Eosinophilic Fasciitis

Common Name(s)

Eosinophilic Fasciitis

Eosinophilic fasciitis is a very rare condition in which muscle tissue underneath the skin, called fascia, becomes swollen and thick. Rapid swelling can occur in the hands, arms, legs, and feet. People with this condition have a buildup of eosinophils, a type of white blood cell, in the affected fascia and muscles. The exact cause of this condition is unknown. Fewer than 300 cases have been reported in the past 35 years. Eosinophilic fasciitis is similar in appearance to scleroderma but is not related.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Eosinophilic Fasciitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Eosinophilic Fasciitis" returned 43 free, full-text research articles on human participants. First 3 results:

Shulman disease (eosinophilic fasciitis) in X-linked agammaglobulinemia.
 

Author(s): A Pituch-Noworolska, H Mach-Tomalska, A Szaflarska, D Adamek

Journal: Pol J Pathol. 2016 Jun;67(2):183-8.

 

X-linked agammaglobulinemia (XLA) diagnosed in the first year of life is an immunodeficiency with a life-long indication for substitution of immunoglobulins, due to lack of B lymphocytes in the periphery. The decrease of bacterial infection frequency and severity is an effect of immunoglobulin ...

Last Updated: 21 Aug 2016

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Eosinophilic Fasciitis and Acute Encephalopathy Toxicity from Pembrolizumab Treatment of a Patient with Metastatic Melanoma.
 

Author(s): Leila Khoja, Catherine Maurice, MaryAnne Chappell, Leslie MacMillan, Ayman S Al-Habeeb, Nada Al-Faraidy, Marcus O Butler, Patrik Rogalla, Warren Mason, Anthony M Joshua, David Hogg

Journal: Cancer Immunol Res. 2016 Mar;4(3):175-8.

 

Anti-PD-1 inhibitors have significant activity in metastatic melanoma. Responses often occur early and may be sustained. The optimal duration of treatment with these agents is unknown. Here, we report the case of a 51-year-old woman treated with pembrolizumab, as part of the Keynote-001 ...

Last Updated: 2 Mar 2016

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Atypical Presentation of Eosinophilic Fasciitis with Pitting Edema.
 

Author(s): Chih-Wei Chang, Matthew S Lau

Journal: Hawaii J Med Public Health. 2015 Sep;74(9 Suppl 2):36-8.

 

Eosinophilic fasciitis (EF) is a rare condition involving inflammation of the fascia and peripheral eosinophilia of unknown etiology leading to tissue fibrosis. Clinical presentation includes peripheral eosinophilia, symmetrical skin thickening with subcutaneous tissue induration ...

Last Updated: 21 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Eosinophilic Fasciitis" returned 6 free, full-text review articles on human participants. First 3 results:

[Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review].
 

Author(s): D Sène

Journal: Rev Med Interne. 2015 Nov;36(11):738-45.

 

Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. The diagnosis of EF is often based on the association of characteristic skin or subcutaneous ...

Last Updated: 30 Oct 2015

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[Eosinophilic fasciitis].
 

Author(s): Karolina Niklas, Arkadiusz Niklas, Mariusz Puszczewicz

Journal:

 

Eosinophilic fasciitis is a rare connective tissue disease with unclear etiology and pathogenesis. It is classified as a scleroderma-like syndrome. The disease is characterized by fibrosis of the skin and subcutaneous tissues with significant thickening of fascia. Visceral involvement ...

Last Updated: 21 Apr 2015

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Eosinophilic fasciitis: typical abnormalities, variants and differential diagnosis of fasciae abnormalities using MR imaging.
 

Author(s): T Kirchgesner, B Dallaudière, P Omoumi, J Malghem, B Vande Berg, F Lecouvet, F Houssiau, C Galant, A Larbi

Journal: Diagn Interv Imaging. 2015 Apr;96(4):341-8.

 

Eosinophilic fasciitis is a rare condition. It is generally limited to the distal parts of the arms and legs. MRI is the ideal imaging modality for diagnosing and monitoring this condition. MRI findings typically evidence only fascial involvement but on a less regular basis signal ...

Last Updated: 20 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)
 

Status: Recruiting

Condition Summary: Thrombotic Thrombocytopenic Purpura; Congenital Thrombotic Thrombocytopenic Purpura; Familial Thrombotic Thrombocytopenic Purpura; Thrombotic Thrombocytopenic Purpura, Congenital; Upshaw-Schulman Syndrome

 

Last Updated: 1 Sep 2016

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Shulman Fasciitis Prevalence Study in Alsace
 

Status: Recruiting

Condition Summary: Shulman Fasciitis

 

Last Updated: 25 Apr 2017

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