Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 296 free, full-text research articles on human participants. First 3 results:

IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis.
 

Author(s): Arijana Pačić, Petar Šenjug, Jasna Bacalja, Miroslav Tišljar, Ivica Horvatić, Stela Bulimbašić, Mladen Knotek, Krešimir Galešić, Danica Galešić Ljubanović

Journal: Croat. Med. J.. 2017 Aug;58(4):281-291.

 

To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS).

Last Updated: 31 Dec 1969

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Pregnancy Is a Risk Factor for Secondary Focal Segmental Glomerulosclerosis in Women with a History of Very Low Birth Weight.
 

Author(s): Mari Tanaka, Sachio Iwanari, Yasushi Tsujimoto, Keisuke Taniguchi, Koichiro Hagihara, Daiki Fumihara, Syo Miki, Saeko Shimoda, Masaki Ikeda, Hiroya Takeoka

Journal: Intern. Med.. 2017 ;56(12):1537-1541.

 

Low birth weight (LBW) has been known to increase the susceptibility to renal injury in adulthood. A 26-year-old woman developed proteinuria in early pregnancy; she had been born with very LBW. The clinical course was progressive, and an emergency Caesarean section was performed at ...

Last Updated: 31 Dec 1969

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Focal Segmental Glomerulosclerosis in a Patient with Ambiguous Genitalia: A Diagnostic Dilemma.
 

Author(s): Oliver E Ross, Dean A Kujubu, John J Sim

Journal: Perm J. 2017 ;21():.

 

The renal condition referred to as focal segmental glomerulosclerosis (FSGS) presents a diagnostic dilemma for the clinician. It encompasses and displays a nonspecific histologic appearance on a kidney biopsy specimen, rather than a unique disease entity. This characteristic of FSGS ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 42 free, full-text review articles on human participants. First 3 results:

Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View.
 

Author(s): Andreas Kronbichler, Moin A Saleem, Björn Meijers, Jae Il Shin

Journal: J Immunol Res. 2016 ;2016():2068691.

 

Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the ...

Last Updated: 31 Dec 1969

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The role of plasma exchange in treating post-transplant focal segmental glomerulosclerosis: A systematic review and meta-analysis of 77 case-reports and case-series.
 

Author(s): Abdullah Kashgary, Jessica M Sontrop, Lihua Li, Ahmed A Al-Jaishi, Zainab N Habibullah, Roaa Alsolaimani, William F Clark

Journal:

 

Evidence on the role of plasma exchange for treating recurrent post-transplant focal segmental glomerulosclerosis (FSGS) comes largely from individual cases and uncontrolled series. We conducted a systematic review and meta-analysis to estimate the remission rate after treatment with ...

Last Updated: 31 Dec 1969

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Infection-Related Focal Segmental Glomerulosclerosis in Children.
 

Author(s): Anne Katrin Dettmar, Jun Oh

Journal: Biomed Res Int. 2016 ;2016():7351964.

 

Focal segmental glomerulosclerosis (FSGS) is the most common cause of steroid resistant nephrotic syndrome in children. It describes a unique histological picture of glomerular damage resulting from several causes. In the majority of patients the causing agent is still unknown, but ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Markers for Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis; HIV-Associated Focal Segmental Glomerulosclerosis

 

Last Updated: 26 Oct 2017

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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis 1

 

Last Updated: 3 Oct 2016

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Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients
 

Status: Recruiting

Condition Summary: Kidney Transplantation; Focal Segmental Glomerulosclerosis (FSGS)

 

Last Updated: 7 Nov 2017

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