Afibrinogenemia

Common Name(s)

Afibrinogenemia

Afibrinogenemia, sometimes called congenital afibrinogenemia, is an inherited blood disorder in which the blood does not clot normally. It occurs when there is a lack (deficiency) of a protein called fibrinogen (or factor I), which is needed for the blood to clot.  Affected individuals may be susceptible to severe bleeding (hemorrhaging) episodes, particularly during infancy and childhood. Afibrinogenemia is thought to be transmitted as an autosomal recessive trait.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Afibrinogenemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Afibrinogenemia" returned 45 free, full-text research articles on human participants. First 3 results:

[Congenital afibrinogenemia: about a case].
 

Author(s): Karim Assani, Lamya Karboubi, Badr Sououd Benjelloun Dakhama

Journal:

 

Afibrinogenemia is a rare dyscrasia characterized by a congenital fibrinogen deficiency It is transmitted in an autosomal recessive manner. Hemorrhagic manifestations are variable and can be life-threatening. A little more than 250 cases have been published up till now. We here report ...

Last Updated: 15 Mar 2017

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Congenital afibrinogenemia: a case report of a spontaneous hepatic hematoma.
 

Author(s): Stephanie Malaquin, Lionel Rebibo, Cyril Chivot, Louise Badoux, Yazine Mahjoub, Herve Dupont

Journal: Medicine (Baltimore). 2016 Jul;95(28):e4150.

 

Afibrinogenemia is a rare coagulation disorder. Clinical features of spontaneous bleeding, bleeding after minor trauma, or after surgery have been described as well as thrombo-embolic complications. In this article, we presented the case of a 19-year old female with congenital afibrinogenemia ...

Last Updated: 19 Jul 2016

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Targeted mutation of zebrafish fga models human congenital afibrinogenemia.
 

Author(s): Richard J Fish, Corinne Di Sanza, Marguerite Neerman-Arbez

Journal: Blood. 2014 Apr;123(14):2278-81.

 

Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is associated with a variable phenotype, which may be influenced by environment and genotype. Here, we present a zebrafish model ...

Last Updated: 4 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Afibrinogenemia" returned 1 free, full-text review articles on human participants. First 3 results:

[Congenital afibrinogenemia].
 

Author(s): P Pastilha, L Coelho, T D Costa, G Deus, H Santos, A Rosa, F Barrocas, L Braga

Journal: Acta Med Port. 1998 Dec;11(12):1117-9.

 

The authors present a case of congenital afibrinogenemia. A review of the literature is made, and some aspects of this rare inherited coagulation disorder are suggested and commented on.

Last Updated: 30 Apr 1999

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 21 Jul 2016

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Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
 

Status: Recruiting

Condition Summary: Congenital Afibrinogenemia; Congenital Hypofibrinogenemia

 

Last Updated: 2 Jun 2016

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Last Updated: 4 May 2016

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