Ewing Sarcoma

Common Name(s)

Ewing Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing Sarcoma" returned 277 free, full-text research articles on human participants. First 3 results:

ProGRP is a possible tumor marker for patients with Ewing sarcoma.
 

Author(s): Ken Yamaguchi, Hirohisa Katagiri, Mitsuru Takahashi, Yuji Ishida, Akira Ono, Toshiaki Takahashi, Keiichi Ohshima, Tohru Mochizuki, Kenichi Urakami, Koji Muramatsu, Toru Kameya, Ichiro Ito, Takashi Nakajima

Journal: Biomed. Res.. 2015 ;36(4):273-7.

 

We analyzed serum ProGRP levels in patients with Ewing sarcoma, and found that 5 out of 9 patients had elevated levels; the values range equally with those of patients with limited disease of small-cell lung carcinoma. Serum ProGRP levels in patients with bone and soft tissue malignancies ...

Last Updated: 24 Aug 2015

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Primary Ewing sarcoma of vulva, confirmed with molecular cytogenetic analysis: A rare case report with diagnostic and treatment implications.
 

Author(s): Bharat Rekhi, Girish Chinnaswamy, Tushar Vora, Sneha Shah, Venkatesh Rangarajan

Journal: Indian J Pathol Microbiol. ;58(3):341-4.

 

Primary vulvar Ewing sarcoma (ES)/PNET is an uncommonly documented tumor, especially with molecular results. A 10-year-old girl presented with left vulvar swelling, a year ago. Her abdominopelvic ultrasound revealed a 12 cm × 8 cm sized, mixed echogenic blood-filled lesion in the ...

Last Updated: 15 Aug 2015

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Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells.
 

Author(s): Ana M Sanchez-Sanchez, Isaac Antolin, Noelia Puente-Moncada, Santos Suarez, Marina Gomez-Lobo, Carmen Rodriguez, Vanesa Martin

Journal:

 

Melatonin kills or inhibits the proliferation of different cancer cell types, and this is associated with an increase or a decrease in reactive oxygen species, respectively. Intracellular oxidants originate mainly from oxidative metabolism, and cancer cells frequently show alterations ...

Last Updated: 8 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing Sarcoma" returned 22 free, full-text review articles on human participants. First 3 results:

Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?
 

Author(s): Elizabeth R Lawlor, Poul H Sorensen

Journal: Crit Rev Oncog. 2015 ;20(3-4):155-71.

 

Ewing sarcoma (ES) is a highly aggressive bone and soft-tissue tumor with peak incidence among adolescents and young adults. Despite advances in local control and systemic chemotherapy, metastatic relapse after an initial clinical remission remains a significant clinical problem. ...

Last Updated: 9 Sep 2015

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Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes.
 

Author(s): Laurens G L Sand, Karoly Szuhai, Pancras C W Hogendoorn

Journal:

 

Ewing sarcoma is an aggressive neoplasm occurring predominantly in adolescent Caucasians. At the genome level, a pathognomonic EWSR1-ETS translocation is present. The resulting fusion protein acts as a molecular driver in the tumor development and interferes, amongst others, with ...

Last Updated: 21 Jul 2015

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Systemic therapy for osteosarcoma and Ewing sarcoma.
 

Author(s): Paul A Meyers

Journal: Am Soc Clin Oncol Educ Book. 2015 ;():e644-7.

 

Curative therapy for both osteosarcoma and Ewing sarcoma requires the combination of effective systemic therapy and local control of all macroscopic tumors. Systemic therapy for osteosarcoma consists of multiagent chemotherapy. The most common regimen uses cisplatin, doxorubicin, ...

Last Updated: 21 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Askin Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

 

Last Updated: 16 May 2016

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Study in Localized and Disseminated Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 19 May 2016

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Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma

 

Last Updated: 5 Apr 2016

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