Esophageal Cancer

Common Name(s)

Esophageal Cancer

Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. As the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. The exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. In the United States, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. Treatments include surgery, radiation, chemotherapy, and laser therapy. Some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Esophageal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Esophageal Cancer Awareness Association, Inc.

The Esophageal Cancer Awareness Association (ECAA) is dedicated to providing outreach for esophageal cancer patients, caregivers and survivors, to foster public awareness of this disease, to stimulate and promote esophageal cancer research efforts, and to offer education and information in a supportive environment.

Last Updated: 19 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Esophageal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Esophageal Cancer Awareness Association, Inc.

The Esophageal Cancer Awareness Association (ECAA) is dedicated to providing outreach for esophageal cancer patients, caregivers and survivors, to foster public awareness of this disease, to stimulate and promote esophageal cancer research efforts, and to offer education and information in a supportive environment.

http://www.ECAware.org

Last Updated: 19 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Esophageal Cancer" returned 967 free, full-text research articles on human participants. First 3 results:

Radiobiological determination of dose escalation and normal tissue toxicity in definitive chemoradiation therapy for esophageal cancer.
 

Author(s): Samantha Warren, Mike Partridge, Rhys Carrington, Chris Hurt, Thomas Crosby, Maria A Hawkins

Journal: Int. J. Radiat. Oncol. Biol. Phys.. 2014 Oct;90(2):423-9.

 

This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity.

Last Updated: 11 Oct 2014

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The intensity of radiotherapy-elicited immune response is associated with esophageal cancer clearance.
 

Author(s): Jin-lu Ma, Long Jin, Yao-Dong Li, Chen-chen He, Xi-jing Guo, Rui Liu, Yun-Yi Yang, Su-xia Han

Journal: J Immunol Res. 2014 ;2014():794249.

 

Radiation therapy is one of the standard therapeutic modalities for esophageal cancer, achieving its main antitumor efficacy through DNA damage. However, accumulating evidence shows that radiotherapy can substantially alter the tumor microenvironment, particularly with respect to ...

Last Updated: 26 Jun 2014

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Screening and selection of peptides specific for esophageal cancer cells from a phage display peptide library.
 

Author(s): Zhe-Feng Zhang, Xue Shan, Yong-Xin Wang, Wei Wang, Shi-Yun Feng, You-Bin Cui

Journal:

 

Esophageal cancer is a common malignant tumor of the gastrointestinal tract and is typically diagnosed at an advanced stage due to the absence of early clinical symptoms. Although surgery, chemotherapy, and radiotherapy represent the major treatment methods employed for this cancer, ...

Last Updated: 3 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Esophageal Cancer" returned 105 free, full-text review articles on human participants. First 3 results:

Physical activity is associated with reduced risk of esophageal cancer, particularly esophageal adenocarcinoma: a systematic review and meta-analysis.
 

Author(s): Siddharth Singh, Swapna Devanna, Jithinraj Edakkanambeth Varayil, Mohammad Hassan Murad, Prasad G Iyer

Journal:

 

Physical activity has been inversely associated with risk of several cancers. We performed a systematic review and meta-analysis to evaluate the association between physical activity and risk of esophageal cancer (esophageal adenocarcinoma [EAC] and/or esophageal squamous cell carcinoma [ESCC]).

Last Updated: 16 Jun 2014

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Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer.
 

Author(s): Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang, Ke Li

Journal:

 

Esophageal cancer (EC) is a frequently occurring cancer with poor prognosis despite combined therapeutic strategies. Many biomarkers have been proposed as predictors of adverse events. We sought to assess the prognostic value of biomarkers in predicting the overall survival of esophageal ...

Last Updated: 17 Jan 2014

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Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis.
 

Author(s): Fa-Jun Xie, Yi-Ping Zhang, Qiu-Qing Zheng, Hong-Chuan Jin, Fa-Liang Wang, Ming Chen, Lan Shao, De-Hong Zou, Xin-Min Yu, Wei-Min Mao

Journal: World J. Gastroenterol.. 2013 Sep;19(36):6098-107.

 

To clarify the association between Helicobacter pylori (H. pylori) infection and the risk of esophageal carcinoma through a meta-analysis of published data.

Last Updated: 9 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase III Study Compare Adjuvant Chemoradiotherapy, Radiotherapy and Surgery Alone for Esophageal Carcinoma
 

Status: Recruiting

Condition Summary: Esophageal Neoplasms; Esophageal Cancer

 

Last Updated: 29 Oct 2014

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Esophageal Cancer Genetics Studies
 

Status: Recruiting

Condition Summary: Esophageal Cancer

 

Last Updated: 11 Nov 2014

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Genetic and Environmental Risk Factors Related to Esophageal Cancer
 

Status: Recruiting

Condition Summary: Esophageal Cancer

 

Last Updated: 17 Dec 2009

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