Ganglioglioma

Common Name(s)

Ganglioglioma

A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.   Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.   This can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  Most gangliogliomas grow slowly and are considered benign.  However, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.     The main treatment for ganglioglioma is removal of the entire tumor during surgery.  If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ganglioglioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ganglioglioma" returned 49 free, full-text research articles on human participants. First 3 results:

Desmoplastic infantile astrocytoma/ganglioglioma with rare BRAF V600D mutation.
 

Author(s): Ashley Greer, Nicholas K Foreman, Andrew Donson, Kurtis D Davies, B K Kleinschmidt-DeMasters

Journal: Pediatr Blood Cancer. 2017 Jun;64(6):.

 

Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile gangliogliomas (DIGs) are rare, massive, cystic and solid tumors of infants usually found in superficial cerebral hemispheres. They manifest prominent desmoplastic stroma, admixed neoplastic astrocytes, primitive-appearing ...

Last Updated: 31 Dec 1969

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Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord.
 

Author(s): Joshua L Wang, Christopher S Hong, Jose Otero, Vinay K Puduvalli, J Bradley Elder

Journal: World Neurosurg. 2016 Dec;96():608.e1-608.e4.

 

Gangliogliomas are rare, low-grade intra-axial tumors that exhibit both neuronal and glial components. Although the vast majority present as an intracranial lesion, a rare subset exist as isolated lesions of the spinal cord. Gangliogliomas have also been shown to harbor mutations ...

Last Updated: 31 Dec 1969

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Clinical Neuropathology image 5-2016: nNeurofibrillary tangle-rich ganglioglioma.
 

Author(s): Ellen Gelpi, Romana Höftberger, Tanja Würger, Johannes Kerschbaumer, Christian F Freyschlag, Tanja Djurdjevic, Johannes A Hainfellner

Journal: Clin. Neuropathol.. ;35(5):278-9.

 

*Both authors contributed equally.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ganglioglioma" returned 12 free, full-text review articles on human participants. First 3 results:

Ganglioglioma Arising From Desmoplastic Medulloblastoma: A Case Report and Review of Literature.
 

Author(s): Santosh Valvi, David S Ziegler

Journal: Pediatrics. 2017 Mar;139(3):.

 

We describe a case of medulloblastoma maturating into ganglioglioma during therapy. A 10-month-old boy was diagnosed with a desmoplastic medulloblastoma and was treated with gross total resection followed by induction chemotherapy. A recurrence in the tumor bed during therapy was ...

Last Updated: 31 Dec 1969

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Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma.
 

Author(s): Chang Y Ho, Melissa Gener, Jose Bonnin, Stephen F Kralik

Journal:

 

We present a case series of a rare tumor, the desmoplastic infantile ganglioglioma (DIG) with MRI diffusion and perfusion imaging quantification as well as histopathologic characterization. Four cases with pathologically-proven DIG had diffusion weighted imaging (DWI) and two of the ...

Last Updated: 31 Dec 1969

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[Atypical ganglioglioma with BRAF V600E mutation: a case report and review of the literature].
 

Author(s): F Martinez-Ricarte, E Martinez-Saez, M Cicuendez, E Cordero, C Auger, M Toledo, A Radoi, J Sahuquillo

Journal: Rev Neurol. 2016 May;62(10):455-9.

 

Gangliogliomas are rare tumours that affect young patients, appear predominantly in the temporal lobe and usually begin with epileptic seizures. Histologically they have a grade I of malignancy, with an anaplastic form that is catalogued as grade III in the 2007 WHO classification. ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Apr 2017

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Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG
 

Status: Recruiting

Condition Summary: Diffuse Astrocytoma; Anaplastic Astrocytoma; Astrocytoma; Oligodendroglioma, Childhood; Anaplastic Oligodendroglioma; Glioblastoma; Pilocytic Astrocytoma; Giant Cell Astrocytoma; Pleomorphic Xanthoastrocytoma; Anaplastic Pleomorphic Xanthoastrocytoma; Angiocentric Glioma; Chordoid Glioma of Third Ventricle; Gangliocytoma; Ganglioglioma; Anaplastic Ganglioglioma; Dysplastic Gangliocytoma of Cerebrellum; Desmoplastic Infantile Astrocytoma and Ganglioglioma; Papillary Glioneuronal Tumor; Rosette-forming Glioneurona Tumor; Central Neurocytoma; Extraventricular Neurocytoma; Cerebellar Iponeurocytoma

 

Last Updated: 8 Mar 2018

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A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
 

Status: Recruiting

Condition Summary: Malignant Glioma of Brain; Astrocytoma; Malignant Astrocytoma; Oligodendroglioma; Anaplastic Oligodendroglioma of Brain (Diagnosis); Mixed Oligo-Astrocytoma; Ependymoma; Ganglioglioma; Pylocytic/Pylomyxoid Astrocytoma; Brain Tumor; Glioma; Brain Cancer; Glioblastoma; Glioblastoma Multiforme

 

Last Updated: 9 Apr 2018

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