Acid reflux

Common Name(s)

Acid reflux, Gastroesophageal Reflux

Acid reflux, also known as gastroesophageal reflux, is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion.

The stomach makes a strong acid to help break down food and to protect the body from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes food from the mouth to the stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. Heartburn usually occurs after a meal, lasts several hours and worsens while lying down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may also trigger an heartburn episode.

Most people manage occasional heartburn with over-the-counter antacids and medications which decrease stomach acid production. Lifestyle changes such as losing weight, changing diet and drinking habits, exercising and stopping smoking may also help. If you are experiencing acid reflux more than 2 times per week, talk to your doctor because you may have a more long-term condition called gastroesophageal reflux disease (GERD). If you or a loved one is experiencing the symptoms of acid reflux, talk to your doctor about which treatment options are right for you. Support groups are also a good source of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acid reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acid reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acid reflux" returned 136 free, full-text research articles on human participants. First 3 results:

Endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer and dextranomer/hyaluronic acid in adults.
 

Author(s): Akif Turk, Ahmet Selimoglu, Kadir Demir, Osman Celik, Erkin Saglam, Fatih Tarhan

Journal: Int Braz J Urol. ;40(3):379-83.

 

Aim of this study is to examine the effectiveness of dextranomer/hyaluronic acid copolymer and polyacrylate polyalcohol copolymer in endoscopic treatment of vesicoureteral reflux disease in adult patients with and without chronic renal failure.

Last Updated: 11 Jul 2014

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Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux.
 

Author(s): B Palmieri, A Merighi, D Corbascio, V Rottigni, G Fistetto, A Esposito

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(24):3272-8.

 

Proton pump inhibitors (PPIs) are a major breakthrough in the medical management of gastroesophageal reflux disease (GERD). In several patients with non erosive reflux disease symptoms (NERD) the response to PPIs is partial or limited and symptoms relief needs the administration of ...

Last Updated: 31 Dec 2013

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Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: is gastroparesis a factor?
 

Author(s): Anna Tavakkoli, Bisma A Sayed, Nicholas J Talley, Baharak Moshiree

Journal: World J. Gastroenterol.. 2013 Oct;19(37):6193-8.

 

To determine whether an increased number and duration of non-acid reflux events as measured using the multichannel intraluminal impedance pH (MII-pH) is linked to gastroparesis (GP).

Last Updated: 11 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acid reflux" returned 15 free, full-text review articles on human participants. First 3 results:

Animal model of acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandins, and amino acids.
 

Author(s): Koji Takeuchi, Kenji Nagahama

Journal: Biomed Res Int. 2014 ;2014():532594.

 

Esophagitis was induced in rats within 3 h by ligating both the pylorus and transitional region between the forestomach and glandular portion under ether anesthesia. This esophageal injury was prevented by the administration of acid suppressants and antipepsin drug and aggravated ...

Last Updated: 27 Mar 2014

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Are there risks associated with empiric acid suppression treatment of infants and children suspected of having gastroesophageal reflux disease?
 

Author(s): Erica Y Chung, Jeremy Yardley

Journal: Hosp Pediatr. 2013 Jan;3(1):16-23.

 

It has become common practice to empirically treat infants and children who have suspected gastroesophageal reflux disease by using acid-suppressive medications. However, evidence to support the effectiveness of these medications in the pediatric population is limited. With multiple ...

Last Updated: 10 Dec 2013

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Helicobacter pylori eradication and reflux disease onset: did gastric acid get "crazy"?
 

Author(s): Angelo Zullo, Cesare Hassan, Alessandro Repici, Vincenzo Bruzzese

Journal: World J. Gastroenterol.. 2013 Feb;19(6):786-9.

 

Gastroesophageal reflux disease (GORD) is highly prevalent in the general population. In the last decade, a potential relationship between Helicobacter pylori (H. pylori) eradication and GORD onset has been claimed. The main putative mechanism is the gastric acid hypersecretion that ...

Last Updated: 22 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy
 

Status: Not yet recruiting

Condition Summary: Acid Reflux Esophagitis; Non-acid Reflux Esophagitis

 

Last Updated: 31 Jan 2014

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The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
 

Status: Recruiting

Condition Summary: Esophagitis; Reflux Esophagitis; Gastroesophageal Reflux Disease

 

Last Updated: 10 Feb 2015

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Effect of Esomeprazole 40 mg.Daily for 7 Days on Acid Reflux and Related Arousals During Sleep in Patients With GERD
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 18 Aug 2010

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