Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 164 free, full-text research articles on human participants. First 3 results:

Histopathological study of adrenocortical carcinoma with special reference to the Weiss system and TNM staging and the role of immunohistochemistry to differentiate it from renal cell carcinoma.
 

Author(s): Santosh Kumar Mondal, Senjuti Dasgupta, Parul Jain, Palash Kumar Mandal, Swapan Kumar Sinha

Journal: J Cancer Res Ther. ;9(3):436-41.

 

Adrenocortical carcinomas (ACC) are rare tumors with an incidence of 1-2/million/year. They account for 0.05-0.2% of all malignancies.

Last Updated: 15 Oct 2013

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Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?
 

Author(s): Cristina L Ronchi, Silviu Sbiera, Ellen Leich, Katharina Henzel, Andreas Rosenwald, Bruno Allolio, Martin Fassnacht

Journal:

 

Adrenocortical tumors consist of benign adenomas and highly malignant carcinomas with a still incompletely understood pathogenesis. A total of 46 adrenocortical tumors (24 adenomas and 22 carcinomas) were investigated aiming to identify novel genes involved in adrenocortical tumorigenesis. ...

Last Updated: 25 Sep 2013

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Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma.
 

Author(s): Reju Korah, James M Healy, John W Kunstman, Annabelle L Fonseca, Amir H Ameri, Manju L Prasad, Tobias Carling

Journal:

 

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease ...

Last Updated: 13 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 19 free, full-text review articles on human participants. First 3 results:

EJE prize 2014: current and evolving treatment options in adrenocortical carcinoma: where do we stand and where do we want to go?
 

Author(s): Cristina L Ronchi, Matthias Kroiss, Silviu Sbiera, Timo Deutschbein, Martin Fassnacht

Journal: Eur. J. Endocrinol.. 2014 Jul;171(1):R1-R11.

 

Adrenocortical carcinoma (ACC) is not only a rare and heterogeneous disease but also one of the most aggressive endocrine tumors. Despite significant advances in the last decade, its pathogenesis is still only incompletely understood and overall therapeutic means are unsatisfactory. ...

Last Updated: 10 Jun 2014

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An unusual presentation of congenital adrenocortical carcinoma: a case report and review of the literature.
 

Author(s): Manphool Singhal, Mandeep Kang, Alka Khadwal, Rajan Duggal, Arvind Rajwanshi, Niranjan Khandelwal

Journal:

 

We describe a case of congenital non-functional adrenocortical carcinoma in a male infant who presented with recurrent pneumonia, paraparesis and sclerotic skeletal metastasis. To the best of our knowledge such presentation has never been reported.

Last Updated: 30 Apr 2012

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Adrenocortical stem and progenitor cells: implications for adrenocortical carcinoma.
 

Author(s): Derek P Simon, Gary D Hammer

Journal: Mol. Cell. Endocrinol.. 2012 Mar;351(1):2-11.

 

The continuous centripetal repopulation of the adrenal cortex is consistent with a population of cells endowed with the stem/progenitor cell properties of self-renewal and pluripotency. The adrenocortical capsule and underlying undifferentiated cortical cells are emerging as critical ...

Last Updated: 20 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Peritoneal Carcinomatosis

 

Last Updated: 14 Mar 2014

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Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma; Adrenal Cancer; ACC

 

Last Updated: 21 Aug 2014

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Natural History and Tissue Acquisition Study of Adrenocortical Carcinoma
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 14 Mar 2014

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