Factor X Deficiency

Common Name(s)

Factor X Deficiency

Factor X deficiency is a rare autosomal recessive bleeding disorder showing variable phenotypic severity. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. The disorder can be caused either by reduced levels of the factor X protein or by synthesis of a dysfunctional factor X protein (summary by {31:Millar et al., 2000}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor X Deficiency" for support, advocacy or research.

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor X Deficiency" for support, advocacy or research.

Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor X Deficiency" returned 31 free, full-text research articles on human participants. First 3 results:

Acquired factor X deficiency associated with atypical AL-amyloidosis.
 

Author(s): Masanori Furuhata, Noriko Doki, Tsunekazu Hishima, Tomomi Okamoto, Takatoshi Koyama, Satoshi Kaito, Gaku Oshikawa, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi

Journal: Intern. Med.. 2014 ;53(16):1841-5.

 

We herein describe the case of a 77-year-old woman with acquired factor X deficiency that was likely caused by atypical amyloidosis. The patient developed severe gastrointestinal bleeding as a result of a significant decrease of factor X activity. Neither proteinuria nor diarrhea ...

Last Updated: 18 Aug 2014

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Utility of factor X concentrate for the treatment of acquired factor X deficiency in systemic light-chain amyloidosis.
 

Author(s): Shameem Mahmood, Julie Blundell, Anja Drebes, Philip N Hawkins, Ashutosh D Wechalekar

Journal: Blood. 2014 May;123(18):2899-900.

 

Last Updated: 5 May 2014

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Transforming growth factor-β (TGF-β) pathway abnormalities in tenascin-X deficiency associated with CAH-X syndrome.
 

Author(s): Rachel Morissette, Deborah P Merke, Nazli B McDonnell

Journal: Eur J Med Genet. 2014 Feb;57(2-3):95-102.

 

Patients with congenital adrenal hyperplasia (CAH) with tenascin-X deficiency (CAH-X syndrome) have both endocrine imbalances and characteristic Ehlers Danlos syndrome phenotypes. Unlike other subtypes, tenascin-X-related Ehlers Danlos syndrome is caused by an extracellular matrix ...

Last Updated: 1 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor X Deficiency" returned 1 free, full-text review articles on human participants. First 3 results:

[Acquired coagulation factor X deficiency: three cases report and literature review].
 

Author(s): Wenjie Liu, Min Xuan, Feng Xue, Renchi Yang

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Jul;35(7):633-6.

 

To deepen the understanding of acquired coagulation factor X (F X) deficiency.

Last Updated: 23 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Investigate BPL's Factor X in the Prophylaxis of Bleeding in Children <12 Years
 

Status: Recruiting

Condition Summary: Factor X Deficiency

 

Last Updated: 26 May 2015

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A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture
 

Status: Recruiting

Condition Summary: Hemophilia A; Factor VIII Deficiency; Hemophilia; Hemophilia B; Factor IX Deficiency

 

Last Updated: 27 Mar 2015

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Last Updated: 26 Jun 2015

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