Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 75 free, full-text research articles on human participants. First 3 results:

Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade.
 

Author(s): Vivek K Arora, Emily Schenkein, Rajmohan Murali, Sumit K Subudhi, John Wongvipat, Minna D Balbas, Neel Shah, Ling Cai, Eleni Efstathiou, Chris Logothetis, Deyou Zheng, Charles L Sawyers

Journal: Cell. 2013 Dec;155(6):1309-22.

 

The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also ...

Last Updated: 9 Dec 2013

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Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE).
 

Author(s): Thang S Han, Nils Krone, Debbie S Willis, Gerard S Conway, Stefanie Hahner, D Aled Rees, Roland H Stimson, Brian R Walker, Wiebke Arlt, Richard J Ross,

Journal:

 

Quality of life (QoL) has been variously reported as normal or impaired in adults with congenital adrenal hyperplasia (CAH). To explore the reasons for this discrepancy we investigated the relationship between QoL, glucocorticoid treatment and other health outcomes in CAH adults.

Last Updated: 6 May 2013

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Persistent glucocorticoid resistance in systemic lupus erythematosus patients during clinical remission.
 

Author(s): A K G Melo, M R Melo, A B A Saramago, G Demartino, B D B Souza, C A Longui

Journal:

 

Glucocorticoids (GCs) are key drugs in the treatment of systemic lupus erythematosus (SLE). GC dose reduction during remission is related to disease activity, GC dose used, length of treatment, and individual GC sensitivity. We compared GC receptor α (GRα) isoform and nuclear factor ...

Last Updated: 25 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 15 free, full-text review articles on human participants. First 3 results:

Primary generalized glucocorticoid resistance and hypersensitivity.
 

Author(s): Evangelia Charmandari

Journal: Horm Res Paediatr. 2011 ;76(3):145-55.

 

The human glucocorticoid receptor (hGR) is a ubiquitously expressed intracellular, ligand-dependent transcription factor, which mediates the action of glucocorticoids and influences physiological functions essential for life. Alterations in the molecular mechanisms of hGR action impair ...

Last Updated: 14 Oct 2011

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Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells.
 

Author(s): George Schlossmacher, Adam Stevens, Anne White

Journal: J. Endocrinol.. 2011 Oct;211(1):17-25.

 

Glucocorticoids (Gcs) are commonly used to treat patients suffering from a wide range of cancers. Their main therapeutic role is based on Gc receptor (GR)-mediated mechanisms that trigger cell death but this varies depending on the cancer type. This review aims to provide an overview ...

Last Updated: 16 Sep 2011

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Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
 

Author(s): Sara De Iudicibus, Raffaella Franca, Stefano Martelossi, Alessandro Ventura, Giuliana Decorti

Journal: World J. Gastroenterol.. 2011 Mar;17(9):1095-108.

 

Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in moderate to severe active Crohn's disease and ...

Last Updated: 30 Mar 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 23 Jul 2014

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Glucocorticoid Induced Inhibition of IGF-I Activity: Exploring Underlying Mechanisms.
 

Status: Recruiting

Condition Summary: Focus of Study: Prednisolone Induced Catabolic Effects

 

Last Updated: 4 Jan 2013

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