Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 78 free, full-text research articles on human participants. First 3 results:

Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade.
 

Author(s): Vivek K Arora, Emily Schenkein, Rajmohan Murali, Sumit K Subudhi, John Wongvipat, Minna D Balbas, Neel Shah, Ling Cai, Eleni Efstathiou, Chris Logothetis, Deyou Zheng, Charles L Sawyers

Journal: Cell. 2013 Dec;155(6):1309-22.

 

The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also ...

Last Updated: 9 Dec 2013

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Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.
 

Author(s): Erich Piovan, Jiyang Yu, Valeria Tosello, Daniel Herranz, Alberto Ambesi-Impiombato, Ana Carolina Da Silva, Marta Sanchez-Martin, Arianne Perez-Garcia, Isaura Rigo, Mireia Castillo, Stefano Indraccolo, Justin R Cross, Elisa de Stanchina, Elisabeth Paietta, Janis Racevskis, Jacob M Rowe, Martin S Tallman, Giuseppe Basso, Jules P Meijerink, Carlos Cordon-Cardo, Andrea Califano, Adolfo A Ferrando

Journal: Cancer Cell. 2013 Dec;24(6):766-76.

 

Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T-ALL. Mechanistically, ...

Last Updated: 16 Dec 2013

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PPARĪ± and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia.
 

Author(s): Stephanie Tung, Yonghong Shi, Karry Wong, Fang Zhu, Reg Gorczynski, Robert C Laister, Mark Minden, Anne-Kareen Blechert, Yvonne Genzel, Udo Reichl, David E Spaner

Journal: Blood. 2013 Aug;122(6):969-80.

 

High-dose glucocorticoids (GCs) can be a useful treatment for aggressive forms of chronic lymphocytic leukemia (CLL). However, their mechanism of action is not well understood, and resistance to GCs is inevitable. In a minimal, serum-free culture system, the synthetic GC dexamethasone ...

Last Updated: 9 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 16 free, full-text review articles on human participants. First 3 results:

Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity.
 

Author(s): Evangelia Charmandari, Tomoshige Kino, George P Chrousos

Journal: Endocr Dev. 2013 ;24():67-85.

 

Familial or sporadic primary generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids and a consequent hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. ...

Last Updated: 8 Feb 2013

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Primary generalized glucocorticoid resistance and hypersensitivity.
 

Author(s): Evangelia Charmandari

Journal: Horm Res Paediatr. 2011 ;76(3):145-55.

 

The human glucocorticoid receptor (hGR) is a ubiquitously expressed intracellular, ligand-dependent transcription factor, which mediates the action of glucocorticoids and influences physiological functions essential for life. Alterations in the molecular mechanisms of hGR action impair ...

Last Updated: 14 Oct 2011

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Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells.
 

Author(s): George Schlossmacher, Adam Stevens, Anne White

Journal: J. Endocrinol.. 2011 Oct;211(1):17-25.

 

Glucocorticoids (Gcs) are commonly used to treat patients suffering from a wide range of cancers. Their main therapeutic role is based on Gc receptor (GR)-mediated mechanisms that trigger cell death but this varies depending on the cancer type. This review aims to provide an overview ...

Last Updated: 16 Sep 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Glucocorticoid Induced Inhibition of IGF-I Activity: Exploring Underlying Mechanisms.
 

Status: Recruiting

Condition Summary: Focus of Study: Prednisolone Induced Catabolic Effects

 

Last Updated: 4 Jan 2013

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Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 7 Oct 2014

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