Glucocorticoid Resistance

Common Name(s)

Glucocorticoid Resistance

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid Resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid Resistance" returned 104 free, full-text research articles on human participants. First 3 results:

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.
 

Author(s): Neel Shah, Ping Wang, John Wongvipat, Wouter R Karthaus, Wassim Abida, Joshua Armenia, Shira Rockowitz, Yotam Drier, Bradley E Bernstein, Henry W Long, Matthew L Freedman, Vivek K Arora, Deyou Zheng, Charles L Sawyers

Journal:

 

In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen resistance is adaptive and reversible ...

Last Updated: 31 Dec 1969

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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
 

Author(s): C Delgado-Martin, L K Meyer, B J Huang, K A Shimano, M S Zinter, J V Nguyen, G A Smith, J Taunton, S S Winter, J R Roderick, M A Kelliher, T M Horton, B L Wood, D T Teachey, M L Hermiston

Journal: Leukemia. 2017 Dec;31(12):2568-2576.

 

While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid (GC) resistance is more common than resistance to other chemotherapies ...

Last Updated: 31 Dec 1969

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Low dose of 2-deoxy-D-glucose kills acute lymphoblastic leukemia cells and reverses glucocorticoid resistance via N-linked glycosylation inhibition under normoxia.
 

Author(s): Ling Gu, Zhihui Yi, Yanle Zhang, Zhigui Ma, Yiping Zhu, Ju Gao

Journal: Oncotarget. 2017 May;8(19):30978-30991.

 

Recent studies showed that 2-deoxy-D-glucose (2-DG), a glucose analog with dual activity of inhibiting glycolysis and N-linked glycosylation, can be selectively taken up by cancer cells and be used as a potential chemo- and radio-sensitizer. Meanwhile, 2-DG can kill cancer cells under ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid Resistance" returned 25 free, full-text review articles on human participants. First 3 results:

Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes.
 

Author(s): Nicolas C Nicolaides, Evangelia Charmandari

Journal: Hormones (Athens). 2017 Apr;16(2):124-138.

 

Glucocorticoids play a fundamental role in many physiologic functions and contribute substantially to the achievement of homeostasis. These pleiotropic glucocorticoid actions are mediated by a ubiquitously expressed transcription factor, the human glucocorticoid receptor (hGR), which ...

Last Updated: 31 Dec 1969

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Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation.
 

Author(s): Carmine M Pariante

Journal: Eur Neuropsychopharmacol. 2017 06;27(6):554-559.

 

Studies over the last 20 years have demonstrated that increased inflammation and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis are two of the most consistent biological findings in major depression and are often associated: but the molecular and clinical mechanisms ...

Last Updated: 31 Dec 1969

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Mechanisms of Brain Glucocorticoid Resistance in Stress-Induced Psychopathologies.
 

Author(s): V M Merkulov, T I Merkulova, N P Bondar

Journal: Biochemistry Mosc.. 2017 Mar;82(3):351-365.

 

Exposure to stress activates the hypothalamic-pituitary-adrenal axis and leads to increased levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal dysfunction, decreases the density of synapses, and impairs neuronal plasticity. Decreased sensitivity ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: General Glucocorticoid Resistance

 

Last Updated: 20 Jun 2016

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Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
 

Status: Recruiting

Condition Summary: Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

 

Last Updated: 5 Mar 2018

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Determinants of Type 2 Diabetes Risk in Middle-aged Black South African Men and Women
 

Status: Recruiting

Condition Summary: Diabetes Mellitus, Type 2; Insulin Resistance; Menopause; Hiv

 

Last Updated: 17 Jan 2018

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