Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 631 free, full-text research articles on human participants. First 3 results:

Serum Bile Acids in Repaired Tetralogy of Fallot: A Marker for Liver and Heart?
 

Author(s): Gernot Grangl, Evelyn Zöhrer, Martin Köstenberger, Alexandra Jud, Günter Fauler, Hubert Scharnagl, Tatjana Stojakovic, Robert Marterer, Andreas Gamillscheg, Jörg Jahnel

Journal:

 

Patients with repaired tetralogy of Fallot may develop chronic right ventricular dysfunction and hepatic congestion over time. We hypothesized that bile acid metabolism is altered in repaired tetralogy of Fallot patients and therefore sought to correlate right ventricular indices ...

Last Updated: 15 Dec 2015

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VEGF Gene Polymorphisms are Associated with Risk of Tetralogy of Fallot.
 

Author(s): Xiang Li, Chao-Liang Liu, Xiao-Xia Li, Qing-Chen Li, Li-Ming Ma, Gao-Li Liu

Journal:

 

The aim of this study was to investigate associations of 3 common polymorphisms in the VEGF gene, -2578C>A, -634C>G, and 936C>T, with risk of tetralogy of Fallot (TOF) in Chinese Han children.

Last Updated: 12 Nov 2015

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Acute Coronary Syndrome in a 60 Year Old Patient with Uncorrected Tetralogy of Fallot.
 

Author(s): Ady Orbach, Jacob Goldstein

Journal: Isr. Med. Assoc. J.. 2015 Aug;17(8):517-9.

 

Last Updated: 23 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 17 free, full-text review articles on human participants. First 3 results:

Late postoperative prosthetic pulmonary valve endocarditis in a 13-year-old girl with repaired tetralogy of fallot.
 

Author(s): Michael C O'Brien, Kamal K Pourmoghadam, William M DeCampli

Journal:

 

Prosthetic pulmonary valve endocarditis has infrequently been described outside large cohort reviews, which have typically focused on infections of the left-sided heart valves. Hence, the pathogenesis, clinical presentation, and management principles of prosthetic pulmonary valve ...

Last Updated: 16 Jul 2015

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Is there a role for mechanical valve prostheses in pulmonary valve replacement late after tetralogy of Fallot repair?
 

Author(s): Jonathan Raihan Abbas, J Andreas Hoschtitzky

Journal: Interact Cardiovasc Thorac Surg. 2014 May;18(5):661-6.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: What is the role of mechanical valve prostheses in pulmonary valve replacement late after tetralogy of Fallot (TOF) repair? Altogether more than 30 papers were found ...

Last Updated: 23 Apr 2014

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Tetralogy of fallot with dextrocardia and situs inversus in a 7-year-old boy.
 

Author(s): Michael Dilorenzo, Samuel Weinstein, Rajesh Shenoy

Journal: Tex Heart Inst J. 2013 ;40(4):481-3.

 

Tetralogy of Fallot is one of the most frequently diagnosed congenital cardiac abnormalities; however, its association with dextrocardia and situs inversus is reported only rarely. We report a case of these findings in a 7-year-old boy, describe the patient's postoperative course, ...

Last Updated: 1 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot With Pulmonary Stenosis

 

Last Updated: 8 Jul 2014

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Biomodel in Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot

 

Last Updated: 19 Dec 2005

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Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
 

Status: Recruiting

Condition Summary: Congenital Heart Defects; Tetralogy Of Fallot

 

Last Updated: 20 Apr 2016

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