Factor VII Deficiency

Common Name(s)

Factor VII Deficiency

Factor VII deficiency is an autosomal recessive bleeding disorder showing variable severity (summary by {22:Millar et al., 2000}). {23:Perry (2002)} provided a comprehensive review of factor VII deficiency with a description of F7 polymorphisms, gene structure, and a summary of 120 mutations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor VII Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor VII Deficiency" returned 59 free, full-text research articles on human participants. First 3 results:

Heterozygous congenital Factor VII deficiency with the 9729del4 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male.
 

Author(s): Thomas J Cramer, Kristin Anderson, Karanjia Navaz, Justin M Brown, Laurent O Mosnier, Annette von Drygalski

Journal: Blood Cells Mol. Dis.. 2016 Mar;57():8-12.

 

In congenital Factor (F) VII deficiency bleeding phenotype and intrinsic FVII activity levels don't always correlate. Patients with FVII activity levels <30% appear to have a higher bleeding propensity, but bleeding can also occur at higher FVII activity levels. Reasons for bleeding ...

Last Updated: 8 Feb 2016

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Prothrombin complex concentrate for factor VII replacement in a patient undergoing left ventricular assist device implantation with factor VII deficiency.
 

Author(s): Katelyn W Sylvester, Gregory Couper, Jean M Connors

Journal: Am. J. Hematol.. 2015 Sep;90(9):E185.

 

Last Updated: 21 Aug 2015

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Management of intracranial surgery for refractory epilepsy in severe factor VII deficiency: choosing the optimal dosing regimen.
 

Author(s): M Rajpurkar, M Callaghan, M J Frey, K Set, H Chugani, S Sood

Journal: Haemophilia. 2014 May;20(3):e234-7.

 

Last Updated: 15 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor VII Deficiency" returned 3 free, full-text review articles on human participants. First 3 results:

Is prophylaxis required for delivery in women with factor VII deficiency?
 

Author(s): L M Baumann Kreuziger, Colleen T Morton, Mark T Reding

Journal: Haemophilia. 2013 Nov;19(6):827-32.

 

Factor VII (fVII) deficiency is a rare congenital bleeding disorder in which fVII activity level and bleeding tendency do not completely correlate. Pregnancy and delivery present a significant haemostatic challenge to women with fVII deficiency. Treatment with recombinant factor VIIa ...

Last Updated: 29 Oct 2013

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Factor VII deficiency and pregnancy: a case report and review of literature.
 

Author(s): Syed Mohammad Asad Zaidi, Rahat Najam Qureshi, Salman Naseem Adil

Journal: J Pak Med Assoc. 2010 Feb;60(2):136-8.

 

Factor VII deficiency is one of the 'rare inherited disorders of coagulation.' Few cases of Factor VII deficiency have been reported during pregnancy, a state which could potentially cause fatal haemorrhage. Here we report a case of a pregnant lady with a history of heavy menorrhagia ...

Last Updated: 8 Mar 2010

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Factor VII deficiency and developmental abnormalities in a patient with partial monosomy of 13q and trisomy of 16p: case report and review of the literature.
 

Author(s): Brian P Brooks, Jeanne M Meck, Bassem R Haddad, Claude Bendavid, Delphine Blain, Jeffrey A Toretsky

Journal:

 

Unbalanced chromosomal translocations may present with a variety of clinical and laboratory findings and provide insight into the functions of genes on the involved chromosomal segments.

Last Updated: 23 Feb 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov