Afibrinogenemia

Common Name(s)

Afibrinogenemia

Afibrinogenemia, sometimes called congenital afibrinogenemia, is an inherited blood disorder in which the blood does not clot normally. It occurs when there is a lack (deficiency) of a protein called fibrinogen (or factor I), which is needed for the blood to clot.  Affected individuals may be susceptible to severe bleeding (hemorrhaging) episodes, particularly during infancy and childhood. Afibrinogenemia is thought to be transmitted as an autosomal recessive trait.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Afibrinogenemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Afibrinogenemia" returned 30 free, full-text research articles on human participants. First 3 results:

Targeted mutation of zebrafish fga models human congenital afibrinogenemia.
 

Author(s): Richard J Fish, Corinne Di Sanza, Marguerite Neerman-Arbez

Journal: Blood. 2014 Apr;123(14):2278-81.

 

Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is associated with a variable phenotype, which may be influenced by environment and genotype. Here, we present a zebrafish model ...

Last Updated: 4 Apr 2014

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[Congenital afibrinogenemia caused by a novel insertion mutation in the FGB gene].
 

Author(s): Jian Zhang, Xiao-juan Zhao, Zhao-yue Wang, Zi-qiang Yu, Li-Juan Cao, Zhen-ni Ma, Jie Zhang, Wei Zhang, Xia Bai, Chang-geng Ruan

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Sep;34(9):751-6.

 

To investigate the genetic defect and its mechanism in a patient with congenital afibrinogenemia.

Last Updated: 9 Oct 2013

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Chronic subdural hematoma in a patient with congenital afibrinogenemia successfully treated with fibrinogen replacement.
 

Author(s): Naoto Sakai, Soichi Akamine, Tsutomu Tokuyama, Kenji Sugiyama, Naohiro Kanayama, Hiroki Namba

Journal: Neurol. Med. Chir. (Tokyo). 2011 ;51(11):780-3.

 

A 37-year-old woman with congenital afibrinogenemia presented with chronic subdural hematoma (CSDH) manifesting as severe headache, nausea, and somnolence after a minor head trauma. Brain computed tomography scans showed a right subdural hematoma associated with midline shift. Laboratory ...

Last Updated: 29 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Afibrinogenemia" returned 1 free, full-text review articles on human participants. First 3 results:

[Congenital afibrinogenemia].
 

Author(s): P Pastilha, L Coelho, T D Costa, G Deus, H Santos, A Rosa, F Barrocas, L Braga

Journal: Acta Med Port. 1998 Dec;11(12):1117-9.

 

The authors present a case of congenital afibrinogenemia. A review of the literature is made, and some aspects of this rare inherited coagulation disorder are suggested and commented on.

Last Updated: 30 Apr 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Human Fibrinogen Concentrate (FGTW) in Pediatric Patients With Congenital Fibrinogen Deficiency
 

Status: Recruiting

Condition Summary: Hypofibrinogenemia, Congenital; Afibrinogenemia, Congenital

 

Last Updated: 20 Oct 2014

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Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
 

Status: Recruiting

Condition Summary: Congenital Afibrinogenemia; Congenital Hypofibrinogenemia

 

Last Updated: 17 Feb 2014

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Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap
 

Status: Recruiting

Condition Summary: Congenital Fibrinogen Deficiency; Afibrinogenemia

 

Last Updated: 20 Jun 2014

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