Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 163 free, full-text research articles on human participants. First 3 results:

Metastatic adrenocortical carcinoma with a prolonged response to mitotane.
 

Author(s): Sumanta K Pal, Benjamin Gartrell, Carl A Olsson, C A Stein

Journal: Oncology (Williston Park, N.Y.). 2014 Jul;28(7):624-5, 642.

 

Last Updated: 22 Aug 2014

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Histopathological study of adrenocortical carcinoma with special reference to the Weiss system and TNM staging and the role of immunohistochemistry to differentiate it from renal cell carcinoma.
 

Author(s): Santosh Kumar Mondal, Senjuti Dasgupta, Parul Jain, Palash Kumar Mandal, Swapan Kumar Sinha

Journal: J Cancer Res Ther. ;9(3):436-41.

 

Adrenocortical carcinomas (ACC) are rare tumors with an incidence of 1-2/million/year. They account for 0.05-0.2% of all malignancies.

Last Updated: 15 Oct 2013

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Adrenocortical carcinoma initially presenting with hypokalemia and hypertension mimicking hyperaldosteronism: a case report.
 

Author(s): Chun-Jui Huang, Ti-Hao Wang, Yuan-Hao Lo, Kuan-Ting Hou, Justin Ging-Shing Won, Tjin-Shing Jap, Chin-Sung Kuo

Journal:

 

Adrenocortical carcinoma is a rare malignancy and rare cause of Cushing's syndrome.

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 18 free, full-text review articles on human participants. First 3 results:

EJE prize 2014: current and evolving treatment options in adrenocortical carcinoma: where do we stand and where do we want to go?
 

Author(s): Cristina L Ronchi, Matthias Kroiss, Silviu Sbiera, Timo Deutschbein, Martin Fassnacht

Journal: Eur. J. Endocrinol.. 2014 Jul;171(1):R1-R11.

 

Adrenocortical carcinoma (ACC) is not only a rare and heterogeneous disease but also one of the most aggressive endocrine tumors. Despite significant advances in the last decade, its pathogenesis is still only incompletely understood and overall therapeutic means are unsatisfactory. ...

Last Updated: 10 Jun 2014

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An unusual presentation of congenital adrenocortical carcinoma: a case report and review of the literature.
 

Author(s): Manphool Singhal, Mandeep Kang, Alka Khadwal, Rajan Duggal, Arvind Rajwanshi, Niranjan Khandelwal

Journal:

 

We describe a case of congenital non-functional adrenocortical carcinoma in a male infant who presented with recurrent pneumonia, paraparesis and sclerotic skeletal metastasis. To the best of our knowledge such presentation has never been reported.

Last Updated: 30 Apr 2012

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Adrenocortical stem and progenitor cells: implications for adrenocortical carcinoma.
 

Author(s): Derek P Simon, Gary D Hammer

Journal: Mol. Cell. Endocrinol.. 2012 Mar;351(1):2-11.

 

The continuous centripetal repopulation of the adrenal cortex is consistent with a population of cells endowed with the stem/progenitor cell properties of self-renewal and pluripotency. The adrenocortical capsule and underlying undifferentiated cortical cells are emerging as critical ...

Last Updated: 20 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Adrenal Cancer; ACC

 

Last Updated: 21 Aug 2014

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Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Peritoneal Carcinomatosis

 

Last Updated: 14 Mar 2014

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German Adrenocortical Carcinoma Registry
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 7 Jul 2010

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