Gestational Trophoblastic Disease

Common Name(s)

Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) is a group of conditions that involve growth of tumors in the uterus. The cells that form these tumors are called trophoblasts, and form from the tissue that usually would become the placenta (the organ that connects the fetus to the mother for oxygen and nutrients) during pregnancy. While a woman with GTD may be initially diagnosed as being pregnant, the cells that would develop into a fetus do not develop normally, and therefore the pregnancy is not viable. GTD is detected early in pregnancy when symptoms include vaginal bleeding, very high levels of a specific hormone, or an abnormal ultrasound which tells the physician that something is wrong with the pregnancy. There are different types of GTD, but all are curable by either surgery, radiation therapy or chemotherapy. A physician will know which treatment option is best depending on the patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gestational Trophoblastic Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gestational Trophoblastic Disease" returned 50 free, full-text research articles on human participants. First 3 results:

Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion.
 

Author(s): Kristen K Rumer, Miriam D Post, Rhea S Larivee, Martina Zink, Jill Uyenishi, Anita Kramer, Deanna Teoh, Kevin Bogart, Virginia D Winn

Journal:

 

Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. ...

Last Updated: 20 Nov 2012

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Severe peritonitis induced by methotrexate during treatment of persistent gestational trophoblastic disease.
 

Author(s): Stefan Zimmermann, Khalil Zaman, Anita Wolfer, William Jacot

Journal: Oncologist. 2012 ;17(8):e18-20.

 

Last Updated: 23 Aug 2012

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[Challenges of the treatment of patients with gestational trophoblastic disease].
 

Author(s): Izildinha Maestá, Antonio Braga

Journal: Rev Bras Ginecol Obstet. 2012 Apr;34(4):143-6.

 

Last Updated: 15 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gestational Trophoblastic Disease" returned 4 free, full-text review articles on human participants. First 3 results:

The role of surgery and radiation therapy in the management of gestational trophoblastic disease.
 

Author(s): Rabbie K Hanna, John T Soper

Journal: Oncologist. 2010 ;15(6):593-600.

 

The primary management of hydatidiform moles remains surgical evacuation followed by human chorionic gonadotropin level monitoring. Although suction dilatation and evacuation is the most frequent technique for molar evacuation, hysterectomy is a viable option in older patients who ...

Last Updated: 25 Jun 2010

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[Hydatidiform mole and gestational trophoblastic disease].
 

Author(s): Jurandyr Moreira de Andrade

Journal: Rev Bras Ginecol Obstet. 2009 Feb;31(2):94-101.

 

The hydatiform mole is a relatively rare pregnancy complication, but with potential to evolve to forms which need systemic treatment and can be a threat to life. There are two histopathological and clinical entities under the name of hydatiform mole: the partial and the complete mole. ...

Last Updated: 1 May 2009

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Gestational trophoblastic disease.
 

Author(s): K Y Loh, N Sivalingam, M Y Suryani

Journal: Med. J. Malaysia. 2004 Dec;59(5):697-702; quiz 703.

 

Gestational trophoblastic disease is a spectrum of pregnancy disorder arising from the placental trophoblastic tissues. It characterised by the secretion of a distinct tumour marker, the beta-HCG. This condition is highly curable even in the presence of metastasis. The incidence of ...

Last Updated: 13 May 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Disease; Gestational Trophoblastic Neoplasia; Gestational Trophoblastic Tumor; Gestational Trophoblastic Neoplasms

 

Last Updated: 29 Mar 2013

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Methotrexate or Dactinomycin in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Tumor; Hydatidiform Mole; Low Risk Metastatic Gestational Trophoblastic Tumor; Uterine Choriocarcinoma

 

Last Updated: 25 Mar 2014

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Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
 

Status: Recruiting

Condition Summary: Hydatidiform Moles

 

Last Updated: 21 Dec 2010

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