Adult Growth Hormone Deficiency

Common Name(s)

Adult Growth Hormone Deficiency

Adult Growth Hormone Deficiency (AGHD) is a genetic condition concerning growth hormone. Growth hormone is also referred to as somatotropin or somatropin and is a hormone that causes cell growth, cell reproduction, and cell regeneration. This hormone is stored in the anterior pituitary gland. Deficiency of this hormone leads to varying effects, depending on the age at which the deficiency occurs. AGHD refers to two different conditions. The first concerns individuals who are transitioning from childhood to adulthood and who were deficient in the growth hormone as a child. The second condition concerns adults who acquire growth hormone deficiency in adulthood. Growth hormone deficiency in adults is rare and is most commonly caused by a pituitary adenoma, a noncancerous tumor occurring in the pituitary gland. Growth hormone deficiency developed in adulthood can also be caused by childhood traumas, structural lesions, or idiopathic, or spontaneous, growth hormone deficiency, which is very rare. Symptoms of growth hormone deficiency include changes in memory, depression, anxiety, fatigue, fibromyalgia syndrome, central adiposity, decreased sweating and thermoregulation, impaired cardiac function, decreased bone density, decreased muscular mass, and neuromuscular dysfunction. AGHD is diagnosed by dynamic testing. The insulin tolerance test, with 96% sensitivity, is the gold standard of testing, but several other tests are used for diagnosis. These tests include the glucagon stimulation test, combined growth hormone releasing hormone (GHRH) and the arginine test, levodopa, clonidine, and growth-hormone-releasing peptide. The most sensitive and specific of these tests are the insulin tolerance test and combined GHRH and arginine test. Other tests, such as insulin-like growth factor-1 and insulin-like growth factor-binding protein 3, are used for diagnostic assistance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adult Growth Hormone Deficiency" for support, advocacy or research.

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Human Growth Foundation

The Human Growth Foundation helps children and adults with disorders related to growth or growth-hormone through education, research, support and advocacy.

Last Updated: 10 Jul 2015

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adult Growth Hormone Deficiency" for support, advocacy or research.

Logo
Human Growth Foundation

The Human Growth Foundation helps children and adults with disorders related to growth or growth-hormone through education, research, support and advocacy.

http://hgfound.org

Last Updated: 10 Jul 2015

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Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adult Growth Hormone Deficiency" returned 31 free, full-text research articles on human participants. First 3 results:

A follow-up study to monitor adult height among Spanish children with growth hormone deficiency who received biosimilar human recombinant growth hormone (Omnitrope®) during a phase III clinical trial.
 

Author(s): Victoria Borrás Pérez, Juan Pedro López-Siguero, Gabriela Martínez, Raquel Corripio, Juan Manuel Fernández, Jose Ignacio Labarta, Marta Ferrer, Nuria Cabrinety, Pablo Prieto, Marta Ramón-Krauel, Jordi Bosch, Rafael Espino, Margarida Palla Garcia, Francisco Jose Rebollo

Journal: Adv Ther. 2015 Feb;32(2):148-56.

 

An initial Phase III clinical trial has evaluated the efficacy and safety of biosimilar recombinant human growth hormone (rhGH; Omnitrope(®), Sandoz) in Spanish children with growth hormone deficiency (GHD). At the end of the study, those patients still growing were offered to remain ...

Last Updated: 5 Mar 2015

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Impact of adult growth hormone deficiency on daily functioning and well-being.
 

Author(s): Meryl Brod, Betsy Pohlman, Lise Højbjerre, Johan Erpur Adalsteinsson, Michael Højby Rasmussen

Journal:

 

Adult Growth Hormone Deficiency (AGHD) is a debilitating condition resulting from tumors, pituitary surgery, radiation of the head, head injury, or hypothalamic-pituitary disease. This qualitative study was conducted to better understand the multi-faceted impacts and treatment effects ...

Last Updated: 2 Dec 2014

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Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.
 

Author(s): J M Garcia, R Swerdloff, C Wang, M Kyle, M Kipnes, B M K Biller, D Cook, K C J Yuen, V Bonert, A Dobs, M E Molitch, G R Merriam

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2422-9.

 

In the absence of panhypopituitarism and low serum IGF-I levels, the diagnosis of adult GH deficiency (AGHD) requires confirmation with a GH stimulation test. Macimorelin is a novel, orally active ghrelin mimetic that stimulates GH secretion.

Last Updated: 3 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adult Growth Hormone Deficiency" returned 1 free, full-text review articles on human participants. First 3 results:

Idiopathic adult growth hormone deficiency.
 

Author(s): Shlomo Melmed

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2187-97.

 

GH secretion is controlled by hypothalamic as well as intrapituitary and peripheral signals, all of which converge upon the somatotroph, resulting in integrated GH synthesis and secretion. Enabling an accurate diagnosis of idiopathic adult GH deficiency (IAGHD) is challenged by the ...

Last Updated: 3 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Adults Growth Hormone Deficiency.

 

Last Updated: 23 Oct 2013

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Open-label Extension Study to Evaluate the Safety of Long-term Monthly Administration of Somavaratan in Adults With GHD
 

Status: Recruiting

Condition Summary: Adult Growth Hormone Deficiency (AGHD)

 

Last Updated: 5 May 2016

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Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency With Pituitary Anomalies

 

Last Updated: 29 Sep 2015

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