Embryonal Carcinoma

Common Name(s)

Embryonal Carcinoma

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Embryonal Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Embryonal Carcinoma" returned 157 free, full-text research articles on human participants. First 3 results:

Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells.
 

Author(s): Paolo B Abada, Stephen B Howell

Journal:

 

Although testicular germ cell tumors are generally quite responsive to treatment with cisplatin, a small fraction of them acquire resistance during therapy. Even when cisplatin treatment is successful the patient is often left with a residual teratoma at the site of the primary tumor ...

Last Updated: 29 Jan 2014

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Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.
 

Author(s): David Pamies, Miguel A Sogorb, Marco Fabbri, Laura Gribaldo, Angelo Collotta, Bibiana Scelfo, Eugenio Vilanova, Georgina Harris, Anna Bal-Price

Journal:

 

Historically, only few chemicals have been identified as neurodevelopmental toxicants, however, concern remains, and has recently increased, based upon the association between chemical exposures and increased developmental disorders. Diminution in motor speed and latency has been ...

Last Updated: 13 Jan 2014

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Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines.
 

Author(s): Ronak Eini, Hans Stoop, Ad J M Gillis, Katharina Biermann, Lambert C J Dorssers, Leendert H J Looijenga

Journal:

 

The transcription factor SOX2, associated with amongst others OCT3/4, is essential for maintenance of pluripotency and self-renewal of embryonic stem cells. SOX2 is highly expressed in embryonal carcinoma (EC), the stem cell component of malignant nonseminomatous germ cell tumors, ...

Last Updated: 9 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Embryonal Carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Extragonadal retroperitoneal embryonal carcinoma successfully treated with chemotherapy.
 

Author(s): Shoji Hirasaki, Toshikazu Moriwaki, Takao Tsuzuki, Ken Hirao, Ichinosuke Hyodo

Journal: Intern. Med.. 2003 Nov;42(11):1122-6.

 

A 27-year-old Japanese man visited our hospital for further evaluation of multiple shadows on his chest X-ray. A 6 cm hard mass was palpable in the left lower abdominal region. Histological examination revealed that the lung tumor resected by the video-assisted thoracoscopic surgery ...

Last Updated: 22 Dec 2003

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Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.
 

Author(s): Michael J Spinella, Joanna S Kerley, Kristina A White, Joshua C Curtin

Journal: J. Nutr.. 2003 Jan;133(1):273S-276S.

 

Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid ...

Last Updated: 6 Jan 2003

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Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.
 

Author(s): S Astigiano, M I Sherman, P AbarzĂșa

Journal: Environ. Health Perspect.. 1989 Mar;80():25-38.

 

Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation ...

Last Updated: 10 May 1989

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 17 Feb 2014

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Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Childhood Germ Cell Tumor; Ovarian Cancer; Teratoma

 

Last Updated: 4 Mar 2014

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Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor

 

Last Updated: 13 Dec 2009

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