Embryonal Carcinoma

Common Name(s)

Embryonal Carcinoma

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Embryonal Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Embryonal Carcinoma" returned 195 free, full-text research articles on human participants. First 3 results:

Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.
 

Author(s): M Lü, H Tian, Y-X Cao, X He, L Chen, X Song, P Ping, H Huang, F Sun

Journal:

 

Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome, have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulating spermatogenesis in human males. Here, using microarray technology, ...

Last Updated: 6 Nov 2015

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BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma.
 

Author(s): Daniel Nettersheim, Sina Jostes, Rakesh Sharma, Simon Schneider, Andrea Hofmann, Humberto J Ferreira, Per Hoffmann, Glen Kristiansen, Manel B Esteller, Hubert Schorle

Journal:

 

Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC) are totipotent and differentiate ...

Last Updated: 3 Aug 2015

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Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.
 

Author(s): Anda Huna, Kristine Salmina, Jekaterina Erenpreisa, Alejandro Vazquez-Martin, Jekabs Krigerts, Inna Inashkina, Bogdan I Gerashchenko, Paul A Townsend, Mark S Cragg, Thomas R Jackson

Journal: Cell Cycle. 2015 ;14(18):2969-84.

 

Tumor cellular senescence induced by genotoxic treatments has recently been found to be paradoxically linked to the induction of "stemness." This observation is critical as it directly impinges upon the response of tumors to current chemo-radio-therapy treatment regimens. Previously, ...

Last Updated: 22 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Embryonal Carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Extragonadal retroperitoneal embryonal carcinoma successfully treated with chemotherapy.
 

Author(s): Shoji Hirasaki, Toshikazu Moriwaki, Takao Tsuzuki, Ken Hirao, Ichinosuke Hyodo

Journal: Intern. Med.. 2003 Nov;42(11):1122-6.

 

A 27-year-old Japanese man visited our hospital for further evaluation of multiple shadows on his chest X-ray. A 6 cm hard mass was palpable in the left lower abdominal region. Histological examination revealed that the lung tumor resected by the video-assisted thoracoscopic surgery ...

Last Updated: 22 Dec 2003

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Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.
 

Author(s): Michael J Spinella, Joanna S Kerley, Kristina A White, Joshua C Curtin

Journal: J. Nutr.. 2003 Jan;133(1):273S-276S.

 

Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid ...

Last Updated: 6 Jan 2003

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Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.
 

Author(s): S Astigiano, M I Sherman, P Abarzúa

Journal: Environ. Health Perspect.. 1989 Mar;80():25-38.

 

Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation ...

Last Updated: 10 May 1989

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 7 Apr 2016

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Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Childhood Germ Cell Tumor; Ovarian Cancer; Teratoma

 

Last Updated: 15 Aug 2016

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Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor

 

Last Updated: 13 Dec 2009

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