Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

Last Updated: 9 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

http://www.netpatientfoundation.org

Last Updated: 9 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 213 free, full-text research articles on human participants. First 3 results:

First Case Report of a Sporadic Adrenocortical Carcinoma With Gastric Metastasis and a Synchronous Gastrointestinal Stromal Tumor of the Stomach.
 

Author(s): Attila Kovecsi, Ioan Jung, Tivadar Bara, Tivadar Bara, Leonard Azamfirei, Zsolt Kovacs, Simona Gurzu

Journal: Medicine (Baltimore). 2015 Sep;94(37):e1549.

 

Adrenocortical carcinoma is a rare tumor with high aggresivity that can associate systemic metastases. A 71-year-old man was hospitalized for gastric cancer. The abdominal computed tomography also revealed a tumor above the right kidney. Total gastrectomy and right adrenalectomy were ...

Last Updated: 17 Sep 2015

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Adrenocortical carcinoma with renal vein tumor thrombus extension.
 

Author(s): Saeid Haghdani, Reza Kafash Nayeri, Homayoun Zargar, Mohammad Ali Zargar

Journal:

 

Last Updated: 23 Feb 2015

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Brain metastasis in patients with adrenocortical carcinoma: a clinical series.
 

Author(s): Mauricio Burotto, Nishant Tageja, Avi Rosenberg, Sowmya Mahalingam, Martha Quezado, Margarita Velarde, Maureen Edgerly, Tito Fojo

Journal: J. Clin. Endocrinol. Metab.. 2015 Feb;100(2):331-6.

 

Adrenocortical carcinoma (ACC) is a heterogeneous and rare disease. At presentation or at the time of a recurrence, the disease commonly spreads to the liver, lungs, lymph nodes, and bones. The brain has only rarely been reported as a site of metastases.

Last Updated: 9 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 24 free, full-text review articles on human participants. First 3 results:

Current and emerging therapies for adrenocortical carcinoma--review.
 

Author(s): Justyna Przytulska, Natalia Rogala, Grażyna Bednarek-Tupikowska

Journal: Adv Clin Exp Med. ;24(2):185-93.

 

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Patients may present with hormone excess or a local mass effect. The most common imaging techniques (CT and MRI) use both size and appearance to distinguish between benign and malignant tumors. Open surgery by ...

Last Updated: 1 May 2015

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Giant nonfunctioning adrenocortical carcinoma: a case report and review of the literature.
 

Author(s): Ahmad Almarzouq, Sami Asfar, Sundus Hussain, Adel Al-Hunayan, Saad Aldousari

Journal:

 

Adrenocortical carcinoma is a rare and aggressive malignancy. Patients usually present early with manifestation of abnormal hormone secretion. However, adrenocortical carcinoma can also be nonfunctioning, and such patients present late with a mass effect or distant metastases.

Last Updated: 5 Nov 2014

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Adrenocortical carcinoma: the management of metastatic disease.
 

Author(s): André P Fay, Aymen Elfiky, Gabriela H Teló, Rana R McKay, Marina Kaymakcalan, Paul L Nguyen, Anand Vaidya, Daniel T Ruan, Joaquim Bellmunt, Toni K Choueiri

Journal: Crit. Rev. Oncol. Hematol.. 2014 Nov;92(2):123-32.

 

Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing ...

Last Updated: 2 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Adrenal Cancer; ACC

 

Last Updated: 20 May 2015

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Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Peritoneal Carcinomatosis

 

Last Updated: 5 Jan 2016

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German Adrenocortical Carcinoma Registry
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 6 Sep 2015

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