Frontotemporal dementia

Common Name(s)

Frontotemporal dementia

Frontotemporal dementia (FTD) is a term that describes a group of neurodegenerative conditions that affect the front and sides of the brain (the areas called the frontal and temporal lobes respectively). The cause of FTD is not fully understood at this time. However, scientists believe that genetics and environmental factors may have an influence. Additionally, many studies have shown unusually high levels of proteins in the nerve cells of individuals with the condition. Ultimately, FTD causes the frontal and temporal lobes of the brain to shrink over time (frontotemporal atrophy).

Symptoms of FTD are often categorized either as behavioral changes or as speech and language difficulties, which reflect the brain areas affected. In certain forms of FTD, motor symptoms may appear as well. Behavioral changes are often seen as a loss of empathy, increasing lack of judgment, and depression. Language problems are seen as an increased difficulty with speaking or understanding language. This disease is most often found in older individuals who are in their 50s or 60s. Sadly, once the process begins, symptoms tend to progressively worsen over time.

Although there is no conclusive test to diagnose FTD, a combination of blood tests, reasoning/memory tests, and various brain scans can aid in diagnosing the condition. With brain imaging scans like MRIs, it is sometimes even possible to see the shrinking of the frontal and temporal lobes. If you or your family member has been diagnosed with FTD, talk with your doctor and specialists about the most current treatment options. Support groups are also a good source of information and help connect you with other individuals and families affected by FTD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia" returned 393 free, full-text research articles on human participants. First 3 results:

[An 87-year-old-man with late-onset frontotemporal dementia: a case-study].
 

Author(s): F Smeets, J W Ummels, F R J Verhey, S P J van Alphen

Journal: Tijdschr Psychiatr. 2016 ;58(7):543-6.

 

An 87-year-old man showed behavioral disinhibition and nocturnal restlessness as well as short-term memory problems. We diagnosed late-onset frontotemporal dementia (LO-FTD), a relatively rare disease. Based on the course of the disease progress, we ruled out medication-induced mania ...

Last Updated: 11 Jul 2016

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Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.
 

Author(s): Mikkel A Rasmussen, Lena E Hjermind, Lis F Hasholt, Gunhild Waldemar, Jørgen E Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst

Journal: Stem Cell Res. 2016 Jan;16(1):105-9.

 

Skin fibroblasts were obtained from a 28-year-old pre-symptomatic woman carrying a R406W mutation in microtubule-associated protein tau (MAPT), known to cause frontotemporal dementia. Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids ...

Last Updated: 27 Jun 2016

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Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT).
 

Author(s): Mikkel A Rasmussen, Lena E Hjermind, Lis F Hasholt, Gunhild Waldemar, Jørgen E Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst

Journal: Stem Cell Res. 2016 Jan;16(1):75-8.

 

Skin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids ...

Last Updated: 27 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia" returned 78 free, full-text review articles on human participants. First 3 results:

Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis.
 

Author(s): Kalyani Kansal, Manisha Mareddy, Kelly L Sloane, Alexa A Minc, Peter V Rabins, John B McGready, Chiadi U Onyike

Journal: Dement Geriatr Cogn Disord. 2016 ;41(1-2):109-22.

 

Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors.

Last Updated: 10 Feb 2016

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The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry.
 

Author(s): Serggio C Lanata, Bruce L Miller

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 May;87(5):501-11.

 

The primary goal of this article is to critically discuss the syndromic overlap that exists between early behavioural variant frontotemporal dementia (bvFTD)--the most common clinical syndrome associated with frontotemporal lobar degeneration (FTLD)--and several primary psychiatric ...

Last Updated: 15 Apr 2016

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Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging.
 

Author(s): Jing Zhang

Journal:

 

Recent findings have led to a renewed interest and support for an active role of inflammation in neurodegenerative dementias and related neurologic disorders. Detection of neuroinflammation in vivo throughout the course of neurodegenerative diseases is of great clinical interest. ...

Last Updated: 2 Jun 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 3 Mar 2016

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Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
 

Status: Recruiting

Condition Summary: Familial Frontotemporal Dementia

 

Last Updated: 7 Nov 2016

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Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia
 

Status: Not yet recruiting

Condition Summary: Frontotemporal Dementia (FTD)

 

Last Updated: 5 Jan 2017

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