Gestational Trophoblastic Disease

Common Name(s)

Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) is a group of conditions that involve growth of tumors in the uterus. The cells that form these tumors are called trophoblasts, and form from the tissue that usually would become the placenta (the organ that connects the fetus to the mother for oxygen and nutrients) during pregnancy. While a woman with GTD may be initially diagnosed as being pregnant, the cells that would develop into a fetus do not develop normally, and therefore the pregnancy is not viable. GTD is detected early in pregnancy when symptoms include vaginal bleeding, very high levels of a specific hormone, or an abnormal ultrasound which tells the physician that something is wrong with the pregnancy. There are different types of GTD, but all are curable by either surgery, radiation therapy or chemotherapy. A physician will know which treatment option is best depending on the patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gestational Trophoblastic Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gestational Trophoblastic Disease" returned 74 free, full-text research articles on human participants. First 3 results:

Characteristics of Three-Dimensional Power Doppler in Gestational Trophoblastic Disease.
 

Author(s): Wei Wang, Xueye Tian, Ting Zhang, Yanyan Wang, Zhen Han, Ruifang An

Journal: Dis. Markers. 2015 ;2015():917687.

 

In the present study, the three-dimensional power Doppler was used as a quantitative method to evaluate its reliability in detecting and assessing of gestational trophoblastic disease (GTD).

Last Updated: 10 Aug 2015

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An investigative study into psychological and fertility sequelae of gestational trophoblastic disease: the impact on patients' perceived fertility, anxiety and depression.
 

Author(s): Valentina E Di Mattei, Letizia Carnelli, Martina Bernardi, Elena Pagani Bagliacca, Paola Zucchi, Luca Lavezzari, Veronica Giorgione, Alessandro Ambrosi, Giorgia Mangili, Massimo Candiani, Lucio Sarno

Journal:

 

Gestational Trophoblastic Disease (GTD) comprises a group of disorders that derive from the placenta. Even if full recovery is generally expected, women diagnosed with GTD have to confront: the loss of a pregnancy, a potentially life-threatening diagnosis and delays in future pregnancies. ...

Last Updated: 2 Jun 2015

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Term delivery of a complete hydatidiform mole with a coexisting living fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease.
 

Author(s): Hsiu-Huei Peng, Kuan-Gen Huang, Ho-Yen Chueh, Aizura-Syafinaz Adlan, Shuenn-Dyn Chang, Chyi-Long Lee

Journal: Taiwan J Obstet Gynecol. 2014 Sep;53(3):397-400.

 

A twin pregnancy consisting of a complete hydatidiform mole with a coexisting normal fetus is extremely rare with an incidence of 1/22,000 to 1/100,000. The incidence of preterm delivery is high and few pregnancies reach near term with a viable fetus.

Last Updated: 7 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gestational Trophoblastic Disease" returned 6 free, full-text review articles on human participants. First 3 results:

The role of surgery and radiation therapy in the management of gestational trophoblastic disease.
 

Author(s): Rabbie K Hanna, John T Soper

Journal: Oncologist. 2010 ;15(6):593-600.

 

The primary management of hydatidiform moles remains surgical evacuation followed by human chorionic gonadotropin level monitoring. Although suction dilatation and evacuation is the most frequent technique for molar evacuation, hysterectomy is a viable option in older patients who ...

Last Updated: 25 Jun 2010

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[Hydatidiform mole and gestational trophoblastic disease].
 

Author(s): Jurandyr Moreira de Andrade

Journal: Rev Bras Ginecol Obstet. 2009 Feb;31(2):94-101.

 

The hydatiform mole is a relatively rare pregnancy complication, but with potential to evolve to forms which need systemic treatment and can be a threat to life. There are two histopathological and clinical entities under the name of hydatiform mole: the partial and the complete mole. ...

Last Updated: 1 May 2009

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Gestational trophoblastic disease.
 

Author(s): K Y Loh, N Sivalingam, M Y Suryani

Journal: Med. J. Malaysia. 2004 Dec;59(5):697-702; quiz 703.

 

Gestational trophoblastic disease is a spectrum of pregnancy disorder arising from the placental trophoblastic tissues. It characterised by the secretion of a distinct tumour marker, the beta-HCG. This condition is highly curable even in the presence of metastasis. The incidence of ...

Last Updated: 13 May 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Disease; Gestational Trophoblastic Neoplasia; Gestational Trophoblastic Tumor; Gestational Trophoblastic Neoplasms

 

Last Updated: 29 Mar 2013

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Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
 

Status: Recruiting

Condition Summary: Choriocarcinoma; FIGO Stage I Gestational Trophoblastic Tumor; FIGO Stage II Gestational Trophoblastic Tumor; FIGO Stage III Gestational Trophoblastic Tumor; Hydatidiform Mole

 

Last Updated: 9 Feb 2016

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Second Curettage in Treating Patients With Persistent Non-Metastatic Gestational Trophoblastic Tumor
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Tumor

 

Last Updated: 29 Mar 2011

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