Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 95 free, full-text research articles on human participants. First 3 results:

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.
 

Author(s): Courtney L Jones, Christy M Gearheart, Susan Fosmire, Cristina Delgado-Martin, Nikki A Evensen, Karen Bride, Angela J Waanders, Faye Pais, Jinhua Wang, Teena Bhatla, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita Dandekar, Eugene Park, Tamara M Burleson, Pillai Pallavi Madhusoodhan, David T Teachey, Elizabeth A Raetz, Michelle L Hermiston, Markus Müschen, Mignon L Loh, Stephen P Hunger, Jinghui Zhang, Michael J Garabedian, Christopher C Porter, William L Carroll

Journal: Blood. 2015 Nov;126(19):2202-12.

 

The outcome for pediatric acute lymphoblastic leukemia (ALL) patients who relapse is dismal. A hallmark of relapsed disease is acquired resistance to multiple chemotherapeutic agents, particularly glucocorticoids. In this study, we performed a genome-scale short hairpin RNA screen ...

Last Updated: 6 Nov 2015

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Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.
 

Author(s): Pedro Escoll, Ismael Ranz, Norman Muñoz-Antón, Ana van-den-Rym, Melchor Alvarez-Mon, Carlos Martínez-Alonso, Eva Sanz, Antonio de-la-Hera

Journal: Mediators Inflamm.. 2015 ;2015():347965.

 

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level ...

Last Updated: 15 May 2015

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NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
 

Author(s): Steven W Paugh, Erik J Bonten, Daniel Savic, Laura B Ramsey, William E Thierfelder, Prajwal Gurung, R K Subbarao Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R Coss, Lucas T Laudermilk, John C Panetta, J Robert McCorkle, Yiping Fan, Kristine R Crews, Gabriele Stocco, Mark R Wilkinson, Antonio M Ferreira, Cheng Cheng, Wenjian Yang, Seth E Karol, Christian A Fernandez, Barthelemy Diouf, Colton Smith, J Kevin Hicks, Alessandra Zanut, Audrey Giordanengo, Daniel Crona, Joy J Bianchi, Linda Holmfeldt, Charles G Mullighan, Monique L den Boer, Rob Pieters, Sima Jeha, Thomas L Dunwell, Farida Latif, Deepa Bhojwani, William L Carroll, Ching-Hon Pui, Richard M Myers, R Kiplin Guy, Thirumala-Devi Kanneganti, Mary V Relling, William E Evans

Journal: Nat. Genet.. 2015 Jun;47(6):607-14.

 

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the prednisolone sensitivity of primary leukemia ...

Last Updated: 28 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 19 free, full-text review articles on human participants. First 3 results:

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes.
 

Author(s): Alex Rafacho, Henrik Ortsäter, Angel Nadal, Ivan Quesada

Journal: J. Endocrinol.. 2014 Dec;223(3):R49-62.

 

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation ...

Last Updated: 25 Oct 2014

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Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism.
 

Author(s): Eliza B Geer, Julie Islam, Christoph Buettner

Journal: Endocrinol. Metab. Clin. North Am.. 2014 Mar;43(1):75-102.

 

Glucocorticoids (GCs) are critical in the regulation of the stress response, inflammation and energy homeostasis. Excessive GC exposure results in whole-body insulin resistance, obesity, cardiovascular disease, and ultimately decreased survival, despite their potent anti-inflammatory ...

Last Updated: 3 Mar 2014

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Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity.
 

Author(s): Evangelia Charmandari, Tomoshige Kino, George P Chrousos

Journal: Endocr Dev. 2013 ;24():67-85.

 

Familial or sporadic primary generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids and a consequent hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. ...

Last Updated: 8 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 16 Jun 2015

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Achilles Tendinopathy Treated With Training and Injections
 

Status: Recruiting

Condition Summary: Achilles Tendinopathy

 

Last Updated: 24 Apr 2016

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