Fatty Oxidation Disorders

Common Name(s)

Fatty Oxidation Disorders

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fatty Oxidation Disorders" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fatty Oxidation Disorders" returned 21 free, full-text research articles on human participants. First 3 results:

Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders and induces a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp/NDmcr rats.
 

Author(s): Linyi Li, Hisae Yoshitomi, Ying Wei, Lingling Qin, Jingxin Zhou, Tunhai Xu, Xinli Wu, Tian Zhou, Wen Sun, Xiangyu Guo, Lili Wu, Haiyan Wang, Yan Zhang, Chunna Li, Tonghua Liu, Ming Gao

Journal:

 

Increased energy intake and reduced physical activity can lead to obesity, diabetes and metabolic syndrome. Transcriptional modulation of metabolic networks has become a focus of current drug discovery research into the prevention and treatment of metabolic disorders associated with ...

Last Updated: 16 Apr 2015

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Bezafibrate in skeletal muscle fatty acid oxidation disorders: a randomized clinical trial.
 

Author(s): Mette Cathrine Ørngreen, Karen Lindhardt Madsen, Nicolai Preisler, Grete Andersen, John Vissing, Pascal Laforêt

Journal: Neurology. 2014 Feb;82(7):607-13.

 

To assess whether bezafibrate increases fatty acid oxidation (FAO) and lowers heart rate (HR) during exercise in patients with carnitine palmitoyltransferase (CPT) II and very long-chain acyl-CoA dehydrogenase (VLCAD) deficiencies.

Last Updated: 18 Feb 2014

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The effect of valinomycin in fibroblasts from patients with fatty acid oxidation disorders.
 

Author(s): Uzochi Chimdinma Ndukwe Erlingsson, Francesco Iacobazzi, Aiping Liu, Orly Ardon, Marzia Pasquali, Nicola Longo

Journal: Biochem. Biophys. Res. Commun.. 2013 Aug;437(4):637-41.

 

Disorders of the carnitine cycle and of the beta oxidation spiral impair the ability to obtain energy from fats at time of fasting and stress. This can result in hypoketotic hypoglycemia, cardiomyopathy, cardiac arrhythmia and other chronic medical problems. The in vitro study of ...

Last Updated: 12 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fatty Oxidation Disorders" returned 6 free, full-text review articles on human participants. First 3 results:

Long-term major clinical outcomes in patients with long chain fatty acid oxidation disorders before and after transition to triheptanoin treatment--A retrospective chart review.
 

Author(s): Jerry Vockley, Deborah Marsden, Elizabeth McCracken, Stephanie DeWard, Amanda Barone, Kristen Hsu, Emil Kakkis

Journal: Mol. Genet. Metab.. ;116(1-2):53-60.

 

Long chain fatty acid oxidation disorders (LC-FAODs) are caused by defects in the metabolic pathway that converts stored long-chain fatty acids into energy, leading to a deficiency in mitochondrial energy production during times of physiologic stress and fasting. Severe and potentially ...

Last Updated: 7 Sep 2015

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Impact of fatty acid oxidation disorders in child neurology: from Reye syndrome to Pandora's box.
 

Author(s): Ingrid Tein

Journal: Dev Med Child Neurol. 2015 Apr;57(4):304-6.

 

Last Updated: 12 Mar 2015

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Fatty acid omega-oxidation as a rescue pathway for fatty acid oxidation disorders in humans.
 

Author(s): Ronald J A Wanders, Jasper Komen, Stephan Kemp

Journal: FEBS J.. 2011 Jan;278(2):182-94.

 

Fatty acids (FAs) can be degraded via different mechanisms including α-, β- and ω-oxidation. In humans, a range of different genetic diseases has been identified in which either mitochondrial FA β-oxidation, peroxisomal FA β-oxidation or FA α-oxidation is impaired. Treatment ...

Last Updated: 5 Jan 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of Triheptanoin (C7) for Fatty Acid Oxidation Disorders and Glycogen Storage Disease
 

Status: Available

Condition Summary: Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency; Carnitine Palmitoyltransferase Deficiencies (CPT1, CPT2); Mitochondrial Trifunctional Protein Deficiency; Long-chain Hydroxyacyl-CoA Dehydrogenase Deficiency; Glycogen Storage Disorders; Pyruvate Carboxylase Deficiency Disease; ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 9, DEFICIENCY of

 

Last Updated: 3 Dec 2015

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Last Updated: 11 May 2016

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Longitudinal Study of Mitochondrial Hepatopathies
 

Status: Recruiting

Condition Summary: Acute Liver Failure,; Mitochondrial Diseases; End Stage Liver Disease,; Respiratory Chain Deficiencies, Mitochondrial; Disorder of Fatty Acid Oxidation

 

Last Updated: 15 Sep 2014

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