Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 3141 free, full-text research articles on human participants. First 3 results:

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
 

Author(s): Saverio Tardito, Anaïs Oudin, Shafiq U Ahmed, Fred Fack, Olivier Keunen, Liang Zheng, Hrvoje Miletic, Per Øystein Sakariassen, Adam Weinstock, Allon Wagner, Susan L Lindsay, Andreas K Hock, Susan C Barnett, Eytan Ruppin, Svein Harald Mørkve, Morten Lund-Johansen, Anthony J Chalmers, Rolf Bjerkvig, Simone P Niclou, Eyal Gottlieb

Journal: Nat. Cell Biol.. 2015 Dec;17(12):1556-68.

 

L-Glutamine (Gln) functions physiologically to balance the carbon and nitrogen requirements of tissues. It has been proposed that in cancer cells undergoing aerobic glycolysis, accelerated anabolism is sustained by Gln-derived carbons, which replenish the tricarboxylic acid (TCA) ...

Last Updated: 27 Nov 2015

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Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.
 

Author(s): Pratheesh Sathyan, Pascal O Zinn, Anantha L Marisetty, Bin Liu, Mohamed Mostafa Kamal, Sanjay K Singh, Pierre Bady, Li Lu, Khalida M Wani, Bethany L Veo, Joy Gumin, Dina Hamada Kassem, Frederick Robinson, Connie Weng, Veerabhadran Baladandayuthapani, Dima Suki, Howard Colman, Krishna P Bhat, Erik P Sulman, Ken Aldape, Rivka R Colen, Roel G W Verhaak, Zhimin Lu, Gregory N Fuller, Suyun Huang, Frederick F Lang, Raymond Sawaya, Monika Hegi, Sadhan Majumder

Journal: J. Neurosci.. 2015 Nov;35(45):15097-112.

 

Glioblastoma (GBM) is the most aggressive human brain tumor. Although several molecular subtypes of GBM are recognized, a robust molecular prognostic marker has yet to be identified. Here, we report that the stemness regulator Sox2 is a new, clinically important target of microRNA-21 ...

Last Updated: 12 Nov 2015

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ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.
 

Author(s): Yuk Kien Chong, Edwin Sandanaraj, Lynnette W H Koh, Moogaambikai Thangaveloo, Melanie S Y Tan, Geraldene R H Koh, Tan Boon Toh, Grace G Y Lim, Joanna D Holbrook, Oi Lian Kon, Mahendran Nadarajah, Ivan Ng, Wai Hoe Ng, Nguan Soon Tan, Kah Leong Lim, Carol Tang, Beng Ti Ang

Journal:

 

Cell surface sialylation is associated with tumor cell invasiveness in many cancers. Glioblastoma is the most malignant primary brain tumor and is highly infiltrative. ST3GAL1 sialyltransferase gene is amplified in a subclass of glioblastomas, and its role in tumor cell self-renewal ...

Last Updated: 9 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 213 free, full-text review articles on human participants. First 3 results:

Advances in the treatment of newly diagnosed glioblastoma.
 

Author(s): Brett J Theeler, Mark R Gilbert

Journal:

 

Glioblastoma is a refractory malignancy with limited treatment options at tumor recurrence. Only a small proportion of patients survive 2 years or longer with the current standard of care. Gene expression profiling can segregate newly diagnosed patients into groups with different ...

Last Updated: 9 Dec 2015

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VEGF Manipulation in Glioblastoma.
 

Author(s): Shiao-Pei Weathers, John de Groot

Journal: Oncology (Williston Park, N.Y.). 2015 Oct;29(10):720-7.

 

Glioblastoma is the most common malignant primary brain tumor that is universally lethal, despite optimized treatment including surgery, radiation, and chemotherapy. Targeting angiogenesis has been and continues to be an attractive therapeutic modality in both newly diagnosed and ...

Last Updated: 16 Oct 2015

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Malignant melanoma mimicking giant cell variant of glioblastoma multiforme: a case report and review of literature.
 

Author(s): Ramir Arcega, William H Yong, Haodong Xu

Journal:

 

We present a case of metastatic malignant melanoma in a patient initially diagnosed with glioblastoma multiforme, giant cell variant. A forty year old female presented to our institution for a re-resection of a recurrent right parietal lobe mass, presumed to be recurrent glioblastoma ...

Last Updated: 20 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Recurrent Glioblastoma
 

Status: Not yet recruiting

Condition Summary: Glioma; Glioblastoma; Glioblastoma Multiforme; GBM; Brain Cancer

 

Last Updated: 18 Mar 2016

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Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
 

Status: Recruiting

Condition Summary: Glioblastoma Multiforme; Glioblastoma - Category

 

Last Updated: 12 Jan 2016

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Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma
 

Status: Recruiting

Condition Summary: Glioblastoma; Glioblastoma Multiforme; Glioma; Astrocytoma; Brain Tumor

 

Last Updated: 29 Mar 2016

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