Embryonal Carcinoma

Common Name(s)

Embryonal Carcinoma

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Embryonal Carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Embryonal Carcinoma" returned 154 free, full-text research articles on human participants. First 3 results:

Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines.
 

Author(s): Yvonne G van der Zwan, Martin A Rijlaarsdam, Fernando J Rossello, Amanda J Notini, Suzan de Boer, D Neil Watkins, Ad J M Gillis, Lambert C J Dorssers, Stefan J White, Leendert H J Looijenga

Journal:

 

Originating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS). During physiological germ cell formation/maturation, ...

Last Updated: 3 Jun 2014

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Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells.
 

Author(s): Jelena Popovic, Danijela Stanisavljevic, Marija Schwirtlich, Andrijana Klajn, Jelena Marjanovic, Milena Stevanovic

Journal:

 

SOX14 is a member of the SOXB2 subgroup of transcription factors implicated in neural development. Although the first SOX14 gene in vertebrates was cloned and characterized more than a decade ago and its expression profile during development was revealed in various animal model systems, ...

Last Updated: 18 Mar 2014

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Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells.
 

Author(s): Paolo B Abada, Stephen B Howell

Journal:

 

Although testicular germ cell tumors are generally quite responsive to treatment with cisplatin, a small fraction of them acquire resistance during therapy. Even when cisplatin treatment is successful the patient is often left with a residual teratoma at the site of the primary tumor ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Embryonal Carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Extragonadal retroperitoneal embryonal carcinoma successfully treated with chemotherapy.
 

Author(s): Shoji Hirasaki, Toshikazu Moriwaki, Takao Tsuzuki, Ken Hirao, Ichinosuke Hyodo

Journal: Intern. Med.. 2003 Nov;42(11):1122-6.

 

A 27-year-old Japanese man visited our hospital for further evaluation of multiple shadows on his chest X-ray. A 6 cm hard mass was palpable in the left lower abdominal region. Histological examination revealed that the lung tumor resected by the video-assisted thoracoscopic surgery ...

Last Updated: 22 Dec 2003

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Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.
 

Author(s): Michael J Spinella, Joanna S Kerley, Kristina A White, Joshua C Curtin

Journal: J. Nutr.. 2003 Jan;133(1):273S-276S.

 

Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid ...

Last Updated: 6 Jan 2003

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Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.
 

Author(s): S Astigiano, M I Sherman, P AbarzĂșa

Journal: Environ. Health Perspect.. 1989 Mar;80():25-38.

 

Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation ...

Last Updated: 10 May 1989

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 17 Feb 2014

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Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Childhood Germ Cell Tumor; Ovarian Cancer; Teratoma

 

Last Updated: 4 Mar 2014

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Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor

 

Last Updated: 13 Dec 2009

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