Factor XII Deficiency

Common Name(s)

Factor XII Deficiency

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests. Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor XII Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor XII Deficiency" returned 13 free, full-text research articles on human participants. First 3 results:

Perioperative management of cardiac surgery patients with factor XII deficiency - two case reports.
 

Author(s): Przemysław Rygał, Alicja Kuc

Journal: Anaesthesiol Intensive Ther. ;44(4):217-20.

 

This paper presents two patients with factor XII deficiency, a rare coagulation disorder, who successfully underwent surgery with cardiopulmonary bypass (CPB) in Cardiac Surgery Clinic of the 4th Military Clinical Hospital in Wroclaw. Diagnosis, intra- and postoperative course as ...

Last Updated: 25 Jan 2013

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with severe factor XII deficiency.
 

Author(s): Nadezda Sternic, Aleksandra Pavlovic, Predrag Miljic, Milos Bajcetic, Maja Lackovic, Vesna Lackovic

Journal: Neurol India. ;57(5):657-9.

 

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited adult-onset microangiopathy caused by missense mutations in the Notch3gene on chromosome 19. However, common vascular risk factors may additionally modify clinical ...

Last Updated: 25 Nov 2009

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A novel mutation in a patient with congenital coagulation factor XII deficiency.
 

Author(s): Ying Feng, Xu Ye, Ying Pang, Jing Dai, Xue-feng Wang, Xu-hong Zhou

Journal: Chin. Med. J.. 2008 Jul;121(13):1241-4.

 

Last Updated: 19 Aug 2008

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor XII Deficiency" returned 2 free, full-text review articles on human participants. First 3 results:

Concomitant ST-elevation myocardial infarction and deep vein thrombosis in a patient with severe factor XII deficiency: case report and review of the literature.
 

Author(s): M Cei, N Mumoli, S Giuntoli, O Marino, P Pasquinelli, P Taddei, C Mandolesi, A Genovesi Ebert

Journal: QJM. 2011 Dec;104(12):1083-6.

 

Last Updated: 30 Nov 2011

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Factor XII deficiency acquired by orthotopic liver transplantation: case report and review of the literature.
 

Author(s): N K Osborn, Y Ustundag, C S Zent, R H Wiesner, C B Rosen, K V Narayanan Menon

Journal: Am. J. Transplant.. 2006 Jul;6(7):1743-5.

 

Transmission of congenital clotting factor deficiencies after orthotopic liver transplantation is rare. There are published reports of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia, protein S, factor VII and factor XI deficiencies. We report ...

Last Updated: 10 Jul 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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