreB 697, and its GC-resistant ...

Last Updated: 29 Oct 2015

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Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.
 

Author(s): Pedro Escoll, Ismael Ranz, Norman Muñoz-Antón, Ana van-den-Rym, Melchor Alvarez-Mon, Carlos Martínez-Alonso, Eva Sanz, Antonio de-la-Hera

Journal: Mediators Inflamm.. 2015 ;2015():347965.

 

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level ...

Last Updated: 15 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 19 free, full-text review articles on human participants. First 3 results:

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes.
 

Author(s): Alex Rafacho, Henrik Ortsäter, Angel Nadal, Ivan Quesada

Journal: J. Endocrinol.. 2014 Dec;223(3):R49-62.

 

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation ...

Last Updated: 25 Oct 2014

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Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism.
 

Author(s): Eliza B Geer, Julie Islam, Christoph Buettner

Journal: Endocrinol. Metab. Clin. North Am.. 2014 Mar;43(1):75-102.

 

Glucocorticoids (GCs) are critical in the regulation of the stress response, inflammation and energy homeostasis. Excessive GC exposure results in whole-body insulin resistance, obesity, cardiovascular disease, and ultimately decreased survival, despite their potent anti-inflammatory ...

Last Updated: 3 Mar 2014

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Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity.
 

Author(s): Evangelia Charmandari, Tomoshige Kino, George P Chrousos

Journal: Endocr Dev. 2013 ;24():67-85.

 

Familial or sporadic primary generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids and a consequent hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. ...

Last Updated: 8 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: General Glucocorticoid Resistance

 

Last Updated: 20 Jun 2016

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Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
 

Status: Recruiting

Condition Summary: Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

 

Last Updated: 6 Jan 2016

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