Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 400 free, full-text research articles on human participants. First 3 results:

Clinical outcomes of patients with advanced gastrointestinal stromal tumors: safety and efficacy in a worldwide treatment-use trial of sunitinib.
 

Author(s): Peter Reichardt, Yoon-Koo Kang, Piotr Rutkowski, Jochen Schuette, Lee S Rosen, Beatrice Seddon, Suayib Yalcin, Hans Gelderblom, Charles C Williams, Elena Fumagalli, Guido Biasco, Herbert I Hurwitz, Pamela E Kaiser, Kolette Fly, Ewa Matczak, Liang Chen, Maria José Lechuga, George D Demetri

Journal: Cancer. 2015 May;121(9):1405-13.

 

The objectives of this study were to provide sunitinib to patients with gastrointestinal stromal tumor (GIST) who were otherwise unable to obtain it and to collect broad safety and efficacy data from a large population of patients with advanced GIST after imatinib failure.

Last Updated: 23 Apr 2015

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Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors.
 

Author(s): Wei Wang, Qichao Ni, Hua Wang, Shu Zhang, Huijun Zhu

Journal: Dis. Markers. 2014 ;2014():942181.

 

Rab proteins of the endocytosis and exocytosis pathways both play critical roles in cancer progression, and Rab27B has a significant relationship with several types of human cancer. However, the association between Rab27B expression and clinical features to determine its clinicopathological ...

Last Updated: 10 Nov 2014

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Clinical presentations of gastric small gastrointestinal stromal tumors mimics functional dyspepsia symptoms.
 

Author(s): Qing-Xiang Yu, Zhan-Kun He, Jiang Wang, Chao Sun, Wei Zhao, Bang-Mao Wang

Journal: World J. Gastroenterol.. 2014 Sep;20(33):11800-7.

 

To explore whether clinical presentations of gastric small gastrointestinal tumors (GISTs) mimics gastrointestinal dyspepsia symptoms.

Last Updated: 10 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 64 free, full-text review articles on human participants. First 3 results:

Coexistence of gastrointestinal stromal tumors (GISTs) and pheochromocytoma in three cases of neurofibromatosis type 1 (NF1) with a review of the literature.
 

Author(s): Ahmet Gorgel, Devrim Dolek Cetinkaya, Fusun Salgur, Mustafa Demirpence, Husnu Yilmaz, Ece Harman Karaman, Pelin Tutuncuoglu, Gonca Oruk, Mitat Bahceci, Aysegul Akder Sari, Aysegul Aksoy Altinboga, Irem Paker

Journal: Intern. Med.. 2014 ;53(16):1783-9.

 

It is well known that neurofibromatosis type 1 (NF1) is uncommonly associated with pheochromocytoma development and also, to a larger extent, with gastrointestinal stromal tumors (GISTs). We herein document three cases with the rare condition of NF1 coexisting with GIST and pheochromocytoma, ...

Last Updated: 18 Aug 2014

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Laparoscopic versus open resection for gastric gastrointestinal stromal tumors: an updated systematic review and meta-analysis.
 

Author(s): Qi-Long Chen, Yu Pan, Jia-Qin Cai, Di Wu, Ke Chen, Yi-Ping Mou

Journal:

 

In past decades, laparoscopic surgery has been introduced for the treatment of gastrointestinal stromal tumors (GISTs). Recently, additional studies comparing laparoscopic versus open surgery for gastric GISTs have been published, and an updated meta-analysis of this subject is necessary.

Last Updated: 7 Aug 2014

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Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
 

Author(s): Markku Miettinen, Jerzy Lasota

Journal: Int. J. Biochem. Cell Biol.. 2014 Aug;53():514-9.

 

Loss of function of the succinate dehydrogenase complex characterizes a rare group of human tumors including some gastrointestinal stromal tumors, paragangliomas, renal carcinomas, and pituitary adenomas, and these can all be characterized as SDH-deficient tumors. Approximately 7.5% ...

Last Updated: 25 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumors; KIT +; Resected Gastrointestinal Stromal Tumors; Non-metastatic; High Risk of Recurrence

 

Last Updated: 8 Jun 2015

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Last Updated: 23 Jul 2015

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A Study of Famitinib in Patients With Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 8 Jan 2015

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