Dystonia

Common Name(s)

Dystonia

Dystonia is a condition that causes your muscles to spontaneously contract, or movement without control. Examples include: uncontrolled blinking, repetitive twisting of your head, and voice changes (e.g. whispering or soft voice). Dystonia can be caused by dysfunction in nerve cell communication, or the way your brain communicates with your muscles, as well as other disease such as Parkinson's disorder, Huntington's disease, strokes, brain tumors. Side effects of dystonia include pain, difficulty with jaw movement or functional blindness. Treatment for dystonia can include oral medications, physical therapy,speech therapy, brain stimulation. There are also alternative medicine options such as yoga, meditation, pilates that can be done at home.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Dystonia Medical Research Foundation

The mission of the DMRF is to advance research for more effective treatments and ultimately a cure for dystonia, to promote awareness and education, and to support the well being of dystonia affected individuals and families.

Last Updated: 29 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

Last Updated: 9 Nov 2012

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The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Dystonia Medical Research Foundation

The mission of the DMRF is to advance research for more effective treatments and ultimately a cure for dystonia, to promote awareness and education, and to support the well being of dystonia affected individuals and families.

http://www.dystonia-foundation.org

Last Updated: 29 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

http://www.dysphonia.org/

Last Updated: 9 Nov 2012

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The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

https://www.dystonia-parkinson.org

Last Updated: 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dystonia" returned 636 free, full-text research articles on human participants. First 3 results:

Mutations in HPCA cause autosomal-recessive primary isolated dystonia.
 

Author(s): Gavin Charlesworth, Plamena R Angelova, Fernando Bartolomé-Robledo, Mina Ryten, Daniah Trabzuni, Maria Stamelou, Andrey Y Abramov, Kailash P Bhatia, Nicholas W Wood

Journal: Am. J. Hum. Genet.. 2015 Apr;96(4):657-65.

 

Reports of primary isolated dystonia inherited in an autosomal-recessive (AR) manner, often lumped together as "DYT2 dystonia," have appeared in the scientific literature for several decades, but no genetic cause has been identified to date. Using a combination of homozygosity mapping ...

Last Updated: 4 Apr 2015

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Subacute sclerosing panencephalitis masquerading as rapid-onset dystonia-Parkinsonism in a child.
 

Author(s): Lakshminarayanan Kannan, Puneet Jain, Suvasini Sharma, Sheffali Gulati

Journal: Neurol India. ;63(1):109-10.

 

Last Updated: 10 Mar 2015

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Levetiracetam for tardive dystonia: a case report.
 

Author(s): Ajish Mangot, Satyakant Trivedi, Ravindra Kurrey, Vaibhav Dubey

Journal: Neurol India. ;62(5):559-60.

 

Last Updated: 12 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dystonia" returned 84 free, full-text review articles on human participants. First 3 results:

Shock waves in the treatment of muscle hypertonia and dystonia.
 

Author(s): Laura Mori, Lucio Marinelli, Elisa Pelosin, Antonio Currà, Luigi Molfetta, Giovanni Abbruzzese, Carlo Trompetto

Journal: Biomed Res Int. 2014 ;2014():637450.

 

Since 1997, focused shock waves therapy (FSWT) has been reported to be useful in the treatment of muscle hypertonia and dystonia. More recently, also radial shock wave therapy (RSWT) has been successfully used to treat muscle hypertonia. The studies where FSWT and RSWT have been used ...

Last Updated: 13 Oct 2014

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Imaging insights into basal ganglia function, Parkinson's disease, and dystonia.
 

Author(s): A Jon Stoessl, Stephane Lehericy, Antonio P Strafella

Journal: Lancet. 2014 Aug;384(9942):532-44.

 

Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. ...

Last Updated: 11 Aug 2014

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Clinical spectrum of dopa-responsive dystonia and related disorders.
 

Author(s): Woong-Woo Lee, Beom Seok Jeon

Journal: Curr Neurol Neurosci Rep. 2014 Jul;14(7):461.

 

Dopa-responsive dystonia (DRD) has a classic presentation of childhood or adolescent-onset dystonia, mild parkinsonism, marked diurnal fluctuations, improvement with sleep or rest, and a dramatic and sustained response to low doses of L-dopa without motor fluctuations or dyskinesias. ...

Last Updated: 21 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity
 

Status: Recruiting

Condition Summary: Dystonia; Focal Dystonia; Musician's Dystonia; Muscle Spasticity

 

Last Updated: 24 Dec 2014

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Neuroimaging of Dystonia
 

Status: Recruiting

Condition Summary: Primary Cervical Dystonia; DYT 1 Dystonia

 

Last Updated: 1 Jun 2015

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Novel Stimulation Patterns for the Treatment of Dystonia
 

Status: Not yet recruiting

Condition Summary: Dystonia; Cervical Dystonia

 

Last Updated: 8 Jun 2015

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