Endomyocardial fibrosis

Common Name(s)

Endomyocardial fibrosis

Endomyocardial fibrosis (EMF) is a heart disorder of unknown origin that is seen in tropical regions. EMF causes restrictive cardiomyopathy, which is a type of heart disease that makes the heart thickened and stiff such that it cannot fill properly. This ultimately impairs the heart’s ability to properly deliver blood to the body, leading to heart failure. EMF can also cause irregular heartbeats (arrhythmia) or clotting (thromboembolism).

EMF mostly affects those living in tropical or subtropical regions in Asia, Africa, and Latin America. In these areas, EMF is one of the most common cardiac diseases. EMF affects both genders, and is often seen in children, adolescents, and the elderly. Symptoms are generally not recognized until late in the clinical course when patients present with chest pain due to heart dysfunction. Early symptoms include facial swelling, body itching, clots, and elevated white blood cells (eosinophils) in the bloodstream. EMF is similar to Loeffler’s endocarditis, although in EMF it is less likely to have an increased number of eosinophils present in the blood. The cause of EMF is not yet fully understood. Malnutrition combined with high concentrations of cerium, a rare earth element found in tuberous food, has been shown to produce similar symptoms, indicating a possible dietary cause. The risk of EMF may also be heritable.

Treatment for EMF may include heart medication and surgery. Possible medications include blood thinners, anticoagulants, and blood pressure lowering drugs. Surgery is often reserved for advanced cases of EMF due to the risk of mortality, but surgery has been shown to improve heart function and increase life expectancy. If you have been diagnosed with EMF, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endomyocardial fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endomyocardial fibrosis" returned 127 free, full-text research articles on human participants. First 3 results:

Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis.
 

Author(s): A O Mocumbi, C Goncalves, A Damasceno, C Carrilho

Journal:

 

Endomyocardial fibrosis (EMF) is a neglected restrictive cardiomyopathy of unknown aetiology and unclear natural history, which causes premature deaths in endemic areas. We present the case of a 13-year-old boy from a highly endemic area, presenting with concurrent signs of chronic ...

Last Updated: 2 Nov 2016

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Endomyocardial fibrosis with right ventricular aneurysm mimicking ARVC - A case report from India.
 

Author(s): Suneesh Kalliath, Rajesh Gopalan Nair, Haridasan Vellani

Journal: Indian Heart J. 2016 Sep;68 Suppl 2():S93-S96.

 

A 48-year-old man presented with chronic right sided heart failure. 2D echocardiography revealed the classical features of left ventricular endomyocardial fibrosis with a prominent right ventricular apical aneurysm. Right ventriculography further defined the aneurysm. Cardiac magnetic ...

Last Updated: 18 Oct 2016

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Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation.
 

Author(s): Mukund A Prabhu, B V Srinivas Prasad, Anees Thajudeen, Narayanan Namboodiri

Journal: Indian Heart J. 2016 Sep;68 Suppl 2():S198-S201.

 

Bundle branch reentry as a mechanism of ventricular tachycardia (VT) in endomyocardial fibrosis (EMF) is not described.

Last Updated: 18 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endomyocardial fibrosis" returned 3 free, full-text review articles on human participants. First 3 results:

Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives.
 

Author(s): Antonio Grimaldi, Ana Olga Mocumbi, Juergen Freers, Matthias Lachaud, Mariana Mirabel, Beatriz Ferreira, Kumar Narayanan, David S Celermajer, Daniel Sidi, Xavier Jouven, Eloi Marijon

Journal: Circulation. 2016 Jun;133(24):2503-15.

 

Tropical endomyocardial fibrosis (EMF) is a neglected disease of poverty that afflicts rural populations in tropical low-income countries, with some certain high-prevalence areas. Tropical EMF is characterized by the deposition of fibrous tissue in the endomyocardium, leading to restrictive ...

Last Updated: 14 Jun 2016

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Endomyocardial fibrosis: still a mystery after 60 years.
 

Author(s): Gene Bukhman, John Ziegler, Eldryd Parry

Journal:

 

The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease ...

Last Updated: 27 Feb 2008

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Endomyocardial fibrosis in Behçet's disease.
 

Author(s): D L Huong, B Wechsler, T Papo, D de Zuttere, O Bletry, A Hernigou, A Delcourt, P Godeau, J C Piette

Journal: Ann. Rheum. Dis.. 1997 Mar;56(3):205-8.

 

To report on four patients with Behçet's disease associated with endomyocardial fibrosis involving the right or the left ventricle.

Last Updated: 19 May 1997

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Genetic Basis of Acquired Heart Disease in Africa
 

Status: Recruiting

Condition Summary: Rheumatic Heart Disease; Rheumatic Fever; Endomyocardial Fibrosis; Acquired Heart Disease

 

Last Updated: 18 Oct 2017

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