Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 230 free, full-text research articles on human participants. First 3 results:

mRNA sequencing of a novel NPHS2 intronic mutation in a child with focal and segmental glomerulosclerosis.
 

Author(s): Elisa Benetti, Gianluca Caridi, Sonia Centi, Manuela Della Vella, Gian Marco Ghiggeri, Lina Artifoni, Luisa Murer

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):854-7.

 

The NPHS2 gene encodes podocin, a membrane protein that acts as the structural scaffold in podocyte foot processes. NPHS2 mutations are associated with steroid-resistant nephrotic syndrome (SRNS), with the pathologic variant being focal and segmental glomerulosclerosis (FSGS), an ...

Last Updated: 27 Jun 2014

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Focal segmental glomerulosclerosis associated with psoriasis.
 

Author(s): Subal Kumar Pradhan, Siba Shankar Beriha

Journal: Saudi J Kidney Dis Transpl. 2014 May;25(3):670-1.

 

Last Updated: 13 May 2014

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Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients.
 

Author(s): Young Eun Kwon, Seung Hyeok Han, Jeong Hae Kie, Seong Yeong An, Yung Ly Kim, Kyoung Sook Park, Ki Heon Nam, Ah Young Leem, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Ea Wha Kang, Shin-Wook Kang, Kyu Hun Choi, Beom Jin Lim, Hyeon Joo Jeong, Tae-Hyun Yoo

Journal:

 

Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations.

Last Updated: 10 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 30 free, full-text review articles on human participants. First 3 results:

Treatment of idiopathic focal segmental glomerulosclerosis: options in the event of resistance to corticosteroids and calcineurin inhibitors.
 

Author(s): Alfonso Segarra-Medrano, Elias Jatem-Escalante, Irene Agraz-Pamplona, Clara Carnicer-Cáceres, Natalia Ramos-Terrades, Elena Ostos-Roldán, M Teresa Quiles-Pérez, M Antonia Arbós-Via

Journal: Nefrologia. 2013 ;33(4):448-61.

 

Half of patients with nephrotic syndrome caused by primary focal segmental glomerulosclerosis (FSGS) have resistance to treatment with steroids. In the case of corticosteroid resistance,  the best evidence-based option has classically been treatment with calcineurin inhibitors, ...

Last Updated: 30 Jul 2013

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Focal segmental glomerulosclerosis and kidney transplantation.
 

Author(s): Osama Gheith, Rashad Hassan

Journal: Iran J Kidney Dis. 2013 Jul;7(4):257-64.

 

The recurrence rate of focal segmental glomerulosclerosis after kidney transplantation is ranging between 20% and 40%. Focal segmental glomerulosclerosis is associated with poor graft survival. In this review, the etiology, pathogenesis, clinicopathological features, risk factors ...

Last Updated: 24 Jul 2013

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Pathophysiology and treatment of focal segmental glomerulosclerosis: the role of animal models.
 

Author(s): Sylvana M L de Mik, Martin J Hoogduijn, Ron W de Bruin, Frank J M F Dor

Journal:

 

Focal segmental glomerulosclerosis (FSGS) is a kidney disease with progressive glomerular scarring and a clinical presentation of nephrotic syndrome. FSGS is a common primary glomerular disorder that causes renal dysfunction which progresses slowly over time to end-stage renal disease. ...

Last Updated: 26 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 10 Aug 2009

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Last Updated: 20 Nov 2014

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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis 1

 

Last Updated: 9 Sep 2014

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