Exostoses

Common Name(s)

Exostoses

Exostoses are abnormal bone growths on the surface of a pre-existing bone caused by having too much calcium in the body. They can cause constant, long-lasting pain ranging from mild to severe, depending on the shape, size, and location of the growth. They normally form on the joints of bones such as the ankle or knee and can grow outward toward the skin. Exostoses are typically noncancerous, but can become cancerous in some instances. Exostoses are usually treated by surgically removing the growth.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exostoses" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exostoses" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exostoses" returned 61 free, full-text research articles on human participants. First 3 results:

[A splicing mutation of EXT1 in a Chinese pedigree with hereditary multiple exostoses].
 

Author(s): Wei Wang, Zheng-Qing Qiu, Hong-Mei Song

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):174-80.

 

Hereditary multiple exostoses (HME) is an autosomal dominant monogenic disorder of paraplasia ossium. Mutations in EXT1 and EXT2 have been suggested to be responsible for over 70% of HME cases. This study aimed to analyze the clinical features and pathogenic mutations in a Chinese ...

Last Updated: 26 Feb 2014

Go To URL
Gradual lengthening of the ulna in patients with multiple hereditary exostoses with a dislocated radial head.
 

Author(s): Yong Jin Cho, Sung Taek Jung

Journal: Yonsei Med. J.. 2014 Jan;55(1):178-84.

 

Multiple hereditary exostoses of the forearm typically form in the distal ulna, causing disturbances in the growth of the ulna and functional disability. Multiple hereditary exostoses inhibit the growth of the ulna, leading to an acquisition of a varus deformity in the radius, which ...

Last Updated: 16 Dec 2013

Go To URL
Multimodality imaging features of hereditary multiple exostoses.
 

Author(s): H K Kok, L Fitzgerald, N Campbell, I D Lyburn, P L Munk, O Buckley, W C Torreggiani

Journal: Br J Radiol. 2013 Oct;86(1030):20130398.

 

Hereditary multiple exostoses (HME) or diaphyseal aclasis is an inherited disorder characterised by the formation of multiple osteochondromas, which are cartilage-capped osseous outgrowths, and the development of associated osseous deformities. Individuals with HME may be asymptomatic ...

Last Updated: 20 Sep 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exostoses" returned 4 free, full-text review articles on human participants. First 3 results:

Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses.
 

Author(s): Julianne Huegel, Federica Sgariglia, Motomi Enomoto-Iwamoto, Eiki Koyama, John P Dormans, Maurizio Pacifici

Journal: Dev. Dyn.. 2013 Sep;242(9):1021-32.

 

Heparan sulfate (HS) is an essential component of cell surface and matrix-associated proteoglycans. Due to their sulfation patterns, the HS chains interact with numerous signaling proteins and regulate their distribution and activity on target cells. Many of these proteins, including ...

Last Updated: 21 Aug 2013

Go To URL
Glycobiology and the growth plate: current concepts in multiple hereditary exostoses.
 

Author(s): Kevin B Jones

Journal: J Pediatr Orthop. ;31(5):577-86.

 

Multiple hereditary exostoses, also termed as multiple osteochondromas, is a heritable disorder of connective tissue with primarily orthopaedic clinical manifestations. Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years.

Last Updated: 9 Jun 2011

Go To URL
Hereditary multiple exostoses and heparan sulfate polymerization.
 

Author(s): Beverly M Zak, Brett E Crawford, Jeffrey D Esko

Journal: Biochim. Biophys. Acta. 2002 Dec;1573(3):346-55.

 

Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis. Members of this multigene family share the ability to transfer N-acetylglucosamine to a variety of oligosaccharide ...

Last Updated: 5 Nov 2002

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project
 

Status: Recruiting

Condition Summary: Exostoses, Multiple Hereditary

 

Last Updated: 27 Mar 2014

Go to URL
Autologous Stem Cells in Achilles Tendinopathy
 

Status: Not yet recruiting

Condition Summary: Achilles Tendinitis, Right Leg; Achilles Tendinitis; Achilles Degeneration; Achilles Tendon Thickening; Tendinopathy; Achilles Tendinitis, Left Leg

 

Last Updated: 13 Feb 2014

Go to URL
Cervical Spondylotic Myelopathy Surgical Trial
 

Status: Recruiting

Condition Summary: Cervical Spondylosis With Myelopathy

 

Last Updated: 8 Aug 2014

Go to URL