Ewing Sarcoma

Common Name(s)

Ewing Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing Sarcoma" returned 226 free, full-text research articles on human participants. First 3 results:

Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone.
 

Author(s): Hyewon Park, Timothy K Turkalo, Kayla Nelson, Stephen Sai Folmsbee, Caroline Robb, Brittany Roper, Mizuki Azuma

Journal: Cell Cycle. 2014 ;13(15):2391-9.

 

Ewing sarcoma is a malignant bone cancer that primarily occurs in children and adolescents. Eighty-five percent of Ewing sarcoma is characterized by the presence of the aberrant chimeric EWS/FLI1 fusion gene. Previously, we demonstrated that an interaction between EWS/FLI1 and wild-type ...

Last Updated: 8 Dec 2014

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Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
 

Author(s): Michelle Marques Howarth, David Simpson, Siu P Ngok, Bethsaida Nieves, Ron Chen, Zurab Siprashvili, Dedeepya Vaka, Marcus R Breese, Brian D Crompton, Gabriela Alexe, Doug S Hawkins, Damon Jacobson, Alayne L Brunner, Robert West, Jaume Mora, Kimberly Stegmaier, Paul Khavari, E Alejandro Sweet-Cordero

Journal: J. Clin. Invest.. 2014 Dec;124(12):5275-90.

 

Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma. EWS-FLI1 alters gene expression through mechanisms that are not completely understood. We performed RNA sequencing ...

Last Updated: 2 Dec 2014

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Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy.
 

Author(s): Edwin Choy, James E Butrynski, David C Harmon, Jeffrey A Morgan, Suzanne George, Andrew J Wagner, David D'Adamo, Gregory M Cote, Yael Flamand, Cyril H Benes, Daniel A Haber, Jose M Baselga, George D Demetri

Journal:

 

Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the efficacy and tolerability of olaparib, a PARP inhibitor, in patients ...

Last Updated: 11 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing Sarcoma" returned 12 free, full-text review articles on human participants. First 3 results:

Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma.
 

Author(s): Britta Vormoor, Nicola J Curtin

Journal: Curr Opin Oncol. 2014 Jul;26(4):428-33.

 

In 2012, two publications revealed a particular sensitivity of Ewing sarcoma cells to the inhibition of poly(ADP-ribose) polymerase (PARP). This review updates the reader on PARP function, the development of PARP inhibitors (PARPi) and the evidence for targeting PARP in Ewing sarcoma. ...

Last Updated: 3 Jun 2014

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Unusual presentation of Ewing sarcoma in the adrenal gland: a secondary malignancy from a survivor of Burkitt lymphoma.
 

Author(s): Sung Hee Lim, Ji Yoon Lee, Ji Young Lee, Ji Hoon Kim, Ki Hong Choi, Ji Yeon Hyun, Young Hyeh Ko, Jeeyun Lee, Seok Jin Kim, Won Seok Kim

Journal: Jpn. J. Clin. Oncol.. 2013 Jun;43(6):676-80.

 

The occurrence of Ewing sarcoma as a secondary malignancy is an extremely rare event in long-term cancer survivors. In addition, the occurrence of Ewing sarcoma in the adrenal gland is highly unusual. In this case report, we treated a 20-year-old male patient with cyclophosphamide, ...

Last Updated: 28 May 2013

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Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.
 

Author(s): Stephen L Lessnick, Marc Ladanyi

Journal: Annu Rev Pathol. 2012 ;7():145-59.

 

Approximately one-third of sarcomas contain specific translocations. Ewing sarcoma is the prototypical member of this group of sarcomas; it was the first to be recognized pathologically as a singular entity and to have its signature translocation defined cytogenetically, which led ...

Last Updated: 8 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Childhood Supratentorial Primitive Neuroectodermal Tumor; Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Peripheral Primitive Neuroectodermal Tumor of the Kidney; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 17 Mar 2015

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Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors
 

Status: Recruiting

Condition Summary: Desmoplastic Small Round Cell Tumor; Ewing Sarcoma of Bone or Soft Tissue; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

 

Last Updated: 4 Feb 2015

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Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Askin Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

 

Last Updated: 12 May 2015

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