Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 91 free, full-text research articles on human participants. First 3 results:

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
 

Author(s): Steven W Paugh, Erik J Bonten, Daniel Savic, Laura B Ramsey, William E Thierfelder, Prajwal Gurung, R K Subbarao Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R Coss, Lucas T Laudermilk, John C Panetta, J Robert McCorkle, Yiping Fan, Kristine R Crews, Gabriele Stocco, Mark R Wilkinson, Antonio M Ferreira, Cheng Cheng, Wenjian Yang, Seth E Karol, Christian A Fernandez, Barthelemy Diouf, Colton Smith, J Kevin Hicks, Alessandra Zanut, Audrey Giordanengo, Daniel Crona, Joy J Bianchi, Linda Holmfeldt, Charles G Mullighan, Monique L den Boer, Rob Pieters, Sima Jeha, Thomas L Dunwell, Farida Latif, Deepa Bhojwani, William L Carroll, Ching-Hon Pui, Richard M Myers, R Kiplin Guy, Thirumala-Devi Kanneganti, Mary V Relling, William E Evans

Journal: Nat. Genet.. 2015 Jun;47(6):607-14.

 

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the prednisolone sensitivity of primary leukemia ...

Last Updated: 28 May 2015

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Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.
 

Author(s): Ajay Palagani, Ken Op de Beeck, Stefan Naulaerts, Jolien Diddens, Chandra Sekhar Chirumamilla, Guy Van Camp, Kris Laukens, Karen Heyninck, Sarah Gerlo, Pieter Mestdagh, Joke Vandesompele, Wim Vanden Berghe

Journal:

 

Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA profiles in a diverse range of haematological ...

Last Updated: 5 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 18 free, full-text review articles on human participants. First 3 results:

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes.
 

Author(s): Alex Rafacho, Henrik Orts├Ąter, Angel Nadal, Ivan Quesada

Journal: J. Endocrinol.. 2014 Dec;223(3):R49-62.

 

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation ...

Last Updated: 25 Oct 2014

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Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism.
 

Author(s): Eliza B Geer, Julie Islam, Christoph Buettner

Journal: Endocrinol. Metab. Clin. North Am.. 2014 Mar;43(1):75-102.

 

Glucocorticoids (GCs) are critical in the regulation of the stress response, inflammation and energy homeostasis. Excessive GC exposure results in whole-body insulin resistance, obesity, cardiovascular disease, and ultimately decreased survival, despite their potent anti-inflammatory ...

Last Updated: 3 Mar 2014

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Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity.
 

Author(s): Evangelia Charmandari, Tomoshige Kino, George P Chrousos

Journal: Endocr Dev. 2013 ;24():67-85.

 

Familial or sporadic primary generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids and a consequent hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. ...

Last Updated: 8 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 16 Jun 2015

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Achilles Tendinopathy Treated With Training and Injections
 

Status: Not yet recruiting

Condition Summary: Achilles Tendinopathy

 

Last Updated: 19 Oct 2015

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