AIDS Dementia Complex

Common Name(s)

AIDS Dementia Complex

AIDS dementia complex (ADC) is typically seen in the late stages of a person with AIDS. HIV, the virus that causes AIDS, has the ability to affect the brain and the central nervous system in the late stages of the disease. The number of people with ADC has dropped significantly since treatment for AIDS has improved. Symptoms of this disorder are seen along with those of AIDS. They include changes in behavior, mental slowness, depression, and confusion, though these may worsen as a person's AIDS worsens. Symptoms vary widely depending on the individual and how advanced their AIDS is. ADC can be confused with other AIDS-related conditions, so individuals should always consult an experienced doctor about ADC. Currently, the treatment for ADC is antiretroviral therapy, especially zidovudine (AZT). Depression drugs may also improve quality of life for some individuals.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "AIDS Dementia Complex" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "AIDS Dementia Complex" returned 22 free, full-text research articles on human participants. First 3 results:

Effects of HIV-1 tat on secretion of TNF-α and IL-1β by U87 cells in AIDS patients with or without AIDS dementia complex.
 

Author(s): Li Zhao, Shuang Shuang Pu, Wen Hua Gao, Yuan Yuan Chi, Hong Ling Wen, Zhi Yu Wang, Yan Yan Song, Xue Jie Yu

Journal: Biomed. Environ. Sci.. 2014 Feb;27(2):111-7.

 

To explore the role of HIV-1 tat gene variations in AIDS dementia complex (ADC) pathogenesis.

Last Updated: 14 Mar 2014

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HIV-1B gp120 genes from one patient with AIDS dementia complex can affect the secretion of tumor necrosis factor and interleukin 1β in glial cells.
 

Author(s): Yu-Fen Yan, Zhi-Yu Wang, Shuang-Shuang Pu, Hong-Ling Wen, Tao Huang, Yan-Yan Song, Hong-Zhi Xu, Li Zhao

Journal: Chin. Med. J.. 2011 Dec;124(24):4217-22.

 

HIV-1 infected and immune-activated macrophages and microglia secrete neurotoxins, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which play major role in the neuronal death. It has been shown that different HIV-1 variants have varying abilities to elicit ...

Last Updated: 20 Feb 2012

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Memantine for AIDS dementia complex: open-label report of ACTG 301.
 

Author(s): Yu Zhao, Bradford A Navia, Christina M Marra, Elyse J Singer, Linda Chang, Joseph Berger, Ronald J Ellis, Dennis L Kolson, David Simpson, Eric N Miller, Stuart A Lipton, Scott R Evans, Giovanni Schifitto,

Journal: HIV Clin Trials. ;11(1):59-67.

 

To evaluate the long-term safety and efficacy of memantine use as treatment of HIV-associated cognitive impairment.

Last Updated: 19 Apr 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "AIDS Dementia Complex" returned 3 free, full-text review articles on human participants. First 3 results:

What's in a name? AIDS dementia complex, HIV-associated dementia, HIV-associated neurocognitive disorder or HIV encephalopathy.
 

Author(s): D Singh

Journal: Afr J Psychiatry (Johannesbg). 2012 May;15(3):172-5.

 

The current paper reviews currently used and proposed nomenclature for neurocognitive disorders associated with HIV, and proposes a unitary system as well as recommends an operational approach to screening/diagnosing severe forms of HIV associated neurocognitive disorder (HAND) in ...

Last Updated: 22 Jun 2012

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Chemokine receptors, neural progenitor cells, and the AIDS dementia complex.
 

Author(s): Aimee W Kao, Richard W Price

Journal: J. Infect. Dis.. 2004 Jul;190(2):211-5.

 

Last Updated: 24 Jun 2004

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Pathogenic mechanisms of neuronal damage in the AIDS dementia complex.
 

Author(s): S Swingler

Journal: MP, Mol. Pathol.. 1997 Apr;50(2):72-6.

 

Last Updated: 11 Aug 1997

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Cenicriviroc on HIV Neurocognitive Impairment
 

Status: Recruiting

Condition Summary: AIDS Dementia Complex; HIV-1-Associated Cognitive Motor Complex; Human Immunodeficiency Virus

 

Last Updated: 29 Apr 2014

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Maraviroc and NeuroAIDS Pathogenesis
 

Status: Not yet recruiting

Condition Summary: AIDS Dementia Complex

 

Last Updated: 6 Jun 2014

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Last Updated: 14 May 2012

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