Ewing Sarcoma

Common Name(s)

Ewing Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing Sarcoma" returned 295 free, full-text research articles on human participants. First 3 results:

Risk stratification and pattern of cardiotoxicity in pediatric Ewing sarcoma.
 

Author(s): Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat

Journal: J Egypt Natl Canc Inst. 2017 Mar;29(1):53-56.

 

Anthracycline chemotherapy contributes to improved outcomes in Ewing sarcoma; however, the most feared complication is cardiotoxicity. Echocardiograms were routinely used to monitor cardiac function after anthracycline treatment. Nevertheless, indices chosen to assess cardiac toxicity ...

Last Updated: 4 Mar 2017

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Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy.
 

Author(s): Rosa Simona Pinca, Maria Cristina Manara, Valentina Chiadini, Piero Picci, Cinzia Zucchini, Katia Scotlandi

Journal: Oncol. Rep.. 2017 Mar;37(3):1387-1393.

 

Understanding the molecular processes characterizing Ewing sarcoma (EWS) cell migration is crucial to highlight novel therapies for patients with disseminated disease. In this study we analyzed the role of ROCK kinases in the regulation of cell migration, growth and differentiation ...

Last Updated: 23 Jan 2017

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The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma.
 

Author(s): Raphaela Schwentner, David Herrero-Martin, Maximilian O Kauer, Cornelia N Mutz, Anna M Katschnig, Grzegorz Sienski, Javier Alonso, Dave N T Aryee, Heinrich Kovar

Journal: Oncotarget. 2017 Feb;8(7):10980-10993.

 

MicroRNAs serve to fine-tune gene expression and play an important regulatory role in tissue specific gene networks. The identification and validation of miRNA target genes in a tissue still poses a significant problem since the presence of a seed sequence in the 3'UTR of an mRNA ...

Last Updated: 28 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing Sarcoma" returned 25 free, full-text review articles on human participants. First 3 results:

Primary intestinal mold infection in children with solid tumors: a case report in an adolescent with Ewing sarcoma, and literature review.
 

Author(s): Aldo Naselli, Alberto Garaventa, Piero Buffa, Claudio Granata, Roberto Bandettini, Giuliana Cangemi, Andrea Moscatelli, Elio Castagnola

Journal: New Microbiol.. 2016 Jul;39(3):232-234.

 

We report a case of primary intestinal infection due to filamentous fungi in an adolescent with Ewing sarcoma. The clinical picture was that of peritonitis secondary to intestinal perforation and the diagnosis was established only on histopathological bases. This condition is very ...

Last Updated: 10 Jun 2016

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Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review.
 

Author(s): Sung Hwan Bae, Jung Hwa Hwang, Bo Da Nam, Hyun Jo Kim, Ki-Up Kim, Dong Won Kim, In Ho Choi

Journal: Medicine (Baltimore). 2016 Feb;95(7):e2725.

 

Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are high-grade malignant neoplasms. These malignancies present very rare tumors of thoracopulmonary area and even rarer in the mediastinum. In our knowledge, ES/PNET presented with multiple mediastinal masses has not been reported ...

Last Updated: 18 Feb 2016

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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.
 

Author(s): Emily R Theisen, Kathleen I Pishas, Ranajeet S Saund, Stephen L Lessnick

Journal: Oncotarget. 2016 Apr;7(14):17616-30.

 

Ewing sarcoma is an aggressive primary pediatric bone tumor, often diagnosed in adolescents and young adults. A pathognomonic reciprocal chromosomal translocation results in a fusion gene coding for a protein which derives its N-terminus from a FUS/EWS/TAF15 (FET) protein family member, ...

Last Updated: 14 Jul 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 26 Apr 2017

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A Two-part Phase IIb Trial of Vigil in Ewing's Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 6 Jul 2017

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Study in Localized and Disseminated Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 19 May 2016

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