Exostoses

Common Name(s)

Exostoses

Exostoses are abnormal bone growths on the surface of a pre-existing bone caused by having too much calcium in the body. They can cause constant, long-lasting pain ranging from mild to severe, depending on the shape, size, and location of the growth. They normally form on the joints of bones such as the ankle or knee and can grow outward toward the skin. Exostoses are typically noncancerous, but can become cancerous in some instances. Exostoses are usually treated by surgically removing the growth.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exostoses" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exostoses" returned 87 free, full-text research articles on human participants. First 3 results:

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
 

Author(s): Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M Ibrahim, Paul C Billings, Kristen Carroll, Eiki Koyama, Kevin B Jones, Maurizio Pacifici

Journal:

 

Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-called osteochondromas- next to the ...

Last Updated: 26 Apr 2017

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Daughter and mother diagnosed with hereditary multiple exostoses: A case report and a review of the literature.
 

Author(s): Cristina Oana Mărginean, Lorena Elena Meliţ, Maria Oana Mărginean

Journal: Medicine (Baltimore). 2017 Jan;96(1):e5824.

 

Hereditary multiple exostoses (HME) or osteochondromatosis is a rare autosomal dominant disease characterized by multiple osteochondromas and skeletal deformities.

Last Updated: 10 Jan 2017

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Multiple hereditary exostoses: A pseudoaneurysm masquerading as tumor.
 

Author(s): Hari Trivedi, Thomas M Link, Richard J O'Donnell, Andrew E Horvai, Daria Motamedi

Journal:

 

Multiple hereditary exostoses is an autosomal dominant condition characterized by numerous benign osteochondromas. Complications are rare and can include deformity, growth abnormality, fracture, adventitial bursa formation, local mass effect on a nerve, malignant degeneration, and ...

Last Updated: 20 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exostoses" returned 4 free, full-text review articles on human participants. First 3 results:

Endoscopic transcanal removal of symptomatic external auditory canal exostoses.
 

Author(s): Elliott D Kozin, Aaron K Remenschneider, Parth V Shah, Edward Reardon, Daniel J Lee

Journal: Am J Otolaryngol. ;36(2):283-6.

 

Exostoses are bony outgrowths of the external auditory canal (EAC) that can lead to cerumen entrapment, recurrent infections, and conductive hearing loss. When surgical removal is indicated, a drill or osteotome may be used via a post-auricular, endaural, or transcanal approach. Studies ...

Last Updated: 16 Feb 2015

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Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses.
 

Author(s): Julianne Huegel, Federica Sgariglia, Motomi Enomoto-Iwamoto, Eiki Koyama, John P Dormans, Maurizio Pacifici

Journal: Dev. Dyn.. 2013 Sep;242(9):1021-32.

 

Heparan sulfate (HS) is an essential component of cell surface and matrix-associated proteoglycans. Due to their sulfation patterns, the HS chains interact with numerous signaling proteins and regulate their distribution and activity on target cells. Many of these proteins, including ...

Last Updated: 21 Aug 2013

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Glycobiology and the growth plate: current concepts in multiple hereditary exostoses.
 

Author(s): Kevin B Jones

Journal: J Pediatr Orthop. ;31(5):577-86.

 

Multiple hereditary exostoses, also termed as multiple osteochondromas, is a heritable disorder of connective tissue with primarily orthopaedic clinical manifestations. Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years.

Last Updated: 9 Jun 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Stem Cells in Achilles Tendinopathy
 

Status: Recruiting

Condition Summary: Achilles Tendinitis, Right Leg; Achilles Tendinitis; Achilles Degeneration; Achilles Tendon Thickening; Tendinopathy; Achilles Tendinitis, Left Leg

 

Last Updated: 11 May 2016

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Baxter: Actifuse SHAPE vs DBX in ACC
 

Status: Recruiting

Condition Summary: Cervical Spine Degenerative Disease Nos; Cervical Spondylosis With Myelopathy

 

Last Updated: 3 Dec 2013

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Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy
 

Status: Recruiting

Condition Summary: Cervical Spondylosis With Myelopathy

 

Last Updated: 14 Oct 2016

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