Exostoses

Common Name(s)

Exostoses

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exostoses" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exostoses" returned 59 free, full-text research articles on human participants. First 3 results:

Gradual lengthening of the ulna in patients with multiple hereditary exostoses with a dislocated radial head.
 

Author(s): Yong Jin Cho, Sung Taek Jung

Journal: Yonsei Med. J.. 2014 Jan;55(1):178-84.

 

Multiple hereditary exostoses of the forearm typically form in the distal ulna, causing disturbances in the growth of the ulna and functional disability. Multiple hereditary exostoses inhibit the growth of the ulna, leading to an acquisition of a varus deformity in the radius, which ...

Last Updated: 16 Dec 2013

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Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.
 

Author(s): Md Ferdous Anower-E-Khuda, Kazu Matsumoto, Hiroko Habuchi, Hiroyuki Morita, Takashi Yokochi, Katsuji Shimizu, Koji Kimata

Journal: Glycobiology. 2013 Jul;23(7):865-76.

 

Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in ...

Last Updated: 5 Jun 2013

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Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
 

Author(s): Julianne Huegel, Christina Mundy, Federica Sgariglia, Patrik Nygren, Paul C Billings, Yu Yamaguchi, Eiki Koyama, Maurizio Pacifici

Journal: Dev. Biol.. 2013 May;377(1):100-12.

 

During limb skeletogenesis the cartilaginous long bone anlagen and their growth plates become delimited by perichondrium with which they interact functionally. Yet, little is known about how, despite being so intimately associated with cartilage, perichondrium acquires and maintains ...

Last Updated: 17 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exostoses" returned 3 free, full-text review articles on human participants. First 3 results:

Glycobiology and the growth plate: current concepts in multiple hereditary exostoses.
 

Author(s): Kevin B Jones

Journal: J Pediatr Orthop. ;31(5):577-86.

 

Multiple hereditary exostoses, also termed as multiple osteochondromas, is a heritable disorder of connective tissue with primarily orthopaedic clinical manifestations. Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years.

Last Updated: 9 Jun 2011

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Hereditary multiple exostoses and heparan sulfate polymerization.
 

Author(s): Beverly M Zak, Brett E Crawford, Jeffrey D Esko

Journal: Biochim. Biophys. Acta. 2002 Dec;1573(3):346-55.

 

Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis. Members of this multigene family share the ability to transfer N-acetylglucosamine to a variety of oligosaccharide ...

Last Updated: 5 Nov 2002

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Acetabular dysplasia associated with hereditary multiple exostoses. A case report.
 

Author(s): N A Felix, J M Mazur, E A Loveless

Journal: J Bone Joint Surg Br. 2000 May;82(4):555-7.

 

Hereditary multiple exostoses is an autosomal dominant disorder characterised by multiple osteochondromata, most commonly affecting the forearm, knee and ankle. Osteochondromata of the proximal femur have been reported to occur in 30% to 90% of affected patients with coxa valga in ...

Last Updated: 29 Jun 2000

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project
 

Status: Recruiting

Condition Summary: Exostoses, Multiple Hereditary

 

Last Updated: 27 Mar 2014

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Autologous Stem Cells in Achilles Tendinopathy
 

Status: Not yet recruiting

Condition Summary: Achilles Tendinitis, Right Leg; Achilles Tendinitis; Achilles Degeneration; Achilles Tendon Thickening; Tendinopathy; Achilles Tendinitis, Left Leg

 

Last Updated: 13 Feb 2014

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Cervical Spondylotic Myelopathy Surgical Trial
 

Status: Recruiting

Condition Summary: Cervical Spondylosis With Myelopathy

 

Last Updated: 27 Jun 2014

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