Lennox-Gastaut Syndrome

Common Name(s)

Lennox-Gastaut Syndrome, Epileptic Encephalopathy Lennox-Gastaut Type

Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability. This condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In about one-third of cases, no cause can be found. Treatment for Lennox-Gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut Syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

View Details
Logo
International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

Last Updated: 19 Feb 2013

View Details
LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to providing information about Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, while raising funds for research, programs, and services for individuals living with LGS, and their families.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut Syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

View Details
Logo
International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

View Details
LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to providing information about Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, while raising funds for research, programs, and services for individuals living with LGS, and their families.

http://www.lgsfoundation.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lennox-Gastaut Syndrome" returned 29 free, full-text research articles on human participants. First 3 results:

Budget impact analysis of antiepileptic drugs for Lennox-Gastaut syndrome.
 

Author(s): Michelle Skornicki, Karen M Clements, Amy K O'Sullivan

Journal: J Manag Care Pharm. 2014 Apr;20(4):400-6.

 

In October 2011, clobazam was FDA-approved for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS), a debilitating childhood epilepsy characterized by drop attacks, for patients 2 years and older.

Last Updated: 1 Apr 2014

Go To URL
Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years.
 

Author(s): Joan A Conry, Yu-Tze Ng, Lydia Kernitsky, Wendy G Mitchell, Rima Veidemanis, Rebecca Drummond, Jouko Isojarvi, Deborah Lee, Juliann M Paolicchi,

Journal: Epilepsia. 2014 Apr;55(4):558-67.

 

To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS).

Last Updated: 23 Apr 2014

Go To URL
Cost-effectiveness analysis of antiepileptic drugs in the treatment of Lennox-Gastaut syndrome.
 

Author(s): Karen M Clements, Michelle Skornicki, Amy K O'Sullivan

Journal: Epilepsy Behav. 2013 Oct;29(1):184-9.

 

An economic model evaluated the costs and outcomes of adjunctive clobazam therapy for Lennox-Gastaut syndrome (LGS) compared with adjunctive lamotrigine, rufinamide, and topiramate. Clinical data were used to estimate baseline frequency and the percentage of drop-seizure reductions ...

Last Updated: 16 Sep 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lennox-Gastaut Syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox-Gastaut syndrome: a meta-analysis.
 

Author(s): Guido Lancman, Michael Virk, Huibo Shao, Madhu Mazumdar, Jeffrey P Greenfield, Steven Weinstein, Theodore H Schwartz

Journal: Seizure. 2013 Jan;22(1):3-8.

 

Lennox-Gastaut syndrome (LGS) is an epileptogenic disorder that arises in childhood and is typically characterized by multiple seizure types, slow spike-and-wave complexes on EEG and cognitive impairment. If medical treatment fails, patients can proceed to one of two palliative surgeries, ...

Last Updated: 14 Jan 2013

Go To URL
[Lennox-Gastaut syndrome--course and treatment].
 

Author(s): Caroline Lund, Eylert Brodtkorb, Karl O Nakken

Journal: Tidsskr. Nor. Laegeforen.. 2011 Jan;131(1):24-7.

 

Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy, which starts in childhood with various seizure types. The children develop cognitive impairment and a typical EEG pattern. The aim of this article is to describe the clinical presentation of LGS, with particular emphasis ...

Last Updated: 14 Jan 2011

Go To URL
Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: literature review.
 

Author(s): Katy Gallop, Diane Wild, Annabel Nixon, Lara Verdian, Joyce A Cramer

Journal: Seizure. 2009 Oct;18(8):554-8.

 

The aim of this study was to conduct a review of the literature to evaluate the impact of LGS on the HRQL of children with LGS and their caregivers. The literature search revealed that there is limited published research on the impact of LGS on the HRQL of the child or caregiver. ...

Last Updated: 8 Sep 2009

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
 

Status: Not yet recruiting

Condition Summary: Lennox-Gastaut Syndrome

 

Last Updated: 9 Jun 2011

Go to URL
An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet or Lennox-Gastaut Syndromes
 

Status: Not yet recruiting

Condition Summary: Epilepsy; Dravet Syndrome; Lennox-Gastaut Syndrome

 

Last Updated: 22 Aug 2014

Go to URL

Last Updated: 12 Dec 2014

Go to URL