Dystonia

Common Name(s)

Dystonia

Dystonia is a condition that causes your muscles to spontaneously contract, or movement without control. Examples include: uncontrolled blinking, repetitive twisting of your head, and voice changes (e.g. whispering or soft voice). Dystonia can be caused by dysfunction in nerve cell communication, or the way your brain communicates with your muscles, as well as other disease such as Parkinson's disorder, Huntington's disease, strokes, brain tumors. Side effects of dystonia include pain, difficulty with jaw movement or functional blindness. Treatment for dystonia can include oral medications, physical therapy,speech therapy, brain stimulation. There are also alternative medicine options such as yoga, meditation, pilates that can be done at home.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Dystonia Medical Research Foundation

The mission of the DMRF is to advance research for more effective treatments and ultimately a cure for dystonia, to promote awareness and education, and to support the well being of dystonia affected individuals and families.

Last Updated: 29 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

Last Updated: 9 Nov 2012

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The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

Last Updated: 15 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Dystonia Medical Research Foundation

The mission of the DMRF is to advance research for more effective treatments and ultimately a cure for dystonia, to promote awareness and education, and to support the well being of dystonia affected individuals and families.

http://www.dystonia-foundation.org

Last Updated: 29 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

http://www.dysphonia.org/

Last Updated: 9 Nov 2012

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The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

https://www.dystonia-parkinson.org

Last Updated: 15 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dystonia" returned 733 free, full-text research articles on human participants. First 3 results:

Exploratory structural assessment in craniocervical dystonia: Global and differential analyses.
 

Author(s): Larissa Vilany, Thiago J R de Rezende, Luiza G Piovesana, Lidiane S Campos, Paula C de Azevedo, Fabio R Torres, Marcondes C França, Augusto C Amato-Filho, Iscia Lopes-Cendes, Fernando Cendes, Anelyssa D'Abreu

Journal:

 

Our goal was to investigate the cortical thickness and subcortical volume in subjects with craniocervical dystonia and its subgroups.

Last Updated: 31 Dec 1969

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Pramipexole-induced limb dystonia and its associated complex regional pain syndrome in idiopathic Parkinson's disease: A case report.
 

Author(s): Donghwi Park

Journal: Medicine (Baltimore). 2017 Jul;96(28):e7530.

 

This case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (D1R) boosted by pramipexole binding on dopamine 3-like receptor (D3R) in a situation where D3R was overexpressed by the chronic treatment of L-dopa.

Last Updated: 31 Dec 1969

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Psychiatric associations of adult-onset focal dystonia phenotypes.
 

Author(s): Brian D Berman, Johanna Junker, Erika Shelton, Stefan H Sillau, H A Jinnah, Joel S Perlmutter, Alberto J Espay, Joseph Jankovic, Marie Vidailhet, Cecilia Bonnet, William Ondo, Irene A Malaty, Ramón Rodríguez, William M McDonald, Laura Marsh, Mateusz Zurowski, Tobias Bäumer, Norbert Brüggemann

Journal: J. Neurol. Neurosurg. Psychiatry. 2017 Jul;88(7):595-602.

 

Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dystonia" returned 107 free, full-text review articles on human participants. First 3 results:

The Role of TOR1A Polymorphisms in Dystonia: A Systematic Review and Meta-Analysis.
 

Author(s): Vasileios Siokas, Efthimios Dardiotis, Evangelia E Tsironi, Georgios Tsivgoulis, Dimitrios Rikos, Maria Sokratous, Stylianos Koutsias, Konstantinos Paterakis, Georgia Deretzi, Georgios M Hadjigeorgiou

Journal:

 

A number of genetic loci were found to be associated with dystonia. Quite a few studies have been contacted to examine possible contribution of TOR1A variants to the risk of dystonia, but their results remain conflicting. The aim of the present study was to systematically evaluate ...

Last Updated: 31 Dec 1969

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Understanding dystonia: diagnostic issues and how to overcome them.
 

Author(s): Sarah Camargos, Francisco Cardoso

Journal: Arq Neuropsiquiatr. 2016 Nov;74(11):921-936.

 

The diagnosis and treatment of dystonia are challenging. This is likely due to gaps in the complete understanding of its pathophysiology, lack of animal models for translational studies, absence of a consistent pathological substrate and highly variable phenotypes and genotypes. The ...

Last Updated: 31 Dec 1969

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Contribution of TMS and rTMS in the Understanding of the Pathophysiology and in the Treatment of Dystonia.
 

Author(s): Pierre Lozeron, Aurélia Poujois, Alexandra Richard, Sana Masmoudi, Elodie Meppiel, France Woimant, Nathalie Kubis

Journal:

 

Dystonias represent a heterogeneous group of movement disorders responsible for sustained muscle contraction, abnormal postures, and muscle twists. It can affect focal or segmental body parts or be generalized. Primary dystonia is the most common form of dystonia but it can also be ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 29 Sep 2017

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Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia
 

Status: Recruiting

Condition Summary: Dystonia

 

Last Updated: 9 Oct 2017

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Transcranial Magnetic Stimulation for Focal Hand Dystonia
 

Status: Recruiting

Condition Summary: Dystonia

 

Last Updated: 18 Oct 2017

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