Familial Mediterranean fever

Common Name(s)

Familial Mediterranean fever

Familial Mediterranean fever (FMF) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). These episodes are often accompanied by fever and sometimes a characteristic ankle rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Between attacks, people often do not have any symptoms. Without treatment, FMF can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). FMF is usually inherited in an autosomal recessive fashion and is caused by mutations in the MEFV gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Arts and Literature

CAPS medical guidebook.

Medical guidebook about Cryopyrin-Associated Periodic syndromes (CAPS).

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Mediterranean fever" returned 381 free, full-text research articles on human participants. First 3 results:

Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever.
 

Author(s): Tomohiro Koga, Kiyoshi Migita, Shuntaro Sato, Masataka Umeda, Fumiaki Nonaka, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Junya Masumoto, Kazunaga Agematsu, Akihiro Yachie, Koh-Ichiro Yoshiura, Katsumi Eguchi, Atsushi Kawakami

Journal: Medicine (Baltimore). 2016 Apr;95(16):e3449.

 

The precise cytokine networks in the serum of individuals with familial Mediterranean fever (FMF) that are associated with its pathogenesis have been unknown. Here, we attempted to identify specific biomarkers to diagnose or assess disease activity in FMF patients. We measured serum ...

Last Updated: 22 Apr 2016

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Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial.
 

Author(s): Adem Polat, Cengizhan Acikel, Betul Sozeri, Ismail Dursun, Ozgur Kasapcopur, Nesrin Gulez, Dogan Simsek, Mehmet Saldir, Ipek Dokurel, Hakan Poyrazoglu, Sevcan Bakkaloglu, Ali Delibas, Zelal Ekinci, Nuray A Ayaz, Yasar Kandur, Harun Peru, Yasemin G Kurt, Safiye R Polat, Erbil Unsal, Balahan Makay, Faysal Gok, Seza Ozen, Erkan Demirkaya,

Journal:

 

In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF).

Last Updated: 8 Apr 2016

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Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF).
 

Author(s): Kerem Fidan, Gülnihal Kavaklıoğlu, Ayyub Ebrahimi, Can Özlü, Nur Zeynep Ay, Arzu Ruacan, Ahmet Gül, Tamer T Önder

Journal: Stem Cell Res. 2015 Nov;15(3):694-6.

 

Fibroblasts from a Familial Mediterranean Fever (FMF) patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs). The resulting iPSC line was characterized to determine the expression ...

Last Updated: 18 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Mediterranean fever" returned 28 free, full-text review articles on human participants. First 3 results:

Update on Auto-Inflammatory Diseases and Familial Mediterranean Fever.
 

Author(s): Yackov Berkun, Eli M Eisenstein

Journal: Isr. Med. Assoc. J.. ;18(3-4):221-4.

 

Last Updated: 27 May 2016

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EULAR recommendations for the management of familial Mediterranean fever.
 

Author(s): Seza Ozen, Erkan Demirkaya, Burak Erer, Avi Livneh, Eldad Ben-Chetrit, Gabriella Giancane, Huri Ozdogan, Illana Abu, Marco Gattorno, Philip N Hawkins, Sezin Yuce, Tilmann Kallinich, Yelda Bilginer, Daniel Kastner, Loreto Carmona

Journal: Ann. Rheum. Dis.. 2016 Apr;75(4):644-51.

 

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals ...

Last Updated: 11 Mar 2016

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Familial Mediterranean Fever.
 

Author(s): Adem Kucuk, Ilknur Albayrak Gezer, Ramazan Ucar, Ali Yavuz Karahan

Journal: Acta Medica (Hradec Kralove). 2014 ;57(3):97-104.

 

Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on ...

Last Updated: 4 Feb 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
 

Status: Recruiting

Condition Summary: Familial Mediterranean Fever (FMF)

 

Last Updated: 27 Sep 2016

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An Extention Study of Safety of Canakinumab in Japanese Patients With Periodic Fever Syndromes
 

Status: Not yet recruiting

Condition Summary: Periodic Fevers Syndrome

 

Last Updated: 21 Sep 2016

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Last Updated: 19 May 2016

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