Epidermolysis Bullosa Acquisita

Common Name(s)

Epidermolysis Bullosa Acquisita

Epidermolysis bullosa acquisita (EBA) is a rare autoimmune disorder that causes the skin to blister in response to minor injury. Common areas of blistering include the hands, feet, knees, elbows, and buttocks. It can also affect the mouth, nose, and eyes. Some affected people have other health problems such as Crohn's disease, systemic lupus erythematosus, amyloidosis, or multiple myeloma. EBA is not inherited and usually occurs in adulthood. Treatment aims to protect the skin, stop the formation of blisters, and promote healing. Immunosuppressive drugs may be used to reduce the body's autoimmune response.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Epidermolysis Bullosa Acquisita" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Epidermolysis Bullosa Acquisita" returned 32 free, full-text research articles on human participants. First 3 results:

B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita.
 

Author(s): Hiroaki Iwata, Katja Bieber, Benjamin Tiburzy, Navina Chrobok, Kathrin Kalies, Atsushi Shimizu, Sarah Leineweber, Akira Ishiko, Artem Vorobyev, Detlef Zillikens, Jörg Köhl, Jürgen Westermann, Karsten Seeger, Rudolf Manz, Ralf J Ludwig

Journal: J. Immunol.. 2013 Sep;191(6):2978-88.

 

In autoimmune bullous dermatoses (AIBD), autoantibodies induce blisters on skin or mucous membranes, or both. Mechanisms of continued autoantibody production and blistering have been well characterized using AIBD animal models. Mechanisms leading to the initial autoantibody production, ...

Last Updated: 9 Sep 2013

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Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice.
 

Author(s): Sarah Schönig, Andreas Recke, Misa Hirose, Ralf J Ludwig, Karsten Seeger

Journal:

 

Epidermolysis bullosa acquisita (EBA) is a rare skin blistering disease with a prevalence of 0.2/ million people. EBA is characterized by autoantibodies against type VII collagen. Type VII collagen builds anchoring fibrils that are essential for the dermal-epidermal junction. The ...

Last Updated: 8 Jul 2013

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Images in clinical medicine. Epidermolysis bullosa acquisita.
 

Author(s): Christina Lam, Ruth Ann Vleugels

Journal: N. Engl. J. Med.. 2013 Mar;368(13):e17.

 

Last Updated: 28 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Epidermolysis Bullosa Acquisita" returned 2 free, full-text review articles on human participants. First 3 results:

Epidermolysis bullosa acquisita.
 

Author(s): Rishu Gupta, David T Woodley, Mei Chen

Journal: Clin. Dermatol.. ;30(1):60-9.

 

Epidermolysis bullosa acquisita (EBA) is a rare, acquired, chronic subepidermal bullous disease of the skin and mucosa characterized by autoantibodies to type VII collagen (C7) structures, a major component of anchoring fibrils, which attach the epidermis to the dermis. EBA patients ...

Last Updated: 5 Dec 2011

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Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen.
 

Author(s): Mei Chen, Gene H Kim, Lori Prakash, David T Woodley

Journal: Autoimmunity. 2012 Feb;45(1):91-101.

 

Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, ...

Last Updated: 30 Jan 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.