Gastroesophageal Reflux

Common Name(s)

Gastroesophageal Reflux

Gastroesphageal Reflux is a condition in which the contents of the stomach, whether food, liquid, or acid, retract back to the esophagus irritating or burning the tract of the person. Gastroesophageal reflux is caused when the sphincter muscle, responsible for keeping the contents of the stomach in a proper digestion order, does not close well, allowing for contents to essentially leak back and potentially damage the esophagus. Alcohol, tobacco, and general obesity tend to propel the frequency in which this reflux occurs. Heartburn is a common associated syndrome with this condition and it is not out of the ordinary for a normal person to experience gastroesophageal reflux occasionally.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal Reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal Reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal Reflux" returned 492 free, full-text research articles on human participants. First 3 results:

Characteristics of refractory gastroesophageal reflux disease (GERD) symptoms -is switching proton pump inhibitors based on the patient's CYP2C19 genotype an effective management strategy?
 

Author(s): Toshihisa Takeuchi, Kazuhiro Oota, Satoshi Harada, Shoko Edogawa, Yuichi Kojima, Makoto Sanomura, Masahiro Sakaguchi, Katsuyoshi Hayashi, Yasushi Hongoh, Tsukasa Itabashi, Hidehiro Kitae, Masahiro Hoshimoto, Nozomi Takeuchi, Kazuhide Higuchi

Journal: Intern. Med.. 2015 ;54(2):97-105.

 

We investigated factors related to proton pump inhibitor (PPI) -refractory gastroesophageal reflux disease (GERD) symptoms, particularly with respect to acid, the CYP2C19 genotype and psychological aspects.

Last Updated: 6 Mar 2015

Go To URL
Relationship between esophageal cardiac glands and gastroesophageal reflux disease.
 

Author(s): Kozue Hanada, Kyoichi Adachi, Tomoko Mishiro, Shino Tanaka, Yoshiko Takahashi, Kazuaki Yoshikawa, Yoshikazu Kinoshita

Journal: Intern. Med.. 2015 ;54(2):91-6.

 

The role of esophageal cardiac glands has not been fully determined. This study was performed to clarify the protective role of esophageal cardiac glands against the development of gastroesophageal reflux disease (GERD).

Last Updated: 6 Mar 2015

Go To URL
Two-year results of intermittent electrical stimulation of the lower esophageal sphincter treatment of gastroesophageal reflux disease.
 

Author(s): Leonardo Rodríguez, Patricia Rodriguez, Beatriz Gómez, Juan C Ayala, Danny Oxenberg, Alberto Perez-Castilla, Manoel G Netto, Edy Soffer, W John Boscardin, Michael D Crowell

Journal: Surgery. 2015 Mar;157(3):556-67.

 

Lower esophageal sphincter (LES) electrical stimulation therapy (EST) has been shown to improve outcome in gastroesophageal reflux disease (GERD) patients at 1 year. The aim of this open-label extension trial (NCT01578642) was to study the 2-year safety and efficacy of LES-EST in GERD patients.

Last Updated: 2 Mar 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal Reflux" returned 159 free, full-text review articles on human participants. First 3 results:

Diagnosis and management of gastroesophageal reflux disease.
 

Author(s): Maria Aparecida Coelho de Arruda Henry

Journal: Arq Bras Cir Dig. ;27(3):210-5.

 

Gastroesophageal reflux disease (GERD) is probably one of the most prevalent diseases in the world that also compromises the quality of life of the affected significantly. Its incidence in Brazil is 12%, corresponding to 20 million individuals.

Last Updated: 4 Sep 2014

Go To URL
Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive review.
 

Author(s): Crina Roman, Stanislas Bruley des Varannes, Lucian Muresan, Alina Picos, Dan L Dumitrascu

Journal: World J. Gastroenterol.. 2014 Jul;20(28):9592-9.

 

To analyze the potential relationship between gastroesophageal reflux disease (GERD) and the development of atrial fibrillation (AF).

Last Updated: 29 Jul 2014

Go To URL
Stretta: a valuable endoscopic treatment modality for gastroesophageal reflux disease.
 

Author(s): George Triadafilopoulos

Journal: World J. Gastroenterol.. 2014 Jun;20(24):7730-8.

 

One potential option for the management of refractory gastro-esophageal reflux disease (GERD) is the delivery of radiofrequency energy to the gastro-esophageal junction (Stretta). This endoscopic therapy is safe, effective, durable, and repeatable if necessary and serves an unmet ...

Last Updated: 30 Jun 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
 

Status: Recruiting

Condition Summary: Esophagitis; Reflux Esophagitis; Gastroesophageal Reflux Disease

 

Last Updated: 10 Feb 2015

Go to URL
Effect of Full-thickness Gastroplication With the GERD-X System on Atypical Gastro-esophageal-reflux-symptoms
 

Status: Recruiting

Condition Summary: Atypical Gastroesophageal Reflux Symptoms; Objectified Gastroesophageal Reflux Disease

 

Last Updated: 28 Jan 2015

Go to URL
Gastroesophageal Reflux During LMA in Control Ventilation (LMA, Laryngeal Mask Airway)
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux

 

Last Updated: 11 May 2015

Go to URL