Frontotemporal Dementia

Common Name(s)

Frontotemporal Dementia

Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). Spatial skills and memory remain intact. There is a strong genetic component to the disease; it often runs in families. There is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.

Although the name and classification of FTD has been a topic of discussion for over a century, the current classification of the syndrome groups together PickÕs disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. You can click on the links to view the GARD pages on these conditions.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal Dementia" returned 284 free, full-text research articles on human participants. First 3 results:

Altered body schema processing in frontotemporal dementia with C9ORF72 mutations.
 

Author(s): Laura E Downey, Phillip D Fletcher, Hannah L Golden, Colin J Mahoney, Jennifer L Agustus, Jonathan M Schott, Jonathan D Rohrer, Jonathan Beck, Simon Mead, Martin N Rossor, Sebastian J Crutch, Jason D Warren

Journal: J. Neurol. Neurosurg. Psychiatr.. 2014 Sep;85(9):1016-23.

 

Mutations in C9ORF72 are an important cause of frontotemporal dementia (FTD) and motor neuron disease. Accumulating evidence suggests that FTD associated with C9ORF72 mutations (C9ORF72-FTD) is distinguished clinically by early prominent neuropsychiatric features that might collectively ...

Last Updated: 7 Aug 2014

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Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).
 

Author(s): Johannes Brettschneider, Kelly Del Tredici, David J Irwin, Murray Grossman, John L Robinson, Jon B Toledo, Lubin Fang, Vivianna M Van Deerlin, Albert C Ludolph, Virginia M-Y Lee, Heiko Braak, John Q Trojanowski

Journal: Acta Neuropathol.. 2014 Mar;127(3):423-39.

 

We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD). Immunohistochemistry was performed on 70 μm sections from FTLD-TDP autopsy cases (n = 39) presenting with behavioral ...

Last Updated: 17 Feb 2014

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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
 

Author(s): Tao Zu, Yuanjing Liu, Monica Bañez-Coronel, Tammy Reid, Olga Pletnikova, Jada Lewis, Timothy M Miller, Matthew B Harms, Annet E Falchook, S H Subramony, Lyle W Ostrow, Jeffrey D Rothstein, Juan C Troncoso, Laura P W Ranum

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Dec;110(51):E4968-77.

 

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9 ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) links ALS/FTD to a large group of unstable microsatellite diseases. Previously, we ...

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal Dementia" returned 55 free, full-text review articles on human participants. First 3 results:

[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

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Functional status in behavioral variant frontotemporal dementia: a systematic review.
 

Author(s): Thais Bento Lima-Silva, Valéria Santoro Bahia, Ricardo Nitrini, Mônica Sanches Yassuda

Journal: Biomed Res Int. 2013 ;2013():837120.

 

The aim was to conduct a systematic review of studies that described the functional profile of patients with behavioral variant frontotemporal dementia (bvFTD), published between 2000 and 2013. The bibliographic search was conducted using the terms "frontotemporal dementia" and "frontotemporal ...

Last Updated: 5 Dec 2013

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Epigenetics of Alzheimer's disease and frontotemporal dementia.
 

Author(s): Chendhore S Veerappan, Sama Sleiman, Giovanni Coppola

Journal: Neurotherapeutics. 2013 Oct;10(4):709-21.

 

This article will review the recent advances in the understanding of the role of epigenetic modifications and the promise of future epigenetic therapy in neurodegenerative dementias, including Alzheimer's disease and frontotemporal dementia.

Last Updated: 23 Oct 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 11 Sep 2014

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)
 

Status: Recruiting

Condition Summary: Behavioral Variant Frontotemporal Dementia (bvFTD)

 

Last Updated: 4 Aug 2014

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