Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 223 free, full-text research articles on human participants. First 3 results:

Focal segmental glomerulosclerosis associated with psoriasis.
 

Author(s): Subal Kumar Pradhan, Siba Shankar Beriha

Journal: Saudi J Kidney Dis Transpl. 2014 May;25(3):670-1.

 

Last Updated: 13 May 2014

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Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
 

Author(s): Uma Potla, Jie Ni, Justin Vadaparampil, Guozhe Yang, Jeremy S Leventhal, Kirk N Campbell, Peter Y Chuang, Alexei Morozov, John C He, Vivette D D'Agati, Paul E Klotman, Lewis Kaufman

Journal: J. Clin. Invest.. 2014 Apr;124(4):1757-69.

 

Injury to the specialized epithelial cells of the glomerulus (podocytes) underlies the pathogenesis of all forms of proteinuric kidney disease; however, the specific genetic changes that mediate podocyte dysfunction after injury are not fully understood. Here, we performed a large-scale ...

Last Updated: 2 Apr 2014

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Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics.
 

Author(s): Xu Hao, Xia Liu, Weiming Wang, Hong Ren, Jingyuan Xie, Pingyan Shen, Donghai Lin, Nan Chen

Journal:

 

Primary focal segmental glomerulosclerosis (FSGS) is pathological entity which is characterized by idiopathic steroid-resistant nephrotic syndrome (SRNS) and progression to end-stage renal disease (ESRD) in the majority of affected individuals. Currently, there is no practical noninvasive ...

Last Updated: 18 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 29 free, full-text review articles on human participants. First 3 results:

Treatment of idiopathic focal segmental glomerulosclerosis: options in the event of resistance to corticosteroids and calcineurin inhibitors.
 

Author(s): Alfonso Segarra-Medrano, Elias Jatem-Escalante, Irene Agraz-Pamplona, Clara Carnicer-Cáceres, Natalia Ramos-Terrades, Elena Ostos-Roldán, M Teresa Quiles-Pérez, M Antonia Arbós-Via

Journal: Nefrologia. 2013 ;33(4):448-61.

 

Half of patients with nephrotic syndrome caused by primary focal segmental glomerulosclerosis (FSGS) have resistance to treatment with steroids. In the case of corticosteroid resistance,  the best evidence-based option has classically been treatment with calcineurin inhibitors, ...

Last Updated: 30 Jul 2013

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Focal segmental glomerulosclerosis and kidney transplantation.
 

Author(s): Osama Gheith, Rashad Hassan

Journal: Iran J Kidney Dis. 2013 Jul;7(4):257-64.

 

The recurrence rate of focal segmental glomerulosclerosis after kidney transplantation is ranging between 20% and 40%. Focal segmental glomerulosclerosis is associated with poor graft survival. In this review, the etiology, pathogenesis, clinicopathological features, risk factors ...

Last Updated: 24 Jul 2013

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Pathophysiology and treatment of focal segmental glomerulosclerosis: the role of animal models.
 

Author(s): Sylvana M L de Mik, Martin J Hoogduijn, Ron W de Bruin, Frank J M F Dor

Journal:

 

Focal segmental glomerulosclerosis (FSGS) is a kidney disease with progressive glomerular scarring and a clinical presentation of nephrotic syndrome. FSGS is a common primary glomerular disorder that causes renal dysfunction which progresses slowly over time to end-stage renal disease. ...

Last Updated: 26 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 10 Aug 2009

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Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 20 Jun 2014

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Last Updated: 14 Aug 2014

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