Epilepsy

Common Name(s)

Epilepsy

Epilepsy is a chronic neurological (brain) condition that is characterized by recurrent unprovoked seizures. In a typical brain, small electrical charges or signals are sent from the nerves in the brain to other areas of the body. A seizure occurs when the normal electrical activity in the brain is interrupted by intense bursts of energy. For someone to be diagnosed with epilepsy, he or she must experience at least two seizures unrelated to any kind of infection or trauma. Epilepsy is caused by improper pathways of these electrical signals in the brain, a chemical imbalance of nerve signaling, or both. These differences or abnormalities may have resulted from previous head injuries, lead poisoning, genetics, or previous infections. However, many times the cause is unknown.

Although the symptoms of a seizure can affect any part of the body, the electrical event that caused the seizure is always in the brain. When an individual experiences a seizure, they may experience strange sensations, emotions, behaviors, convulsions, muscle spasms, and loss of consciousness. The frequency of seizures is variable among persons with the condition. Epilepsy not only affects one's health, but also impacts their relationships, driving abilities, safety, and work. The goal of treatment is to stop or manage seizures and to improve quality of life. This can often be done through proper medications. The majority of individuals with proper treatment can become seizure free within a few years, others may experience occasional seizures and still others may continue with uncontrolled seizures. It is best to talk to your doctor to find the right treatment plan for you. Support groups are also a good source of information and way to connect with other individuals and families affected by epilepsy.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Epilepsy" for support, advocacy or research.

Citizens United for Research in Epilepsy

Citizens United for Research in Epilepsy (CURE) is a nonprofit organization dedicated to finding a cure for epilepsy by raising funds for research and by increasing awareness of the prevalence and devastation of this disease.

Last Updated: 6 May 2014

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

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Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

Last Updated: 11 Apr 2013

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Epilepsy Support Network of Orange County

The Epilepsy Support Network of Orange County is committed to building a community of support to improve the lives of those affected by epilepsy through education, programs and advocacy.

Last Updated: 19 Feb 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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Idic15 Canada

Idic15 Canada is a national non-profit with a Global reach, responsible for expediting quality, coordination, accessibility and research of medical care and social support innovations for families living with the rare disorder Chromosome 15q11.2-13.1 Duplication Syndrome. We will uphold our mission by: Providing information and emotional support to individuals with Chromosome 15q11.2-13.1 Duplication Syndrome, their families, and the professionals who work with them. Developing resources and increasing global awareness and understanding of this syndrome to help build medical collaborations globally. Encouraging, supporting, and raising funds for global research into a wide range of issues related to this Syndrome. Idic15 Canada has facilitated the development of 4 national syndrome specific clinics and coordinated medical teams throughout the country. We also have the development of a Chromosome 15q11.2-13.1 Duplication Syndrome patient registry designed to spark in

Last Updated: 1 Oct 2014

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International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

Last Updated: 19 Feb 2013

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Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

Last Updated: 2 Aug 2013

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

Last Updated: 15 Apr 2014

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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The Arc of East Central Iowa

The Arc of East Central Iowa empowers people with intellectual and related disabilities to engage in lifelong opportunities to live, learn, work and play with dignity, freedom and full inclusion in their communities.

Last Updated: 11 Apr 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Epilepsy" for support, advocacy or research.

Citizens United for Research in Epilepsy

Citizens United for Research in Epilepsy (CURE) is a nonprofit organization dedicated to finding a cure for epilepsy by raising funds for research and by increasing awareness of the prevalence and devastation of this disease.

http://www.CUREepilepsy.org

Last Updated: 6 May 2014

View Details
Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

View Details
Logo
Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

http://www.epilepsyfoundation.org

Last Updated: 11 Apr 2013

View Details
Epilepsy Support Network of Orange County

The Epilepsy Support Network of Orange County is committed to building a community of support to improve the lives of those affected by epilepsy through education, programs and advocacy.

http://www.EpilepsySupportNet.org

Last Updated: 19 Feb 2013

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

View Details
Idic15 Canada

Idic15 Canada is a national non-profit with a Global reach, responsible for expediting quality, coordination, accessibility and research of medical care and social support innovations for families living with the rare disorder Chromosome 15q11.2-13.1 Duplication Syndrome. We will uphold our mission by: Providing information and emotional support to individuals with Chromosome 15q11.2-13.1 Duplication Syndrome, their families, and the professionals who work with them. Developing resources and increasing global awareness and understanding of this syndrome to help build medical collaborations globally. Encouraging, supporting, and raising funds for global research into a wide range of issues related to this Syndrome. Idic15 Canada has facilitated the development of 4 national syndrome specific clinics and coordinated medical teams throughout the country. We also have the development of a Chromosome 15q11.2-13.1 Duplication Syndrome patient registry designed to spark in

http://www.idic15canada.ca

Last Updated: 1 Oct 2014

View Details
Logo
International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

View Details
Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

http://www.isabellasaviary.com

Last Updated: 2 Aug 2013

View Details
Logo
Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

http://www.mofamilytofamily.org

Last Updated: 15 Apr 2014

View Details
Logo
Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

View Details
The Arc of East Central Iowa

The Arc of East Central Iowa empowers people with intellectual and related disabilities to engage in lifelong opportunities to live, learn, work and play with dignity, freedom and full inclusion in their communities.

http://www.arceci.org

Last Updated: 11 Apr 2013

View Details

 

General Support Organizations

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General Resources

Family Resources

Supports, ideas, tools and more are available for families to review in the Family Resources category. Learn about financial benefits in your province, to a printable caregiver sheet.

Uploaded By: Idic15 Canada

Updated 1 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Epilepsy" returned 3735 free, full-text research articles on human participants. First 3 results:

In vivo P-glycoprotein function before and after epilepsy surgery.
 

Author(s): Martin Bauer, Rudolf Karch, Markus Zeitlinger, Joan Liu, Matthias J Koepp, Marie-Claude Asselin, Sanjay M Sisodiya, Johannes A Hainfellner, Wolfgang Wadsak, Markus Mitterhauser, Markus Müller, Ekaterina Pataraia, Oliver Langer

Journal: Neurology. 2014 Oct;83(15):1326-31.

 

To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure ...

Last Updated: 7 Oct 2014

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Chronic neuroborreliosis by B. garinii: an unusual case presenting with epilepsy and multifocal brain MRI lesions.
 

Author(s): Giovanni Matera, Angelo Labate, Angela Quirino, Angelo G Lamberti, Giuseppe BorzÃ, Giorgio S Barreca, Laura Mumoli, Cinzia Peronace, Aida Giancotti, Antonio Gambardella, Alfredo FocÃ, Aldo Quattrone

Journal: New Microbiol.. 2014 Jul;37(3):393-7.

 

Late/chronic Lyme neuroborreliosis (LNB) represents a challenging entity whose diagnosis requires a combination of clinical and laboratory findings, surrounded by much controversy. Here we describe a patient who had a peculiar form of late LNB with CNS lesions shown by magnetic resonance ...

Last Updated: 3 Sep 2014

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Describing the genetic architecture of epilepsy through heritability analysis.
 

Author(s): Doug Speed, Terence J O'Brien, Aarno Palotie, Kirill Shkura, Anthony G Marson, David J Balding, Michael R Johnson

Journal: Brain. 2014 Oct;137(Pt 10):2680-9.

 

Epilepsy is a disease with substantial missing heritability; despite its high genetic component, genetic association studies have had limited success detecting common variants which influence susceptibility. In this paper, we reassess the role of common variants on epilepsy using ...

Last Updated: 14 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Epilepsy" returned 643 free, full-text review articles on human participants. First 3 results:

The relationship between neurocysticercosis and epilepsy: an endless debate.
 

Author(s): Arturo Carpio, Matthew L Romo

Journal: Arq Neuropsiquiatr. 2014 May;72(5):383-90.

 

Neurocysticercosis (NC), or cerebral infection with Taenia solium, is an important public health problem worldwide. Among the neurological sequelae of NC, seizures have been described as the most common symptom. Acute symptomatic seizures often result from degeneration of a viable ...

Last Updated: 27 May 2014

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National epilepsy surgery program: realistic goals and pragmatic solutions.
 

Author(s): Chaturbhuj Rathore, Malla Bhaskara Rao, Kurupath Radhakrishnan

Journal: Neurol India. ;62(2):124-9.

 

There are multiple social, economic, and medical challenges in establishing successful epilepsy surgery programs in India and in other low- and middle-income countries (LAMIC). These can be overcome by reproducing pragmatic and proven epilepsy surgery models throughout the country ...

Last Updated: 14 May 2014

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The search for circulating epilepsy biomarkers.
 

Author(s): Manu Hegde, Daniel H Lowenstein

Journal: Biomark Med. 2014 ;8(3):413-27.

 

Few would experience greater benefit from the development of biomarkers than those who suffer from epilepsy. Both the timing of individual seizures and the overall course of the disease are highly unpredictable, and the associated morbidity is considerable. Thus, there is an urgent ...

Last Updated: 9 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Severe Early Onset Epilepsies
 

Status: Recruiting

Condition Summary: Epilepsy; Epileptic Encephalopathy; Ohtahara Syndrome; Infantile Spasms; Dravet Syndrome; Malignant Migrating Partial Epilepsy of Infancy; Early Myoclonic Epileptic Encephalopathy

 

Last Updated: 2 Apr 2014

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Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study
 

Status: Recruiting

Condition Summary: Childhood Absence Epilepsy; Epilepsy; Seizures

 

Last Updated: 9 Aug 2012

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Physical Exercise in Subjects With Juvenile Myoclonic Epilepsy
 

Status: Recruiting

Condition Summary: Epilepsy; Epilepsia; Epileptic Seizures; Seizure Disorder

 

Last Updated: 9 Oct 2011

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