Adult Growth Hormone Deficiency

Common Name(s)

Adult Growth Hormone Deficiency

Adult Growth Hormone Deficiency (AGHD) is a genetic condition concerning growth hormone. Growth hormone is also referred to as somatotropin or somatropin and is a hormone that causes cell growth, cell reproduction, and cell regeneration. This hormone is stored in the anterior pituitary gland. Deficiency of this hormone leads to varying effects, depending on the age at which the deficiency occurs. AGHD refers to two different conditions. The first concerns individuals who are transitioning from childhood to adulthood and who were deficient in the growth hormone as a child. The second condition concerns adults who acquire growth hormone deficiency in adulthood. Growth hormone deficiency in adults is rare and is most commonly caused by a pituitary adenoma, a noncancerous tumor occurring in the pituitary gland. Growth hormone deficiency developed in adulthood can also be caused by childhood traumas, structural lesions, or idiopathic, or spontaneous, growth hormone deficiency, which is very rare. Symptoms of growth hormone deficiency include changes in memory, depression, anxiety, fatigue, fibromyalgia syndrome, central adiposity, decreased sweating and thermoregulation, impaired cardiac function, decreased bone density, decreased muscular mass, and neuromuscular dysfunction. AGHD is diagnosed by dynamic testing. The insulin tolerance test, with 96% sensitivity, is the gold standard of testing, but several other tests are used for diagnosis. These tests include the glucagon stimulation test, combined growth hormone releasing hormone (GHRH) and the arginine test, levodopa, clonidine, and growth-hormone-releasing peptide. The most sensitive and specific of these tests are the insulin tolerance test and combined GHRH and arginine test. Other tests, such as insulin-like growth factor-1 and insulin-like growth factor-binding protein 3, are used for diagnostic assistance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adult Growth Hormone Deficiency" for support, advocacy or research.

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Human Growth Foundation

The Human Growth Foundation helps children and adults with disorders related to growth or growth-hormone through education, research, support and advocacy.

Last Updated: 24 Nov 2009

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 7 Nov 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adult Growth Hormone Deficiency" for support, advocacy or research.

Logo
Human Growth Foundation

The Human Growth Foundation helps children and adults with disorders related to growth or growth-hormone through education, research, support and advocacy.

http://hgfound.org

Last Updated: 24 Nov 2009

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Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 7 Nov 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adult Growth Hormone Deficiency" returned 23 free, full-text research articles on human participants. First 3 results:

Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.
 

Author(s): J M Garcia, R Swerdloff, C Wang, M Kyle, M Kipnes, B M K Biller, D Cook, K C J Yuen, V Bonert, A Dobs, M E Molitch, G R Merriam

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2422-9.

 

In the absence of panhypopituitarism and low serum IGF-I levels, the diagnosis of adult GH deficiency (AGHD) requires confirmation with a GH stimulation test. Macimorelin is a novel, orally active ghrelin mimetic that stimulates GH secretion.

Last Updated: 3 Jun 2013

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Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency.
 

Author(s): Toshio Hirohata, Nobuhito Saito, Koji Takano, So Yamada, Jae-Hyun Son, Shoko M Yamada, Hiroshi Nakaguchi, Katsumi Hoya, Mineko Murakami, Akiko Mizutani, Hiroko Okinaga, Akira Matsuno

Journal: Endocr. J.. 2013 ;60(3):369-73.

 

Adult growth hormone (GH) deficiency (AGHD) in Japan is diagnosed based on peak GH concentrations during GH provocative tests such as GHRP-2 stimulation test. In this study, we aimed to evaluate the ability of serum insulin-like growth factor-1 (sIGF-1) and urinary GH (uGH) at the ...

Last Updated: 2 Apr 2013

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Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.
 

Author(s): L Groban, M Lin, K A Kassik, R L Ingram, W E Sonntag

Journal: Growth Horm. IGF Res.. 2011 Apr;21(2):81-8.

 

The primary goal of growth hormone (GH) replacement is to promote linear growth in children with growth hormone deficiency (GHD). GH and insulin-like growth factor-1 (IGF-1) are also known to have roles in cardiac development and as modulators of myocardial structure and function ...

Last Updated: 2 May 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adult Growth Hormone Deficiency" returned 1 free, full-text review articles on human participants. First 3 results:

Idiopathic adult growth hormone deficiency.
 

Author(s): Shlomo Melmed

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2187-97.

 

GH secretion is controlled by hypothalamic as well as intrapituitary and peripheral signals, all of which converge upon the somatotroph, resulting in integrated GH synthesis and secretion. Enabling an accurate diagnosis of idiopathic adult GH deficiency (IAGHD) is challenged by the ...

Last Updated: 3 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 27 Oct 2014

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Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Adults Growth Hormone Deficiency.

 

Last Updated: 23 Oct 2013

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Trial to Compare the Efficacy and Safety of NNC0195-0092 With Placebo and Norditropin® FlexPro® in Adults With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Disorder; Adult Growth Hormone Deficiency

 

Last Updated: 17 Dec 2014

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