Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 314 free, full-text research articles on human participants. First 3 results:

Crystalloid podocytopathy with focal segmental glomerulosclerosis in PCM: a case report.
 

Author(s): You La Jeon, Woo In Lee, Yujin Choi, So Young Kang, Myeong Hee Kim, Sung-Jig Lim, Sang Ho Lee

Journal:

 

Crystalloid podocytopathy with focal segmental glomerulosclerosis in plasma cell myeloma (PCM) is rare.

Last Updated: 16 Dec 2015

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Trends in the histopathology of childhood nephrotic syndrome in Ibadan Nigeria: preponderance of idiopathic focal segmental glomerulosclerosis.
 

Author(s): Adanze O Asinobi, Adebowale D Ademola, Clement A Okolo, Joseph O Yaria

Journal:

 

Reports on the histopathology of childhood nephrotic syndrome (NS) had emanated from our Centre since the 1960s and by the late 1980s and early 1990s, a change was observed and reported. Taking into consideration the worldwide changing trend in the histopathology of the NS and our ...

Last Updated: 16 Dec 2015

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Understanding the pathogenesis of focal segmental glomerulosclerosis: morphology vs. molecules.
 

Author(s): Muhammed Mubarak

Journal: J Pak Med Assoc. 2015 Sep;65(9):913-4.

 

Last Updated: 4 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 44 free, full-text review articles on human participants. First 3 results:

Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature.
 

Author(s): Ning Jia, Fionnuala C Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R Gralow

Journal:

 

Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) ...

Last Updated: 22 Jul 2015

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Focal segmental glomerulosclerosis: molecular genetics and targeted therapies.
 

Author(s): Ying Maggie Chen, Helen Liapis

Journal:

 

Recent advances show that human focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy caused by podocyte-specific gene mutations including NPHS1, NPHS2, WT-1, LAMB2, CD2AP, TRPC6, ACTN4 and INF2. This review focuses on genes discovered in the investigation of complex ...

Last Updated: 9 Jul 2015

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Causes and pathogenesis of focal segmental glomerulosclerosis.
 

Author(s): Agnes B Fogo

Journal: Nat Rev Nephrol. 2015 Feb;11(2):76-87.

 

Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury. The initial injuries vary widely. Monogenetic forms of FSGS are largely due to alterations in structural genes ...

Last Updated: 27 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Markers for Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis; HIV-Associated Focal Segmental Glomerulosclerosis

 

Last Updated: 11 May 2016

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Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 10 Aug 2009

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Allogenic AD-MSC Transplantation in Idiopathic Nephrotic Syndrome (Focal Segmental Glomerulosclerosis)
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 3 Dec 2015

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