Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 290 free, full-text research articles on human participants. First 3 results:

IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis.
 

Author(s): Arijana Pačić, Petar Šenjug, Jasna Bacalja, Miroslav Tišljar, Ivica Horvatić, Stela Bulimbašić, Mladen Knotek, Krešimir Galešić, Danica Galešić Ljubanović

Journal: Croat. Med. J.. 2017 Aug;58(4):281-291.

 

To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS).

Last Updated: 31 Aug 2017

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Focal Segmental Glomerulosclerosis in a Patient with Ambiguous Genitalia: A Diagnostic Dilemma.
 

Author(s): Oliver E Ross, Dean A Kujubu, John J Sim

Journal: Perm J. 2017 ;21():.

 

The renal condition referred to as focal segmental glomerulosclerosis (FSGS) presents a diagnostic dilemma for the clinician. It encompasses and displays a nonspecific histologic appearance on a kidney biopsy specimen, rather than a unique disease entity. This characteristic of FSGS ...

Last Updated: 23 Mar 2017

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Urinary Exosomal miR-193a Can Be a Potential Biomarker for the Diagnosis of Primary Focal Segmental Glomerulosclerosis in Children.
 

Author(s): Zhibin Huang, Yong Zhang, Jianhua Zhou, Yu Zhang

Journal: Biomed Res Int. 2017 ;2017():7298160.

 

Background. Glomerular upregulation of miR-193a has been detected in primary focal segmental glomerulosclerosis (FSGS) but not in other glomerular diseases. We aimed to isolate exosomes from urine of children with primary FSGS and to assess the diagnostic potential of urinary exosomal ...

Last Updated: 1 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 41 free, full-text review articles on human participants. First 3 results:

Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View.
 

Author(s): Andreas Kronbichler, Moin A Saleem, Björn Meijers, Jae Il Shin

Journal: J Immunol Res. 2016 ;2016():2068691.

 

Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the ...

Last Updated: 9 Aug 2016

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Infection-Related Focal Segmental Glomerulosclerosis in Children.
 

Author(s): Anne Katrin Dettmar, Jun Oh

Journal: Biomed Res Int. 2016 ;2016():7351964.

 

Focal segmental glomerulosclerosis (FSGS) is the most common cause of steroid resistant nephrotic syndrome in children. It describes a unique histological picture of glomerular damage resulting from several causes. In the majority of patients the causing agent is still unknown, but ...

Last Updated: 13 Jun 2016

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Practical Application of Columbia Classification for Focal Segmental Glomerulosclerosis.
 

Author(s): Man-Hoon Han, Yong-Jin Kim

Journal: Biomed Res Int. 2016 ;2016():9375753.

 

Focal segmental glomerulosclerosis (FSGS) is a heterogeneous clinicopathological entity. Two frameworks for the classification of FSGS have been described: etiologic and morphologic. The etiologic classification is distinguished among genetic, adaptive, virus-associated, drug-induced, ...

Last Updated: 1 Jun 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Allogenic AD-MSC Transplantation in Idiopathic Nephrotic Syndrome (Focal Segmental Glomerulosclerosis)
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 3 Dec 2015

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Genetic Markers for Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis; HIV-Associated Focal Segmental Glomerulosclerosis

 

Last Updated: 18 Oct 2017

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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis 1

 

Last Updated: 3 Oct 2016

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