Gastroparesis

Common Name(s)

Gastroparesis

Gastroparesis is a condition in which the stomach muscles do not function properly. When food moves into the stomach, muscles contract and relax to break down the food before it passes into the small intestine. If the stomach muscles do not work correctly, food does not move on to the small intestine, causing problems with digestion. Types of gastroparesis include idiopathic and diabetic. Sometimes gastroparesis may get better on its own but more often it is a lifelong condition (chronic).

Symptoms of gastroparesis include vomiting, nausea, feeling full after just a few bites, bloating, abdominal pain, lack of appetite, malnutrition, and changes in blood sugar levels. Complications include severe dehydration, malnutrition, and blood sugar fluctuations. The cause of gastroparesis is not clear, but seems to involve damage to the nerve that controls stomach muscles (the vagus nerve).

Risk factors include diabetes, abdominal or esophageal surgery, radiation therapy, infection, narcotic pain medications, and hypothyroidism (low thyroid function). Certain conditions such as Ehlers Danlos syndrome, postural orthostatic tachycardia syndrome, scleroderma, multiple sclerosis and Parkinson disease also increase a person’s risk. Idiopathic gastroparesis is more likely to affect young and middle aged women.

Diagnosis may include and upper GI scan, MRI, CT scan, special breath test, stomach emptying test and/or an endoscopy. There is no cure for gastroparesis and the treatments may not help everyone. Treatments may include diet changes, medication, and/or devices or procedures that help move the digested food through the stomach and controlling underlying causes. If you or a family member has been diagnosed with gastroparesis, talk to your doctor and specialists about the most current treatment options. Support groups are a good source for information and will help connect you with others living with gastroparesis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroparesis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

Last Updated: 17 Aug 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

Last Updated: 28 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroparesis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details
Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

http://www.ehlers-danlos.org

Last Updated: 17 Aug 2015

View Details
G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

http://www.g-pact.org

Last Updated: 28 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroparesis" returned 148 free, full-text research articles on human participants. First 3 results:

Mirtazapine for symptom control in refractory gastroparesis.
 

Author(s): Mark Malamood, Aaron Roberts, Rahul Kataria, Henry P Parkman, Ron Schey

Journal:

 

Gastroparesis symptoms can be severe and debilitating. Many patients do not respond to currently available treatments. Mirtazapine has been shown in case reports to reduce symptoms in gastroparesis.

Last Updated: 14 Apr 2017

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Severe gastroparesis after catheter ablation for atrial fibrillation.
 

Author(s): Jonathan S Zipursky, Steven Shadowitz

Journal: CMAJ. 2017 03;189(9):E368.

 

Last Updated: 10 Mar 2017

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Twenty-five years of advocacy for patients with gastroparesis: support group therapy and patient reported outcome tool development.
 

Author(s): Teresa Cutts, Sandra Holmes, Archana Kedar, Karen Beatty, Mohammad K Mohammad, Thomas Abell

Journal:

 

Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decades. Using symptoms scores as a basis for documentation, 12 years of support/focus ...

Last Updated: 31 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroparesis" returned 34 free, full-text review articles on human participants. First 3 results:

Psychological controversies in gastroparesis: A systematic review.
 

Author(s): Sally Woodhouse, Geoff Hebbard, Simon R Knowles

Journal: World J. Gastroenterol.. 2017 Feb;23(7):1298-1309.

 

To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis.

Last Updated: 9 Mar 2017

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[Gastroparesis - causes, diagnosis and treatment].
 

Author(s): Dag A Sangnes, Eirik Søfteland, Martin Biermann, Odd Helge Gilja, Hrafnkell Thordarson, Georg Dimcevski

Journal:

 

BACKGROUND Gastroparesis is a motility disorder of the stomach. The symptoms are non-specific: nausea and vomiting are most common. Stomach pains, early satiety, postprandial fullness and bloating are also frequent symptoms. Current diagnostic criteria require delayed gastric emptying ...

Last Updated: 25 May 2016

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Novel Diet, Drugs, and Gastric Interventions for Gastroparesis.
 

Author(s): Michael Camilleri

Journal: Clin. Gastroenterol. Hepatol.. 2016 Aug;14(8):1072-80.

 

This review of the pathophysiologic basis for gastroparesis and recent advances in the treatment of patients with gastroparesis shows that there are several novel approaches to advance treatment of gastroparesis including diet, novel prokinetics, interventions on the pylorus, and ...

Last Updated: 19 Jul 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Promethazine for Treatment of Diabetic Gastroparesis
 

Status: Recruiting

Condition Summary: Diabetic Gastroparesis

 

Last Updated: 10 May 2017

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A Pilot Study on the Efficacy and Safety of Olanzapine in Gastroparesis
 

Status: Recruiting

Condition Summary: Idiopathic Gastroparesis

 

Last Updated: 29 Jun 2017

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Escalating Temporary Gastric Electrical Stimulation (GES) for Severe Gastroparesis
 

Status: Recruiting

Condition Summary: Gastroparesis

 

Last Updated: 12 Oct 2017

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