Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

Last Updated: 9 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

http://www.netpatientfoundation.org

Last Updated: 9 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 283 free, full-text research articles on human participants. First 3 results:

Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: A case report and literature review.
 

Author(s): Ying He, Lian Xu, Qingli Li, Min Feng, Wei Wang

Journal: Medicine (Baltimore). 2018 May;97(20):e10730.

 

Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors.

Last Updated: 31 Dec 1969

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Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma.
 

Author(s): Rui Kuai, Chitra Subramanian, Peter T White, Barbara N Timmermann, James J Moon, Mark S Cohen, Anna Schwendeman

Journal:

 

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival rate of <35%. ACC cells require cholesterol for steroid hormone production, and this requirement is met via expression on the cell surface of a high level of SRB1, responsible for the uptake of ...

Last Updated: 31 Dec 1969

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Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study.
 

Author(s): Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht, Ulrich Steger,

Journal:

 

Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can be achieved. To date there are only limited data on the outcome after surgical ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 40 free, full-text review articles on human participants. First 3 results:

MANAGEMENT OF ENDOCRINE DISEASE: Adrenocortical carcinoma: differentiating the good from the poor prognosis tumors.
 

Author(s): Anne Jouinot, Jérôme Bertherat

Journal: Eur. J. Endocrinol.. 2018 May;178(5):R215-R230.

 

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However, there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the ...

Last Updated: 31 Dec 1969

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Adrenocortical Oncocytic Carcinoma: A Case Report and Review of the Histopathologic Diagnostic Criteria.
 

Author(s): Deniz Arik, Funda Canaz, Emine Dündar

Journal: Turk Patoloji Derg. 2016 ;32(3):211-5.

 

Oncocytic tumors are rare in the adrenal gland. The histopathological diagnosis of adrenocortical carcinoma is difficult due to the lack of precise diagnostic criteria for malignancy. A 44-year-old man was admitted to our hospital with left flank pain. Radiologically an adrenal mass ...

Last Updated: 31 Dec 1969

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Molecular pathways of human adrenocortical carcinoma - translating cell signalling knowledge into diagnostic and treatment options.
 

Author(s): Paulina Szyszka, Ashley B Grossman, Salvador Diaz-Cano, Krzysztof Sworczak, Dorota Dworakowska

Journal: Endokrynol Pol. 2016 ;67(4):427-50.

 

Adrenocortical carcinoma is associated with a low cure rate and a high recurrence rate. The prognosis is poor, and at diagnosis 30-40% of cases are already metastatic. The current therapeutic options (surgical resection, followed by adjuvant mitotane treatment +/- chemotherapy) are ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Apr 2018

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Cabozantinib in Unresectable/Metastatic Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 7 May 2018

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Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 8 May 2018

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