Evans Syndrome

Common Name(s)

Evans Syndrome

Evans syndrome is a very rare autoimmune disorder in which the body makes antibodies that destroy the red blood cells, platelets and white blood cells. Affected individuals usually experience thrombocytopenia (too few platelets) and Coombs' positive hemolytic anemia (premature destruction of red blood cells).  People with Evans syndrome may have low levels of all three types of blood cells at one time, or may only have problems with one or two of them. The exact cause of this condition is unknown.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Evans Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Evans Syndrome" returned 29 free, full-text research articles on human participants. First 3 results:

A case report of Evans Syndrome.
 

Author(s): R V Dosi, A P Ambaliya, R D Patell, R S Patil, P J Shah

Journal: Indian J Med Sci. ;66(3-4):82-5.

 

Evans Syndrome (ES) is the rare simultaneous or subsequent development of immune thrombocytopenia purpura (ITP) and autoimmune hemolytic anemia (AIHA). It portends a poorer prognosis and a more aggressive line of management than either condition presenting alone. Here we report a ...

Last Updated: 22 Apr 2013

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The hot foot syndrome: Evans' sign and the old way.
 

Author(s): R J Evans, C Peter N Watson

Journal: Pain Res Manag. ;17(1):31-4.

 

Pelvic cancers such as cancer of the cervix can spread locally to involve adjacent structures such as the lumbosacral plexus and the sympathetic chain. When this happens the prognosis is usually poor. An early suspicion of recurrence may result in investigation leading to earlier ...

Last Updated: 20 Apr 2012

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Successful rituximab therapy in refractory autoimmune hepatitis and Evans syndrome.
 

Author(s): Elizabeth J Carey, Krishni Somaratne, Jorge Rakela

Journal: Rev Med Chil. 2011 Nov;139(11):1484-7.

 

A 44-year-old woman was found to have elevated aminotransferases, twice the upper limit of normal. Liver biopsy demonstrated a mixed inflammatory process suggestive of both primary biliary cirrhosis and autoimmune hepatitis (AIH). Prednisone and azathioprine were started, with normalization ...

Last Updated: 26 Mar 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Evans Syndrome" returned 6 free, full-text review articles on human participants. First 3 results:

CD56+ angioimmunoblastic T-cell lymphoma with evans syndrome : a case report and review of the literature.
 

Author(s): Yasunobu Sekiguchi, Asami Shimada, Hidenori Imai, Mutsumi Wakabayashi, Keiji Sugimoto, Noriko Nakamura, Tomonori Sawada, Norio Komatsu, Masaaki Noguchi

Journal: J Clin Exp Hematop. 2013 ;53(1):37-47.

 

A 67-year-old man was diagnosed with CD56(+) angioimmunoblastic T cell lymphoma (AITL), which was associated with autoimmune thrombocytopenic purpura (ATP) and autoimmune hemolytic anemia (AIHA) (Evans syndrome). The ATP was refractory to Helicobacter pylori eradication therapy and ...

Last Updated: 26 Jun 2013

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Allogeneic stem cell transplantation for Evans syndrome.
 

Author(s): Y Oyama, E B Papadopoulos, M Miranda, A E Traynor, R K Burt

Journal: Bone Marrow Transplant.. 2001 Nov;28(9):903-5.

 

Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic steroids, vincristine, alkylating agents, or cyclosporine. ...

Last Updated: 8 Jan 2002

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Splenectomy for refractory Evans' syndrome associated with antiphospholipid antibodies: report of two cases.
 

Author(s): J Font, S Jiménez, R Cervera, M García-Carrasco, M Ramos-Casals, J Campdelacreu, M Ingelmo

Journal: Ann. Rheum. Dis.. 2000 Nov;59(11):920-3.

 

The main haematological manifestations seen in patients with antiphospholipid antibodies (aPL) are thrombocytopenia, usually mild, and haemolytic anaemia with a positive Coombs test. Owing to the shared characteristics with idiopathic thrombocytopenic purpura, similar rules are followed ...

Last Updated: 5 Dec 2000

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sirolimus for Autoimmune Disease of Blood Cells
 

Status: Recruiting

Condition Summary: Autoimmune Pancytopenia; Autoimmune Lymphoproliferative Syndrome (ALPS); Evans Syndrome; Idiopathic Thrombocytopenic Purpura; Anemia, Hemolytic, Autoimmune; Autoimmune Neutropenia; Lupus Erythematosus, Systemic; Inflammatory Bowel Disease; Rheumatoid Arthritis

 

Last Updated: 3 Feb 2014

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