Gigantomastia

Common Name(s)

Gigantomastia

Gigantomastia is a rare condition that is characterized by excessive breast growth that may occur spontaneously, during puberty or pregnancy, or while taking certain medications. To date, there is no universally accepted definition for gigantomastia; however, Dancey et al. (2007) state that a review of the medical literature suggests that definitions range from a D-cup bra size to breast enlargement requiring reduction of over 0.8 - 2 kg, which is equivalent to about 1.75 - 4.5 pounds. The exact cause of gigantomastia has not been determined. Nonetheless, the following theories have been proposed to explain gigantomastia: (1) end-organ hypersensitivity (a condition in which the breast tissue is more sensitive to hormones circulating in the body), (2) autoimmune issues, (3) high IGF-1 (insulin growth factor-1, a hormone involved in regulating bone growth) and (4) hyperprolactanemia (high levels of prolactin). Gigantomastia has been noted as a side effect of treatment with certain medications like D-pencillamine and in one case as an apparently hereditary condition. Symptoms of gigantomastic may include mastalgia (breast pain), ulceration/infection, posture problems, back pain and chronic traction injury to 4th/5th/6th intercostal nerves with resultant loss of nipple sensation. It is may also associated with decreased fetal growth, if the gigantomastia is present during pregnancy. Treatment is based on the person's symptoms and may include breast reduction, mastectomy with or without reconstruction, hormonal treatment, or a combination of treatments.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gigantomastia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gigantomastia" returned 5 free, full-text research articles on human participants. First 3 results:

Functional annotation of the microRNA-mediated network in gigantomastia by integrating microRNA and mRNA expression profiling.
 

Author(s): Jing-yi Li, Da-li Mu, Lan-hua Mu, Min-qiang Xin, Jie Luan

Journal: Chin. Med. J.. 2013 Feb;126(4):740-6.

 

Gigantomastia is the overdevelopment of the female mammary gland, and it causes great physiological and psychological burdens to patients. A better understanding of the molecular mechanisms involved in gigantomastia is needed to develop less invasive and more effective medical treatments. ...

Last Updated: 20 Feb 2013

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Gestational gigantomastia and anesthesia.
 

Author(s): Manuel Á Gómez-Ríos, Laura Nieto-Serradilla, Krzysztof M Kuczkowski, Emilio Couceiro Naveira

Journal: Anesthesiology. 2012 Jan;116(1):193.

 

Last Updated: 26 Dec 2011

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[Gigantomastia complicating pregnancy. A case report].
 

Author(s): J Rausky, B Burin des Roziers, G Daoud, S Cartier

Journal: J Gynecol Obstet Biol Reprod (Paris). 2011 Jun;40(4):367-70.

 

The authors report a very rare case of gestational gigantomastia and the pregnancy could be carried out in term. The repetition being inescapable, the mastectomy is the advised intervention if there is a later desire of pregnancy, in other cases a post-partum mammoplasty can be discussed.

Last Updated: 30 May 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gigantomastia" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Sep 2005

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