Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 98 free, full-text research articles on human participants. First 3 results:

Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3.
 

Author(s): Konrad Pazdrak, Young Moon, Christof Straub, Susan Stafford, Alexander Kurosky

Journal: Apoptosis. 2016 Apr;21(4):421-31.

 

The mainstay of asthma therapy, glucocorticoids (GCs) exert their therapeutic effects through the inhibition of inflammatory signaling and induction of eosinophil apoptosis. However, laboratory and clinical observations of GC-resistant asthma suggest that GCs' effects on eosinophil ...

Last Updated: 27 Feb 2016

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Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.
 

Author(s): Garrett I Ash, Matthew A Kostek, Harold Lee, Theodore J Angelopoulos, Priscilla M Clarkson, Paul M Gordon, Niall M Moyna, Paul S Visich, Robert F Zoeller, Thomas B Price, Joseph M Devaney, Heather Gordish-Dressman, Paul D Thompson, Eric P Hoffman, Linda S Pescatello

Journal:

 

Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a ...

Last Updated: 29 Jan 2016

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Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer.
 

Author(s): Jan Kroon, Martin Puhr, Jeroen T Buijs, Geertje van der Horst, Daniëlle M Hemmer, Koen A Marijt, Ming S Hwang, Motasim Masood, Stefan Grimm, Gert Storm, Josbert M Metselaar, Onno C Meijer, Zoran Culig, Gabri van der Pluijm

Journal: Endocr. Relat. Cancer. 2016 Jan;23(1):35-45.

 

Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used in combination with docetaxel, it is unclear to what extent GCs and their receptor, the glucocorticoid receptor (GR), contribute to the chemotherapy ...

Last Updated: 24 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 21 free, full-text review articles on human participants. First 3 results:

Mechanisms of Brain Glucocorticoid Resistance in Stress-Induced Psychopathologies.
 

Author(s): V M Merkulov, T I Merkulova, N P Bondar

Journal: Biochemistry Mosc.. 2017 Mar;82(3):351-365.

 

Exposure to stress activates the hypothalamic-pituitary-adrenal axis and leads to increased levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal dysfunction, decreases the density of synapses, and impairs neuronal plasticity. Decreased sensitivity ...

Last Updated: 21 Mar 2017

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Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance.
 

Author(s): Nicolas Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, Evangelia Charmandari

Journal: Hormones (Athens). ;15(1):23-34.

 

Primary Generalized Glucocorticoid Resistance is a rare condition characterized by generalized, partial, target tissue insensitivity to glucocorticoids owing to inactivating mutations, insertions or deletions in the human glucocorticoid receptor (hGR) gene (NR3C1). Recent advances ...

Last Updated: 18 Apr 2016

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Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes.
 

Author(s): Alex Rafacho, Henrik Ortsäter, Angel Nadal, Ivan Quesada

Journal: J. Endocrinol.. 2014 Dec;223(3):R49-62.

 

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation ...

Last Updated: 25 Oct 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: General Glucocorticoid Resistance

 

Last Updated: 20 Jun 2016

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Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
 

Status: Recruiting

Condition Summary: Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

 

Last Updated: 15 Mar 2017

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Steroid Treatment for Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilia

 

Last Updated: 13 Jul 2017

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