Gastroparesis

Common Name(s)

Gastroparesis

Gastroparesis is a condition in which the stomach muscles do not function properly. When food moves into the stomach, muscles contract and relax to break down the food before it passes into the small intestine. If the stomach muscles do not work correctly, food does not move on to the small intestine, causing problems with digestion. Types of gastroparesis include idiopathic and diabetic. Sometimes gastroparesis may get better on its own but more often it is a lifelong condition (chronic).

Symptoms of gastroparesis include vomiting, nausea, feeling full after just a few bites, bloating, abdominal pain, lack of appetite, malnutrition, and changes in blood sugar levels. Complications include severe dehydration, malnutrition, and blood sugar fluctuations. The cause of gastroparesis is not clear, but seems to involve damage to the nerve that controls stomach muscles (the vagus nerve).

Risk factors include diabetes, abdominal or esophageal surgery, radiation therapy, infection, narcotic pain medications, and hypothyroidism (low thyroid function). Certain conditions such as Ehlers Danlos syndrome, postural orthostatic tachycardia syndrome, scleroderma, multiple sclerosis and Parkinson disease also increase a person’s risk. Idiopathic gastroparesis is more likely to affect young and middle aged women.

Diagnosis may include and upper GI scan, MRI, CT scan, special breath test, stomach emptying test and/or an endoscopy. There is no cure for gastroparesis and the treatments may not help everyone. Treatments may include diet changes, medication, and/or devices or procedures that help move the digested food through the stomach and controlling underlying causes. If you or a family member has been diagnosed with gastroparesis, talk to your doctor and specialists about the most current treatment options. Support groups are a good source for information and will help connect you with others living with gastroparesis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroparesis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

Last Updated: 17 Aug 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroparesis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details
Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

http://www.ehlers-danlos.org

Last Updated: 17 Aug 2015

View Details
G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

http://www.g-pact.org

Last Updated: 28 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroparesis" returned 163 free, full-text research articles on human participants. First 3 results:

Blunting of Colon Contractions in Diabetics with Gastroparesis Quantified by Wireless Motility Capsule Methods.
 

Author(s): Radoslav Coleski, Gregory E Wilding, John R Semler, William L Hasler

Journal:

 

Generalized gut transit abnormalities are observed in some diabetics with gastroparesis. Relations of gastric emptying abnormalities to colon contractile dysfunction are poorly characterized. We measured colon transit and contractility using wireless motility capsules (WMC) in 41 ...

Last Updated: 29 Oct 2015

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Chronic recurrent emesis in a geriatric patient with jejunal cavernous hemangioma misdiagnosed as diabetic gastroparesis.
 

Author(s): Li Yan Liu, Xun Sun, Yan Zhu, Xiang Wei Meng, Quan Wang, Yuan Jie Sun

Journal: Turk J Gastroenterol. 2015 Sep;26(5):443-5.

 

Last Updated: 9 Sep 2015

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Gastric electrical stimulation for refractory gastroparesis: predictors of response and redefining a successful outcome.
 

Author(s): Bryan Richmond, Benny Chong, Asmita Modak, Mary Emmett, Kimball Knackstedt, Benjamin Dyer, Zachary AbuRahma

Journal: Am Surg. 2015 May;81(5):467-71.

 

Predictors of a favorable response and measures of success with gastric electrical stimulation (GES) for gastroparesis remain elusive. Published results remain inconsistent with respect to patient perceived benefit, despite statistical improvements in objective measures of symptom ...

Last Updated: 15 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroparesis" returned 31 free, full-text review articles on human participants. First 3 results:

Polyradiculopathy and Gastroparesis due to Cytomegalovirus Infection in AIDS: A Case Report and Review of Literature.
 

Author(s): Supat Thongpooswan, Eric Chyn, Mostafa Alfishawy, Erfidia Restrepo, Charles Berman, Kawser Ahmed, Sethu Muralidharan

Journal:

 

Cytomegalovirus (CMV) infection has been well described as an opportunistic infection of patients with human immunodeficiency virus (HIV). To the best of our knowledge, this is the first case report of a patient with AIDS and lumbosacral polyradiculopathy, associated with gastroparesis ...

Last Updated: 10 Nov 2015

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[Gastroparesis and other gastrointestinal symptoms in Parkinson's disease].
 

Author(s): D Santos-Garcia, T de Deus, C Tejera-Perez, I Exposito-Ruiz, E Suarez-Castro, P Carpintero, M Macias-Arribi

Journal: Rev Neurol. 2015 Sep;61(6):261-70.

 

Different gastrointestinal symptoms, such as excessive salivation, deterioration and other disorders affecting the teeth, dysphagia, gastroparesis, gastroesophageal reflux, constipation, difficult defecation or loss of weight are frequent events in all the stages of the development ...

Last Updated: 9 Sep 2015

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Endoscopic treatment of gastroparesis.
 

Author(s): Thomas R McCarty, Tarun Rustagi

Journal: World J. Gastroenterol.. 2015 Jun;21(22):6842-9.

 

Gastroparesis has traditionally been a largely medically managed disease with refractory symptoms typically falling under the umbrella of the surgical domain. Surgical options include, but are not limited to, gastrostomy, jejunostomy, pyloromyotomy, or pyloroplasty, and the Food and ...

Last Updated: 16 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

G-POEM for Treatment of Refractory Gastroparesis
 

Status: Recruiting

Condition Summary: Diabetic Gastroparesis; Idiopathic Gastroparesis; Gastroparesis Postoperative

 

Last Updated: 5 May 2016

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Treatment Use of Domperidone for Gastroparesis
 

Status: Available

Condition Summary: Gastroesophageal Reflux Disease; GERD; Gastroparesis

 

Last Updated: 15 Aug 2015

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RQ-00000010 for Gastroparesis and Constipation in Parkinson's Disease
 

Status: Recruiting

Condition Summary: Parkinson's Disease; Gastroparesis; Constipation

 

Last Updated: 29 Aug 2016

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