Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 2432 free, full-text research articles on human participants. First 3 results:

Glioblastoma in England: 2007-2011.
 

Author(s): Andrew Brodbelt, David Greenberg, Tim Winters, Matt Williams, Sally Vernon, V Peter Collins,

Journal: Eur. J. Cancer. 2015 Mar;51(4):533-42.

 

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumour in adults, with a poor prognosis. Changing treatment paradigms suggest improved outcome, but whole nation data for England is scarce. The aim of this report is to examine the incidence of patients ...

Last Updated: 15 Mar 2015

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Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
 

Author(s): Mona Meyer, Jüri Reimand, Xiaoyang Lan, Renee Head, Xueming Zhu, Michelle Kushida, Jane Bayani, Jessica C Pressey, Anath C Lionel, Ian D Clarke, Michael Cusimano, Jeremy A Squire, Stephen W Scherer, Mark Bernstein, Melanie A Woodin, Gary D Bader, Peter B Dirks

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Jan;112(3):851-6.

 

Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and phenotypically diverse cells. However, an understanding of the functional significance of intratumoral heterogeneity is lacking. We devised a method to isolate and functionally profile tumorigenic clones ...

Last Updated: 21 Jan 2015

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Complement activation in Glioblastoma multiforme pathophysiology: evidence from serum levels and presence of complement activation products in tumor tissue.
 

Author(s): T A M Bouwens, L A Trouw, R Veerhuis, C M F Dirven, M L M Lamfers, H Al-Khawaja

Journal: J. Neuroimmunol.. 2015 Jan;278():271-6.

 

Inflammation plays a key role in the pathophysiology of Glioblastoma Multiforme (GBM). Here we focus on the contribution of the so far largely ignored complement system. ELISA and immunohistochemistry were combined to assess levels and localization of critical components of the initiation- ...

Last Updated: 17 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 160 free, full-text review articles on human participants. First 3 results:

Eph receptors as therapeutic targets in glioblastoma.
 

Author(s): B W Day, B W Stringer, A W Boyd

Journal: Br. J. Cancer. 2014 Sep;111(7):1255-61.

 

The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine ...

Last Updated: 24 Sep 2014

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Extracellular vesicles as a platform for 'liquid biopsy' in glioblastoma patients.
 

Author(s): David R Santiago-Dieppa, Jeffrey Steinberg, David Gonda, Vincent J Cheung, Bob S Carter, Clark C Chen

Journal: Expert Rev. Mol. Diagn.. 2014 Sep;14(7):819-25.

 

Extracellular vesicles (EVs) are cell-secreted vesicles that range from 30-2000 nm in size. These vesicles are secreted by both normal and neoplastic cells. Physiologically, EVs serve multiple critical biologic functions, including cellular remodeling, intracellular communication, ...

Last Updated: 20 Aug 2014

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Use of high-resolution volumetric MR spectroscopic imaging in assessing treatment response of glioblastoma to an HDAC inhibitor.
 

Author(s): Hyunsuk Shim, Li Wei, Chad A Holder, Ying Guo, Xiaoping P Hu, Andrew H Miller, Jeffrey J Olson

Journal: AJR Am J Roentgenol. 2014 Aug;203(2):W158-65.

 

Improved predictive imaging would enable personalization and adjustment of treatment, which are critical for patients with glioblastomain whom therapy is likely to fail. This article describes the use of MR spectroscopic imaging (MRSI) to predict early clinical and behavioral response ...

Last Updated: 24 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
 

Status: Recruiting

Condition Summary: Glioma; Glioblastoma; Glioblastoma Multiforme

 

Last Updated: 6 Apr 2015

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Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
 

Status: Not yet recruiting

Condition Summary: Glioblastoma Multiforme; Glioblastoma - Category

 

Last Updated: 18 Apr 2014

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Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma
 

Status: Recruiting

Condition Summary: Giant Cell Glioblastoma; Glioblastoma; Gliosarcoma

 

Last Updated: 3 Dec 2014

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