Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

View Details
Logo
NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

Last Updated: 9 Nov 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
Logo
NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

http://www.netpatientfoundation.org

Last Updated: 9 Nov 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 241 free, full-text research articles on human participants. First 3 results:

Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature.
 

Author(s): Nada El Ghorayeb, Geneviève Rondeau, Mathieu Latour, Christian Cohade, Harold Olney, André Lacroix, Paul Perrotte, Alexis Sabourin, Tania L Mazzuco, Isabelle Bourdeau

Journal: Medicine (Baltimore). 2016 Mar;95(13):e3180.

 

Mitotane has been used for more than 5 decades as therapy for adrenocortical carcinoma (ACC). However its mechanism of action and the extent of tumor response remain incompletely understood. To date no cases of rapid and complete remission of metastatic ACC with mitotane monotherapy ...

Last Updated: 5 Apr 2016

Go To URL
Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group.
 

Author(s): Lauren M Postlewait, Cecilia G Ethun, Thuy B Tran, Jason D Prescott, Timothy M Pawlik, Tracy S Wang, Jason Glenn, Ioannis Hatzaras, Rivfka Shenoy, John E Phay, Kara Keplinger, Ryan C Fields, Linda X Jin, Sharon M Weber, Ahmed Salem, Jason K Sicklick, Shady Gad, Adam C Yopp, John C Mansour, Quan-Yang Duh, Natalie Seiser, Carmen C Solorzano, Colleen M Kiernan, Konstantinos I Votanopoulos, Edward A Levine, Charles A Staley, George A Poultsides, Shishir K Maithel

Journal: J. Am. Coll. Surg.. 2016 Apr;222(4):480-90.

 

Current treatment guidelines recommend adjuvant mitotane after resection of adrenocortical carcinoma with high-risk features (eg, tumor rupture, positive margins, positive lymph nodes, high grade, elevated mitotic index, and advanced stage). Limited data exist on the outcomes associated ...

Last Updated: 28 Mar 2016

Go To URL
Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report.
 

Author(s): Kennosuke Ohashi, Takeshi Hayashi, Masaya Sakamoto, Hiroyuki Iuchi, Hirofumi Suzuki, Takanori Ebisawa, Katsuyoshi Tojo, Hironobu Sasano, Kazunori Utsunomiya

Journal:

 

Aldosterone-producing adrenocortical carcinoma is a rare malignancy, which is usually diagnosed by histopathological examination of the excised tumor. In inoperable cases, aldosterone-producing ACC diagnosed by immunohistochemical staining of the metastatic tumor for Cytochrome P450 ...

Last Updated: 16 Jan 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 31 free, full-text review articles on human participants. First 3 results:

Assessment and management of advanced adrenocortical carcinoma using a precision oncology care model.
 

Author(s): Aymen A Elfiky, Hari K Krishnan Nair

Journal: Discov Med. 2016 Jan;21(113):49-56.

 

Within the category of orphan diseases and rare malignancies, adrenocortical carcinoma (ACC) represents an aggressive entity with high mortality and morbidity. While localized tumors which are diagnosed early can be cured with surgical intervention, there are prognostic factors which ...

Last Updated: 21 Feb 2016

Go To URL
Future directions in the diagnosis and medical treatment of adrenocortical carcinoma.
 

Author(s): S G Creemers, L J Hofland, E Korpershoek, G J H Franssen, F J van Kemenade, W W de Herder, R A Feelders

Journal: Endocr. Relat. Cancer. 2016 Jan;23(1):R43-69.

 

Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. Discrimination between ACCs and adrenocortical adenomas (ACAs) remains challenging, with the current gold standard being the Weiss score, consisting of several histopathological characteristics. However, new markers ...

Last Updated: 26 Nov 2015

Go To URL
Developing treatment for adrenocortical carcinoma.
 

Author(s): T M A Kerkhofs, M H T Ettaieb, I G C Hermsen, H R Haak

Journal: Endocr. Relat. Cancer. 2015 Dec;22(6):R325-38.

 

Cancer of the adrenal cortex (ACC) is a rare endocrine malignancy with limited treatment options. Patients typically present with autonomous hormonal overproduction and/or a large abdominal mass. Hormonal assays and medical imaging can be diagnostic, but urinary steroid profiling ...

Last Updated: 13 Oct 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

German Adrenocortical Carcinoma Registry
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 28 Oct 2016

Go to URL
Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 7 Oct 2016

Go to URL
Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Peritoneal Carcinomatosis

 

Last Updated: 1 Dec 2016

Go to URL