Embryonal Carcinoma

Common Name(s)

Embryonal Carcinoma

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Embryonal Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Embryonal Carcinoma" returned 197 free, full-text research articles on human participants. First 3 results:

Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.
 

Author(s): M Lü, H Tian, Y-X Cao, X He, L Chen, X Song, P Ping, H Huang, F Sun

Journal:

 

Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome, have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulating spermatogenesis in human males. Here, using microarray technology, ...

Last Updated: 6 Nov 2015

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Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma.
 

Author(s): Duncan C Gilbert, Reem Al-Saadi, Khin Thway, Ian Chandler, Daniel Berney, Rhian Gabe, Sally P Stenning, Joan Sweet, Robert Huddart, Janet M Shipley

Journal: Clin. Cancer Res.. 2016 Mar;22(5):1265-73.

 

Up to 50% of patients diagnosed with stage I nonseminomatous germ cell tumors (NSGCTs) harbor occult metastases. Patients are managed by surveillance with chemotherapy at relapse or adjuvant treatment up front. Late toxicities from chemotherapy are increasingly recognized. Based on ...

Last Updated: 2 Mar 2016

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Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms.
 

Author(s): Pei-Li Yao, Li Ping Chen, Tomasz P Dobrzański, Dylan A Phillips, Bokai Zhu, Boo-Hyon Kang, Frank J Gonzalez, Jeffrey M Peters

Journal: Oncotarget. 2015 Nov;6(34):36319-37.

 

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) has important physiological functions in control of cell growth, lipid and glucose homeostasis, differentiation and inflammation. To investigate the role of PPARβ/δ in cancer, stable human testicular embryonal carcinoma ...

Last Updated: 20 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Embryonal Carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Extragonadal retroperitoneal embryonal carcinoma successfully treated with chemotherapy.
 

Author(s): Shoji Hirasaki, Toshikazu Moriwaki, Takao Tsuzuki, Ken Hirao, Ichinosuke Hyodo

Journal: Intern. Med.. 2003 Nov;42(11):1122-6.

 

A 27-year-old Japanese man visited our hospital for further evaluation of multiple shadows on his chest X-ray. A 6 cm hard mass was palpable in the left lower abdominal region. Histological examination revealed that the lung tumor resected by the video-assisted thoracoscopic surgery ...

Last Updated: 22 Dec 2003

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Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.
 

Author(s): Michael J Spinella, Joanna S Kerley, Kristina A White, Joshua C Curtin

Journal: J. Nutr.. 2003 Jan;133(1):273S-276S.

 

Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid ...

Last Updated: 6 Jan 2003

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Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.
 

Author(s): S Astigiano, M I Sherman, P Abarzúa

Journal: Environ. Health Perspect.. 1989 Mar;80():25-38.

 

Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation ...

Last Updated: 10 May 1989

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Germ Cell Tumors; Testis Cancer; Testicular Cancer; Embryonal Carcinoma; Nonseminomatous Germ Cell Tumor

 

Last Updated: 8 Feb 2017

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Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
 

Status: Not yet recruiting

Condition Summary: Adult Germ Cell Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Grade 2 Immature Ovarian Teratoma; Grade 3 Immature Ovarian Teratoma; Malignant Germ Cell Tumor; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma; Stage I Ovarian Teratoma; Stage I Ovarian Yolk Sac Tumor; Stage I Testicular Choriocarcinoma; Stage I Testicular Embryonal Carcinoma; Stage I Testicular Yolk Sac Tumor; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma; Stage II Ovarian Yolk Sac Tumor; Stage II Testicular Choriocarcinoma; Stage II Testicular Embryonal Carcinoma; Stage II Testicular Yolk Sac Tumor; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma; Stage III Ovarian Yolk Sac Tumor; Stage III Testicular Choriocarcinoma; Stage III Testicular Embryonal Carcinoma; Stage III Testicular Yolk Sac Tumor; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma; Stage IV Ovarian Yolk Sac Tumor; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

 

Last Updated: 24 Apr 2017

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 5 Oct 2016

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