Glioblastoma

Common Name(s)

Glioblastoma

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 2196 free, full-text research articles on human participants. First 3 results:

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression.
 

Author(s): Roberto Ferrarese, Griffith R Harsh, Ajay K Yadav, Eva Bug, Daniel Maticzka, Wilfried Reichardt, Stephen M Dombrowski, Tyler E Miller, Anie P Masilamani, Fangping Dai, Hyunsoo Kim, Michael Hadler, Denise M Scholtens, Irene L Y Yu, Jürgen Beck, Vinodh Srinivasasainagendra, Fabrizio Costa, Nicoleta Baxan, Dietmar Pfeifer, Dominik von Elverfeldt, Rolf Backofen, Astrid Weyerbrock, Christine W Duarte, Xiaolin He, Marco Prinz, James P Chandler, Hannes Vogel, Arnab Chakravarti, Jeremy N Rich, Maria S Carro, Markus Bredel

Journal: J. Clin. Invest.. 2014 Jul;124(7):2861-76.

 

Tissue-specific alternative splicing is critical for the emergence of tissue identity during development, yet the role of this process in malignant transformation is undefined. Tissue-specific splicing involves evolutionarily conserved, alternative exons that represent only a minority ...

Last Updated: 3 Jul 2014

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Bevacizumab for newly diagnosed glioblastoma.
 

Author(s): Mark R Gilbert, Erik P Sulman, Minesh P Mehta

Journal: N. Engl. J. Med.. 2014 May;370(21):2048-9.

 

Last Updated: 22 May 2014

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Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.
 

Author(s): M Signore, F Pelacchi, S di Martino, D Runci, M Biffoni, S Giannetti, L Morgante, M De Majo, E F Petricoin, L Stancato, L M Larocca, R De Maria, R Pallini, L Ricci-Vitiani

Journal:

 

Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs) ...

Last Updated: 9 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 145 free, full-text review articles on human participants. First 3 results:

Eph receptors as therapeutic targets in glioblastoma.
 

Author(s): B W Day, B W Stringer, A W Boyd

Journal: Br. J. Cancer. 2014 Sep;111(7):1255-61.

 

The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine ...

Last Updated: 24 Sep 2014

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Novel approaches and mechanisms of immunotherapy for glioblastoma.
 

Author(s): Meenakshi Hegde, Kevin J Bielamowicz, Nabil Ahmed

Journal: Discov Med. 2014 Mar;17(93):145-54.

 

Glioblastoma (GBM) is the most aggressive primary brain tumor. Combination therapy with surgery, radiation, and chemotherapy is not curative at present and carries a significant risk of toxicity. Advancements in the knowledge of tumor biology and tumor microenvironment have led to ...

Last Updated: 19 Mar 2014

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Treatment options and outcomes for glioblastoma in the elderly patient.
 

Author(s): Nils D Arvold, David A Reardon

Journal:

 

Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence rate of GBM in patients aged over 65 years is increasing rapidly. Median survival for elderly GBM ...

Last Updated: 4 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma
 

Status: Recruiting

Condition Summary: Glioblastoma; Small Cell Glioblastoma; Giant Cell Glioblastoma; Gliosarcoma; Glioblastoma With Oligodendroglial Component; Recurrent Glioblastoma; Relapsed Glioblastoma

 

Last Updated: 3 Sep 2014

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Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
 

Status: Recruiting

Condition Summary: Glioma; Glioblastoma; Glioblastoma Multiforme

 

Last Updated: 22 Sep 2014

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Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
 

Status: Not yet recruiting

Condition Summary: Glioblastoma Multiforme; Glioblastoma - Category

 

Last Updated: 18 Apr 2014

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