Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 99 free, full-text research articles on human participants. First 3 results:

Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment.
 

Author(s): Bart V J Cuppen, Katerina Pardali, Maarten C Kraan, Anne C A Marijnissen, Linda Yrlid, Marita Olsson, Johannes W J Bijlsma, Floris P J G Lafeber, Ruth D E Fritsch-Stork

Journal: Rheumatol. Int.. 2017 Apr;37(4):531-536.

 

A substantial proportion of rheumatoid arthritis (RA)-patients experience an insufficient response to glucocorticoids, an important therapeutic agent in RA. The multidrug-resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is an efflux pump that actively transports substrates, ...

Last Updated: 31 Dec 1969

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Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
 

Author(s): Konrad Pazdrak, Christof Straub, Rosario Maroto, Susan Stafford, Wendy I White, William J Calhoun, Alexander Kurosky

Journal: J. Immunol.. 2016 Nov;197(10):3782-3791.

 

The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocorticoid signaling in in vitro activated ...

Last Updated: 31 Dec 1969

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Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3.
 

Author(s): Konrad Pazdrak, Young Moon, Christof Straub, Susan Stafford, Alexander Kurosky

Journal: Apoptosis. 2016 Apr;21(4):421-31.

 

The mainstay of asthma therapy, glucocorticoids (GCs) exert their therapeutic effects through the inhibition of inflammatory signaling and induction of eosinophil apoptosis. However, laboratory and clinical observations of GC-resistant asthma suggest that GCs' effects on eosinophil ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 23 free, full-text review articles on human participants. First 3 results:

[Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia].
 

Author(s): Jin-Yun Xu, Jian-Ming Luo

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2017 Aug;19(8):945-949.

 

Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children ...

Last Updated: 31 Dec 1969

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Mechanisms of Brain Glucocorticoid Resistance in Stress-Induced Psychopathologies.
 

Author(s): V M Merkulov, T I Merkulova, N P Bondar

Journal: Biochemistry Mosc.. 2017 Mar;82(3):351-365.

 

Exposure to stress activates the hypothalamic-pituitary-adrenal axis and leads to increased levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal dysfunction, decreases the density of synapses, and impairs neuronal plasticity. Decreased sensitivity ...

Last Updated: 31 Dec 1969

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Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance.
 

Author(s): Nicolas Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, Evangelia Charmandari

Journal: Hormones (Athens). ;15(1):23-34.

 

Primary Generalized Glucocorticoid Resistance is a rare condition characterized by generalized, partial, target tissue insensitivity to glucocorticoids owing to inactivating mutations, insertions or deletions in the human glucocorticoid receptor (hGR) gene (NR3C1). Recent advances ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: General Glucocorticoid Resistance

 

Last Updated: 20 Jun 2016

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Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
 

Status: Recruiting

Condition Summary: Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

 

Last Updated: 20 Sep 2017

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Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 18 Oct 2017

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