Endomyocardial fibrosis

Common Name(s)

Endomyocardial fibrosis

Endomyocardial fibrosis (EMF) is a heart disorder of unknown origin that is seen in tropical regions. EMF causes restrictive cardiomyopathy, which is a type of heart disease that makes the heart thickened and stiff such that it cannot fill properly. This ultimately impairs the heart’s ability to properly deliver blood to the body, leading to heart failure. EMF can also cause irregular heartbeats (arrhythmia) or clotting (thromboembolism).

EMF mostly affects those living in tropical or subtropical regions in Asia, Africa, and Latin America. In these areas, EMF is one of the most common cardiac diseases. EMF affects both genders, and is often seen in children, adolescents, and the elderly. Symptoms are generally not recognized until late in the clinical course when patients present with chest pain due to heart dysfunction. Early symptoms include facial swelling, body itching, clots, and elevated white blood cells (eosinophils) in the bloodstream. EMF is similar to Loeffler’s endocarditis, although in EMF it is less likely to have an increased number of eosinophils present in the blood. The cause of EMF is not yet fully understood. Malnutrition combined with high concentrations of cerium, a rare earth element found in tuberous food, has been shown to produce similar symptoms, indicating a possible dietary cause. The risk of EMF may also be heritable.

Treatment for EMF may include heart medication and surgery. Possible medications include blood thinners, anticoagulants, and blood pressure lowering drugs. Surgery is often reserved for advanced cases of EMF due to the risk of mortality, but surgery has been shown to improve heart function and increase life expectancy. If you have been diagnosed with EMF, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endomyocardial fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endomyocardial fibrosis" returned 123 free, full-text research articles on human participants. First 3 results:

Case 3/2015 - 53-year-old female with cardiogenic shock 12 years after surgical correction of endomyocardial fibrosis.
 

Author(s): Michel Abi Kalansky Ponczek, Fernanda Seligmann Feitosa, Léa Maria Macruz Ferreira Demarchi

Journal: Arq. Bras. Cardiol.. 2015 Sep;105(3):309-15.

 

Last Updated: 15 Oct 2015

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Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report.
 

Author(s): Marc Pineton de Chambrun, Philippe Charron, Danièle Vauthier-Brouzes, Philippe Cluzel, Julien Haroche, Jean-Emmanuel Kahn, Zahir Amoura, Fleur Cohen Aubart

Journal: Medicine (Baltimore). 2015 Aug;94(32):e1307.

 

Idiopathic hypereosinophilic syndrome (HES) is a condition of unknown origin characterized by clinical manifestations attributable to eosinophilia and eosinophilic infiltration of tissues. Cardiac involvement is rare and threatening accounting for 33% to 43% of death in HES. Management ...

Last Updated: 13 Aug 2015

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Endomyocardial fibrosis associated with Schistosoma haematobium infection.
 

Author(s): J Assimeng, C I Segbefia, J Neequaye

Journal: Ghana Med J. 2014 Dec;48(4):225-7.

 

Endomyocardial fibrosis (EMF) is a form of restrictive cardiomyopathy common in the tropics and subtropics. The aetiology of EMF is unknown but helminth infestations such as schistosomiasis have been implicated. Two boys aged 8 and 10 years with EMF associated with Schistosoma haematobium, ...

Last Updated: 24 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endomyocardial fibrosis" returned 2 free, full-text review articles on human participants. First 3 results:

Endomyocardial fibrosis: still a mystery after 60 years.
 

Author(s): Gene Bukhman, John Ziegler, Eldryd Parry

Journal:

 

The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease ...

Last Updated: 27 Feb 2008

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Endomyocardial fibrosis in Behçet's disease.
 

Author(s): D L Huong, B Wechsler, T Papo, D de Zuttere, O Bletry, A Hernigou, A Delcourt, P Godeau, J C Piette

Journal: Ann. Rheum. Dis.. 1997 Mar;56(3):205-8.

 

To report on four patients with Behçet's disease associated with endomyocardial fibrosis involving the right or the left ventricle.

Last Updated: 19 May 1997

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Genetic Basis of Acquired Heart Disease in Africa
 

Status: Recruiting

Condition Summary: Rheumatic Heart Disease; Rheumatic Fever; Endomyocardial Fibrosis; Acquired Heart Disease

 

Last Updated: 12 Feb 2016

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Left Atrial Volume Index in Asymptomatic Aortic Stenosis
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis; Heart Failure

 

Last Updated: 20 Mar 2015

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