Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 523 free, full-text research articles on human participants. First 3 results:

Gastrointestinal stromal tumors: Fibrinogen levels are associated with prognosis of patients as blood-based biomarker.
 

Author(s): Jing Lu, Shuangjiang Chen, Xuqi Li, Guanglin Qiu, Shicai He, Haijiang Wang, Libo Zhou, Yaheng Jing, Xiangming Che, Lin Fan

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0568.

 

Improved prediction of prognosis for primary gastrointestinal stromal tumors (GISTs) after curative resection is an important goal in clinical practice. Coagulation factor of fibrinogen may inform prognosis of tumor patients as blood-based biomarker. Here, we aimed to analyze the ...

Last Updated: 31 Dec 1969

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F-18 FDG PET, CT, and MRI for detecting the malignant potential in patients with gastrointestinal stromal tumors: A protocol for a network meta-analysis of diagnostic test accuracy.
 

Author(s): Kongyuan Wei, Bei Pan, Huan Yang, Cuncun Lu, Long Ge, Nong Cao

Journal: Medicine (Baltimore). 2018 Apr;97(16):e0389.

 

Gastrointestinal stromal tumor (GIST) is a rare cancer in gastrointestinal carcinomas and has been widely known as a curable disease among all the digestive tumors. However, early detection of malignant potential in patients with GIST has still been a huge challenge all around the ...

Last Updated: 31 Dec 1969

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Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.
 

Author(s): Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelmann

Journal:

 

Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 92 free, full-text review articles on human participants. First 3 results:

[Rare digestive tumors: gastrointestinal stromal tumors (GISTs): about a case of small bowel location and literature review].
 

Author(s): Habib Bellamlih, Lamiae Bouimetarhan, Touriya Amil, Hassan En-Nouali, Naoufal Chouaib, Said Jidane, Mostafa Rafai, Ahmed Belkouch, Lahcen Belyamani

Journal:

 

Gastrointestinal stromal tumors (GISTs) are a rare group of mesenchymal tumors mainly occurring in the gastrointestinal tract. Previously, GISTs were classified as smooth muscle tumors also known as leiomyomas, leiomyosarcomas or leiomyoblastomas. However, since the advent of immunohistochemistry, ...

Last Updated: 31 Dec 1969

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[Gastrointestinal Stromal Tumors "GIST": status and news through our experience on 54 cases and review of literature].
 

Author(s): Nezha Taoufiq, Asmaa Naim, Zineb Bouchbika, Nadia Benchekroune, Hassan Jouhadi, Souha Sahraoui, Abdelatif Benider

Journal:

 

Tumors Gastrointestinal Stromal "GIST" are a very rare form of digestive tract cancers belonging to the family of sarcomas. The aim of this study is to establish the epidemiological profile, the diagnostic and therapeutic difficulties of this malignancy supported in a developing country. ...

Last Updated: 31 Dec 1969

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Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis.
 

Author(s): Yu Zhou, Wenqing Hu, Ping Chen, Masanobu Abe, Lei Shi, Si-Yuan Tan, Yong Li, Liang Zong

Journal: Medicine (Baltimore). 2017 Aug;96(34):e7911.

 

Ki67 is a good marker of cell proliferation in a variety of tumors. High ki67 levels are usually associated with poor prognosis. However, the relationship between Ki67 expression and the risk of malignancy of gastrointestinal stromal tumors (GISTs) is still poorly defined. The current ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 11 Oct 2016

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Last Updated: 7 Aug 2017

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Expanded Access to Everolimus, for an Individual Patient With GIST (Gastrointestinal Stromal Tumors)(CTMS#18-0019)
 

Status: Available

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 2 Apr 2018

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