Familial Dilated Cardiomyopathy

Common Name(s)

Familial Dilated Cardiomyopathy

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Dilated Cardiomyopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Dilated Cardiomyopathy" returned 74 free, full-text research articles on human participants. First 3 results:

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
 

Author(s): Stephen Pan, Ruth F Sommese, Karim I Sallam, Suman Nag, Shirley Sutton, Susan M Miller, James A Spudich, Kathleen M Ruppel, Euan A Ashley

Journal:

 

As next generation sequencing for the genetic diagnosis of cardiovascular disorders becomes more widely used, establishing causality for putative disease causing variants becomes increasingly relevant. Diseases of the cardiac sarcomere provide a particular challenge in this regard ...

Last Updated: 27 Oct 2015

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Novel familial dilated cardiomyopathy mutation in MYL2 affects the structure and function of myosin regulatory light chain.
 

Author(s): Wenrui Huang, Jingsheng Liang, Chen-Ching Yuan, Katarzyna Kazmierczak, Zhiqun Zhou, Ana Morales, Kim L McBride, Sara M Fitzgerald-Butt, Ray E Hershberger, Danuta Szczesna-Cordary

Journal: FEBS J.. 2015 Jun;282(12):2379-93.

 

Dilated cardiomyopathy (DCM) is a disease of the myocardium characterized by left ventricular dilatation and diminished contractile function. Here we describe a novel DCM mutation in the myosin regulatory light chain (RLC), in which aspartic acid at position 94 is replaced by alanine ...

Last Updated: 17 Jun 2015

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TBX5 loss-of-function mutation contributes to familial dilated cardiomyopathy.
 

Author(s): Xian-Ling Zhang, Xing-Biao Qiu, Fang Yuan, Juan Wang, Cui-Mei Zhao, Ruo-Gu Li, Lei Xu, Ying-Jia Xu, Hong-Yu Shi, Xu-Min Hou, Xin-Kai Qu, Ya-Wei Xu, Yi-Qing Yang

Journal: Biochem. Biophys. Res. Commun.. 2015 Mar;459(1):166-71.

 

The cardiac T-box transcription factor TBX5 is crucial for proper cardiovascular development, and mutations in TBX5 have been associated with various congenital heart diseases and arrhythmias in humans. However, whether mutated TBX5 contributes to dilated cardiomyopathy (DCM) remains ...

Last Updated: 17 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Dilated Cardiomyopathy" returned 7 free, full-text review articles on human participants. First 3 results:

Update 2011: clinical and genetic issues in familial dilated cardiomyopathy.
 

Author(s): Ray E Hershberger, Jill D Siegfried

Journal: J. Am. Coll. Cardiol.. 2011 Apr;57(16):1641-9.

 

A great deal of progress has recently been made in the discovery and understanding of the genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a new diagnosis of idiopathic dilated cardiomyopathy (IDC), the clinical screening of first-degree family ...

Last Updated: 15 Apr 2011

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Cardiomyopathy, familial dilated.
 

Author(s): Matthew R G Taylor, Elisa Carniel, Luisa Mestroni

Journal:

 

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilatation and impaired systolic function. Patients with DCM suffer from heart failure, arrhythmia, and are at risk of premature death. DCM has a prevalence of one case out of 2500 individuals with ...

Last Updated: 4 Sep 2006

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Clinical and genetic issues in familial dilated cardiomyopathy.
 

Author(s): Emily L Burkett, Ray E Hershberger

Journal: J. Am. Coll. Cardiol.. 2005 Apr;45(7):969-81.

 

Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and systolic dysfunction after known causes have been excluded. Idiopathic dilated cardiomyopathy occurring in families, or familial dilated cardiomyopathy (FDC), may occur in 20% to 50% of IDC ...

Last Updated: 5 Apr 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.