Exstrophy of the Bladder

Common Name(s)

Exstrophy of the Bladder, Bladder Exstrophy

Bladder exstrophy and epispadias complex (BEEC) is an anterior midline defect with variable expression involving the infraumbilical abdominal wall including the pelvis, urinary tract, and external genitalia ({1:Gearhart and Jeffs, 1998}). BEEC is one of the most severe urologic birth defects because of its profound impact on continence, sexual function, and morbidity due to the effect of chronic and recurrent infections on renal function. The term 'exstrophy,' derived from the Greek work ekstriphein, which literally means 'turn inside out,' was first used by Chaussier in 1780. {3:Martinez-Frias et al. (2001)} emphasized that exstrophy of the cloaca and exstrophy of the bladder are 2 different expressions of a primary developmental field defect. Cloacal exstrophy is a feature of the OEIS (omphalocele-exstrophy-imperforate anus-spinal defects) complex ({258040}). Exstrophy of the cloaca includes the persistence and exstrophy of a common cloaca that receives ureters, ileum, and a rudimentary hindgut and is associated with failure of fusion of the genital tubercles and pubic rami, incomplete development of the lumbosacral vertebrae with spinal dysraphism, imperforate anus, cryptorchidism and epispadias in males and anomalies of the mullerian duct derivatives in females, and a wide range of urinary tract anomalies. Omphalocele is common, and most patients have a single umbilical artery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exstrophy of the Bladder" for support, advocacy or research.

Logo
Association for the Bladder Exstrophy Community

The ABC is an international support network of individuals with bladder exstrophy (includes classic exstrophy, cloacal exstrophy, and epispadias), local parent-exstrophy support groups, and health care providers working with patients and families living with bladder exstrophy.

Last Updated: 25 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exstrophy of the Bladder" for support, advocacy or research.

Logo
Association for the Bladder Exstrophy Community

The ABC is an international support network of individuals with bladder exstrophy (includes classic exstrophy, cloacal exstrophy, and epispadias), local parent-exstrophy support groups, and health care providers working with patients and families living with bladder exstrophy.

http://www.bladderexstrophy.com

Last Updated: 25 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exstrophy of the Bladder" returned 0 free, full-text research articles on human participants.

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exstrophy of the Bladder" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomechanical Assessment of Level Gait in Patient's Status Post Bladder Exstrophy
 

Status: Recruiting

Condition Summary: Bladder Exstrophy

 

Last Updated: 14 Jun 2011

Go to URL
Kidney Function in Patients With Bladder Exstrophy
 

Status: Not yet recruiting

Condition Summary: Classic Bladder Exstrophy; Renal Function; GFR; Proteinuria

 

Last Updated: 16 Jul 2014

Go to URL
Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence
 

Status: Not yet recruiting

Condition Summary: Bladder Exstrophy; Urinary Incontinence

 

Last Updated: 1 Jul 2013

Go to URL