Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 2953 free, full-text research articles on human participants. First 3 results:

Bevacizumab and Glioblastoma: The Ecstasy and the Agony.
 

Author(s): Glenn J Lesser

Journal: Oncology (Williston Park, N.Y.). 2015 Oct;29(10):728-9.

 

Last Updated: 16 Oct 2015

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Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma.
 

Author(s): Jennifer Johnson, Maria Libera Ascierto, Sandeep Mittal, David Newsome, Liang Kang, Michael Briggs, Kirk Tanner, Francesco M Marincola, Michael E Berens, George F Vande Woude, Qian Xie

Journal:

 

Constitutive MET signaling promotes invasiveness in most primary and recurrent GBM. However, deployment of available MET-targeting agents is confounded by lack of effective biomarkers for selecting suitable patients for treatment. Because endogenous HGF overexpression often causes ...

Last Updated: 19 Sep 2015

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Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme.
 

Author(s): Shuai-Lai Wu, Xing Fu, Jinyan Huang, Ting-Ting Jia, Feng-Yang Zong, Shi-Rong Mu, Hong Zhu, Yong Yan, Shuwei Qiu, Qun Wu, Wei Yan, Ying Peng, Juxiang Chen, Jingyi Hui

Journal: Nucleic Acids Res.. 2015 Sep;43(17):8516-28.

 

Altered miRNA expression is believed to play a crucial role in a variety of human cancers; however, the mechanisms leading to the dysregulation of miRNA expression remain elusive. In this study, we report that the human Y box-binding protein (YB-1), a major mRNA packaging protein, ...

Last Updated: 30 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 193 free, full-text review articles on human participants. First 3 results:

VEGF Manipulation in Glioblastoma.
 

Author(s): Shiao-Pei Weathers, John de Groot

Journal: Oncology (Williston Park, N.Y.). 2015 Oct;29(10):720-7.

 

Glioblastoma is the most common malignant primary brain tumor that is universally lethal, despite optimized treatment including surgery, radiation, and chemotherapy. Targeting angiogenesis has been and continues to be an attractive therapeutic modality in both newly diagnosed and ...

Last Updated: 16 Oct 2015

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Cancer stem cells in glioblastoma.
 

Author(s): Justin D Lathia, Stephen C Mack, Erin E Mulkearns-Hubert, Claudia L L Valentim, Jeremy N Rich

Journal: Genes Dev.. 2015 Jun;29(12):1203-17.

 

Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains ...

Last Updated: 25 Jun 2015

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5-ALA Fluorescence Image Guided Resection of Glioblastoma Multiforme: A Meta-Analysis of the Literature.
 

Author(s): Samy Eljamel

Journal:

 

Glioblastoma multiforme (GBM) is one of the most deadly cancers in humans. Despite recent advances in anti-cancer therapies, most patients with GBM die from local disease progression. Fluorescence image guided surgical resection (FIGR) was recently advocated to enhance local control ...

Last Updated: 12 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
 

Status: Recruiting

Condition Summary: Glioma; Glioblastoma; Glioblastoma Multiforme

 

Last Updated: 6 Apr 2015

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Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
 

Status: Recruiting

Condition Summary: Glioblastoma Multiforme; Glioblastoma - Category

 

Last Updated: 12 Jan 2016

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Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma
 

Status: Recruiting

Condition Summary: Giant Cell Glioblastoma; Glioblastoma; Gliosarcoma

 

Last Updated: 3 Sep 2015

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