Gestational Trophoblastic Disease

Common Name(s)

Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) is a group of conditions that involve growth of tumors in the uterus. The cells that form these tumors are called trophoblasts, and form from the tissue that usually would become the placenta (the organ that connects the fetus to the mother for oxygen and nutrients) during pregnancy. While a woman with GTD may be initially diagnosed as being pregnant, the cells that would develop into a fetus do not develop normally, and therefore the pregnancy is not viable. GTD is detected early in pregnancy when symptoms include vaginal bleeding, very high levels of a specific hormone, or an abnormal ultrasound which tells the physician that something is wrong with the pregnancy. There are different types of GTD, but all are curable by either surgery, radiation therapy or chemotherapy. A physician will know which treatment option is best depending on the patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gestational Trophoblastic Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gestational Trophoblastic Disease" returned 67 free, full-text research articles on human participants. First 3 results:

Qualitative and quantitative analysis of diffusion-weighted imaging of gestational trophoblastic disease: Can it predict progression of molar pregnancy to persistent form of disease?
 

Author(s): Sepideh Sefidbakht, Fatemeh Hosseini, Bijan Bijan, Bahareh Hamedi, Tayyebeh Azizi

Journal: Eur J Radiol. 2017 Mar;88():71-76.

 

To describe the diffusion-weighted imaging (DWI) appearance of gestational trophoblastic disease (GTD) and to determine its apparent diffusion coefficient (ADC) values. To evaluate the feasibility of DWI to predict progression of hydatidiform mole (HM) to persistent disease.

Last Updated: 12 Feb 2017

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Comparing and evaluating the efficacy of methotrexate and actinomycin D as first-line single chemotherapy agents in low risk gestational trophoblastic disease.
 

Author(s): Young Jae Lee, Jeong Yeol Park, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam

Journal: J Gynecol Oncol. 2017 Mar;28(2):e8.

 

The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D).

Last Updated: 7 Nov 2016

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Mental Representations of Illness in Patients with Gestational Trophoblastic Disease: How Do Patients Perceive Their Condition?
 

Author(s): Valentina E Di Mattei, Letizia Carnelli, Martina Mazzetti, Martina Bernardi, Rossella Di Pierro, Alice Bergamini, Giorgia Mangili, Massimo Candiani, Lucio Sarno

Journal:

 

Gestational Trophoblastic Disease comprises a group of benign and malignant disorders that derive from the placenta. Using Leventhal's Common-Sense Model as a theoretical framework, this paper examines illness perception in women who have been diagnosed with this disease.

Last Updated: 22 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gestational Trophoblastic Disease" returned 7 free, full-text review articles on human participants. First 3 results:

Is Doppler ultrasound useful for evaluating gestational trophoblastic disease?
 

Author(s): Lawrence H Lin, Lisandra S Bernardes, Eliane A Hase, Koji Fushida, Rossana P V Francisco

Journal: Clinics (Sao Paulo). 2015 Dec;70(12):810-5.

 

Doppler ultrasound is a non-invasive method for evaluating vascularization and is widely used in clinical practice. Gestational trophoblastic neoplasia includes a group of highly vascularized malignancies derived from placental cells. This review summarizes data found in the literature ...

Last Updated: 7 Jan 2016

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The role of surgery and radiation therapy in the management of gestational trophoblastic disease.
 

Author(s): Rabbie K Hanna, John T Soper

Journal: Oncologist. 2010 ;15(6):593-600.

 

The primary management of hydatidiform moles remains surgical evacuation followed by human chorionic gonadotropin level monitoring. Although suction dilatation and evacuation is the most frequent technique for molar evacuation, hysterectomy is a viable option in older patients who ...

Last Updated: 25 Jun 2010

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[Hydatidiform mole and gestational trophoblastic disease].
 

Author(s): Jurandyr Moreira de Andrade

Journal: Rev Bras Ginecol Obstet. 2009 Feb;31(2):94-101.

 

The hydatiform mole is a relatively rare pregnancy complication, but with potential to evolve to forms which need systemic treatment and can be a threat to life. There are two histopathological and clinical entities under the name of hydatiform mole: the partial and the complete mole. ...

Last Updated: 1 May 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor
 

Status: Not yet recruiting

Condition Summary: Gestational Trophoblastic Neoplasms

 

Last Updated: 20 Dec 2015

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Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia
 

Status: Not yet recruiting

Condition Summary: Gestational Trophoblastic Disease

 

Last Updated: 11 Sep 2017

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Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Neoplasias (GTN)

 

Last Updated: 22 Aug 2017

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