Lennox-Gastaut syndrome

Common Name(s)

Lennox-Gastaut syndrome, Epileptic encephalopathy Lennox-Gastaut type, LGS

Lennox-Gastaut syndrome (LGS) is a rare and severe form of childhood-onset epilepsy. This condition is typically diagnosed between the ages of 3 and 5 and typically continues into adulthood. Children with LGS experience many different types of seizures. The most common type of seizures found in children with LGS are seizures that cause the arms and legs to suddenly stiffen (tonic seizures), seizures that cause a partial or complete loss of consciousness (atypical absence seizures), and seizures that are caused by a sudden loss of muscle tone (drop attacks). In addition to various types of seizures, children with LGS may also experience learning difficulties, developmental delays, and behavior disturbances. These symptoms are typically a result of the frequent seizures that are difficult to control.

In order to diagnose LGS, a doctor will look for three common characteristics that include a slow spike wave electroencephalogram (EEG) pattern, moderate to severe cognitive impairment, and multiple seizure types. An EEG is a test used to examine the electrical activity in the brain. Doctors can use this test to detect the slow spike wave pattern. Unfortunately, there is not a cure for LGS at this time. Children typically do not respond well to the medications that are available to control this condition. If your child has been diagnosed with Lennox-Gastaut syndrome, it may be helpful to speak with a doctor or therapist to gain additional information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut syndrome" for support, advocacy or research.

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International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

Last Updated: 19 Feb 2013

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LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to improving the lives of individuals with Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, through research, programs, and education.

Last Updated: 27 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut syndrome" for support, advocacy or research.

Logo
International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

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LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to improving the lives of individuals with Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, through research, programs, and education.

http://www.lgsfoundation.org

Last Updated: 27 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lennox-Gastaut syndrome" returned 31 free, full-text research articles on human participants. First 3 results:

Budget impact analysis of antiepileptic drugs for Lennox-Gastaut syndrome.
 

Author(s): Michelle Skornicki, Karen M Clements, Amy K O'Sullivan

Journal: J Manag Care Spec Pharm. 2014 Apr;20(4):400-6.

 

In October 2011, clobazam was FDA-approved for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS), a debilitating childhood epilepsy characterized by drop attacks, for patients 2 years and older.

Last Updated: 1 Apr 2014

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Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years.
 

Author(s): Joan A Conry, Yu-Tze Ng, Lydia Kernitsky, Wendy G Mitchell, Rima Veidemanis, Rebecca Drummond, Jouko Isojarvi, Deborah Lee, Juliann M Paolicchi,

Journal: Epilepsia. 2014 Apr;55(4):558-67.

 

To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS).

Last Updated: 23 Apr 2014

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Cost-effectiveness analysis of antiepileptic drugs in the treatment of Lennox-Gastaut syndrome.
 

Author(s): Karen M Clements, Michelle Skornicki, Amy K O'Sullivan

Journal: Epilepsy Behav. 2013 Oct;29(1):184-9.

 

An economic model evaluated the costs and outcomes of adjunctive clobazam therapy for Lennox-Gastaut syndrome (LGS) compared with adjunctive lamotrigine, rufinamide, and topiramate. Clinical data were used to estimate baseline frequency and the percentage of drop-seizure reductions ...

Last Updated: 16 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lennox-Gastaut syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox-Gastaut syndrome: a meta-analysis.
 

Author(s): Guido Lancman, Michael Virk, Huibo Shao, Madhu Mazumdar, Jeffrey P Greenfield, Steven Weinstein, Theodore H Schwartz

Journal: Seizure. 2013 Jan;22(1):3-8.

 

Lennox-Gastaut syndrome (LGS) is an epileptogenic disorder that arises in childhood and is typically characterized by multiple seizure types, slow spike-and-wave complexes on EEG and cognitive impairment. If medical treatment fails, patients can proceed to one of two palliative surgeries, ...

Last Updated: 14 Jan 2013

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[Lennox-Gastaut syndrome--course and treatment].
 

Author(s): Caroline Lund, Eylert Brodtkorb, Karl O Nakken

Journal: Tidsskr. Nor. Laegeforen.. 2011 Jan;131(1):24-7.

 

Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy, which starts in childhood with various seizure types. The children develop cognitive impairment and a typical EEG pattern. The aim of this article is to describe the clinical presentation of LGS, with particular emphasis ...

Last Updated: 14 Jan 2011

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Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: literature review.
 

Author(s): Katy Gallop, Diane Wild, Annabel Nixon, Lara Verdian, Joyce A Cramer

Journal: Seizure. 2009 Oct;18(8):554-8.

 

The aim of this study was to conduct a review of the literature to evaluate the impact of LGS on the HRQL of children with LGS and their caregivers. The literature search revealed that there is limited published research on the impact of LGS on the HRQL of the child or caregiver. ...

Last Updated: 8 Sep 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
 

Status: Not yet recruiting

Condition Summary: Lennox-Gastaut Syndrome

 

Last Updated: 9 Jun 2011

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An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet or Lennox-Gastaut Syndromes
 

Status: Not yet recruiting

Condition Summary: Epilepsy; Dravet Syndrome; Lennox-Gastaut Syndrome

 

Last Updated: 8 Jan 2015

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Last Updated: 23 Apr 2015

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