Fetal Valproate Syndrome

Common Name(s)

Fetal Valproate Syndrome

Fetal valproate syndrome occurs when a baby develops signs and symptoms as a result of an exposure to valproic acid during fetal development.  Fetal exposure to valproic acid is associated with 2 to 3 times the general population risk for birth defects.  This results in roughly a 6 to 9% risk of having a child with a birth defect versus the general population risk of 2 to 3%.  Some children with this syndrome share common subtle facial characteristics, including thin arched eyebrows that may be spaced far apart, a wide nasal bridge, short nose with anteverted nostrils, thin upper lip, and smooth long philtrum (space between nose and lip). These features may become less prominent with time. Fetal valproate syndrome may also be associated with a wide range of other birth defects, as well as intellectual disability. In most cases the risks for a particular symptom or defect is not currently known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fetal Valproate Syndrome" for support, advocacy or research.

Organisation for Anti-Convulsant Syndromes

To support those with an anti-convulsant syndromes and their families. To generate a greater awareness fo this condition. We also promote research, to further the understanding of this condition

Last Updated: 21 Nov 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fetal Valproate Syndrome" for support, advocacy or research.

Organisation for Anti-Convulsant Syndromes

To support those with an anti-convulsant syndromes and their families. To generate a greater awareness fo this condition. We also promote research, to further the understanding of this condition

http://www.oacscharity.org

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fetal Valproate Syndrome" returned 8 free, full-text research articles on human participants. First 3 results:

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.
 

Author(s): Nina V Balmer, Matthias K Weng, Bastian Zimmer, Violeta N Ivanova, Stuart M Chambers, Elena Nikolaeva, Smita Jagtap, Agapios Sachinidis, Jürgen Hescheler, Tanja Waldmann, Marcel Leist

Journal: Hum. Mol. Genet.. 2012 Sep;21(18):4104-14.

 

Exposure to the antiepileptic drug valproic acid (VPA) during gestation causes neurofunctional and anatomic deficits in later life. At present, there are little human data on how early neural development is affected by chemicals. We used human embryonic stem cells, differentiating ...

Last Updated: 28 Aug 2012

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Fetal valproate syndrome in a 2-month-old male infant.
 

Author(s): Syed A Zaki, Amol Phulsundar, Preeti Shanbag, Anupama Mauskar

Journal: Ann Saudi Med. ;30(3):233-5.

 

Fetal valproate syndrome (FVS) results from prenatal exposure to valproic acid. It is characterized by a distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction. We describe a 2-month-old male infant with the typical dysmorphic ...

Last Updated: 29 Apr 2010

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Fetal sodium valproate exposure causes Baller-Gerold syndrome phenotype: both phenotypes in the same family.
 

Author(s): Ozmert M A Ozdemir, Ilknur Kiliç, Tamer Ozsari, B Alper Kiliç, Laurence Faivre, Bernard Aral, Dolunay Gürses, C Nur Semerci

Journal: Turk. J. Pediatr.. ;51(6):631-6.

 

Baller-Gerold syndrome (BGS) is characterized by craniosynostosis and preaxial upper-limb malformations, and it has an autosomal recessive inheritance. Valproate syndrome occurs after exposure to valproic acid in utero, and is characterized by trigonocephaly. Both syndromes can also ...

Last Updated: 3 Mar 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fetal Valproate Syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.