Congenital adrenal hyperplasia

Common Name(s)

Congenital adrenal hyperplasia, Adrenogenital syndrome

Adrenogenital syndrome, also called congenital adrenal hyperplasia (CAH), is a group of genetic disorders. These conditions cause various abnormalities in the adrenal glands and a person’s hormones, which are a chemical produced in the adrenal glands and used to send signals throughout the body. In these conditions, some hormones are unable to be produced and some are also overproduced. This can result in high blood pressure and electrolyte abnormalities in infants born with this condition. It can also cause abnormal genitalia development in both males and females. Patients are usually diagnosed with these conditions at birth or when delayed puberty is apparent. These conditions can be controlled using steroid replacements, although underdevelopment of male genitalia is often permanent and requires specialist involvement.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital adrenal hyperplasia" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital adrenal hyperplasia" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital adrenal hyperplasia" returned 326 free, full-text research articles on human participants. First 3 results:

Cardiovascular risk factors and increased carotid intima-media thickness in young patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
 

Author(s): Tânia Maria Barreto Rodrigues, Cristina Botelho Barra, Jovita Lane Soares Santos, Eugênio Marcos Andrade Goulart, Adaliene Versiani Matos Ferreira, Ivani Novato Silva

Journal: Arch Endocrinol Metab. 2015 Dec;59(6):541-7.

 

Increased arterial intima-media thickness has been observed in adults with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). CAH has also been associated with obesity, insulin resistance, and hypertension. The aim of the present study was to compare youths ...

Last Updated: 17 Dec 2015

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Newborn screening for congenital adrenal hyperplasia in Tokyo, Japan from 1989 to 2013: a retrospective population-based study.
 

Author(s): Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Toshikazu Onishi, Makoto Ono, Tomohiro Morio, Teruo Kitagawa, Kenichi Kashimada

Journal:

 

Congenital adrenal hyperplasia (CAH) cause life-threatening adrenal crisis. It also affects fetal sex development and can result in incorrect sex assignment at birth. In 1989, a newborn screening program for congenital adrenal hyperplasia (CAH) was introduced in Tokyo. Here we present ...

Last Updated: 16 Dec 2015

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CYP21A2 gene mutation in South Indian children with congenital adrenal hyperplasia.
 

Author(s): Ramaswamy Ganesh, Natarajan Suresh, Lalitha Janakiraman, Karnam Ravikumar

Journal: Indian Pediatr. 2015 Aug;52(8):710-1.

 

Last Updated: 21 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital adrenal hyperplasia" returned 32 free, full-text review articles on human participants. First 3 results:

Adrenal steroidogenesis and congenital adrenal hyperplasia.
 

Author(s): Adina F Turcu, Richard J Auchus

Journal: Endocrinol. Metab. Clin. North Am.. 2015 Jun;44(2):275-96.

 

Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under the stimulation of ACTH and other regulators. The syntheses of mineralocorticoids (primarily aldosterone), glucocorticoids (primarily cortisol), and adrenal androgens (primarily dehydroepiandrosterone ...

Last Updated: 3 Jun 2015

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The role of imaging in congenital adrenal hyperplasia.
 

Author(s): Sara Reis Teixeira, Paula Condé Lamparelli Elias, Marco Túlio Soares Andrade, Andrea Farias Melo, Jorge Elias Junior

Journal: Arq Bras Endocrinol Metabol. 2014 Oct;58(7):701-8.

 

Congenital adrenal hyperplasia (CAH) is an autossomic recessive disorder caused by impaired steroidogenesis. Patients with CAH may present adrenal insufficiency with or without salt-wasting, as well as various degrees of virilization and fertility impairment, carrying a high incidence ...

Last Updated: 6 Nov 2014

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[Congenital adrenal hyperplasia in the adult women: management of old and new challenges].
 

Author(s): Flávia A Costa-Barbosa, Mariana Telles-Silveira, Claudio E Kater

Journal: Arq Bras Endocrinol Metabol. 2014 Mar;58(2):124-31.

 

Due to major improvements in the management and therapy of patients with congenital adrenal hyperplasia owing to 21-hydroxylase deficiency (21OHD) along childhood and adolescence, affected women are able to reach adulthood. Therefore, management throughout adult life became even more ...

Last Updated: 16 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of ATR-101 for the Treatment of Congenital Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: Congenital Adrenal Hyperplasia

 

Last Updated: 14 Jun 2016

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COrticosteroid in Congenital Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: Congenital Adrenal Hyperplasia

 

Last Updated: 15 Sep 2015

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Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: Congenital Adrenal Hyperplasia

 

Last Updated: 17 Mar 2016

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