Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 238 free, full-text research articles on human participants. First 3 results:

Focal and segmental glomerulosclerosis: does prognosis vary with the variants?
 

Author(s): Guditi Swarnalatha, R Ram, Kiran Mai Ismal, Sharmas Vali, Manisha Sahay, K V Dakshinamurty

Journal: Saudi J Kidney Dis Transpl. 2015 Jan;26(1):173-81.

 

Focal and segmental glomerulosclerosis (FSGS) is a clinicopathological entity. The following five FSGS variants: Collapsing, cellular, glomerular tip, peri-hilar and not otherwise specified (NOS) are recognized, which may have prognostic value. The aim of this study was to highlight ...

Last Updated: 12 Jan 2015

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Re: Kartagener syndrome with focal segmental glomerulosclerosis.
 

Author(s): Mohammad-Reza Ardalan, Hamid Nasri

Journal: Iran J Kidney Dis. 2014 Jul;8(4):348-9.

 

Last Updated: 8 Jul 2014

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mRNA sequencing of a novel NPHS2 intronic mutation in a child with focal and segmental glomerulosclerosis.
 

Author(s): Elisa Benetti, Gianluca Caridi, Sonia Centi, Manuela Della Vella, Gian Marco Ghiggeri, Lina Artifoni, Luisa Murer

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):854-7.

 

The NPHS2 gene encodes podocin, a membrane protein that acts as the structural scaffold in podocyte foot processes. NPHS2 mutations are associated with steroid-resistant nephrotic syndrome (SRNS), with the pathologic variant being focal and segmental glomerulosclerosis (FSGS), an ...

Last Updated: 27 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 32 free, full-text review articles on human participants. First 3 results:

Renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis.
 

Author(s): Crislaine Aparecida da Silva, Mariana Molinar Mauad Cintra, Eliângela de Castro Côbo, Marcos Vinícius da Silva, Fabiano Bichuette Custódio, Rosana Rosa Miranda Corrêa, Lúcio Roberto Castellano, Marlene Antônia dos Reis, Juliana Reis Machado

Journal: Dis. Markers. 2014 ;2014():192836.

 

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological ...

Last Updated: 10 Apr 2014

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Treatment of idiopathic focal segmental glomerulosclerosis: options in the event of resistance to corticosteroids and calcineurin inhibitors.
 

Author(s): Alfonso Segarra-Medrano, Elias Jatem-Escalante, Irene Agraz-Pamplona, Clara Carnicer-Cáceres, Natalia Ramos-Terrades, Elena Ostos-Roldán, M Teresa Quiles-Pérez, M Antonia Arbós-Via

Journal: Nefrologia. 2013 ;33(4):448-61.

 

Half of patients with nephrotic syndrome caused by primary focal segmental glomerulosclerosis (FSGS) have resistance to treatment with steroids. In the case of corticosteroid resistance,  the best evidence-based option has classically been treatment with calcineurin inhibitors, ...

Last Updated: 30 Jul 2013

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Focal segmental glomerulosclerosis and kidney transplantation.
 

Author(s): Osama Gheith, Rashad Hassan

Journal: Iran J Kidney Dis. 2013 Jul;7(4):257-64.

 

The recurrence rate of focal segmental glomerulosclerosis after kidney transplantation is ranging between 20% and 40%. Focal segmental glomerulosclerosis is associated with poor graft survival. In this review, the etiology, pathogenesis, clinicopathological features, risk factors ...

Last Updated: 24 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Markers for Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis; HIV-Associated Focal Segmental Glomerulosclerosis

 

Last Updated: 14 Jan 2015

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Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 10 Aug 2009

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Allogenic AD-MSC Transplantation in Idiopathic Nephrotic Syndrome (Focal Segmental Glomerulosclerosis)
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 6 Mar 2015

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