Acid reflux

Common Name(s)

Acid reflux, Gastroesophageal reflux

Acid reflux, also known as gastroesophageal reflux, is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion.

The stomach makes a strong acid to help break down food and to protect the body from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes food from the mouth to the stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. Heartburn usually occurs after a meal, lasts several hours and worsens while lying down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may also trigger an heartburn episode.

Most people manage occasional heartburn with over-the-counter antacids and medications which decrease stomach acid production. Lifestyle changes such as losing weight, changing diet and drinking habits, exercising and stopping smoking may also help. If you are experiencing acid reflux more than 2 times per week, talk to your doctor because you may have a more long-term condition called gastroesophageal reflux disease (GERD). If you or a loved one is experiencing the symptoms of acid reflux, talk to your doctor about which treatment options are right for you. Support groups are also a good source of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acid reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acid reflux" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acid reflux" returned 164 free, full-text research articles on human participants. First 3 results:

Banhasasim-Tang Treatment Reduces the Severity of Esophageal Mucosal Ulcer on Chronic Acid Reflux Esophagitis in Rats.
 

Author(s): Mi-Rae Shin, Bu-Il Seo, Chang Gue Son, Seong-Soo Roh, Hyo-Jin An

Journal: Biomed Res Int. 2017 ;2017():7157212.

 

The present study was conducted to evaluate both antioxidant and anti-inflammatory activity of Banhasasim-tang (BHSST) on chronic acid reflux esophagitis (CRE) model. Rat CRE model was established operatively and then treated with BHSST (1 g/kg body weight per day) for 15 days Esophageal ...

Last Updated: 28 Mar 2017

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Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation.
 

Author(s): V Savarino, F Pace, C Scarpignato,

Journal: Aliment. Pharmacol. Ther.. 2017 Mar;45(5):631-642.

 

Several studies have shown that patients with non-erosive reflux disease (NERD) are less responsive to proton pump inhibitors (PPIs) than those with erosive disease as they belong to different subgroups, in whom factors other than acid can trigger symptoms.

Last Updated: 24 Jan 2017

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Dose-Finding Study of Omeprazole on Gastric pH in Neonates with Gastro-Esophageal Acid Reflux Using a Bayesian Sequential Approach.
 

Author(s): Florentia Kaguelidou, Corinne Alberti, Valerie Biran, Olivier Bourdon, Caroline Farnoux, Sarah Zohar, Evelyne Jacqz-Aigrain

Journal:

 

Proton pump inhibitors are frequently administered on clinical symptoms in neonates but benefit remains controversial. Clinical trials validating omeprazole dosage in neonates are limited. The objective of this trial was to determine the minimum effective dose (MED) of omeprazole ...

Last Updated: 21 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acid reflux" returned 22 free, full-text review articles on human participants. First 3 results:

Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis.
 

Author(s): Yue Yang, Haitao Wu, Jian Zhou

Journal: Medicine (Baltimore). 2016 Oct;95(40):e4868.

 

This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL).

Last Updated: 17 Oct 2016

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Dimercaptosuccinic acid scan challenges in childhood urinary tract infection, vesicoureteral reflux and renal scarring investigation and management.
 

Author(s): Stylianos Roupakias, Xenophon Sinopidis, George Tsikopoulos, Ioannis Spyridakis, Ageliki Karatza, Anastasia Varvarigou

Journal: Minerva Urol Nefrol. 2017 Apr;69(2):144-152.

 

Vesicoureteral reflux (VUR) is a precipitating factor in acute pyelonephritis (APN), and a risk factor for renal scar formation, even if VUR and APN occur independently. There is no scientific evidence on a specific diagnostic evaluation of children after a febrile urinary tract infection ...

Last Updated: 29 Jun 2016

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Animal model of acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandins, and amino acids.
 

Author(s): Koji Takeuchi, Kenji Nagahama

Journal: Biomed Res Int. 2014 ;2014():532594.

 

Esophagitis was induced in rats within 3 h by ligating both the pylorus and transitional region between the forestomach and glandular portion under ether anesthesia. This esophageal injury was prevented by the administration of acid suppressants and antipepsin drug and aggravated ...

Last Updated: 27 Mar 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study
 

Status: Recruiting

Condition Summary: Non-erosive Reflux Disease

 

Last Updated: 24 May 2017

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Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures
 

Status: Not yet recruiting

Condition Summary: Bile Reflux

 

Last Updated: 25 Mar 2017

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Last Updated: 24 Feb 2009

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