Eclampsia

Common Name(s)

Eclampsia

Eclampsia is a very serious condition in pregnant women. Eclampsia follows a condition called preeclampsia, which is caused by high blood pressure and large amounts of protein in the urine. If not treated, preeclampsia may turn into eclampsia, in which symptoms include intense headaches, confusion, vision changes, seizures and unconsciousness that may lead to a coma. Eclampsia is dangerous for both the mother and the baby, but in the majority of cases, preeclampsia is diagnosed and treated by a physician before it develops into eclampsia. Primary treatment for eclampsia involves recognition of preeclampsia and anti-seizure medication to prevent the woman from moving into eclampsia. If this is not done, treatment of eclampsia includes immediately delivering the baby and medication to control high blood pressure and stop seizures. Eclampsia is dangerous, but recognizing symptoms of preeclampsia early is the best way to prevent it.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Eclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Eclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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General Resources

The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Eclampsia" returned 585 free, full-text research articles on human participants. First 3 results:

Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia.
 

Author(s): Alison E Wallace, Guy S Whitley, Baskaran Thilaganathan, Judith E Cartwright

Journal: J. Leukoc. Biol.. 2015 Jan;97(1):79-86.

 

During pregnancy, a specialized type of NK cell accumulates in the lining of the uterus (decidua) and interacts with semiallogeneic fetal trophoblast cells. dNK cells are functionally and phenotypically distinct from PB NK and are implicated in regulation of trophoblast transformation ...

Last Updated: 6 Jan 2015

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Differential expression of microRNAs in decidua-derived mesenchymal stem cells from patients with pre-eclampsia.
 

Author(s): Guangfeng Zhao, Xue Zhou, Shiwen Chen, Huishuang Miao, Hongye Fan, Zhiqun Wang, Yali Hu, Yayi Hou

Journal:

 

Mesenchymal stem cells (MSCs) at maternal-fetal interface are considered to play an important role in the pathogenesis of pre-eclampsia (PE). microRNAs (miRNAs) also have an important influence on differentiation, maturation, and functions of MSCs. Our aim in this study was to determine ...

Last Updated: 30 Aug 2014

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Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia.
 

Author(s): Hong Wa Yung, Daniel Atkinson, Tim Campion-Smith, Matts Olovsson, D Stephen Charnock-Jones, Graham J Burton

Journal: J. Pathol.. 2014 Oct;234(2):262-76.

 

Based on gestational age at diagnosis and/or delivery, pre-eclampsia (PE) is commonly divided into early-onset (<34 weeks) and late-onset (≥34 weeks) forms. Recently, the distinction between 'placental' and 'maternal' causation has been proposed, with 'placental' cases being more ...

Last Updated: 10 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Eclampsia" returned 75 free, full-text review articles on human participants. First 3 results:

Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary.
 

Author(s): G J Hofmeyr, J M Belizán, P von Dadelszen,

Journal: BJOG. 2014 Jul;121(8):951-7.

 

Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic ...

Last Updated: 24 Jun 2014

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Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis.
 

Author(s): Elina Hyppönen, Alana Cavadino, David Williams, Abigail Fraser, Attila Vereczkey, William D Fraser, Ferenc Bánhidy, Deborah Lawlor, Andrew E Czeizel

Journal: Ann. Nutr. Metab.. 2013 ;63(4):331-40.

 

Vitamin D may protect from pre-eclampsia through influences on immune modulation and vascular function. To evaluate the role of vitamin D in the development of pre-eclampsia, we conducted a systematic review and meta-analysis including novel data from 2 large-scale epidemiological studies.

Last Updated: 25 Mar 2014

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Pre-eclampsia and cardiovascular disease.
 

Author(s): Christina W Chen, Iris Z Jaffe, S Ananth Karumanchi

Journal: Cardiovasc. Res.. 2014 Mar;101(4):579-86.

 

Heart disease is the leading cause of death in women in all countries. A history of pre-eclampsia, one of the most deadly hypertensive complications of pregnancy, increases cardiovascular risk by two to four times, which is comparable with the risk induced by smoking. Substantial ...

Last Updated: 5 Mar 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Community Level Interventions for Pre-eclampsia
 

Status: Recruiting

Condition Summary: Pre-eclampsia; Hypertension, Pregnancy Induced

 

Last Updated: 23 Dec 2014

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The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia; Eclampsia

 

Last Updated: 16 Mar 2014

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Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
 

Status: Recruiting

Condition Summary: Pre-eclampsia; Intra-uterine Growth Restriction

 

Last Updated: 8 Apr 2015

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