Erythema Multiforme

Common Name(s)

Erythema Multiforme

Erythema multiforme (EM) refers to a group of hypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus, suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome. The most severe of the three is toxic epidermal necrolysis (TEN).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Erythema Multiforme" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Erythema Multiforme" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Erythema Multiforme" returned 78 free, full-text research articles on human participants. First 3 results:

Erythema exsudativum multiforme after a Leishmania skin test.
 

Author(s): Bas S Wind, Luiz H GuimarĂ£es, Paulo R L Machado

Journal: Am. J. Trop. Med. Hyg.. 2014 Apr;90(4):587-8.

 

A 45-year-old otherwise healthy male from an endemic region for Leishmania braziliensis infection in Bahia, Brazil, presented with three erosive hemorrhagic infiltrated plaques on the left shin accompanied with lymphadenopathy in the groin since one month. A Leishmania skin test performed ...

Last Updated: 3 Apr 2014

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Secondary syphilis: a case mimicking erythema multiforme clinically and pathologically.
 

Author(s): Apphia Wang, Sara Risner-Rumohr, Paul Rodriguez-Waitkus, Harry Dao

Journal:

 

Secondary syphilis, the hematogenous spread of Treponema pallidum, usually occurs 4-10 weeks after initial exposure. The skin is involved in 70% of cases, with maculopapular, vesiculobullous, and ulcerative morphologies possible at presentation, making the diagnosis of secondary syphilis ...

Last Updated: 9 Dec 2013

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Erythema multiforme in children: the steroid debate.
 

Author(s): Melissa Chan, Ran D Goldman

Journal: Can Fam Physician. 2013 Jun;59(6):635-6.

 

In my office I occasionally see children who have rashes with "target lesions" and who are diagnosed with erythema multiforme (EM). When should these children receive steroids, and when should the illness be allowed to follow its natural course without steroid treatment?

Last Updated: 14 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Erythema Multiforme" returned 3 free, full-text review articles on human participants. First 3 results:

Lupus erythematosus masquerading as erythema multiforme: does Rowell syndrome really exist?
 

Author(s): Gunjan M Modi, Angela Shen, Ali Mazloom, Janine Mawad, Aivlys Perez, Michael L Sonabend, Sylvia Hsu

Journal:

 

Last Updated: 1 Apr 2009

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Erythema multiforme.
 

Author(s): Michele R Lamoreux, Marna R Sternbach, W Teresa Hsu

Journal: Am Fam Physician. 2006 Dec;74(11):1883-8.

 

Erythema multiforme is a skin condition considered to be a hypersensitivity reaction to infections or drugs. It consists of a polymorphous eruption of macules, papules, and characteristic "target" lesions that are symmetrically distributed with a propensity for the distal extremities. ...

Last Updated: 15 Dec 2006

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Use of steroids for erythema multiforme in children.
 

Author(s): Alfred K Yeung, Ran D Goldman

Journal: Can Fam Physician. 2005 Nov;51():1481-3.

 

I recently diagnosed an erythema multiforme rash in several patients, two of whom had the major variant, Stevens-Johnson syndrome. Should these patients be managed with corticosteroids?

Last Updated: 15 Dec 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
 

Status: Not yet recruiting

Condition Summary: Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis (Lyell) Syndrome; Mucous Membrane Pemphigoid

 

Last Updated: 27 Apr 2014

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Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
 

Status: Recruiting

Condition Summary: Toxic Epidermal Necrolysis; Stevens-Johnson Syndrome

 

Last Updated: 13 Jan 2014

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Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
 

Status: Recruiting

Condition Summary: Chemical Injuries; Unspecified Complication of Corneal Transplant; Autoimmune Diseases; Ocular Cicatricial Pemphigoid; Stevens Johnson Syndrome; Lupus Erythematosus, Systemic; Rheumatoid Arthritis; Other Autoimmune Diseases

 

Last Updated: 20 Mar 2013

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