Glaucoma

Common Name(s)

Glaucoma

Glaucoma is a group of diseases in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve that brings information from the back of the eye (retina) resulting in vision loss and blindness. This group of diseases makes up the second most common cause of blindness.

There are multiple types of glaucoma, the most common of which is open-angle glaucoma. In open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens (cornea). In this form of glaucoma, side or peripheral vision is usually lost first. Other types of glaucoma include low-tension or normal-tension glaucoma, angle-closure glaucoma, congenital glaucoma, secondary glaucoma, neovascular glaucoma, pigmentary glaucoma, and pseudoexfoliation glaucoma. In angle-closure glaucoma, the iris blocks the channel that normally allows fluid leave the front of the eye. Symptoms of angle-closure glaucoma include eye pain, nausea, blurred vision, and redness of the eye. Medical attention should be sought promptly if angle-closure glaucoma is suspected.

Glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because some forms of glaucoma are often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glaucoma" for support, advocacy or research.

Glaucoma Research Foundation

We work to prevent vision loss from glaucoma by investing in innovative research, education, and support with the ultimate goal of finding a cure.

Last Updated: 14 May 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glaucoma" for support, advocacy or research.

Glaucoma Research Foundation

We work to prevent vision loss from glaucoma by investing in innovative research, education, and support with the ultimate goal of finding a cure.

http://www.glaucoma.org

Last Updated: 14 May 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

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General Resources

Glaucoma Care and Treatment Information

Glaucoma Care and Treatment options

Updated 14 May 2015

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Free Glaucoma Newsletter

Information for glaucoma patients

Updated 14 May 2015

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Glaucoma Research Progress Reports

Information about glaucoma research progress

Updated 14 May 2015

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Low Vision Resources

Links to products and services available for people with low vision.

Updated 14 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glaucoma" returned 3693 free, full-text research articles on human participants. First 3 results:

CDKN2B gene rs1063192 polymorphism decreases the risk of glaucoma.
 

Author(s): Zhenxian Hu, Chenliang He

Journal: Oncotarget. 2017 Mar;8(13):21167-21176.

 

The aim of this meta-analysis was to evaluate the association between cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene rs1063192 polymorphism and glaucoma risk. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated ...

Last Updated: 18 Apr 2017

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Goniosynechialysis and Repositioning of Intraocular Lens in a Case of Secondary Angle Closure Glaucoma.
 

Author(s): Masaru Fujita, Masafumi Ogata, Yasuyuki Suzuki, Tsunetomo Ichihashi, Miyuki Nagahara, Kenji Kawai

Journal:

 

Implanting intraocular lens (IOL) in proper direction is important in cataract surgery to reduce the possibility of undesirable complications. We experienced a case who underwent vitrectomy combined with cataract surgery and developed secondary angle closure glaucoma caused by IOL ...

Last Updated: 17 Apr 2017

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Predicted patient demand for a new delivery system for glaucoma medicine.
 

Author(s): Semra Ozdemir, Tina T Wong, Robert Rand Allingham, Eric A Finkelstein

Journal: Medicine (Baltimore). 2017 Apr;96(15):e6626.

 

Sustained-release drug delivery systems that replace the need for daily glaucoma medications will improve outcomes for those who are nonadherent and reduce the inconvenience of having to take medications on a recurring basis.The objective is to estimate uptake (i.e., demand) for a ...

Last Updated: 13 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glaucoma" returned 383 free, full-text review articles on human participants. First 3 results:

Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis.
 

Author(s): Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Takahiko Noro, Chikako Harada, Takayuki Harada

Journal: Oxid Med Cell Longev. 2017 ;2017():2817252.

 

Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells (RGCs) and their axons, namely, the optic nerve, usually associated with elevated intraocular pressure ...

Last Updated: 8 Mar 2017

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Epigenetics and Signaling Pathways in Glaucoma.
 

Author(s): Angela C Gauthier, Ji Liu

Journal: Biomed Res Int. 2017 ;2017():5712341.

 

Glaucoma is the most common cause of irreversible blindness worldwide. This neurodegenerative disease becomes more prevalent with aging, but predisposing genetic and environmental factors also contribute to increased risk. Emerging evidence now suggests that epigenetics may also be ...

Last Updated: 17 Feb 2017

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The Pathway From Genes to Gene Therapy in Glaucoma: A Review of Possibilities for Using Genes as Glaucoma Drugs.
 

Author(s): Teresa BorrĂ¡s

Journal: Asia Pac J Ophthalmol (Phila). ;6(1):80-93.

 

Treatment of diseases with gene therapy is advancing rapidly. The use of gene therapy has expanded from the original concept of re-placing the mutated gene causing the disease to the use of genes to con-trol nonphysiological levels of expression or to modify pathways known to affect ...

Last Updated: 5 Feb 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Incidence of Dyschromatopsia in Glaucoma
 

Status: Not yet recruiting

Condition Summary: Glaucoma

 

Last Updated: 14 Nov 2016

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Triamcinolone for Ahmed Glaucoma Valve
 

Status: Recruiting

Condition Summary: Glaucoma

 

Last Updated: 12 Jan 2016

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Improve Glaucoma Medication Adherence
 

Status: Not yet recruiting

Condition Summary: Glaucoma

 

Last Updated: 3 Mar 2017

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