Familial Dilated Cardiomyopathy

Common Name(s)

Familial Dilated Cardiomyopathy

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Dilated Cardiomyopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Dilated Cardiomyopathy" returned 62 free, full-text research articles on human participants. First 3 results:

Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy.
 

Author(s): Nzali Campbell, Gianfranco Sinagra, Kenneth L Jones, Dobromir Slavov, Katherine Gowan, Marco Merlo, Elisa Carniel, Pamela R Fain, Pierluigi Aragona, Andrea Di Lenarda, Luisa Mestroni, Matthew R G Taylor

Journal:

 

Dilated cardiomyopathy (DCM) commonly causes heart failure and shows extensive genetic heterogeneity that may be amenable to newly developed next-generation DNA sequencing of the exome. In this study we report the successful use of exome sequencing to identify a pathogenic variant ...

Last Updated: 8 Nov 2013

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GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.
 

Author(s): Ruo-Gu Li, Li Li, Xing-Biao Qiu, Fang Yuan, Lei Xu, Xin Li, Ying-Jia Xu, Wei-Feng Jiang, Jin-Qi Jiang, Xu Liu, Wei-Yi Fang, Min Zhang, Lu-Ying Peng, Xin-Kai Qu, Yi-Qing Yang

Journal: Biochem. Biophys. Res. Commun.. 2013 Oct;439(4):591-6.

 

The cardiac transcription factor GATA4 is essential for cardiac development, and mutations in this gene have been implicated in a wide variety of congenital heart diseases in both animal models and humans. However, whether mutated GATA4 predisposes to dilated cardiomyopathy (DCM) ...

Last Updated: 2 Oct 2013

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Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy.
 

Author(s): Quinn S Wells, Jason R Becker, Yan R Su, Jonathan D Mosley, Peter Weeke, Laura D'Aoust, Natalie L Ausborn, Andrea H Ramirez, Jean P Pfotenhauer, Allen J Naftilan, Larry Markham, Vernat Exil, Dan M Roden, Charles C Hong

Journal: Circ Cardiovasc Genet. 2013 Aug;6(4):317-26.

 

Whole exome sequencing is a powerful technique for Mendelian disease gene discovery. However, variant prioritization remains a challenge. We applied whole exome sequencing to identify the causal variant in a large family with familial dilated cardiomyopathy of unknown pathogenesis.

Last Updated: 21 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Dilated Cardiomyopathy" returned 7 free, full-text review articles on human participants. First 3 results:

Update 2011: clinical and genetic issues in familial dilated cardiomyopathy.
 

Author(s): Ray E Hershberger, Jill D Siegfried

Journal: J. Am. Coll. Cardiol.. 2011 Apr;57(16):1641-9.

 

A great deal of progress has recently been made in the discovery and understanding of the genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a new diagnosis of idiopathic dilated cardiomyopathy (IDC), the clinical screening of first-degree family ...

Last Updated: 15 Apr 2011

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Cardiomyopathy, familial dilated.
 

Author(s): Matthew R G Taylor, Elisa Carniel, Luisa Mestroni

Journal:

 

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilatation and impaired systolic function. Patients with DCM suffer from heart failure, arrhythmia, and are at risk of premature death. DCM has a prevalence of one case out of 2500 individuals with ...

Last Updated: 4 Sep 2006

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Clinical and genetic issues in familial dilated cardiomyopathy.
 

Author(s): Emily L Burkett, Ray E Hershberger

Journal: J. Am. Coll. Cardiol.. 2005 Apr;45(7):969-81.

 

Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and systolic dysfunction after known causes have been excluded. Idiopathic dilated cardiomyopathy occurring in families, or familial dilated cardiomyopathy (FDC), may occur in 20% to 50% of IDC ...

Last Updated: 5 Apr 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 19 Apr 2012

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