Esophageal Cancer

Common Name(s)

Esophageal Cancer

Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. As the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. The exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. In the United States, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. Treatments include surgery, radiation, chemotherapy, and laser therapy. Some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Esophageal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Esophageal Cancer Awareness Association, Inc.

The Esophageal Cancer Awareness Association (ECAA) is dedicated to providing outreach for esophageal cancer patients, caregivers and survivors, to foster public awareness of this disease, to stimulate and promote esophageal cancer research efforts, and to offer education and information in a supportive environment.

Last Updated: 19 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Esophageal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Esophageal Cancer Awareness Association, Inc.

The Esophageal Cancer Awareness Association (ECAA) is dedicated to providing outreach for esophageal cancer patients, caregivers and survivors, to foster public awareness of this disease, to stimulate and promote esophageal cancer research efforts, and to offer education and information in a supportive environment.

http://www.ECAware.org

Last Updated: 19 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Esophageal Cancer" returned 876 free, full-text research articles on human participants. First 3 results:

The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
 

Author(s): Kousaku Mimura, Kensuke Shiraishi, Anja Mueller, Shinichiro Izawa, Ley-Fang Kua, Jimmy So, Wei-Peng Yong, Hideki Fujii, Barbara Seliger, Rolf Kiessling, Koji Kono

Journal: J. Immunol.. 2013 Dec;191(12):6261-72.

 

Downregulation of HLA class I expression may contribute to a poor prognosis in cancer patients. There is limited information about epigenetic and oncogenic regulation of HLA class I, and multiple mechanisms may be involved. In the current study, we examined the relationship between ...

Last Updated: 9 Dec 2013

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Effects of metallothionein-3 and metallothionein-1E gene transfection on proliferation, cell cycle, and apoptosis of esophageal cancer cells.
 

Author(s): Z Q Tian, Y Z Xu, Y F Zhang, G F Ma, M He, G-Y Wang

Journal:

 

Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study ...

Last Updated: 13 Nov 2013

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Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.
 

Author(s): J J Hu, Z T Wang, B Li

Journal:

 

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the ...

Last Updated: 13 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Esophageal Cancer" returned 96 free, full-text review articles on human participants. First 3 results:

Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer.
 

Author(s): Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang, Ke Li

Journal:

 

Esophageal cancer (EC) is a frequently occurring cancer with poor prognosis despite combined therapeutic strategies. Many biomarkers have been proposed as predictors of adverse events. We sought to assess the prognostic value of biomarkers in predicting the overall survival of esophageal ...

Last Updated: 17 Jan 2014

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Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis.
 

Author(s): Fa-Jun Xie, Yi-Ping Zhang, Qiu-Qing Zheng, Hong-Chuan Jin, Fa-Liang Wang, Ming Chen, Lan Shao, De-Hong Zou, Xin-Min Yu, Wei-Min Mao

Journal: World J. Gastroenterol.. 2013 Sep;19(36):6098-107.

 

To clarify the association between Helicobacter pylori (H. pylori) infection and the risk of esophageal carcinoma through a meta-analysis of published data.

Last Updated: 9 Oct 2013

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Epidemiology of esophageal cancer.
 

Author(s): Yuwei Zhang

Journal: World J. Gastroenterol.. 2013 Sep;19(34):5598-606.

 

Esophageal cancer (EsC) is one of the least studied and deadliest cancers worldwide because of its extremely aggressive nature and poor survival rate. It ranks sixth among all cancers in mortality. In retrospective studies of EsC, smoking, hot tea drinking, red meat consumption, poor ...

Last Updated: 16 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Intensity Modulated Radiation Therapy After Surgery in Early Stage of Esophageal Carcinoma;
 

Status: Recruiting

Condition Summary: Esophageal Neoplasm; Esophageal Cancer TNM Staging Primary Tumor (T) T2; Esophageal Cancer TNM Staging Primary Tumor (T) T3; Esophageal Cancer TNM Staging Regional Lymph Nodes (N) N0; Esophageal Cancer TNM Staging Distal Metastasis (M) M0

 

Last Updated: 28 Dec 2012

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Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer
 

Status: Recruiting

Condition Summary: Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Stage IB Esophageal Cancer; Stage IIA Esophageal Cancer; Stage IIB Esophageal Cancer; Stage IIIA Esophageal Cancer; Stage IIIB Esophageal Cancer

 

Last Updated: 23 Jun 2014

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Pilot Trial of CRLX101 in Treatment of Patients With Advanced or Metastatic Stomach, Gastroesophageal, or Esophageal Cancer That Cannot be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Diffuse Adenocarcinoma of the Stomach; Intestinal Adenocarcinoma of the Stomach; Mixed Adenocarcinoma of the Stomach; Recurrent Esophageal Cancer; Recurrent Gastric Cancer; Squamous Cell Carcinoma of the Esophagus; Stage IIIB Esophageal Cancer; Stage IIIB Gastric Cancer; Stage IIIC Esophageal Cancer; Stage IIIC Gastric Cancer; Stage IV Esophageal Cancer; Stage IV Gastric Cancer

 

Last Updated: 30 Apr 2014

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