Gallbladder cancer

Common Name(s)

Gallbladder cancer

Gallbladder cancer is a type of cancer that begins in the gallbladder, an organ under the liver in the upper abdomen. The gallbladder stores bile, which is made by the liver for fat digestion. Signs of gallbladder cancer include yellowing of the skin or eyes (jaundice), pain in the upper right part of the abdomen, fever, nausea, vomiting, bloating, weight loss, loss of appetite, itchiness, and lumps in the abdomen.

Gallbladder cancer occurs when cells in the gallbladder develop mutations that result in the cells dividing rapidly and resisting death. Those cells form a tumor. Being female and being Native American increases one’s risk of developing gallbladder cancer. Other risk factors include being older, obesity, and having a history of gallstones.

Because the symptoms are consistent with those of many other diseases, gallbladder cancer is difficult to detect early. With that said, there are several tests used to diagnose gallbladder cancer. High levels of a chemical in bile called bilirubin are a sign of gallbladder cancer and can be detected through blood tests. Tumor markers, or proteins that present in the blood with certain cancers, may also be detected by blood tests. X-ray imaging, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, and ultrasounds can also be used to diagnose gallbladder cancer. Additional tests may be performed to determine the stage of the disease.

Treatment for gallbladder cancer often involves surgical removal of the gallbladder and surrounding tissues in a procedure called a cholecystectomy. If the cancer cannot be removed, symptoms may be lessened through additional surgery, chemotherapy, radiation therapy, or clinical trials. If you have been diagnosed with gallbladder cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gallbladder cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gallbladder cancer" returned 298 free, full-text research articles on human participants. First 3 results:

Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.
 

Author(s): Kazuharu Igarashi, Keishi Yamashita, Hiroshi Katoh, Keita Kojima, Yosuke Ooizumi, Nobuyuki Nishizawa, Ryo Nishiyama, Hiroshi Kawamata, Hiroshi Tajima, Takashi Kaizu, Yusuke Kumamoto, Masahiko Watanabe

Journal:

 

Aberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome. In this study, we assessed for the first time the clinicopathological significance of CDO1 methylation in primary gallbladder cancer ...

Last Updated: 31 Dec 1969

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MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer.
 

Author(s): Min He, Ming Zhan, Wei Chen, Sunwang Xu, Manmei Long, Hui Shen, Yongheng Shi, Qiang Liu, Man Mohan, Jian Wang

Journal: Cell. Physiol. Biochem.. 2017 ;42(5):2078-2092.

 

Early metastasis plays a pivotal role in tumor-caused death in gallbladder cancer (GBC) patients. Increasing evidence suggest that miR-143-5p is an active player involved in cancer metastasis and a potential therapeutic target. However, its role in the development of GBC cells remains ...

Last Updated: 31 Dec 1969

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Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile.
 

Author(s): Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer

Journal:

 

Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gallbladder cancer" returned 30 free, full-text review articles on human participants. First 3 results:

Gallbladder cancer: South American experience.
 

Author(s): Gerardo F Arroyo, Alberto Gentile, Luis A Parada

Journal: Chin Clin Oncol. 2016 Oct;5(5):67.

 

Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational ...

Last Updated: 31 Dec 1969

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Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis.
 

Author(s): Jill Koshiol, Aniela Wozniak, Paz Cook, Christina Adaniel, Johanna Acevedo, Lorena Azócar, Ann W Hsing, Juan C Roa, Marcela F Pasetti, Juan F Miquel, Myron M Levine, Catterina Ferreccio,

Journal: Cancer Med. 2016 Nov;5(11):3310-3235.

 

In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until the 1990s, we evaluated the association between Salmonella enterica serovar Typhi (S. Typhi) antibodies and GBC. We tested 39 GBC cases, 40 gallstone controls, and 39 population-based controls ...

Last Updated: 31 Dec 1969

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Technical Aspects of Gallbladder Cancer Surgery.
 

Author(s): Motaz Qadan, T Peter Kingham

Journal: Surg. Clin. North Am.. 2016 Apr;96(2):229-45.

 

In this review, the authors present an updated description of gallbladder cancer in 2 sections based on presentation: disease that presents incidentally following laparoscopic cholecystectomy and malignancy that is suspected preoperatively. Elements pertaining to technical aspects ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer
 

Status: Recruiting

Condition Summary: Gallbladder Cancer

 

Last Updated: 28 Sep 2016

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Last Updated: 13 Aug 2016

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Adjuvant Chemotherapy vs no Chemotherapy for Patients With GallBllader Carcinoma
 

Status: Recruiting

Condition Summary: Gallbladder Cancer

 

Last Updated: 18 May 2016

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