Ganglioglioma

Common Name(s)

Ganglioglioma

A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.   Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.   This can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  Most gangliogliomas grow slowly and are considered benign.  However, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.     The main treatment for ganglioglioma is removal of the entire tumor during surgery.  If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ganglioglioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ganglioglioma" returned 53 free, full-text research articles on human participants. First 3 results:

Desmoplastic infantile astrocytoma/ganglioglioma with rare BRAF V600D mutation.
 

Author(s): Ashley Greer, Nicholas K Foreman, Andrew Donson, Kurtis D Davies, B K Kleinschmidt-DeMasters

Journal: Pediatr Blood Cancer. 2017 Jun;64(6):.

 

Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile gangliogliomas (DIGs) are rare, massive, cystic and solid tumors of infants usually found in superficial cerebral hemispheres. They manifest prominent desmoplastic stroma, admixed neoplastic astrocytes, primitive-appearing ...

Last Updated: 18 Nov 2016

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Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord.
 

Author(s): Joshua L Wang, Christopher S Hong, Jose Otero, Vinay K Puduvalli, J Bradley Elder

Journal: World Neurosurg. 2016 Dec;96():608.e1-608.e4.

 

Gangliogliomas are rare, low-grade intra-axial tumors that exhibit both neuronal and glial components. Although the vast majority present as an intracranial lesion, a rare subset exist as isolated lesions of the spinal cord. Gangliogliomas have also been shown to harbor mutations ...

Last Updated: 27 Sep 2016

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Clinical Neuropathology image 5-2016: nNeurofibrillary tangle-rich ganglioglioma.
 

Author(s): Ellen Gelpi, Romana Höftberger, Tanja Würger, Johannes Kerschbaumer, Christian F Freyschlag, Tanja Djurdjevic, Johannes A Hainfellner

Journal: Clin. Neuropathol.. ;35(5):278-9.

 

*Both authors contributed equally.

Last Updated: 14 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ganglioglioma" returned 10 free, full-text review articles on human participants. First 3 results:

Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma.
 

Author(s): Chang Y Ho, Melissa Gener, Jose Bonnin, Stephen F Kralik

Journal:

 

We present a case series of a rare tumor, the desmoplastic infantile ganglioglioma (DIG) with MRI diffusion and perfusion imaging quantification as well as histopathologic characterization. Four cases with pathologically-proven DIG had diffusion weighted imaging (DWI) and two of the ...

Last Updated: 20 Oct 2016

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Anaplastic ganglioglioma: a report of three cases and review of the literature.
 

Author(s): John Thomas Lucas, Andrew Jonathan Huang, Ryan T Mott, Glenn J Lesser, Stephen Bradley Tatter, Michael David Chan

Journal: J. Neurooncol.. 2015 May;123(1):171-7.

 

Gangliogliomas are rare tumors of the central nervous system that are thought to arise from a glioneuronal precursor and consist of both neuronal and glial elements. Grade III, or anaplastic ganglioglioma (AGG), most commonly affects children and young adults, generally arises in ...

Last Updated: 21 May 2015

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Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor.
 

Author(s): Christian Schneider, Jürg Vosbeck, Michael A Grotzer, Eugen Boltshauser, Karl F Kothbauer

Journal: Pediatr Neurosurg. 2012 ;48(1):42-7.

 

Gangliogliomas (GGs) are a small subset of intramedullary spinal cord tumors in children. The anaplastic variant (WHO grade III) appears to be an extreme rarity. A literature research revealed only 15 case reports of intramedullary anaplastic GGs (aGGs) and only 4 pediatric patients. ...

Last Updated: 18 Oct 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Apr 2017

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A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
 

Status: Recruiting

Condition Summary: Malignant Glioma of Brain; Astrocytoma; Malignant Astrocytoma; Oligodendroglioma; Anaplastic Oligodendroglioma of Brain (Diagnosis); Mixed Oligo-Astrocytoma; Ependymoma; Ganglioglioma; Pylocytic/Pylomyxoid Astrocytoma

 

Last Updated: 18 Jul 2017

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Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma; Giant Cell Glioblastoma; Gliosarcoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma; Choroid Plexus Carcinoma; Anaplastic Ganglioglioma; Pineal Parenchymal Tumor; Pineoblastoma; Medulloblastoma; PNET; Rhabdoid Tumor; Perineurioma; MPNST; Malignant Meningloma; Anaplastic Hemangiopericytoma

 

Last Updated: 10 Oct 2017

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