Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 475 free, full-text research articles on human participants. First 3 results:

The cut-off value of tumor size and appropriate timing of follow-up for management of minimal EUS-suspected gastric gastrointestinal stromal tumors.
 

Author(s): Zhidong Gao, Chao Wang, Qian Xue, Jingtong Wang, Zhanlong Shen, Kewei Jiang, Kai Shen, Bin Liang, Xiaodong Yang, Qiwei Xie, Shan Wang, Yingjiang Ye

Journal:

 

The detectable rate of minimal gastric GISTs has continuously increased. While the surveillance and management of GIST <2 cm have been deemed controversial or lack evidence-based approaches.  The aim of the current study is to propose a cut-off value of tumor size for treatment ...

Last Updated: 12 Jan 2017

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A lower dosage of imatinib in patients with gastrointestinal stromal tumors with toxicity of the treatment.
 

Author(s): Yuan Yin, Jin Xiang, Sumin Tang, Jiaju Chen, Qin Yu, Bo Zhang

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5488.

 

This study investigated the efficiency and safety of imatinib in the lower dose (300 mg/d) in patients with gastrointestinal stromal tumor (GIST) who cannot tolerate imatinib in the standard dose (400 mg/d).Steady-state imatinib trough concentration (Cmin) values in 18 patients ...

Last Updated: 8 Dec 2016

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Gastrointestinal stromal tumors (GISTs) and second malignancies: A novel "sentinel tumor"? A monoinstitutional, STROBE-compliant observational analysis.
 

Author(s): Maria Grazia Rodriquenz, Sabrina Rossi, Riccardo Ricci, Maurizio Martini, Mario Larocca, Angelo Dipasquale, Michela Quirino, Giovanni Schinzari, Michele Basso, Ettore D'Argento, Antonia Strippoli, Carlo Barone, Alessandra Cassano

Journal: Medicine (Baltimore). 2016 Sep;95(38):e4718.

 

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically ...

Last Updated: 24 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 83 free, full-text review articles on human participants. First 3 results:

Talking KIT of the gastrointestinal stromal tumors.
 

Author(s): Kim Vaiphei

Journal: Indian J Pathol Microbiol. ;59(4):441-443.

 

Last Updated: 10 Oct 2016

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Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
 

Author(s): Zoltan Szucs, Khin Thway, Cyril Fisher, Ramesh Bulusu, Anastasia Constantinidou, Charlotte Benson, Winette Ta van der Graaf, Robin L Jones

Journal: Future Oncol. 2017 Jan;13(2):185-194.

 

Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase clinical trials novel systemic treatments are currently being ...

Last Updated: 7 Sep 2016

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Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.
 

Author(s): Zoltan Szucs, Khin Thway, Cyril Fisher, Ramesh Bulusu, Anastasia Constantinidou, Charlotte Benson, Winette Ta van der Graaf, Robin L Jones

Journal: Future Oncol. 2017 Jan;13(1):93-107.

 

Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated as 'wild-type' GISTs; however, they represent a heterogeneous ...

Last Updated: 7 Sep 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Jun 2016

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Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 11 Oct 2016

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A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumors

 

Last Updated: 14 Mar 2017

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