Lennox-Gastaut syndrome

Common Name(s)

Lennox-Gastaut syndrome, Epileptic encephalopathy Lennox-Gastaut type, LGS

Lennox-Gastaut syndrome (LGS) is a rare and severe form of childhood-onset epilepsy. This condition is typically diagnosed between the ages of 3 and 5 and typically continues into adulthood. Children with LGS experience many different types of seizures. The most common type of seizures found in children with LGS are seizures that cause the arms and legs to suddenly stiffen (tonic seizures), seizures that cause a partial or complete loss of consciousness (atypical absence seizures), and seizures that are caused by a sudden loss of muscle tone (drop attacks). In addition to various types of seizures, children with LGS may also experience learning difficulties, developmental delays, and behavior disturbances. These symptoms are typically a result of the frequent seizures that are difficult to control.

In order to diagnose LGS, a doctor will look for three common characteristics that include a slow spike wave electroencephalogram (EEG) pattern, moderate to severe cognitive impairment, and multiple seizure types. An EEG is a test used to examine the electrical activity in the brain. Doctors can use this test to detect the slow spike wave pattern. Unfortunately, there is not a cure for LGS at this time. Children typically do not respond well to the medications that are available to control this condition. If your child has been diagnosed with Lennox-Gastaut syndrome, it may be helpful to speak with a doctor or therapist to gain additional information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut syndrome" for support, advocacy or research.

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International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

Last Updated: 19 Feb 2013

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LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to improving the lives of individuals with Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, through research, programs, and education.

Last Updated: 27 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut syndrome" for support, advocacy or research.

Logo
International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

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LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to improving the lives of individuals with Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, through research, programs, and education.

http://www.lgsfoundation.org

Last Updated: 27 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lennox-Gastaut syndrome" returned 65 free, full-text research articles on human participants. First 3 results:

Clobazam is equally safe and efficacious for seizures associated with Lennox-Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results.
 

Author(s): Yu-Tze Ng, Joan Conry, Wendy G Mitchell, Jeffrey Buchhalter, Jouko Isojarvi, Deborah Lee, Rebecca Drummond, Steve Chung

Journal: Epilepsy Behav. 2015 May;46():221-6.

 

The peak age at onset of Lennox-Gastaut syndrome (LGS) is between 3 and 5years. Patients with LGS frequently experience multiple types of treatment-refractory seizures and require lifelong therapy with several antiepileptic drugs. Here, post hoc analyses of clinical trials (phase ...

Last Updated: 6 Jun 2015

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Retention rates of rufinamide in pediatric epilepsy patients with and without Lennox-Gastaut Syndrome.
 

Author(s): Sudha Kilaru Kessler, Ann McCarthy, Avital Cnaan, Dennis J Dlugos

Journal: Epilepsy Res.. 2015 May;112():18-26.

 

To evaluate the effectiveness of rufinamide (RFM) in patients with Lennox-Gastaut Syndrome (LGS) compared to those with other epilepsy syndromes using time to treatment failure (retention rate) as the outcome measure.

Last Updated: 7 Apr 2015

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In response: Lennox-Gastaut syndrome may be a curable, reversible epileptic encephalopathy.
 

Author(s): John M Pellock, James W Wheless, Laurie M Douglass

Journal: Epilepsia. 2015 Mar;56(3):500-1.

 

Last Updated: 17 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lennox-Gastaut syndrome" returned 12 free, full-text review articles on human participants. First 3 results:

Lennox-Gastaut syndrome. Management update.
 

Author(s): Muradi H Al-Banji, Doaa K Zahr, Mohammed M Jan

Journal: Neurosciences (Riyadh). 2015 Jul;20(3):207-12.

 

Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by mixed seizures, cognitive decline, and generalized slow (<3 Hz) spike wave discharges on electroencephalography. Atonic seizures result in dangerous drop attacks with risks of injury and impairment ...

Last Updated: 13 Jul 2015

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Nonpharmacologic care for patients with Lennox-Gastaut syndrome: ketogenic diets and vagus nerve stimulation.
 

Author(s): Eric H W Kossoff, W Donald Shields

Journal: Epilepsia. 2014 Sep;55 Suppl 4():29-33.

 

Individuals with Lennox-Gastaut syndrome (LGS) often do not respond to or become resistant to pharmacologic treatments. Ketogenic diets (KDs) and vagus nerve stimulation (VNS) are nonpharmacologic treatment options for these intractable patients. The classic KD, a high-fat, low-carbohydrate ...

Last Updated: 6 Oct 2014

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Surgical options for patients with Lennox-Gastaut syndrome.
 

Author(s): Laurie M Douglass, Jay Salpekar

Journal: Epilepsia. 2014 Sep;55 Suppl 4():21-8.

 

Despite ongoing investigation into pharmacologic treatments for Lennox-Gastaut syndrome (LGS), outcomes for chronic administration of medications remain disappointing. In many instances LGS is treatment refractory, resulting in poor prognoses that include intellectual disability, ...

Last Updated: 6 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
 

Status: Not yet recruiting

Condition Summary: Lennox-Gastaut Syndrome

 

Last Updated: 9 Jun 2011

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Last Updated: 15 Apr 2016

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Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut Syndrome
 

Status: Recruiting

Condition Summary: Lennox-Gastaut Syndrome

 

Last Updated: 18 Mar 2016

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