Evans Syndrome

Common Name(s)

Evans Syndrome

Evans syndrome is a very rare autoimmune disorder in which the immune system destroys the body's red blood cells, white blood cells and/or platelets. Affected people often experience thrombocytopenia (too few platelets) and Coombs' positive hemolytic anemia (premature destruction of red blood cells). Signs and symptoms may include purpura, paleness, fatigue, and light-headedness.The exact cause of this condition is unknown. The best treatment options for Evans syndrome depend on many factors, including the severity of the condition; the signs and symptoms present; and each person's response to certain therapies.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Evans Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Evans Syndrome" returned 44 free, full-text research articles on human participants. First 3 results:

Clinical Features of Systemic Lupus Erythematosus Patients Complicated With Evans Syndrome: A Case-Control, Single Center Study.
 

Author(s): Lili Zhang, Xiuhua Wu, Laifang Wang, Jing Li, Hua Chen, Yan Zhao, Wenjie Zheng

Journal: Medicine (Baltimore). 2016 Apr;95(15):e3279.

 

The aim of the study was to investigate the clinical features of systemic lupus erythematous (SLE) complicated with Evans syndrome (ES). We conducted a retrospective case-control study to compare the clinical and laboratory features of age- and gender-matched lupus patients with and ...

Last Updated: 16 Apr 2016

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Evans syndrome and its link with systemic lupus erythematosus.
 

Author(s): Satish Mendonca, Sachin Srivastava, Rajan Kapoor, Devika Gupta, Pooja Gupta, M L Sharma

Journal: Saudi J Kidney Dis Transpl. 2016 Jan;27(1):147-9.

 

Evans syndrome is a rare syndrome associated with the presence of autoimmune hemolytic anemia and simultaneous or sequential development of thrombocytopenia. It was first described by Evan and Duane in 1951. It is one of the rare presenting features of autoimmune disorders, especially ...

Last Updated: 20 Jan 2016

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A Case of a TSH-secreting Pituitary Adenoma Associated with Evans' Syndrome.
 

Author(s): Atsushi Yasuda, Toshiro Seki, Masayuki Oki, Atsushi Takagi, Chie Inomoto, Naoya Nakamura, Hideki Atsumi, Tanefumi Baba, Mitsunori Matsumae, Noriko Sasaki, Yasuo Suzuki, Masafumi Fukagawa

Journal:

 

We present a case of a TSH-secreting pituitary adenoma (TSHoma) associated with Evans' syndrome. A 30-year-old woman was referred to our hospital due to purpura and ecchymoses on her limb and body and epistaxis. Evans' syndrome was diagnosed based on idiopathic thrombocytopenic purpura ...

Last Updated: 7 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Evans Syndrome" returned 7 free, full-text review articles on human participants. First 3 results:

CD56+ angioimmunoblastic T-cell lymphoma with evans syndrome : a case report and review of the literature.
 

Author(s): Yasunobu Sekiguchi, Asami Shimada, Hidenori Imai, Mutsumi Wakabayashi, Keiji Sugimoto, Noriko Nakamura, Tomonori Sawada, Norio Komatsu, Masaaki Noguchi

Journal: J Clin Exp Hematop. 2013 ;53(1):37-47.

 

A 67-year-old man was diagnosed with CD56(+) angioimmunoblastic T cell lymphoma (AITL), which was associated with autoimmune thrombocytopenic purpura (ATP) and autoimmune hemolytic anemia (AIHA) (Evans syndrome). The ATP was refractory to Helicobacter pylori eradication therapy and ...

Last Updated: 26 Jun 2013

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Rituximab for refractory Evans syndrome and other immune-mediated hematologic diseases.
 

Author(s): Elpis Mantadakis, Vassiliki Danilatou, Eftichia Stiakaki, Maria Kalmanti

Journal: Am. J. Hematol.. 2004 Nov;77(3):303-10.

 

The authors describe a 21-year-old man with long-lasting Evans syndrome refractory to corticosteroids and immunosuppressive agents; the patient responded to four weekly infusions of rituximab. The patient relapsed with thrombocytopenia 7 months post-therapy and was successfully re-treated ...

Last Updated: 25 Oct 2004

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Allogeneic stem cell transplantation for Evans syndrome.
 

Author(s): Y Oyama, E B Papadopoulos, M Miranda, A E Traynor, R K Burt

Journal: Bone Marrow Transplant.. 2001 Nov;28(9):903-5.

 

Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic steroids, vincristine, alkylating agents, or cyclosporine. ...

Last Updated: 8 Jan 2002

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.