Glaucoma

Common Name(s)

Glaucoma

Glaucoma is a group of diseases in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve that brings information from the back of the eye (retina) resulting in vision loss and blindness. This group of diseases makes up the second most common cause of blindness.

There are multiple types of glaucoma, the most common of which is open-angle glaucoma. In open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens (cornea). In this form of glaucoma, side or peripheral vision is usually lost first. Other types of glaucoma include low-tension or normal-tension glaucoma, angle-closure glaucoma, congenital glaucoma, secondary glaucoma, neovascular glaucoma, pigmentary glaucoma, and pseudoexfoliation glaucoma. In angle-closure glaucoma, the iris blocks the channel that normally allows fluid leave the front of the eye. Symptoms of angle-closure glaucoma include eye pain, nausea, blurred vision, and redness of the eye. Medical attention should be sought promptly if angle-closure glaucoma is suspected.

Glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because some forms of glaucoma are often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glaucoma" for support, advocacy or research.

Glaucoma Research Foundation

We work to prevent vision loss from glaucoma by investing in innovative research, education, and support with the ultimate goal of finding a cure.

Last Updated: 14 May 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glaucoma" for support, advocacy or research.

Glaucoma Research Foundation

We work to prevent vision loss from glaucoma by investing in innovative research, education, and support with the ultimate goal of finding a cure.

http://www.glaucoma.org

Last Updated: 14 May 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

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General Resources

Glaucoma Care and Treatment Information

Glaucoma Care and Treatment options

Updated 14 May 2015

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Free Glaucoma Newsletter

Information for glaucoma patients

Updated 14 May 2015

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Glaucoma Research Progress Reports

Information about glaucoma research progress

Updated 14 May 2015

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Low Vision Resources

Links to products and services available for people with low vision.

Updated 14 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glaucoma" returned 3573 free, full-text research articles on human participants. First 3 results:

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial.
 

Author(s): Augusto Azuara-Blanco, Jennifer Burr, Craig Ramsay, David Cooper, Paul J Foster, David S Friedman, Graham Scotland, Mehdi Javanbakht, Claire Cochrane, John Norrie,

Journal: Lancet. 2016 Oct;388(10052):1389-1397.

 

Primary angle-closure glaucoma is a leading cause of irreversible blindness worldwide. In early-stage disease, intraocular pressure is raised without visual loss. Because the crystalline lens has a major mechanistic role, lens extraction might be a useful initial treatment.

Last Updated: 6 Oct 2016

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Screening of the LTBP2 gene in 214 Chinese sporadic CYP1B1-negative patients with primary congenital glaucoma.
 

Author(s): Xueli Chen, Yuhong Chen, Bao Jian Fan, Mingying Xia, Li Wang, Xinghuai Sun

Journal:

 

To identify deleterious mutations in the latent transforming growth factor-β-binding protein 2 (LTBP2) gene in sporadic patients with primary congenital glaucoma (PCG) from a Han Chinese population, which had been excluded for mutations in the CYP1B1 gene.

Last Updated: 13 Jun 2016

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Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.
 

Author(s): David W Collins, Harini V Gudiseva, Benjamin Trachtman, Anita S Bowman, Anna Sagaser, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Joan M O'Brien

Journal:

 

To estimate the population frequencies of all common mitochondrial variants and ancestral haplogroups among 1,999 subjects recruited for the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study, including 1,217 primary open-angle glaucoma (POAG) cases and 782 controls, ...

Last Updated: 24 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glaucoma" returned 345 free, full-text review articles on human participants. First 3 results:

The Effects of Bevacizumab in Augmenting Trabeculectomy for Glaucoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
 

Author(s): Xiaoyan Liu, Liang Du, Ni Li

Journal: Medicine (Baltimore). 2016 Apr;95(15):e3223.

 

The aim of the study was to assess the effects of bevacizumab in augmenting trabeculectomy for glaucoma. We searched the databases of Cochrane Library, PubMed, Embase, CNKI, and VIP. All the databases were retrieved from the time databases established to September, 2015. The keywords ...

Last Updated: 16 Apr 2016

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Association of MMP-9 Gene Polymorphisms with Glaucoma: A Meta-Analysis.
 

Author(s): Yiqun Zhang, Mingjie Wang, Sunyi Zhang

Journal: Ophthalmic Res.. 2016 ;55(4):172-9.

 

The aim of this study was to evaluate the associations between matrix metalloproteinase-9 (MMP-9) gene polymorphisms (rs17576 and rs3918249) and glaucoma risk. All eligible studies were searched in PubMed, Embase, the Cochrane Library and the China Knowledge Resource Integrated Database. ...

Last Updated: 11 Mar 2016

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Neovascular glaucoma: a retrospective review from a tertiary center in China.
 

Author(s): Na Liao, Chaohong Li, Huilv Jiang, Aiwu Fang, Shengjie Zhou, Qinmei Wang

Journal:

 

The purpose of this study is to report the prevalence, etiology, treatment and outcomes of neovascular glaucoma (NVG) in a tertiary care ophthalmic center in China.

Last Updated: 28 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Incidence of Dyschromatopsia in Glaucoma
 

Status: Not yet recruiting

Condition Summary: Glaucoma

 

Last Updated: 14 Nov 2016

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Triamcinolone for Ahmed Glaucoma Valve
 

Status: Recruiting

Condition Summary: Glaucoma

 

Last Updated: 12 Jan 2016

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