Ewing Sarcoma

Common Name(s)

Ewing Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing Sarcoma" returned 261 free, full-text research articles on human participants. First 3 results:

Revision Surgical Treatment of a Second Lumbar Ewing Sarcoma: A Report of a Rare Case.
 

Author(s): Helin Feng, Jin Wang, Peng Guo, Jianfa Xu, Jiangang Feng

Journal: Medicine (Baltimore). 2015 Jul;94(30):e1190.

 

We report a case of a 58-year-old man who presented initially with lumbar pain.According to radiography, computed tomography, magnetic resonance imaging, and bone biopsy results, Ewing sarcoma (ES) was diagnosed. Tumor resection was performed, followed by chemotherapy and radiotherapy; ...

Last Updated: 30 Jul 2015

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High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases.
 

Author(s): Sung-Hyeok Hong, Jason U Tilan, Susana Galli, Ewa Izycka-Swieszewska, Taylor Polk, Meredith Horton, Akanksha Mahajan, David Christian, Shari Jenkins, Rachel Acree, Katherine Connors, Phuong Ledo, Congyi Lu, Yi-Chien Lee, Olga Rodriguez, Jeffrey A Toretsky, Chris Albanese, Joanna Kitlinska

Journal: Oncotarget. 2015 Mar;6(9):7151-65.

 

Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein ...

Last Updated: 21 Apr 2015

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Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.
 

Author(s): Laurie K Svoboda, Ashley Harris, Natashay J Bailey, Raphaela Schwentner, Eleni Tomazou, Cornelia von Levetzow, Brian Magnuson, Mats Ljungman, Heinrich Kovar, Elizabeth R Lawlor

Journal: Epigenetics. 2014 Dec;9(12):1613-25.

 

The polycomb proteins BMI-1 and EZH2 are highly overexpressed by Ewing sarcoma (ES), a tumor of stem cell origin that is driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. In the current study we analyzed expression of transcription programs that are controlled by polycomb ...

Last Updated: 28 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing Sarcoma" returned 18 free, full-text review articles on human participants. First 3 results:

Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
 

Author(s): Toshifumi Ozaki

Journal: J Orthop Sci. 2015 Mar;20(2):250-63.

 

Ewing sarcoma (ES) is rare in Japanese people, and only 30-40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. ...

Last Updated: 20 Mar 2015

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Primary spinal intradural extraskeletal Ewing sarcoma mimicking a giant nerve sheath tumor: case report and review of the literature.
 

Author(s): Mingfei Zhao, Buyi Zhang, Feng Liang, Jianmin Zhang

Journal:

 

Primary intradural extraskeletal Ewing sarcoma is a very rare form of malignant neoplasm. Only few cases have been reported on the literature. Here, we report a case of a 14-year-old boy who had a chief complaint of pain and tingling in the right lower limb. The patient initially ...

Last Updated: 12 Feb 2015

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Bone- and cartilage-forming tumors and ewing sarcoma: an update with a gnathic emphasis.
 

Author(s): Brian D Stewart, John D Reith, Jacquelyn A Knapik, Angela C Chi

Journal: Head Neck Pathol. 2014 Dec;8(4):454-62.

 

Over the past decade, there have been remarkable advances in bone tumor pathology. Insights into the genetic basis and pathobiology of many tumor types have impacted diagnosis, classification, and treatment. However, because gnathic lesions may comprise only a small proportion of ...

Last Updated: 27 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Eurosarc Trial of Linsitinib in Advanced Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Relapsed Ewing Sarcoma; Refractory Ewing Sarcoma

 

Last Updated: 18 Jan 2016

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Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Childhood Supratentorial Primitive Neuroectodermal Tumor; Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Peripheral Primitive Neuroectodermal Tumor of the Kidney; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 28 Sep 2015

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Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Askin Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

 

Last Updated: 12 Nov 2015

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