Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 3435 free, full-text research articles on human participants. First 3 results:

Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review.
 

Author(s): Chia-Ying Lin, Hsiu-Mei Huang

Journal:

 

Malignant optic gliomas are rare, but they rapidly become lethal visual pathway tumors. We present the clinical course, treatment, and prognosis of a case of unilateral malignant optic glioma in a young man with a history of brain glioblastoma multiforme (GBM).

Last Updated: 12 Mar 2017

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Continuous dose-intense temozolomide and cisplatin in recurrent glioblastoma patients.
 

Author(s): Yu Wang, Xiangyi Kong, Yi Guo, Renzhi Wang, Wenbin Ma

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6261.

 

In glioblastoma multiforme (GBM), both temozolomide (TMZ) and cisplatin are very active at various toxic levels. Previous studies demonstrated that cisplatin with the standard regimen of TMZ is active in patients suffering from recurrent GBM, generating a moderate level of toxicity. ...

Last Updated: 8 Mar 2017

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Prediction and Analysis of Key Genes in Glioblastoma Based on Bioinformatics.
 

Author(s): Hao Long, Chaofeng Liang, Xi'an Zhang, Luxiong Fang, Gang Wang, Songtao Qi, Haizhong Huo, Ye Song

Journal: Biomed Res Int. 2017 ;2017():7653101.

 

Understanding the mechanisms of glioblastoma at the molecular and structural level is not only interesting for basic science but also valuable for biotechnological application, such as the clinical treatment. In the present study, bioinformatics analysis was performed to reveal and ...

Last Updated: 13 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 259 free, full-text review articles on human participants. First 3 results:

Critical review of the addition of tumor treating fields (TTFields) to the existing standard of care for newly diagnosed glioblastoma patients.
 

Author(s): M Mehta, P Wen, R Nishikawa, D Reardon, K Peters

Journal: Crit. Rev. Oncol. Hematol.. 2017 Mar;111():60-65.

 

Since 2005, the standard of care for patients with newly diagnosed glioblastoma (GBM) has consisted of maximal resection followed by radiotherapy plus daily temozolomide (TMZ), followed by maintenance TMZ. In patients selected for clinical trials, median overall survival (OS) and ...

Last Updated: 5 Mar 2017

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Management of glioblastoma after recurrence: A changing paradigm.
 

Author(s): Supriya Mallick, Rony Benson, Abdul Hakim, Goura K Rath

Journal: J Egypt Natl Canc Inst. 2016 Dec;28(4):199-210.

 

Glioblastoma remains the most common primary brain tumor after the age of 40years. Maximal safe surgery followed by adjuvant chemoradiotherapy has remained the standard treatment for glioblastoma (GBM). But recurrence is an inevitable event in the natural history of GBM with most ...

Last Updated: 1 Aug 2016

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The evolving roles and controversies of radiotherapy in the treatment of glioblastoma.
 

Author(s): Eric Hau, Han Shen, Catherine Clark, Peter H Graham, Eng-Siew Koh, Kerrie L McDonald

Journal: J Med Radiat Sci. 2016 Jun;63(2):114-23.

 

Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted ...

Last Updated: 28 Jun 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

INtraoperative photoDYnamic Therapy of GliOblastoma
 

Status: Not yet recruiting

Condition Summary: Glioblastoma

 

Last Updated: 6 Mar 2017

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 9 Feb 2017

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Impact of the Platelet Level in Patients Treated for Glioblastoma With Temozolomid
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 27 Jul 2016

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