Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 333 free, full-text research articles on human participants. First 3 results:

Focal Segmental Glomerulosclerosis: Genetics, Mechanism, and Therapies.
 

Author(s): Andreas Kronbichler, Jun Oh, Björn Meijers, Jae Il Shin

Journal: Biomed Res Int. 2016 ;2016():9643785.

 

Last Updated: 19 Jul 2016

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Serum sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of patients with membranous nephropathy and focal and segmental glomerulosclerosis.
 

Author(s): Pragya Pant, R G Singh, , Santosh K Singh, Vijay P Singh, Prodip K Doley, M Sivasankar

Journal: Saudi J Kidney Dis Transpl. 2016 May;27(3):539-45.

 

Diagnosis of membranous nephropathy (MN) and focal and segmental glomerulo- sclerosis (FSGS) needs a renal biopsy, which is an invasive procedure with potentially serious complications. Proteomics may be applied for the development of a biomarker for these diseases which will obviate ...

Last Updated: 24 May 2016

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A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
 

Author(s): Haiyang Yu, Mykyta Artomov, Sebastian Brähler, M Christine Stander, Ghaidan Shamsan, Matthew G Sampson, J Michael White, Matthias Kretzler, Jeffrey H Miner, Sanjay Jain, Cheryl A Winkler, Robi D Mitra, Jeffrey B Kopp, Mark J Daly, Andrey S Shaw

Journal: J. Clin. Invest.. 2016 Mar;126(3):1067-78.

 

Focal segmental glomerulosclerosis (FSGS) is a syndrome that involves kidney podocyte dysfunction and causes chronic kidney disease. Multiple factors including chemical toxicity, inflammation, and infection underlie FSGS; however, highly penetrant disease genes have been identified ...

Last Updated: 1 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 47 free, full-text review articles on human participants. First 3 results:

Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis.
 

Author(s): Jae Seok Kim, Byoung Geun Han, Seung Ok Choi, Seung-Kuy Cha

Journal: Biomed Res Int. 2016 ;2016():1630365.

 

Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those ...

Last Updated: 18 Apr 2016

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Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis.
 

Author(s): Andreas Kronbichler, Johannes Leierer, Jun Oh, Björn Meijers, Jae Il Shin

Journal: Biomed Res Int. 2016 ;2016():2150451.

 

Focal segmental glomerulosclerosis is a histological pattern on renal biopsy caused by diverse mechanisms. In its primary form, a circulatory factor is implicated in disease onset and recurrence. The natural history of primary FSGS is unpredictable, since some patients are unresponsive ...

Last Updated: 18 Mar 2016

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Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature.
 

Author(s): Ning Jia, Fionnuala C Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R Gralow

Journal:

 

Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) ...

Last Updated: 22 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Allogenic AD-MSC Transplantation in Idiopathic Nephrotic Syndrome (Focal Segmental Glomerulosclerosis)
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 3 Dec 2015

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Genetic Markers for Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis; HIV-Associated Focal Segmental Glomerulosclerosis

 

Last Updated: 9 Dec 2016

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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis 1

 

Last Updated: 3 Oct 2016

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