Factor X Deficiency

Common Name(s)

Factor X Deficiency

Factor X deficiency is a rare autosomal recessive bleeding disorder showing variable phenotypic severity. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. The disorder can be caused either by reduced levels of the factor X protein or by synthesis of a dysfunctional factor X protein (summary by {31:Millar et al., 2000}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor X Deficiency" for support, advocacy or research.

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor X Deficiency" for support, advocacy or research.

Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor X Deficiency" returned 41 free, full-text research articles on human participants. First 3 results:

Acquired factor X deficiency associated with atypical AL-amyloidosis.
 

Author(s): Masanori Furuhata, Noriko Doki, Tsunekazu Hishima, Tomomi Okamoto, Takatoshi Koyama, Satoshi Kaito, Gaku Oshikawa, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi

Journal: Intern. Med.. 2014 ;53(16):1841-5.

 

We herein describe the case of a 77-year-old woman with acquired factor X deficiency that was likely caused by atypical amyloidosis. The patient developed severe gastrointestinal bleeding as a result of a significant decrease of factor X activity. Neither proteinuria nor diarrhea ...

Last Updated: 18 Aug 2014

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Successful perioperative use of prothrombin complex concentrate in the treatment of acquired factor X deficiency in the setting of systemic light-chain (AL) amyloidosis.
 

Author(s): Anya Litvak, Anita Kumar, Richard J Wong, Larry Smith, Hani Hassou, Gerald Soff

Journal: Am. J. Hematol.. 2014 Dec;89(12):1153-4.

 

Last Updated: 21 Nov 2014

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Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion.
 

Author(s): Yonghua Jiang, Zhaohui Kou, Tong Wu, Weidong An, Ran Zhou, Hong Wang, Yawei Gao, Shaorong Gao

Journal: Stem Cells Dev.. 2014 Oct;23(19):2283-96.

 

The deficiency of X-inactive specific transcript (XIST) on the inactive X chromosome affects the behavior of female human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), and further chromosomal erosion can occur with continued passaging of these cells. ...

Last Updated: 20 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor X Deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Investigate BPL's Factor X in the Prophylaxis of Bleeding in Children <12 Years
 

Status: Recruiting

Condition Summary: Factor X Deficiency

 

Last Updated: 4 Mar 2016

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A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture
 

Status: Recruiting

Condition Summary: Hemophilia A; Factor VIII Deficiency; Hemophilia; Hemophilia B; Factor IX Deficiency

 

Last Updated: 27 Mar 2015

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Natural History Study of Factor IX Treatment and Complications
 

Status: Recruiting

Condition Summary: Factor IX Deficiency

 

Last Updated: 16 Mar 2016

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