Ganglioglioma

Common Name(s)

Ganglioglioma

A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.   Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.   This can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  Most gangliogliomas grow slowly and are considered benign.  However, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.     The main treatment for ganglioglioma is removal of the entire tumor during surgery.  If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ganglioglioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ganglioglioma" returned 49 free, full-text research articles on human participants. First 3 results:

Non-infantile variant of desmoplastic ganglioglioma: Conventional and advanced MR imaging characteristics.
 

Author(s): Betul E Derinkuyu, Murat Ucar, Alp O Borcek, Cagri Damar, Cigdem Oztunali, Ayse Gul Alimli, Oznur Boyunaga

Journal: Neuroradiol J. 2015 Jun;28(3):259-63.

 

Desmoplastic infantile ganglioglioma is a paediatric brain tumor that is commonly seen in the infantile age group. Literature on the non-infantile variant of this low-grade supratentorial neoplasm is very scarce, except for a few case reports. Herein, we report a case of desmoplastic ...

Last Updated: 6 Aug 2015

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Pediatric low-grade ganglioglioma: epidemiology, treatments, and outcome analysis on 348 children from the surveillance, epidemiology, and end results database.
 

Author(s): Roy W R Dudley, Michelle R Torok, Danielle R Gallegos, Jean M Mulcahy-Levy, Lindsey M Hoffman, Arthur K Liu, Michael H Handler, Todd C Hankinson

Journal: Neurosurgery. 2015 Mar;76(3):313-9; discussion 319; quiz 319-20.

 

Low-grade gangliogliomas/gangliocytomas (GGs) are rare tumors of the central nervous system that occur mostly in young people. Because of their rarity, large-scale, population-based studies focusing on epidemiology and outcomes are lacking.

Last Updated: 18 Feb 2015

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Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent.
 

Author(s): Francesca del Bufalo, Andrea Carai, Lorenzo Figà-Talamanca, Benedetta Pettorini, Conor Mallucci, Felice Giangaspero, Manila Antonelli, Manuela Badiali, Loredana Moi, Giuseppe Bianco, Antonella Cacchione, Franco Locatelli, Elisabetta Ferretti, Angela Mastronuzzi

Journal:

 

Ganglioglioma (GG) and pilocytic astrocytoma (PA) represent the most frequent low-grade gliomas (LGG) occurring in paediatric age. LGGs not amenable of complete resection (CR) represent a challenging subgroup where traditional treatments often fail. Activation of the MAP Kinase (MAPK) ...

Last Updated: 27 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ganglioglioma" returned 8 free, full-text review articles on human participants. First 3 results:

Anaplastic ganglioglioma: a report of three cases and review of the literature.
 

Author(s): John Thomas Lucas, Andrew Jonathan Huang, Ryan T Mott, Glenn J Lesser, Stephen Bradley Tatter, Michael David Chan

Journal: J. Neurooncol.. 2015 May;123(1):171-7.

 

Gangliogliomas are rare tumors of the central nervous system that are thought to arise from a glioneuronal precursor and consist of both neuronal and glial elements. Grade III, or anaplastic ganglioglioma (AGG), most commonly affects children and young adults, generally arises in ...

Last Updated: 21 May 2015

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Cerebellar ganglioglioma.
 

Author(s): Badr Fedoul, Zouhayr Souirti

Journal: Pan Afr Med J. 2012 ;12():12.

 

The cerebellar location of ganglioglioma (GG) is exceptional. We report one case of a 27-year-old man who underwent an intracranial hypertension syndrome and a static cerebellar syndrome. Brain magnetic resonance images revealed a cyst image in the vermis. Histological study after ...

Last Updated: 24 Jul 2012

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Infiltrative cerebellar ganglioglioma: conventional and advanced MRI, proton MR spectroscopic, and FDG PET findings in an 18-month-old child.
 

Author(s): U Löbel, D W Ellison, B L Shulkin, Z Patay

Journal: Clin Radiol. 2011 Feb;66(2):194-201.

 

Last Updated: 10 Jan 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation
 

Status: Recruiting

Condition Summary: Brain Tumor; Low Grade Glioma; Astrocytoma; Ependymoma; Ganglioglioma

 

Last Updated: 1 Sep 2016

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Phase II Pediatric Study With Dabrafenib in HGG Patients
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma; Giant Cell Glioblastoma; Gliosarcoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma; Choroid Plexus Carcinoma; Anaplastic Ganglioglioma; Pineal Parenchymal Tumor; Pineoblastoma; Medulloblastoma; PNET; Rhabdoid Tumor; Perineurioma; MPNST; Malignant Meningloma; Anaplastic Hemangiopericytoma

 

Last Updated: 9 Sep 2016

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