Gardner Syndrome

Common Name(s)

Gardner Syndrome

Gardner syndrome is a specific type of familial adenomatous polyposis (FAP), a genetic condition that causes growths (polyps) in the large intestine (colon) and rectum that become cancerous over time. Like all forms of FAP, Gardner syndrome also causes polyps to form in these areas. However, in addition to the polyps that form in the colon and rectum, individuals with Gardner syndrome are also at risk of developing both cancerous and noncancerous (benign) tumors in other areas of the body. These tumors tend to develop as fluid filled sacs (cysts) in the skin (called sebaceous and epidermoid cysts) or in bone (called osteomas). Other symptoms of Gardner syndrome may include too many teeth and a benign abnormality of the back of the eye (retina), called retinal pigment epithelial hypertrophy.

Gardner syndrome is caused by a change (mutation) in a gene affecting cell growth, called APC. This gene, when mutated, causes abnormal cell growth and division, which can lead to the creation of polyps and tumors. Gardner syndrome is inherited in a dominant manner, meaning a mutation in only one of the two APC gene copies a person has causes the condition. Each child of a person with Gardner syndrome has a 50% of also having Gardner syndrome.

Gardner syndrome is considered in a person with multiple polyps in their colon, along with other tumors or cysts in other parts of their body. The diagnosis is confirmed with genetic testing. Treatments include close monitoring and screening for colon polyps using a camera that is inserted into the colon (colonoscopy), removal of the polyps, and removal of the colon. If you or your child has been diagnosed with Gardner syndrome, talk to a doctor about all treatment options. Support groups are also available to connect with others who are affected by Gardner syndrome.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gardner Syndrome" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gardner Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gardner Syndrome" returned 13 free, full-text research articles on human participants. First 3 results:

Refractory ulcerative chronic pouchitis in a patient with Gardner syndrome following restorative proctocolectomy with ileal pouch-anal anastomosis.
 

Author(s): Juan J Sebastián-Domingo, Mara Charro-Calvillo, Mónica Navarro-Dourdi, Tomás Cabrera-Chaves, Gloria Ceña-Lázaro, María Ortiz-Lucas

Journal: Rev Esp Enferm Dig. 2011 Nov;103(11):600-1.

 

Last Updated: 14 Dec 2011

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Images in cardiovascular medicine. Left atrial fibroma in gardner syndrome: real-time 3-dimensional transesophageal echo imaging.
 

Author(s): Hyun Suk Yang, Francisco A Arabia, Hari P Chaliki, Giovanni De Petris, Bijoy K Khandheria, Krishnaswamy Chandrasekaran

Journal: Circulation. 2008 Nov;118(20):e692-6.

 

Last Updated: 12 Nov 2008

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Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature.
 

Author(s): Guo-Li Gu, Shi-Lin Wang, Xue-Ming Wei, Li Bai

Journal: World J. Gastroenterol.. 2008 Apr;14(13):2121-3.

 

Gardner syndrome (GS) is an autosomal dominant disease characterized by the presence of colonic polyposis, osteoma and soft tissue tumors. It is regarded as a clinical subgroup of familial adenomatous polyposis (FAP) and may present at any age from 2 mo to 70 years with a variety ...

Last Updated: 8 Apr 2008

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gardner Syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

[Familial adenomatous polyposis or Gardner syndrome--review of the literature and presentation of 2 clinical cases].
 

Author(s): M Karazivan, K Manoukian, B Lalonde

Journal: J Can Dent Assoc. 2000 Jan;66(1):26-30.

 

Gardner syndrome is a type of hereditary gastrointestinal polyposis. Dental professionals should be aware that this syndrome can present as multiple impacted teeth and sometimes as large osteomas in the head and neck area. Following a brief review of literature, we present two cases ...

Last Updated: 9 Mar 2000

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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